|
Category:flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white colorless crystals (est) |
| Assay: | 97.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 178.80 °C. @ 760.00 mm Hg
|
| Boiling Point: | 207.40 °C. @ 760.00 mm Hg
|
| Vapor Pressure: | 4.000000 mm/Hg @ 25.00 °C. |
| Vapor Density: | 5.24 ( Air = 1 ) |
| Flash Point: | 148.00 °F. TCC ( 64.44 °C. )
|
| logP (o/w): | 3.040 |
| Soluble in: |
| | alcohol | | | water, 100 mg/L @ 25 °C (exp) |
| Insoluble in: |
| | water | | | glycerin |
Organoleptic Properties:
| Odor Type: camphoreous |
Odor Strength:high ,
recommend smelling in a 10.00 % solution or less |
| Substantivity:160 hour(s) at 20.00 % in dipropylene glycol |
| camphoreous minty phenolic herbal woody |
Odor Description:at 10.00 % in dipropylene glycol. camphor minty phenolic herbal woody
Luebke, William tgsc, (1988) |
| Odor sample from: Berje Inc. |
| camphoreous medicinal mentholic cooling green |
Odor Description:Camphoreous, medicinal, mentholic, with a cooling green nuance
Mosciano, Gerard P&F 18, No. 2, 38, (1993) |
| Flavor Type: medicinal |
| medicinal camphoreous mentholic woody |
Taste Description: at 20.00 ppm. Medicinal, camphoreous, mentholic and woody
Mosciano, Gerard P&F 18, No. 2, 38, (1993) |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Aceto |
| Camphor Flake USP24
|
| Berjé |
| Camphor Gum Natural
|
| Happening at Berje |
| Berjé |
| Camphor Gum Synthetic
|
| BOC Sciences |
| For experimental / research use only. |
| D(+)-Camphor =>98%
|
| Diffusions Aromatiques |
| CAMPHRE-D NATUREL
|
| Ernesto Ventós |
| CAMPHOR-D NATURAL
|
| Excellentia International |
| Camphor, d- Natural
|
| ExtraSynthese |
| For experimental / research use only. |
| (+)-Camphor (GC) ≥97% (sum of enantiomers)
|
| Fleurchem |
| camphor (gum) powder USP
|
| Fleurchem |
| camphor (gum) powder, technical
|
| Indukern F&F |
| CAMPHOR POWDER NATURAL
Odor: AROMATIC, FRESH, CONIFEROUS |
| Kunshan Sainty |
| Camphor Powder, Kosher
|
| Liberty Natural Products |
| CAMPHOR POWDER
|
| Lluch Essence |
| CAMPHOR POWDER NATURAL
|
| M&U International |
| CAMPHOR POWDER, Kosher
|
| Moellhausen |
| CAMPHOR NAT.
|
| Penta International |
| CAMPHOR POWDER NATURAL, Kosher
|
| PerfumersWorld |
| Camphor Powder
Odor: camphor conifer fresh-woody cool |
| Phoenix Aromas & Essential Oils |
| Camphor Natural
|
| Prodasynth |
| CAMPHOR-D, NATURAL
(> 96%) |
| R C Treatt & Co Ltd |
| Camphor Powder
|
| Reincke & Fichtner |
| D-Camphor natural
|
| Reincke & Fichtner |
| D-Camphor
|
| Sigma-Aldrich |
| D-Camphor, ≥97%, FG
Odor: medicinal; woody; vanilla |
| Certified Food Grade Products |
| Sigma-Aldrich |
| D-Camphor, natural, 96%, FG
|
| SRS Aromatics |
| CAMPHOR POWDER
Odor: Camphor, Minty, Phenolic, Herbal, Woody |
| TCI AMERICA |
| For experimental / research use only. |
| (+)-Camphor >98.0%(GC)
|
| WholeChem |
| D-Camphor, Natural
|
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xn - Harmful. |
R 10 - Flammable.
R 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
|
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 1310 mg/kg
Food and Cosmetics Toxicology. Vol. 16, Pg. 665, 1978.
intraperitoneal-cat LDLo 400 mg/kg
Food and Cosmetics Toxicology. Vol. 16, Pg. 665, 1978.
intravenous-mouse LD90 525 mg/kg
Food and Cosmetics Toxicology. Vol. 16, Pg. 665, 1978.
intraperitoneal-rat LDLo 3500 mg/kg
Food and Cosmetics Toxicology. Vol. 16, Pg. 665, 1978.
|
| Dermal Toxicity: |
subcutaneous-mouse LDLo 2200 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Food and Cosmetics Toxicology. Vol. 16, Pg. 665, 1978.
subcutaneous-rat LDLo 1700 mg/kg
Food and Cosmetics Toxicology. Vol. 16, Pg. 665, 1978.
