perilla leaf oil
essential oil obtained from the leaves of the plant, perilla frutescens, labiatae
an oil rich in alpha-linolenic acid. tsca definition 2008: extractives and their physically modified derivatives. perilla frutescens, var. crispa, labiatae.
  • Berjé
    • Berje Inc.
      The solution is clear
      Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.
      Berjé is a family-owned business that has been in operation for six decades. The company's origins and strength lie in a profound understanding of the supply and the quality of the diverse raw materials consumed by the flavor and fragrance industries. This base was expanded upon more than two decades ago to include fragrance production. The company's unparalleled raw material expertise is focused on the supply of essential oils and aromatic chemicals. This is supported by our long-standing relationships with a worldwide fabric of producers ensuring the greatest prospects for uninterrupted supply in markets that are often volatile and unpredictable.
      Email: For Information
      Email: For Sales
      Voice: 973-748-8980
      Fax: 973-680-9618
      Flavor Ingredients
      Fragrance Ingredients
      Functional Ingredients
      Happening at Berje
      Perilla Oil
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
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      16-15200 PERILLA LEAF OIL, Kosher
  • Robertet
  • Soda Aromatic
    • Soda Aromatic Co., Ltd.
      Depth of Experience
      We guarantees product safety and quality.
      Our international sales department is happy to design the most suitable flavor & fragrance for specific uses of processed food, cosmetics, and fragrance manufactures all over the world, specializing in Asia.Let us help you with your flavor & fragrance needs.
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      611212007 Perilla Leaf Oil
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Name: perilla frutescens leaf oil
CAS Number: 68132-21-8 
Also Contains: perilla frutescens leaf extract
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
PubMed: Search
NCBI: Search
FEMA Number: 4013  perilla leaf oil
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Physical Properties:
Appearance: pale yellow to yellow clear liquid (est)
Food Chemicals Codex Listed: No
Specific Gravity: 0.90900 to 0.92900 @  20.00 °C.
Pounds per Gallon - (est).: 7.573 to  7.739
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Organoleptic Properties:
Odor Type: herbal
Odor Strength: medium
 herbal  green  spicy  caraway  apple  tea  
Odor Description:
at 100.00 %. 
herbal green spicy caraway apple tea
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
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Perilla Oil
Happening at Berje
Liberty Natural Products
Penta International
Shiso Ess. oil (for fragrance)
Shiso Essential Oil Asia
Odor: Shiso scent is green, caraway, apple pip, producing a sensation of freshness and naturalness in perfumes
Use: Hydrodistillation of Japanese Perilla Nankin leaves.
Soda Aromatic
Perilla Leaf Oil
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50  2770 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 397, 1988.

oral-rat LDLo  5000 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 397, 1988.

Dermal Toxicity:
skin-guinea pig LDLo 5000 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 397, 1988.

