rue oil cuba
volatile oil distilled from the herb rue, ruta graveolens l., rutaceae
 
Notes:
Do not use on any part of the body because of phototoxic effects. Rue Oil is steam distilled from freshly harvested, blooming or fruit bearing, wild growing plants of Ruta Montana, cultivated plants of Ruta Graveolens, or other species of Ruta. The plants are natives of the Mediterranean countries and they grow wild in Spain, Morocco, Corsica, Sardinia and Algeria. Cultivation also takes place in France and Spain, to a small degree in Italy and Yugoslavia. Spain is the largest producer of rue oil. Rue Oil is a yellow to orange yellow material, liquid at room temperature, but solid at lower temperature. Its odor is sharp herbaceous, distinctly fruity orange like, with a characteristic bitteracrid backnote that makes the overall impression an unpleasant one. For most people, however, rue oil is harmful to the mucous membranes and will often irritate the skin. On account of certain haemorrhage producing effects of the oil when taken internally. tsca definition 2008: extractives and their physically modified derivatives. ruta graveolens, rutaceae.
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Name: ruta graveolens l. oil
CAS Number: 8014-29-7 
Also Contains: ruta graveolens herb extract
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
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PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1699 Oil of Rue View-review
FEMA Number: 2995  rue oil cuba
FDA Mainterm: RUE, OIL (RUTA GRAVEOLENS L.)
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1699 Oil of rue.
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Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Food Chemicals Codex Listed: No
Soluble in:
 alcohol
 water, 19.71 mg/L @ 25 °C (est)
Insoluble in:
 water
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Organoleptic Properties:
Odor Type: herbal
Odor Strength: medium
 sharp  herbal  fruity  orange  acidic  
Odor Description:
at 100.00 %. 
sharp herbal fruity orange acrid
 rue  
Taste Description:
rue
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: masking agents
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 455, 1975.

oral-mouse LD50  2070 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 455, 1975.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 455, 1975.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
IFRA Critical Effect: Phototoxicity
IFRA fragrance material specification:
 Where the bergapten (5-methoxypsoralen) content of all relevant oils present in a compound has been determined, it is recommended that for applications on areas of skin exposed to sunshine, excluding bath preparations, soaps and other products which are washed off the skin, the total level of bergapten in the consumer products should not exceed 0.0015% (15 ppm). This is equivalent to 0.0075% (75 ppm) in a fragrance compound used at 20% in the consumer product. Where the level of bergapten has not been determined by appropriate methods, the limits specified in the guidelines on individual oils should apply. In those cases, where such oils are used in combination with other phototoxic ingredients, the additive effect has to be taken into consideration and the use levels have to be reduced accordingly. The sum of the concentrations of all phototoxic fragrance ingredients, expressed in % of their recommended maximum level in the consumer product, shall not exceed 100.
IFRA: View Standard
limits in the finished product for - "leave on the skin contact":
  0.1500 % Restriction.
Recommendation for rue oil cuba usage levels up to:
  4.0000 % in the fragrance concentrate.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -3.30000
beverages(nonalcoholic): -1.20000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -1.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -1.30000
fruit ices: -1.30000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -4.10000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
EPI System: View
ClinicalTrials.gov: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 8014-29-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 ruta graveolens l. oil
Chemidplus: 0008014297
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References:
 ruta graveolens l. oil
Canada Domestic Sub. List: 8014-29-7
Pubchem (sid): 135297220
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Other Information:
FDA Everything Added to Food in the United States (EAFUS): View
Export Tariff Code: 3301.29.6000
 Typical G.C.
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
FAO: BASIC PRINCIPLES OF STEAM DISTILLATION
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Potential Blenders and core components note
 
