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glycyrrhiza glabra root extract
extract of the roots of the licorice, glycyrrhiza glabra l., leguminosae

Sponsors

Name:glycyrrhiza glabra root extract
CAS Number: 84775-66-6
ECHA EC Number:283-895-2
FDA UNII:2788Z9758H
Category:cosmetic, flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1408 Glycyrrhiza View-review
184.1408 Licorice, Glycyrrhiza, and Ammoniated Glycyrrhizin View-review
FEMA Number:2628 licorice root extract
FDA Mainterm: LICORICE EXTRACT (GLYCYRRHIZA SPP.)
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1408 Licorice and licorice derivatives.
 
Physical Properties:
Appearance:black liquid to solid (est)
Food Chemicals Codex Listed: No
Specific Gravity:0.99130 to 1.06130 @ 25.00 °C.
Pounds per Gallon - (est).: 8.249 to 8.831
Refractive Index:1.34000 to 1.39000 @ 20.00 °C.
Shelf Life: 6.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light.
 
Organoleptic Properties:
Odor Type: licorice
Odor Strength:medium
sweet licorice
Odor Description:at 100.00 %. sweet licorice root
Flavor Type: licorice
">licorice
Taste Description: licorice
Odor and/or flavor descriptions from others (if found).
Frutarom
Licorice Root Extract
Taste Description:Sweet, Herbal, Roasted, Tea-like
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: bleaching agents
emollients
perfuming agents
skin conditioning
smoothing agents
soothing agents
 
Suppliers:
Advanced Biotech
LICORICE ROOT EXTRACT ORGANIC
Amax Nutrasource
Licorice Root Extract, 20% Glycyrrhizic Acid
Aromaplant
Licorice Root Extract
Flavor: characteristic
The source material of licorice extract, licorice root (Glycyrrhiza Glabra), grows in various countries, including China, Turkey, Russia and Italy. The chemical specifications, flavour and aroma of this voluntary plant are affected by climatic conditions.
Bell Flavors & Fragrances
Licorice Extract Natural
Bio-Botanica®
Licorice Root Glycyrrhiza Glabra (Licorice) Root Extract
Bio-Botanica®
Licorice Root, AF – 5498
Bio-Botanica®
Licorice Root, FE – 5083
Carrubba
licorice extract
Changsha Organic Herb
Licorice Root Extract
Chemical-navi - Nikkol
AQUA LICORICE EXTRACT P-T
Odor: characteristic
Use: Extract from licorice root with Glabridin content 1.50 - 2.50 % enhancing better whitening effect. Freely soluble in water.
Chemical-navi - Nikkol
POLYOL SOLUBLE LICORICE EXTRACT HG
Odor: characteristic
Use: Extract from licorice root with strong anti-pigmentation effect.
Chemical-navi - Nikkol
POLYOL SOLUBLE LICORICE EXTRACT P-T(40)
Odor: characteristic
Use: Licorice derivative with 40% glabridin content. Strong anti-pigmentation effect.
Frutarom
Licorice Root Extract
Flavor: Sweet, Herbal, Roasted, Tea-like
Grau Aromatics
LICORICE ROOT EXTRACT HS 2511 G
(hydrosoluble)
Grau Aromatics
LICORICE ROOT EXTRACT LS 3304 G
(liposoluble)
Haldin International
Licorice
Horner International
Licorice Extract
Indo World Trading
Glycyrrhiza Glabra (mulethi) Extract
Lipotec USA
Actiphyte® of Licorice Root Extract
Sabinsa Corporation
Glycyrrhizinic Acid
Sabinsa Corporation
Licorice Extract CG
Shank's Extracts
Licorice Root Extract, Natural
SRS Aromatics
LICORICE ROOT EXTRACT HS 2511 G
SRS Aromatics
LICORICE ROOT EXTRACT LS 3304 G
Vege Tech
licorice extract
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 14200 mg/kg

intraperitoneal-rat LD50 1420 mg/kg

oral-mouse LD50 > 7500 mg/kg

intraperitoneal-mouse LD50 1500 mg/kg

Dermal Toxicity:
subcutaneous-rat LD50 4200 mg/kg

subcutaneous-mouse LD50 4000 mg/kg

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: cosmetic, flavor and fragrance agents
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -84.00000
beverages(nonalcoholic): -33.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -29000.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -39.00000
fruit ices: -39.00000
gelatins / puddings: -4.00000
granulated sugar: --
gravies: --
hard candy: -130.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
glycyrrhiza glabra root extract
Chemidplus:0084775666
 
