EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2-butyl-3-methyl pyrazine
pyrazine, 2-butyl-3-methyl-

Sponsors

Name:2-butyl-3-methylpyrazine
CAS Number: 15987-00-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:240-126-5
Nikkaji Web:J208.107E
MDL:MFCD00038031
XlogP3:2.10 (est)
Molecular Weight:150.22458000
Formula:C9 H14 N2
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
FLAVIS Number:14.091 (Old)
DG SANTE Food Flavourings:14.091 2-butyl-3-methylpyrazine
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 100.00 °C. @ 760.00 mm Hg
Boiling Point: 212.00 to 214.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.059000 mm/Hg (est)
Flash Point: 181.00 °F. TCC ( 83.00 °C. ) (est)
logP (o/w): 2.100
Soluble in:
 alcohol
 water, 1218 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Type: licorice
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
anise licorice
Odor Description:at 0.10 % in propylene glycol. anise licorice
Flavor Type: licorice
anise licorice
Taste Description: anise-like, licorice
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Beijing Lys Chemicals
2-Butyl-3-methylpyrazine
BOC Sciences
For experimental / research use only.
2-Butyl-3-methylpyrazine
Jinan Enlighten Chemical Technology(Wutong Aroma )
2-Butyl-3-methyl pyrazine
Penta International
2-BUTYL-3-METHYL PYRAZINE
Synerzine
2-Butyl-3-Methylpyrazine
TCI AMERICA
For experimental / research use only.
2-Butyl-3-methylpyrazine >97.0%(GC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for 2-butyl-3-methyl pyrazine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.12 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 270 (μg/person/day)
Threshold of Concern:540 (μg/person/day)
Structure Class: II
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.400002.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.100000.50000
Edible ices, including sherbet and sorbet (03.0): 0.400002.00000
Processed fruit (04.1): 0.400002.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 1.000005.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 1.000005.00000
Meat and meat products, including poultry and game (08.0): 0.100000.40000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.100000.40000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.100000.50000
Foodstuffs intended for particular nutritional uses (13.0): 0.200001.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 0.200001.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 1.000005.00000
Ready-to-eat savouries (15.0): 1.000005.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.200001.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 3 (FGE.17Rev3): Pyrazine derivatives from chemical group 24
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):15987-00-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :85228
National Institute of Allergy and Infectious Diseases:Data
2-butyl-3-methylpyrazine
Chemidplus:0015987005
 