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | flavor and fragrance agents |
| Recommendation for dextro-camphor usage levels up to: | | | 3.0000 % in the fragrance concentrate.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 50.00 (μg/capita/day) |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 3 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 11.00000 |
| beverages(nonalcoholic): | - | - |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | 20.00000 |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 0.10000 |
| fruit ices: | - | 0.10000 |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | 1.10000 | 25.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
| For Odor |
| aldehydic |
decanal (aldehyde C-10)
FL/FR |
dodecanal (aldehyde C-12 lauric)
FL/FR |
nonanal (aldehyde C-9)
FL/FR |
10- undecenal (aldehyde C-11 undecylenic)
FL/FR |
| amber |
angelica archangelica root oil CO2 extract
FL/FR |
cistus ladaniferus resinoid
FR |
| animal |
1-oxa spiro-4,7-dodecane
FR |
| anise |
anise seed oil
FL/FR |
star anise seed oil china
FL/FR |
anise seed oil colombia
FL/FR |
star anise seed oil spain
FL/FR |
| balsamic |
iso amyl benzoate
FL/FR |
amyris wood oil
FL/FR |
benzoin
FL/FR |
siam benzoin resinoid
FL/FR |
benzyl benzoate
FL/FR |
benzyl salicylate
FL/FR |
dextro,laevo-iso borneol
FL/FR |
bornyl acetate
FL/FR |
iso bornyl acetate
FL/FR |
iso bornyl formate
FL/FR |
iso bornyl propionate
FL/FR |
cedar forest fragrance
FR |
conifer acetate
FR |
fir balsam absolute
FR |
frankincense absolute
FL/FR |
3- phenyl propyl alcohol
FL/FR |
| camphoreous |
cyclohexanol
FL/FR |
melaleuca viridiflora leaf oil
FR |
| citrus |
methyl heptenone
FL/FR |
neroli ketone
FR |
| creamy |
veratraldehyde
FL/FR |
| earthy |
2- octanone
FL/FR |
| fatty |
decanol
FL/FR |
| floral |
aglaia odorata absolute
FR |
alpha- amyl cinnamaldehyde
FL/FR |
iso amyl salicylate
FL/FR |
bigarade oxide
FR |
iso butyl salicylate
FL/FR |
alpha- hexyl cinnamaldehyde
FL/FR |
ho leaf oil
FR |
karo karounde absolute
FR |
karo karounde absolute replacer
FR |
lavender oil
FL/FR |
nonanol
FL/FR |
petitgrain bigarade oil
FL/FR |
phenethyl alcohol
FL/FR |
sambucus nigra flower oil CO2 extract
FR |
5- tricyclodecenyl acetate
FR |
| fruity |
allyl cyclohexyl propionate
FL/FR |
3- benzyl-4-heptanone
FL/FR |
| green |
iso cyclocitral (IFF)
FL/FR |
dicyclopentadiene propionate
FR |
alpha- hexyl cinnamaldehyde dimethyl acetal
FR |
para- methyl hydratropaldehyde
FL/FR |
seaweed absolute (fucus vesiculosus et serratus)
FL/FR |
| hay |
tobacco leaf absolute
FL/FR |
| herbal |
ajowan seed oil
FL/FR |
1- allyl-2,2,7,7-tetramethyl cycloheptanol
FR |
angelica archangelica seed extract
FL/FR |
anthemis nobilis flower oil roman
FL/FR |
artemisia vestita wall. leaf oil
FR |
bornyl 2-methyl butyrate
FL/FR |
bornyl butyrate
FL/FR |
beta- bourbonene
FL/FR |
3- butyl phthalide
FL/FR |
calamintha clinopodium oil
FR |
cardamom liquid resin
FR |
carum carvi fruit oil
FL/FR |
1,8- cineole
FL/FR |
dill seed oil
FL/FR |
dill seed oil CO2 extract
FL/FR |
eucalyptus globulus oil
FL/FR |
eucalyptus oil replacer
FR |
herbal undecanone
FR |
immortelle flower oil
FL/FR |
abrialis lavandin oil
FL/FR |
lavandin water absolute
FL/FR |
spike lavender oil
FL/FR |
2- methyl butyl salicylate
FL/FR |
origanum oil greece
FL/FR |
alpha- pinene
FL/FR |
pinocarveol
FL/FR |
piperitone
FL/FR |
rosemary oil spain
FL/FR |
rosemary oleoresin
FL/FR |
safranal
FL/FR |
white thyme oil
FL/FR |
thyme oil (thymus zygis gracillis) spain
FL/FR |
red thyme oil india
FL/FR |
red thyme oil spain
FL/FR |