References:
 glycyrrhiza glabra root extract
Pubchem (sid):135314337
 
Other Information:
FDA Everything Added to Food in the United States (EAFUS):View
Export Tariff Code:1302.12.0000
Wikipedia:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
gentiana lutea root extract
FL/FR
anise
anise
anise oleoresin
FL/FR
anise seed absolute
FL/FR
anise seed concrete
FR
anise seed oil
FL/FR
star
anise seed oil china
FL/FR
anise seed oil colombia
FL/FR
star
anise seed oil spain
FL/FR
star
anise seed oil terpeneless
FL/FR
anise seed tincture
FL/FR
sweet
fennel absolute
FL/FR
sweet
fennel oleoresin
FL/FR
sweet
fennel seed oil
FL/FR
foeniculum vulgare fruit extract
FL/FR
foeniculum vulgare mill. var. dulce d.c. fruit extract
FL/FR
glycyrrhiza glabra rhizome/root
CS
glycyrrhiza glabra root
CS
licorice concrete
FR
pimpinella anisum seed extract
FL/FR
anisic
para-
anisyl propanal
FR
dihydroanethol
FL/FR
estragole
FL/FR
ethyl para-anisate
FL/FR
ocimum basilicum herb oil egypt
FL/FR
ocimum basilicum leaf oil CO2 extract
FL/FR
ocimum basilicum leaf oil india
FL/FR
sassafras acetate
FL/FR
caramellic
caramel pentadione
FL/FR
mesitene lactone
FR
citrus
2-
heptanol
FL/FR
floral
methyl ionyl acetate
FL/FR
beta-
ocimene
FL/FR
fruity
iso
butyl 2-butenoate
FL/FR
(E,E)-
ethyl sorbate
FL/FR
fruity ketal
FL/FR
hexanal propylene glycol acetal
FL/FR
herbal
1-
octen-3-yl acetate
FL/FR
thymyl methyl ether
FL/FR
tricyclo(5.2.1.02,6)dec-3-enyl acetate
FR
licorice
(E)-
anethol
FL/FR
anethol
FL/FR
sweet
basil oleoresin
FL/FR
glycyrrhiza glabra rhizome/root extract
FL/FR
glycyrrhiza glabra root tincture
FL/FR
glycyrrhiza uralensis root oil CO2 extract
FL/FR
licorice absolute
FL/FR
licorice extract
FL/FR
licorice fragrance
FR
licorice infusions
FL/FR
licorice oil
FL/FR
licorice root oil
FL/FR
ocimum basilicum herb oil poland
FL/FR
ocimum basilicum herb oil vietnam
FL/FR
ocimum basilicum leaf oil
FL/FR
ocimum basilicum leaf oil terpeneless
FL/FR
minty
bitter
fennel seed oil (foeniculum vulgare capillaceum)
FR
bitter
fennel seed oil lithuania
CS
foeniculum vulgare capillaceum fruit extract
FR
musk
omega-
pentadecalactone
FL/FR
musty
2-
acetyl pyrrole
FL/FR
nutty
2-
methyl-3-propyl pyrazine
FL/FR
powdery
para-
anisyl acetate
FL/FR
para-
anisyl alcohol
FL/FR
spicy
tarragon oil replacer
FL/FR
sweet
2-
hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one
FL/FR
waxy
waxy acetate
FR
yeasty
2-
octen-4-one
FL/FR
For Flavor
No flavor group found for these
anethol
FL/FR
fleabane oil (erigeron canadensis)
FL
2-
hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one
FL/FR
tarragon oil replacer
FL/FR
anise
anise
(E)-
anethol
FL/FR
anise oleoresin
FL/FR
anise seed absolute
FL/FR
anise seed oil
FL/FR
star
anise seed oil china
FL/FR
anise seed oil colombia
FL/FR
star
anise seed oil spain
FL/FR
star
anise seed oil terpeneless
FL/FR
anise seed tincture
FL/FR
ethyl para-anisate
FL/FR
sweet
fennel absolute
FL/FR
sweet
fennel oleoresin
FL/FR
sweet
fennel seed oil
FL/FR
foeniculum vulgare fruit extract
FL/FR
foeniculum vulgare mill. var. dulce d.c. fruit extract
FL/FR
pimpinella anisum seed extract
FL/FR
anisic
ocimum basilicum herb oil egypt
FL/FR
caramellic
caramel pentadione
FL/FR
earthy
2-
methyl-3-propyl pyrazine
FL/FR
fruity
para-
anisyl acetate
FL/FR
para-
anisyl alcohol
FL/FR
ethyl 3-oxohexanoate
FL
(E,E)-
ethyl sorbate
FL/FR
fruity ketal
FL/FR
furfuryl isovalerate
FL
2-
heptanol
FL/FR
hexanal propylene glycol acetal
FL/FR
(E,E)-
methyl sorbate
FL
green
iso
butyl 2-butenoate
FL/FR
gentiana lutea root extract
FL/FR
3-
methyl pyridine
FL
beta-
ocimene
FL/FR
1-
octen-3-yl acetate
FL/FR
propylene glycol acetone ketal
FL
herbal
dihydroanethol
FL/FR
ocimum basilicum leaf oil CO2 extract
FL/FR
ocimum basilicum leaf oil india
FL/FR
licorice
anise flavor
FL
anise orange flavor
FL
sweet
basil oleoresin
FL/FR
estragole
FL/FR
glycyrrhiza glabra rhizome/root extract
FL/FR
glycyrrhiza glabra root extract powder
FL
glycyrrhiza glabra root tincture
FL/FR
glycyrrhiza uralensis root oil CO2 extract
FL/FR
licorice absolute
FL/FR
licorice extract
FL/FR
black
licorice flavor
FL
licorice flavor
FL
red
licorice flavor
FL
licorice infusions
FL/FR
licorice oil
FL/FR
licorice root oil
FL/FR
ocimum basilicum herb oil poland
FL/FR
ocimum basilicum herb oil vietnam
FL/FR
ocimum basilicum leaf oil
FL/FR
ocimum basilicum leaf oil terpeneless
FL/FR
musty
thymyl methyl ether
FL/FR
nutty
2-
acetyl pyrrole
FL/FR
tarragon
sassafras acetate
FL/FR
vanilla
omega-
pentadecalactone
FL/FR
vegetable
2-
octen-4-one
FL/FR
woody
methyl ionyl acetate
FL/FR
 