References:
 2-butyl-3-methylpyrazine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:15987-00-5
Pubchem (cid):85228
Pubchem (sid):135044527
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.99.9700
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
meta-
anisaldehyde
FL/FR
acidic
acidic
cyclohexyl acetic acid
FL/FR
alliaceous
methyl furfuryl disulfide
FL/FR
anise
anise oleoresin
FL/FR
anise seed oil
FL/FR
star
anise seed oil china
FL/FR
anise seed oil colombia
FL/FR
star
anise seed oil spain
FL/FR
star
anise seed oil terpeneless
FL/FR
sweet
fennel absolute
FL/FR
sweet
fennel oleoresin
FL/FR
anisic
ortho-
acetanisole
FL/FR
para-
acetanisole
FL/FR
amyl furoate
FL/FR
para-
anisyl phenyl acetate
FL/FR
dihydroanethol
FL/FR
estragole
FL/FR
ethyl para-anisate
FL/FR
ocimum basilicum herb oil egypt
FL/FR
ocimum basilicum leaf oil CO2 extract
FL/FR
balsamic
2-
acetyl furan
FL/FR
iso
amyl cinnamate
FL/FR
amyl cinnamate
FL/FR
amyl phenyl acetate
FL/FR
butyl cinnamate
FL/FR
guaiacyl phenyl acetate
FL/FR
caramellic
caramel furanone solution
FL/FR
caramel pentadione
FL/FR
coffee dione
FL/FR
cyclotene
FL/FR
fenugreek absolute
FL/FR
fenugreek oleoresin
FL/FR
5-
methyl furfural
FL/FR
chocolate
iso
amyl phenyl acetate
FL/FR
iso
butyl phenyl acetate
FL/FR
chocolate pyrazine A
FL/FR
cocoa hexenal
FL/FR
cocoa oleoresin
FL/FR
cocoa pentenal
FL/FR
2,6-
dimethyl pyrazine
FL/FR
2,5-
dimethyl pyrazine
FL/FR
2-
methoxy-3-methyl pyrazine
FL/FR
2-
methoxypyrazine
FL/FR
2-
methyl butyraldehyde
FL/FR
tetrahydrofurfuryl phenyl acetate
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
cocoa
2-iso
butyl-3,5-(and 3,6)-dimethyl pyrazine
FL/FR
cocoa absolute
FL/FR
theobroma cacao extract
FL/FR
coffee
cichorium intybus root extract
FL/FR
cichorium intybus root solid extract
FL/FR
coffea arabica seed extract
FL/FR
roasted arabica
coffee bean oil
FL/FR
roasted arabica
coffee bean oil CO2 extract
FL/FR
coffee difuran
FL/FR
furfuryl mercaptan
FL/FR
1-
hydroxy-2-butanone
FL/FR
2-
methyl-3-,5 or 6-(furfuryl thio) pyrazine
FL/FR
coumarinic
phthalide
FL/FR
earthy
nutty pyrazine
FL/FR
ethereal
iso
propyl formate
FL/FR
fermented
3-
methyl-1-pentanol
FL/FR
valeraldehyde
FL/FR
floral
para-
anisyl butyrate
FL/FR
benzyl phenyl acetate
FL/FR
ethyl phenyl acetate
FL/FR
lilac pentanol
FL/FR
ortho-
methyl acetophenone
FL/FR
orris rhizome resinoid (iris pallida)
FL/FR
phenethyl phenyl acetate
FL/FR
fruity
allyl phenoxyacetate
FL/FR
para-
anisyl methyl ketone
FL/FR
iso
butyl 2-butenoate
FL/FR
cherry oxyacetate
FL/FR
(E,E)-
ethyl sorbate
FL/FR
hexanal propylene glycol acetal
FL/FR
tropical thiazole
FL/FR
green
butyl 2-methyl butyrate
FL/FR
neryl butyrate
FL/FR
phenyl acetaldehyde
FL/FR
tiglaldehyde
FL/FR
herbal
thymyl methyl ether
FL/FR
gamma-
valerolactone
FL/FR
wormwood oil america
FL/FR
wormwood oil cuba
FL/FR
wormwood oil italy
FL/FR
wormwood oil poland
FL/FR
licorice
(E)-
anethol
FL/FR
glycyrrhiza glabra root extract
FL/FR
minty
carvone
FL/FR
ethyl salicylate
FL/FR
musk
omega-
pentadecalactone
FL/FR
musty
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
cocoa butenal
FL/FR
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
nutty
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-5-methyl furan
FL/FR
3,5-
cocoa pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
2,3-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2-
ethyl pyrazine