thyme oil wild or creeping
FL/FR |
thymol
FL/FR |
| mentholic |
peppermint cyclohexanone
FL/FR |
| minty |
mint fragrance
FR |
mint specialty
FR |
pennyroyal oil
FL/FR |
| mossy |
veramoss (IFF)
FR |
| musk |
angelica root absolute
FL/FR |
| naphthyl |
1- methyl naphthalene
FL/FR |
| nutty |
pentanoic acid, 3-methyl-2-oxo-, ethyl ester
FL/FR |
| orris |
para-iso propyl acetophenone
FL/FR |
| powdery |
para- anisyl alcohol
FL/FR |
| spicy |
bayberry fragrance
FR |
cardamom oil replacer
FR |
cassia bark oil china
FL/FR |
cinnamon acrolein
FL/FR |
clove bud oil
FL/FR |
clove leaf oil
FL/FR |
elettaria cardamomum seed oil
FL/FR |
elettaria cardamomum seed oil guatemala
FL/FR |
ginger oleoresin africa
FL/FR |
ginger root absolute
FL/FR |
ginger root oil cochin
FL/FR |
maja fragrance
FR |
myrcene
FR |
2- octanol
FL/FR |
black pepper absolute
FL/FR |
black pepper oil
FL/FR |
white pepper oil
FL/FR |
black pepper oleoresin
FL/FR |
4-iso propyl-2-cyclohexenone
FL/FR |
| terpenic |
cypress leaf oil
FR |
frankincense oil
FL/FR |
juniperus communis fruit oil
FL/FR |
| thujonic |
cedarleaf oil western red
FR |
sage oil dalmatian
FL/FR |
common tansy flower oil argentina
FL/FR |
woody ketone
FL/FR |
| tonka |
tonka bean absolute
FR |
| waxy |
ethyl laurate
FL/FR |
| woody |
angelica archangelica root extract
FL/FR |
angelica archangelica root tincture
FL/FR |
angelica archangelica root water
FL/FR |
cadinene
FL/FR |
camphene
FL/FR |
(+)- camphene
FL/FR |
cypress essence
FR |
dalbergia sissoo leaf oil
FR |
dihydro-alpha-terpinyl acetate
FR |
fougere woody fragrance
FR |
laitone
FR |
manevoro oil
FR |
marine formate
FR |
melaleuca bracteata leaf oil
FR |
methyl cedryl ketone
FL/FR |
patchouli ethanone
FR |
patchouli oil
FL/FR |
polylimonene
FL/FR |
santol pentenol
FR |
spruce needle oil canada
FL/FR |
tetrahydromugol
FR |
thuja occidentalis leaf oil
FL/FR |
vetiver oil haiti
FL/FR |
woody acetate
FR |
| For Flavor |
| No flavor group found for these |
angelica archangelica root extract
FL/FR |
angelica archangelica root oil CO2 extract
FL/FR |
angelica archangelica root tincture
FL/FR |
angelica archangelica root water
FL/FR |
benzoin
FL/FR |
bornyl 2-methyl butyrate
FL/FR |
bornyl butyrate
FL/FR |
beta- bourbonene
FL/FR |
3- butyl phthalide
FL/FR |
(+)- camphene
FL/FR |
cyclohexanol
FL/FR |
2- methyl butyl salicylate
FL/FR |
3- methyl cyclohexanone
FL |
1- methyl pyrrole
FL |
polylimonene
FL/FR |
4-iso propyl-2-cyclohexenone
FL/FR |
seaweed absolute (fucus vesiculosus et serratus)
FL/FR |
woody ketone
FL/FR |
| aldehydic |
| aldehydic |
nonanal (aldehyde C-9)
FL/FR |
| anise |
anise seed oil
FL/FR |
star anise seed oil china
FL/FR |
anise seed oil colombia
FL/FR |
star anise seed oil spain
FL/FR |
| balsamic |
siam benzoin resinoid
FL/FR |
benzyl benzoate
FL/FR |
benzyl salicylate
FL/FR |
iso bornyl propionate
FL/FR |
| camphoreous |
dextro,laevo-iso borneol
FL/FR |
bornyl acetate
FL/FR |
camphene
FL/FR |
pinocarveol
FL/FR |
| citrus |
petitgrain bigarade oil
FL/FR |
| cooling |
iso butyl salicylate
FL/FR |
spike lavender oil
FL/FR |
| creamy |
veratraldehyde
FL/FR |
| dairy |
2- octanone
FL/FR |
| fatty |
10- undecenal (aldehyde C-11 undecylenic)
FL/FR |
| floral |
phenethyl alcohol
FL/FR |
| fruity |
allyl cyclohexyl propionate
FL/FR |
iso amyl benzoate
FL/FR |
para- anisyl alcohol
FL/FR |
3- benzyl-4-heptanone
FL/FR |
| grassy |
tobacco leaf absolute
FL/FR |
| green |
iso amyl salicylate
FL/FR |
iso cyclocitral (IFF)
FL/FR |
methyl heptenone
FL/FR |
para- methyl hydratropaldehyde
FL/FR |
| herbal |
ajowan seed oil
FL/FR |
