R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
Oral/Parenteral Toxicity :
gavage-rat LD50 8800 mg/kg (Deichmann et al., 1945)
oral-rat LD50 > 5000 mg/kg (Moreno, 1978e)
gavage-rabbit LD50 2480 mg/kg (Deichmann et al., 1945)
oral-rabbit LD50 2480 mg/kg BEHAVIORAL: GENERAL ANESTHETIC
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BEHAVIORAL: MUSCLE WEAKNESS Journal of Industrial Hygiene and Toxicology. Vol. 27, Pg. 263, 1945.
oral-rat LD50 8800 mg/kg BEHAVIORAL: GENERAL ANESTHETIC
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BEHAVIORAL: MUSCLE WEAKNESS Journal of Industrial Hygiene and Toxicology. Vol. 27, Pg. 263, 1945.
Dermal Toxicity :
skin-rabbit LD50 > 5000 mg/kg Food and Chemical Toxicology. Vol. 20, Pg. 847, 1982.
European Food Safety Authority (EFSA) reference(s) :
Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000):page or pdf
Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC):page or pdf
Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30:page or pdf