FL/FR
2-
ethyl-4-methyl thiazole
FL/FR
filbert heptenone
FL/FR
2,6-
lutidine
FL/FR
2-
methyl pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
2-
methyl-3-(methyl thio) pyrazine
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
vinyl sulfurol
FL/FR
phenolic
para-alpha-
dimethyl styrene
FL/FR
popcorn
2-
acetyl pyrazine
FL/FR
powdery
para-
anisyl acetate
FL/FR
para-
anisyl alcohol
FL/FR
roasted
fenugreek resinoid
FL/FR
spicy
homo
anisaldehyde
FL/FR
para-
anisyl formate
FL/FR
artemisia dracunculus herb oil
FL/FR
sulfurous
benzothiazole
FL/FR
furfuryl thioacetate
FL/FR
S-
furfuryl thioformate
FL/FR
2-
methyl 5-(methyl thio) furan
FL/FR
vanilla
propenyl guaethol
FL/FR
vegetable
1-
furfuryl pyrrole
FL/FR
tetrahydrofurfuryl alcohol
FL/FR
waxy
phenethyl octanoate
FL/FR
woody
juniper berry oleoresin
FL/FR
For Flavor
No flavor group found for these
amyl furoate
FL/FR
amyl phenyl acetate
FL/FR
homo
anisaldehyde
FL/FR
meta-
anisaldehyde
FL/FR
butyl 2-methyl butyrate
FL/FR
butyl cinnamate
FL/FR
2-iso
butyl-3,5-(and 3,6)-dimethyl pyrazine
FL/FR
2(4)-iso
butyl-4(2),6-dimethyl dihydro-4H-1,3,5-dithiazine
FL
carvone
FL/FR
chocolate pyrazine A
FL/FR
chocolate pyrazine B
FL
4,5-
dimethyl-2-ethyl thiazole
FL
2,5-
dimethyl-3-thiofuroyl furan
FL
4-
ethyl anisole
FL
fleabane oil (erigeron canadensis)
FL
2-
methoxypyrazine
FL/FR
2-
methyl-3-,5 or 6-(furfuryl thio) pyrazine
FL/FR
2-
methyl-3-(methyl thio) pyrazine
FL/FR
2-
methyl-3-furyl tetrasulfide
FL
peanut dithiazine
FL
pyrazines mixture
FL
rosa canina seed extract
FL
tetrahydrofurfuryl phenyl acetate
FL/FR
alliaceous
alliaceous
benzyl mercaptan
FL
dicyclohexyl disulfide
FL
tropical thiazole
FL/FR
anise
(E)-
anethol
FL/FR
anise oleoresin
FL/FR
anise seed oil
FL/FR
star
anise seed oil china
FL/FR
anise seed oil colombia
FL/FR
star
anise seed oil spain
FL/FR
star
anise seed oil terpeneless
FL/FR
ethyl para-anisate
FL/FR
sweet
fennel absolute
FL/FR
sweet
fennel oleoresin
FL/FR
anisic
para-
acetanisole
FL/FR
para-
anisyl butyrate
FL/FR
para-
anisyl phenyl acetate
FL/FR
ortho-
methyl acetophenone
FL/FR
ocimum basilicum herb oil egypt
FL/FR
balsamic
amyl cinnamate
FL/FR
bitter
methyl ethoxypyrazine
FL
paullinia cupana seed extract
FL
brown
fenugreek oleoresin
FL/FR
1-
hydroxy-2-butanone
FL/FR
5-
methyl furfural
FL/FR
burnt
furfuryl alcohol
FL
2-
methyl quinoxaline
FL
tea pyrrole
FL
caramellic
caramel furanone
FL
caramel furanone solution
FL/FR
caramel pentadione
FL/FR
cyclotene
FL/FR
fenugreek absolute
FL/FR
fenugreek resinoid
FL/FR
chocolate
cocoa oleoresin
FL/FR
cocoa propanal
FL
cocoa
iso
butyl phenyl acetate
FL/FR
butyraldehyde
FL
cocoa absolute
FL/FR
cocoa hexenal
FL/FR
theobroma cacao extract
FL/FR
coffee
cichorium intybus root extract
FL/FR
cichorium intybus root solid extract
FL/FR
coffea arabica seed extract
FL/FR
roasted arabica
coffee bean oil CO2 extract
FL/FR
coffee difuran
FL/FR
coffee dione
FL/FR
coffee distillates
FL
coffee enhancers
FL
coffee pyrazine
FL
difurfuryl ether
FL
diisoamyl thiomalate
FL
2,4-
dimethyl thiazole
FL
2-
ethyl-4-methyl thiazole
FL/FR
furfuryl mercaptan
FL/FR
methyl furfuryl disulfide
FL/FR
methyl furfuryl thiol
FL
2-
methyl-5-vinyl pyrazine
FL
2-
thiophene thiol
FL
coumarinic
phthalide
FL/FR
earthy
difurfuryl sulfide
FL
fatty
cocoa butter distillates
FL
floral
iso
amyl cinnamate
FL/FR
iso
amyl phenyl acetate
FL/FR
cocoa pentenal
FL/FR