angelica archangelica seed extract
FL/FR |
anthemis nobilis flower oil roman
FL/FR |
cardamom distillates
FL |
cardamom flavor
FL |
carum carvi fruit oil
FL/FR |
celery seed oleoresin
FL |
dill seed oil
FL/FR |
dill seed oil CO2 extract
FL/FR |
eucalyptus flavor
FL |
eucalyptus globulus oil
FL/FR |
immortelle flower oil
FL/FR |
abrialis lavandin oil
FL/FR |
lavandin water absolute
FL/FR |
lavender oil
FL/FR |
origanum oil greece
FL/FR |
rosemary oil spain
FL/FR |
rosemary oleoresin
FL/FR |
white thyme oil
FL/FR |
thyme oil (thymus zygis gracillis) spain
FL/FR |
red thyme oil india
FL/FR |
red thyme oil spain
FL/FR |
thyme oil wild or creeping
FL/FR |
| medicinal |
frankincense absolute
FL/FR |
| mentholic |
peppermint cyclohexanone
FL/FR |
| minty |
1,8- cineole
FL/FR |
pennyroyal oil
FL/FR |
piperitone
FL/FR |
| musk |
angelica root absolute
FL/FR |
| naphthyl |
1- methyl naphthalene
FL/FR |
| nutty |
pentanoic acid, 3-methyl-2-oxo-, ethyl ester
FL/FR |
| phenolic |
thymol
FL/FR |
| pine |
spruce beer flavor
FL |
| soapy |
dodecanal (aldehyde C-12 lauric)
FL/FR |
| spicy |
cassia bark oil china
FL/FR |
cinnamon acrolein
FL/FR |
clove bud oil
FL/FR |
clove leaf oil
FL/FR |
elettaria cardamomum seed oil
FL/FR |
elettaria cardamomum seed oil guatemala
FL/FR |
ginger oleoresin africa
FL/FR |
ginger root absolute
FL/FR |
ginger root oil cochin
FL/FR |
2- octanol
FL/FR |
black pepper absolute
FL/FR |
black pepper oil
FL/FR |
white pepper oil
FL/FR |
black pepper oleoresin
FL/FR |
3- phenyl propyl alcohol
FL/FR |
para-iso propyl acetophenone
FL/FR |
| terpenic |
juniperus communis fruit oil
FL/FR |
| thujonic |
sage oil dalmatian
FL/FR |
common tansy flower oil argentina
FL/FR |
| tropical |
alpha- amyl cinnamaldehyde
FL/FR |
| waxy |
decanal (aldehyde C-10)
FL/FR |
decanol
FL/FR |
ethyl laurate
FL/FR |
alpha- hexyl cinnamaldehyde
FL/FR |
nonanol
FL/FR |
| woody |
amyris wood oil
FL/FR |
iso bornyl acetate
FL/FR |
iso bornyl formate
FL/FR |
cadinene
FL/FR |
frankincense oil
FL/FR |
methyl cedryl ketone
FL/FR |
patchouli oil
FL/FR |
alpha- pinene
FL/FR |
safranal
FL/FR |
spruce needle oil canada
FL/FR |
thuja occidentalis leaf oil
FL/FR |
vetiver oil haiti
FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-, (1R,4R)- | | | bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R,4R)- | | (+)- | bornan-2-one | | (+)-2- | bornanone | | (1R)- * (+)-2- | bornanone | | D-2- | bornanone | | dextro-2- | bornanone | | D-2- | camphanone | | dextro-2- | camphanone | | (+)- | camphor | | (1R,4R)-(+)- | camphor | | (1R)- | camphor | | (1R)- * (+)- | camphor | | (1R)-(+)- | camphor | | (R)- | camphor | | (R)-(+)- | camphor | | D- | camphor | | D-(+)- | camphor | | D-formosa | camphor | | D-laurel | camphor | | dextro-(+)- | camphor | | dextro-formosa | camphor | | dextro-laurel | camphor | | japanese | camphor | | | camphor (gum) powder USP | | | camphor (gum) powder, technical | | | camphor flake USP24 | | | camphor gum | | | camphor gum natural | | | camphor gum synthetic | | | camphor powder | | | camphor powder natural | | | camphor powder natural USP/FCC | | | camphor powder synthetic | | | camphor-D natural | | | camphor, (1R,4R)-(+)- | | D- | gum camphor | | dextro- | gum camphor | | (R)-1,7,7- | trimethyl bicyclo(2.2.1)-2-heptanone | | (1R)-1,7,7- | trimethyl bicyclo(2.2.1)heptan-2-one | | 2-keto-1,7,7- | trimethyl norcamphane | | (R)-1,7,7- | trimethylbicyclo(2.2.1)-2-heptanone | | (1R,4R)-1,7,7- | trimethylbicyclo(2.2.1)heptan-2-one | | (1R)-1,7,7- | trimethylbicyclo(2.2.1)heptan-2-one | | (1R,4R)-1,7,7- | trimethylbicyclo[2.2.1]heptan-2-one | | (1R,4R)-1,7,7- | trimethylnorbornan-2-one | | 2-keto-1,7,7- | trimethylnorcamphane |