For Odor
acidic
2-ethyl butyric acidFL/FR
anisic
 amyl furoateFL/FR
caramellic
 diethyl malateFL/FR
earthy
 spathulenol 
ethereal
 ethyl 4-pentenoateFL/FR
floral
alpha-amyl cinnamaldehydeFL/FR
 benzyl acetoneFL/FR
 butyl tiglateFR
 cassis cyclohexeneFR
 dimethyl benzyl carbinyl butyrateFL/FR
 geranyl tiglateFL/FR
 menthadienyl formateFR
 methyl benzyl acetate (mixed ortho-,meta-,para-)FL/FR
 nerolin fragarolFL/FR
 nonan-3-yl acetateFL/FR
3-nonanoneFL/FR
 rose undeceneFR
fruity
para-anisyl propionateFL/FR
para-menth-1-ene-9-olFL/FR
2-methyl butyl isovalerateFL/FR
 methyl dimethyl anthranilateFL/FR
2-undecenalFL/FR
green
isobutyl heptanoateFL/FR
 butyl heptanoateFL/FR
isobutyl methyl ketoneFL/FR
 hexyl tiglateFL/FR
herbal
isoamyl heptanoateFL/FR
 buchu mercaptan acetateFL/FR
 butyl levulinateFL/FR
 chamomile propionateFR
 chamomile valerateFR
 cuminyl acetateFL/FR
 linalyl octanoateFL/FR
1-para-menthen-9-yl acetateFL/FR
 methyl hexyl etherFL/FR
(1S,5R)-myrtenyl acetateFL/FR
3-octanon-1-olFL/FR
beta-sesquiphellandrene 
 tagete oil CO2 extractFL/FR
 tagete oil rwandaFL/FR
 tagete oil south africaFL/FR
 tagete oil turkeyFL/FR
 tagete oil zambiaFL/FR
 tricyclodecenyl propionateFR
 viridiflorolFL/FR
medicinal
meta-dimethyl hydroquinoneFL/FR
orris
 orris capronateFL/FR
 
For Flavor
 
No flavor group found for these
 amyl furoateFL/FR
para-anisyl propionateFL/FR
 benzyl methyl tiglateFL
isobutyl heptanoateFL/FR
 cuminyl acetateFL/FR
 diethyl malateFL/FR
 ethyl 4-pentenoateFL/FR
 methyl benzyl acetate (mixed ortho-,meta-,para-)FL/FR
 methyl dimethyl anthranilateFL/FR
 nonan-3-yl acetateFL/FR
3-nonanoneFL/FR
3-octanon-1-olFL/FR
beta-sesquiphellandrene 
 spathulenol 
 viridiflorolFL/FR
acidic
2-ethyl butyric acidFL/FR
(E)-2-hexenoic acidFL
chemical
meta-dimethyl hydroquinoneFL/FR
coconut
 butyl heptanoateFL/FR
ethereal
 methyl hexyl etherFL/FR
floral
 dimethyl benzyl carbinyl butyrateFL/FR
 geranyl tiglateFL/FR
fruity
 benzyl acetoneFL/FR
 buchu mercaptan acetateFL/FR
1-para-menthen-9-yl acetateFL/FR
2-methyl butyl isovalerateFL/FR
 nerolin fragarolFL/FR
 tagete oil CO2 extractFL/FR
 tagete oil rwandaFL/FR
 tagete oil south africaFL/FR
 tagete oil turkeyFL/FR
 tagete oil zambiaFL/FR
green
isobutyl methyl ketoneFL/FR
 hexyl tiglateFL/FR
herbal
isoamyl heptanoateFL/FR
 butyl levulinateFL/FR
 linalyl octanoateFL/FR
para-menth-1-ene-9-olFL/FR
 orris capronateFL/FR
sour
2,4-dimethyl-2-pentenoic acidFL
tropical
alpha-amyl cinnamaldehydeFL/FR
waxy
2-undecenalFL/FR
woody
(1S,5R)-myrtenyl acetateFL/FR
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 rue
Search Trop  Picture
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Synonyms:
 herb-of-grace oil cuba
 rue oil cuba
 ruta graveolens oil cuba
 ruta hortensis oil cuba
 volatile oil distilled from the herb rue, ruta graveolens l., rutaceae
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Articles:
PubMed: [The fatty acid composition of Ruta graveolens seed oil and its byological activity].
PubMed: Identity and pharmacognosy of Ruta graveolens Linn.
PubMed: Chemical composition and antimicrobial activity of the essential oils from four Ruta species growing in Algeria.
PubMed: Repellent activity of plant-derived compounds against Amblyomma cajennense (Acari: Ixodidae) nymphs.
PubMed: In vitro antimicrobial activity of plants in Acute Otitis Externa.
PubMed: Potential allelochemicals from the essential oil of Ruta graveolens.
PubMed: Saprophytic and cycloheximide resistant fungi isolated from golden hamster.
PubMed: [The volatile oil of tissue cultures of Ruta graveolens L. I. The composition of the coil (author's transl)].
PubMed: [Volatile oil from Ruta graveolens L. II. Geijerene, principle component of the root oil].
PubMed: [The essential oil of Ruta graveolens L. I].
PubMed: [Investigations on the content of oil in various organs of Ruta graveolens L. subsp. hortensis (Miller) Gams. during 1 year of its growth].
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