myristica fragrans fruit extract
extract obtained from the fruits of the nutmeg, myristica fragrans, myristicaceae
Nutmeg Extract is prepared from the dried, ripe seed of the fruit from Myristica Fragrans, a tree originating in the East Indian archipelago. The nutmeg tree is now cultivated widely all over the tropical zones. Indonesia is the main supplier of East Indian nutmeg while the Federation of the West Indies are main suppliers of West Indian nutmeg. Ceylon produces East Indian nutmeg. West Indian nutmegs yield slightly more monoterpenes by distillation than do the East Indian nutmegs. Nutmeg Extract is usually a dark orange, somewhat grainy, viscous mass of very warm, spicy balsamic and strongly aromatic odor. The flavor is slightly burning, warm and spicy, truly reminiscent of nutmeg. The extract finds now and then use in old fashioned types of oriental perfume where it procudes delightful effects in combination with sandalwood, vetiver, clary sage, oakmoss, lavender absolute, tonka absolute, labdanum extracts, bergamot oil, patchouli oil and geranium oil. Minute additions of nutmeg extract can have very interesting effects in rose bases.
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      14-86100 NUTMEG FLAVOR EXTRACT, Kosher
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Name: myristica fragrans houtt. fruit extract
CAS Number: 84082-68-8 
ECHA EC Number: 282-013-3
Category: cosmetic, flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
182.10 Nutmeg and Mace View-review
FDA Regulation:
Subpart A--General Provisions
Sec. 182.20 Essential oils, oleoresins (solvent-free), and natural extractives (including distillates).
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Physical Properties:
Appearance: colorless to dark orange viscous liquid (est)
Food Chemicals Codex Listed: No
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Organoleptic Properties:
Odor Type: spicy
Odor Strength: medium
 spicy  woody  balsamic  green  waxy  floral  
Odor Description:
at 100.00 %. 
spicy woody balsam green waxy floral
 nutmeg  spicy  
Taste Description:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
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AuNutra® Industries
Nutmeg P.E.
nutmeg extract
Penta International
Nutmeg Extract
Vege Tech
nutmeg extract
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-human TDLo  214 mg/kg
Journal of Neuropsychiatry. Vol. 2, Pg. 205, 1961.

oral-man TDLo  143 mg/kg
Japanese Journal of Toxicology. Vol. 2, Pg. 169, 1989.

intraperitoneal-rat LD50  500 mg/kg
Journal of Neuropsychiatry. Vol. 2, Pg. 205, 1961.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic, flavor and fragrance agents
Recommendation for myristica fragrans fruit extract flavor usage levels up to:
  50.0000 ppm in the finished product.
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Safety References: search
Daily Med: search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 myristica fragrans houtt. fruit extract
Chemidplus: 0084082688
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 myristica fragrans houtt. fruit extract
Pubchem (sid): 135361447
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Other Information:
Export Tariff Code: 3301.29.5045
Household Products: Search
MedlinePlusSupp: View
Wikipedia: View
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Potential Blenders and core components note
None Found
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Potential Uses:
 egg nogFL
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Occurrence (nature, food, other): note
 nutmeg seed
Search Trop  Picture
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 extract obtained from the fruits of the nutmeg, myristica fragrans, myristicaceae
 nutmeg extract
 nutmeg flavor extract
 nutmeg P.E.
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PubMed: Potent acetylcholinesterase inhibitory compounds from Myristica fragrans.
PubMed: In Vitro Antibacterial Activity of Several Plant Extracts and Oils against Some Gram-Negative Bacteria.
PubMed: A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine.
PubMed: Myristica fragrans seed extract protects against dextran sulfate sodium-induced colitis in mice.
PubMed: Evaluation of analgesic activity and toxicity of alkaloids in Myristica fragrans seeds in mice.
PubMed: In vitro evaluation of five different herbal extracts as an antimicrobial endodontic irrigant using real time quantitative polymerase chain reaction.
PubMed: Antiglycation, antioxidant and toxicological potential of polyphenol extracts of alligator pepper, ginger and nutmeg from Nigeria.
PubMed: Antimalarial activities of medicinal plants and herbal formulations used in Thai traditional medicine.
PubMed: Antibacterial Activity of Myristica fragrans against Oral Pathogens.
PubMed: Extraction of betulin, trimyristin, eugenol and carnosic acid using water-organic solvent mixtures.
PubMed: Antibacterial activity of crude extracts of prasaprohyai formula and its components against pathogenic bacteria.
PubMed: Evaluation of the anti-depressant activity of Myristica fragrans (Nutmeg) in male rats.
PubMed: Mutagenic and antimutagenic assessment of methanol leaf extract of Myristica fragrans (Houtt.) using in vitro and in vivo genetic assays.
PubMed: Antioxidants in aqueous extract of Myristica fragrans (Houtt.) suppress mitosis and cyclophosphamide-induced chromosomal aberrations in Allium cepa L. cells.
PubMed: A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease.
PubMed: Standardization of the Unani drug - Myristica fragrans Houtt. (Javetri) - with modern analytical techniques.
PubMed: AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect.
PubMed: Towards a better understanding of the psychopharmacology of nutmeg: Activities in the mouse tetrad assay.
PubMed: Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes.
PubMed: Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation.
PubMed: Isolation and antifungal activity of lignans from Myristica fragrans against various plant pathogenic fungi.
PubMed: Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity.
PubMed: Toxicity of Myristica fagrans seed compounds against Blattella germanica (Dictyoptera: Blattellidae).
PubMed: Comparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myristica fragrans, ascorbic acid, and metrifonate in mice.
PubMed: Inhibition of protein tyrosine phosphatase 1B by lignans from Myristica fragrans.
PubMed: Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice.
PubMed: Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans.
PubMed: Antimicrobial activity of nutmeg against Escherichia coli O157.
PubMed: Comparison of effects of extract of Myristica fragrans and verapamil on the volume and acidity of carbachol induced gastric secretion in fasting rabbits.
PubMed: An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg).
PubMed: Improvement of mouse memory by Myristica fragrans seeds.
PubMed: Pharmacological studies on Myristica fragrans--antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters.
PubMed: Anxiogenic activity of Myristica fragrans seeds.
PubMed: [Quality standards of processed nutmegs].
PubMed: Screening of Chinese herbal drug extracts for inhibitory activity on nitric oxide production and identification of an active compound of Zanthoxylum bungeanum.
PubMed: Biological effects of Myristica fragrans (nutmeg) extract.
PubMed: Microbial stability of mango (Mangifera indica L.) juice preserved by combined application of mild heat and extracts of two tropical spices.
PubMed: Hypolipidaemic effect of Myristica fragrans fruit extract in rabbits.
PubMed: Occupational asthma due to different spices.
PubMed: Prevention of hypercholesterolemia and atherosclerosis in rabbits after supplementation of Myristica fragrans seed extract.
PubMed: Antiinflammatory effect of mace, aril of Myristica fragrans Houtt., and its active principles.
PubMed: Acute and chronic effects of a nutmeg extract on the toad heart.
PubMed: Effect of nutmeg on ethanol and d-amphetamine-produced alteration of locomotor activity in the mouse.
PubMed: The pharmacological effects of the ligroin extract of nutmeg (Myristica fragrans).
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