Articles:
| PubMed:Total synthesis of chiriquitoxin, an analogue of tetrodotoxin isolated from the skin of a dart frog. |
| PubMed:Hot-spot residues in the cytochrome P450cam-putidaredoxin binding interface. |
| PubMed:Optically pure, monodisperse cis-oligodiacetylenes: aggregation- induced chirality enhancement. |
| PubMed:[About flavouring substances and flavouring preparations regulation in the field of manufacturing of flavourings and foodstuffs]. |
| PubMed:Reaction of an "invisible" frustrated N/B Lewis pair with dihydrogen. |
| PubMed:Nona-coordinated chiral Eu(III) complexes with stereoselective ligand-ligand noncovalent interactions for enhanced circularly polarized luminescence. |
| PubMed:Desymmetrization of cyclohexadienones viad-camphor-derived triazolium salt catalyzed intramolecular Stetter reaction. |
| PubMed:In vivo antioxidant activities of essential oils and their constituents from leaves of the Taiwanese Cinnamomum osmophloeum. |
| PubMed:Spectroscopic evidence for the unusual stereochemical configuration of an endosome-specific lipid. |
| PubMed:Analysis of volatile compositions of Magnolia biondii pamp by steam distillation and headspace solid phase micro-extraction. |
| PubMed:Formation of repressor-inducer-operator ternary complex: negative cooperativity of d-camphor binding to CamR. |
| PubMed:Topological and experimental approach to the pressure-temperature-composition phase diagram of the binary enantiomer system d- and l-camphor. |
| PubMed:Changing the substrate specificity of P450cam towards diphenylmethane by semi-rational enzyme engineering. |
| PubMed:Breeding and identification of novel koji molds with high activity of acid protease by genome recombination between Aspergillus oryzae and Aspergillus niger. |
| PubMed:Improvement of the embryonic stem cell test endpoint analysis by use of field potential detection. |
| PubMed:Preparation of functionalized cyclic enol phosphates by halogen-magnesium exchange and directed deprotonation reactions. |
| PubMed:Circularly polarized luminescence of Eu(III) complexes with point- and axis-chiral ligands dependent on coordination structures. |
| PubMed:Highly enantioselective intramolecular Michael reactions by D-camphor-derived triazolium salts. |
| PubMed:Resolution of planar chiral cationic (eta6-arene)tricarbonylmanganese complexes. |
| PubMed:Biotransformations of (+/-)-geosmin by terpene-degrading bacteria. |
| PubMed:D-camphor-crataegus berry extract combination increases blood pressure and cognitive functioning in the elderly - a randomized, placebo controlled double blind study. |
| PubMed:Skin disposition of d-camphor and l-menthol alone and together. |
| PubMed:Tetraaquabis(D-camphor-10-sulfonato)calcium(II). |
| PubMed:A role of the heme-7-propionate side chain in cytochrome P450cam as a gate for regulating the access of water molecules to the substrate-binding site. |
| PubMed:Diamagnetic lanthanide tris beta-diketonates as organic-soluble chiral NMR shift reagents. |
| PubMed:D-Camphor-derived triazolium salts for catalytic intramolecular crossed aldehyde-ketone benzoin reactions. |
| PubMed:Hexaaqua-magnesium(II) bis-(d-camphor-10-sulfonate). |
| PubMed:Polyploid formation between Aspergillus niger and Trichoderma viride for enhanced citric acid production from cellulose. |
| PubMed:Preparation of highly conductive, self-assembled gold/polyaniline nanocables and polyaniline nanotubes. |