skin-rabbit LDLo 5000 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 397, 1988.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
perillaldehyde Max. Found: <60.00 % and Reason: Sensitization
Recommendation for perilla leaf oil usage levels up to:
  6.0000 % in the fragrance concentrate.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 20
Click here to view publication 20
 average usual ppmaverage maximum ppm
baked goods: 10.00000100.00000
beverages(nonalcoholic): 2.00000200.00000
beverages(alcoholic): 1.0000010.00000
breakfast cereal: --
cheese: --
chewing gum: 20.000002000.00000
condiments / relishes: --
confectionery froastings: 1.0000020.00000
egg products: --
fats / oils: 1.0000010.00000
fish products: --
frozen dairy: 2.00000200.00000
fruit ices: 2.00000200.00000
gelatins / puddings: 2.00000200.00000
granulated sugar: --
gravies: --
hard candy: 2.00000200.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: 5.00000100.00000
reconstituted vegetables: --
seasonings / flavors: 100.00000500.00000
snack foods: 1.00000100.00000
soft candy: 2.00000200.00000
soups: 1.00000100.00000
sugar substitutes: --
sweet sauces: --
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Safety References:
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 68132-21-8
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 perilla frutescens leaf oil
Chemidplus: 0068132218
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 perilla frutescens leaf oil
Canada Domestic Sub. List: 68132-21-8
Pubchem (sid): 199105
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Other Information:
FDA Everything Added to Food in the United States (EAFUS): View
Wikipedia: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
Search Trop  Picture
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 essential oil obtained from the leaves of the plant, perilla frutescens, labiatae
 ocimum frutescens leaf oil
 perilla frutescens leaf oil
 perilla frutescens var. frutescens leaf oil
 perilla leaf oil
 perilla ocymoides leaf oil
 salvia infuscata leaf oil
 shiso ess. oil (for fragrance) (Robertet)
 shiso essential oil asia (Robertet)
 shiso leaf oil
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PubMed: Anti-inflammatory effects of Perilla frutescens leaf extract on lipopolysaccharide-stimulated RAW264.7 cells.
PubMed: Synthesis of gold and silver nanoparticles using leaf extract of Perilla frutescens--a biogenic approach.
PubMed: Rosmarinic acid extract for antioxidant, antiallergic, and α-glucosidase inhibitory activities, isolated by supramolecular technique and solvent extraction from Perilla leaves.
PubMed: Perilla frutescens leaf extract inhibits mite major allergen Der p 2-induced gene expression of pro-allergic and pro-inflammatory cytokines in human bronchial epithelial cell BEAS-2B.
PubMed: Accumulation of PrLeg, a Perilla legumin protein in potato tuber results in enhanced level of sulphur-containing amino acids.
PubMed: Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice.
PubMed: Perilla frutescens (L.) Britton: honeybee forage and preliminary results on the metabolic profiling by NMR spectroscopy.
PubMed: Nuclear Factor-κB: central regulator in ocular surface inflammation and diseases.
PubMed: Optimization of antibacterial activity of Perilla frutescens var. acuta leaf against Staphylococcus aureus using evolutionary operation factorial design technique.
PubMed: Controllable spectrum artificial sunlight source system using LEDs with 32 different peak wavelengths of 385-910 nm.
PubMed: Effect of Perilla frutescens var. acuta Kudo and rosmarinic acid on allergic inflammatory reactions.
PubMed: Optimization of antibacterial activity of Perilla frutescens var. acuta leaf against Pseudomonas aeruginosa using the evolutionary operation-factorial design technique.
PubMed: Monoterpene engineering in a woody plant Eucalyptus camaldulensis using a limonene synthase cDNA.
PubMed: Characteristic aroma-active compounds of Korean perilla (Perilla frutescens Britton) leaf.
PubMed: Perilla leaf, Perilla frutescens, induces apoptosis and G1 phase arrest in human leukemia HL-60 cells through the combinations of death receptor-mediated, mitochondrial, and endoplasmic reticulum stress-induced pathways.
PubMed: Antioxidant activities of polyphenols extracted from Perilla frutescens varieties.
PubMed: Antidepressant-like Effect of l-perillaldehyde in Stress-induced Depression-like Model Mice through Regulation of the Olfactory Nervous System.
PubMed: Rosmarinic acid from Perillae Herba produces an antidepressant-like effect in mice through cell proliferation in the hippocampus.
PubMed: Perilla frutescens var. frutescens in northern Laos.
PubMed: Growth inhibitory and apoptosis inducing effect of Perilla frutescens extract on human hepatoma HepG2 cells.
PubMed: Protective effect of aqueous extract of Perilla frutescens on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in rats.
PubMed: Anthocyanin and flavonoid production from Perilla frutescens: pilot plant scale processing including cross-flow microfiltration and reverse osmosis.
PubMed: Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model.
PubMed: Limonene production in tobacco with Perilla limonene synthase cDNA.
PubMed: Inhibitory effect of Perilla leaf extract and luteolin on mouse skin tumor promotion.
PubMed: Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens.
PubMed: [Inhibition of antigen-specific T helper type 2 responses by Perilla frutescens extract].
PubMed: The effects of developmental stage and source leaf position on integration and sectorial patterns of carbohydrate movement in an annual plant, Perilla frutescens (Lamiaceae).
PubMed: Genetic analysis of essential oil variants in Perilla frutescens.
PubMed: Genetic Control of Peltate Glandular Trichome Formation in Perilla frutescens.
PubMed: An Intestinal Propulsion Promoting Substance from Perilla frutescens and Its Mechanism of Action.
PubMed: Separation and measurement of direct and indirect effects of light on stomata.
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