Potential Uses:
 emollients
FLlicorice
 skin conditioning
 smoothing agents
 soothing agents
 
Occurrence (nature, food, other):note
 licorice
Search Trop Picture
 
Synonyms:
 aqua licorice extract P-T
 extract of the roots of the licorice, glycyrrhiza glabra l., leguminosae
 glycyrrhiza glabra (mulethi) extract
 licorice root extract
actiphyte of licorice root extract
 licorice root extract natural
 licorice root extract, 20% glycyrrhizic acid
 polyol soluble licorice extract HG
 polyol soluble licorice extract P-T(40)
 vedaplex 146
 

Articles:

PubMed:Evaluation of sodium benzoate and licorice (Glycyrrhiza glabra) root extract as heat-sensitizing additives against Escherichia coli O157:H7 in mildly heated young coconut liquid endosperm.
PubMed:Enhancement of Hippocampal CA3 Neuronal Dendritic Arborization by Glycyrrhiza glabra root extract Treatment in Wistar Albino Rats.
PubMed:Beneficial effect of aqueous root extract of Glycyrrhiza glabra on learning and memory using different behavioral models: An experimental study.
PubMed:Improving the thrombin inhibitory activity of glycyrrhizin, a triterpenic saponin, through a molecular simplification of the carbohydrate moiety.
PubMed:Effect of GutGard in the Management of Helicobacter pylori: A Randomized Double Blind Placebo Controlled Study.
PubMed:Anti-convulsant action and amelioration of oxidative stress by Glycyrrhiza glabra root extract in pentylenetetrazole- induced seizure in albino rats.
PubMed:Chromolithic method development, validation and system suitability analysis of ultra-sound assisted extraction of glycyrrhizic acid and glycyrrhetinic acid from Glycyrrhiza glabra.
PubMed:18β-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-κB inactivation in interleukin-10-deficient mice.
PubMed:Protection of DNA and microsomal membranes in vitro by Glycyrrhiza glabra L. against gamma irradiation.
PubMed:Immunological studies of Revitonil, a phytopharmaceutical containing Echinacea purpurea and Glycyrrhiza glabra root extract.
PubMed:Inhibition of human complement by beta-glycyrrhetinic acid.
PubMed:Transdermal microemulsions of Glycyrrhiza glabra L.: characterization, stability and evaluation of antioxidant potential.
PubMed:Evaluation of the genotoxic potential of standardized extract of Glycyrrhiza glabra (GutGard™).
PubMed:Exploring the possible metabolism mediated interaction of Glycyrrhiza glabra extract with CYP3A4 and CYP2D6.
PubMed:Memory enhancing activity of Glycyrrhiza glabra in mice.
PubMed:Screening of traditionally used South African plants for antifungal activity against Candida albicans.
PubMed:[Differences between the root and rhizome of Ural licorice (Glycyrrhiza uralensis Fisch.) and those of smooth licorice (Glycyrrhiza glabra L.)].
 
Notes:
Licorice or, more correctly, Licorice Extract is produced from the rhizomes and roots of Glycyrrhiza Glabra, a leguminous plant. There are two main varieties of this plant: the Typica which is known commercially as Spanish licorice and the Glandulifera which is generally called Russian licorice. The former comes from Spain and Italy, the latter from Turkey, U.S.S.R. and the countries around Asia Minor towards India. By extraction of the comminuted rhizomes and roots with boiling water, followed by evaporation of the aqueous extract, the well known solid Licorice Extract is prepared. Licorice Extract is black and brittle and has a sweet, mild odor somewhat different from that of the botanical starting material. Licorice extract has a very sweet taste and a rich, root like, slightly spicy caramellic body of flavor. It leaves a faintly scratching feeling in the back of the mouth and it is used in medicine for its mildly expectorant effect. Used for blemished skin preparations by containing glycyrrhizin, a saponin that has anti-inflammatory properties.
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