| PubMed:Expression, crystallization and preliminary diffraction studies of the Pseudomonas putida cytochrome P450cam operon repressor CamR. |
| PubMed:[Efficacy and safety of a herbal drug containing hawthorn berries and D-camphor in hypotension and orthostatic circulatory disorders/results of a retrospective epidemiologic cohort study]. |
| PubMed:A randomized trial of Korodin Herz-Kreislauf-Tropfen as add-on treatment in older patients with orthostatic hypotension. |
| PubMed:Detection of a high-barrier conformational change in the active site of cytochrome P450cam upon binding of putidaredoxin. |
| PubMed:L358P mutation on cytochrome P450cam simulates structural changes upon putidaredoxin binding: the structural changes trigger electron transfer to oxy-P450cam from electron donors. |
| PubMed:Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam. |
| PubMed:Discriminative power of an assay for automated in vitro screening of teratogens. |
| PubMed:NMR study on the structural changes of cytochrome P450cam upon the complex formation with putidaredoxin. Functional significance of the putidaredoxin-induced structural changes. |
| PubMed:Dose-response related efficacy in orthostatic hypotension of a fixed combination of D-camphor and an extract from fresh crataegus berries and the contribution of the single components. |
| PubMed:A delicate balance of energetics. Subtleties associated with alpha-ketol-based bridge migration to afford 9-keto-10beta-p-methoxybenzyloxytaxanes. |
| PubMed:Optical cell with a temperature-control unit for a vacuum-ultraviolet circular dichroism spectrophotometer. |
| PubMed:Camphor-Crataegus berry extract combination dose-dependently reduces tilt induced fall in blood pressure in orthostatic hypotension. |
| PubMed:Selection of test chemicals for the ECVAM international validation study on in vitro embryotoxicity tests. European Centre for the Validation of Alternative Methods. |
| PubMed:Energetic stabilization of d-camphor via weak neutral currents. |
| PubMed:Adrenodoxin-cytochrome P450scc interaction as revealed by EPR spectroscopy: comparison with the putidaredoxin-cytochrome P450cam system. |
| PubMed:Putidaredoxin-cytochrome P450cam interaction. |
| PubMed:X-ray crystal structure and catalytic properties of Thr252Ile mutant of cytochrome P450cam: roles of Thr252 and water in the active center. |
| PubMed:Roles of the axial push effect in cytochrome P450cam studied with the site-directed mutagenesis at the heme proximal site. |
| PubMed:In vitro transcriptional analysis of the cytochrome P-450cam hydroxylase operon. |
| PubMed:Construction and application of MCBL plate for facilitation of chromosome recombination in fungi. |
| PubMed:Putidaredoxin-cytochrome p450cam interaction. Spin state of the heme iron modulates putidaredoxin structure. |
| PubMed:Reproductive toxicity studies of D-camphor in rats and rabbits. |
| PubMed:Preparation of Enantiomerically Enriched (2R,3R)- or (2S,3S)-trans-2,3-Diaryloxiranes via Camphor-Derived Sulfonium Ylides. |
| PubMed:NMR studies of recombinant cytochrome P450cam mutants. |
| PubMed:Purification and characterization of a cam repressor (CamR) for the cytochrome P-450cam hydroxylase operon on the Pseudomonas putida CAM plasmid. |
| PubMed:Substrate interactions in cytochrome P-450: correlation between carbon-13 nuclear magnetic resonance chemical shifts and C-O vibrational frequencies. |
| PubMed:Thermodynamic aspects of the CO-binding reaction to cytochrome P-450cam. Relevance with their biological significance and structure. |
| PubMed:Heterologous expression of the cytochrome P450cam hydroxylase operon and the repressor gene of Pseudomonas putida in Escherichia coli. |