orris rhizome resinoid (iris pallida)
FL/FR
fruity
allyl phenoxyacetate
FL/FR
para-
anisyl acetate
FL/FR
para-
anisyl alcohol
FL/FR
cherry oxyacetate
FL/FR
ethyl 3-oxohexanoate
FL
(E,E)-
ethyl sorbate
FL/FR
furfuryl isovalerate
FL
furfuryl propionate
FL
hexanal propylene glycol acetal
FL/FR
lilac pentanol
FL/FR
(E,E)-
methyl sorbate
FL
phenethyl octanoate
FL/FR
iso
propyl formate
FL/FR
tiglaldehyde
FL/FR
fusel
2-
methyl butyraldehyde
FL/FR
3-
methyl-2-butanol
FL
green
iso
butyl 2-butenoate
FL/FR
cocoa butenal
FL/FR
2-
ethyl butyraldehyde
FL
2-
methyl-5-isopropyl pyrazine
FL
neryl butyrate
FL/FR
herbal
dihydroanethol
FL/FR
ocimum basilicum leaf oil CO2 extract
FL/FR
wormwood oil america
FL/FR
wormwood oil cuba
FL/FR
wormwood oil italy
FL/FR
wormwood oil poland
FL/FR
honey
benzyl phenyl acetate
FL/FR
ethyl phenyl acetate
FL/FR
phenethyl phenyl acetate
FL/FR
phenyl acetaldehyde
FL/FR
licorice
estragole
FL/FR
glycyrrhiza glabra root extract
FL/FR
glycyrrhiza glabra root extract powder
FL
meaty
benzothiazole
FL/FR
3-
mercapto-2-butanone
FL
2-
methyl 3-(methyl thio) furan
FL
minty
ethyl salicylate
FL/FR
mustard
furfuryl methyl ether
FL
musty
2,5-
dimethyl pyrazine
FL/FR
2-
ethoxythiazole
FL
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
2-
methyl 5-(methyl thio) furan
FL/FR
propionaldehyde
FL
thymyl methyl ether
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
nutty
2-
acetyl furan
FL/FR
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-5-methyl furan
FL/FR
3,6-
cocoa pyrazine
FL/FR
3,5(6)-
cocoa pyrazine
FL
3,5-
cocoa pyrazine
FL/FR
2,6-
dimethyl pyrazine
FL/FR
2,3-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2,4-
dimethyl-5-vinyl thiazole
FL
2-
ethyl pyrazine
FL/FR
filbert heptenone
FL/FR
2,6-
lutidine
FL/FR
2-
methoxy-3-methyl pyrazine
FL/FR
2-
methyl pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
nutty pyrazine
FL/FR
nutty thiazole
FL
peanut oxazole
FL
tetrahydrofurfuryl alcohol
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
vinyl sulfurol
FL/FR
onion
furfuryl isopropyl sulfide
FL
phenolic
guaiacyl phenyl acetate
FL/FR
powdery
ortho-
acetanisole
FL/FR
powdery ketone
FL
roasted
2-
acetyl pyrazine
FL/FR
roasted arabica
coffee bean oil
FL/FR
ethyl 3-(furfuryl thio) propionate
FL
furfuryl thioacetate
FL/FR
solvent
2-
ethyl furan
FL
methyl phenyl sulfide
FL
spicy
para-
anisyl formate
FL/FR
para-
anisyl methyl ketone
FL/FR
artemisia dracunculus herb oil
FL/FR
para-alpha-
dimethyl styrene
FL/FR
sulfurous
butyl mercaptan
FL
ethyl methyl sulfide
FL
S-
ethyl thioacetate
FL
S-
furfuryl thioformate
FL/FR
furfuryl thiopropionate
FL
3-
methyl-2-butane thiol
FL
2-
thienyl mercaptan
FL
sweet
cyclohexyl acetic acid
FL/FR
neo
hesperidin dihydrochalcone
FL
tonka
gamma-
valerolactone
FL/FR
vanilla
omega-
pentadecalactone
FL/FR
propenyl guaethol
FL/FR
vegetable
1-
furfuryl pyrrole
FL/FR
whiskey
3-
methyl-1-pentanol
FL/FR
winey
valeraldehyde
FL/FR
woody
juniper berry oleoresin
FL/FR
 
Potential Uses:
FLanise
FLchocolate
FLcoffee
 
Occurrence (nature, food, other):note
 cocoa - 1 mg/kg
Search Trop Picture
 coffee
Search PMC Picture
 
Synonyms:
2-N-butyl-3-methyl pyrazine
2-butyl-3-methylpyrazine
2-N-butyl-3-methylpyrazine
2-methyl-3-butyl pyrazine
2-methyl-3-butyl-pyrazine
2-methyl-3-butylpyrazine
 pyrazine, 2-butyl-3-methyl-
 
 
Notes:
None found
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