| PubMed:High-pressure flash photolysis study of hemoprotein: effects of substrate analogues on the recombination of carbon monoxide to cytochrome P450CAM. |
| PubMed:Significant contribution of arginine-112 and its positive charge of Pseudomonas putida cytochrome P-450cam in the electron transport from putidaredoxin. |
| PubMed:Spectral intermediate in the reaction of ferrous cytochrome P450cam with superoxide anion. |
| PubMed:Putative functions of phenylalanine-350 of Pseudomonas putida cytochrome P-450cam. |
| PubMed:Transcription of the cam operon and camR genes in Pseudomonas putida PpG1. |
| PubMed:Development of bacterial cytochrome P-450(cam) (cytochrome m) production. |
| PubMed:[d-Camphor reference standard (Control 911) and dl-Camphor Reference Standard (Control 911) of the National Institute of Hygienic Sciences]. |
| PubMed:Observation of the O-O stretching Raman band for cytochrome P-450cam under catalytic conditions. |
| PubMed:Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. |
| PubMed:[d-Camphor Reference Standard (Control 901) and dl-Camphor Reference Standard (Control 901) of National Institute of Hygienic Sciences]. |
| PubMed:Cloning and nucleotide sequences of NADH-putidaredoxin reductase gene (camA) and putidaredoxin gene (camB) involved in cytochrome P-450cam hydroxylase of Pseudomonas putida. |
| PubMed:Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation. |
| PubMed:Theoretical study of the product specificity in the hydroxylation of camphor, norcamphor, 5,5-difluorocamphor, and pericyclocamphanone by cytochrome P-450cam. |
| PubMed:Oxime-metabolizing activity of liver aldehyde oxidase. |
| PubMed:[D-camphor-beta-sulfonic acid as an ion-pair reagent for the determination of biogenic amines and their metabolites in the rat brain by reverse phase high performance liquid chromatography]. |
| PubMed:Anticonvulsant properties of spirohydantoins derived from optical isomers of camphor. |
| PubMed:[Central depressant effect of l-tetrahydroberberine-d-camphor sulfonate (THB-CS). Electroencephalographic study]. |
| PubMed:High-pressure investigations of cytochrome P-450 spin and substrate binding equilibria. |
| PubMed:Novel reactivity of cytochrome P-450-CAM. Methyl hydroxylation of 5,5-difluorocamphor. |
| PubMed:Regioselectivity in the cytochromes P-450: control by protein constraints and by chemical reactivities. |
| PubMed:Proton coupling in the ligand-binding reaction of ferric cytochrome P-450 from Pseudomonas putida. |
| PubMed:Sequential cold-sensitive mutations in Aspergillus fumigatus. II. Analysis by the parasexual cycle. |
| PubMed:Cytochrome P-450cam and putidaredoxin interaction during electron transfer. |
| PubMed:Magnetic circular dichroism of Pseudomonas putida cytochrome P-450 in near infrared region. |
| PubMed:Growth inhibition of Vibrio cholerae by d-camphor. |
| PubMed:Inhibition of oxidative metabolism in Escherichia coli by d-camphor and restoration of oxidase activity by quinones. |
| PubMed:Growth inhibition of Escherichia coli strain 82-r by d-camphor. |
| PubMed:Proton magnetic resonance reveals high-spin iron (II) in ferrous cytochrome P450 cam from Pseudomonas putida. |
| PubMed:Induction specificity and catabolite repression of the early enzymes in camphor degradation by Pseudomonas putida. |
| PubMed:Approximation of rotational strengths from molar rotation data and generation of rotatory dispersion curves for d-camphor-10-sulfonate. |
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