EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

4-isopropyl phenol
phenol, 4-(1-methylethyl)-

Sponsors

Name:4-propan-2-ylphenol
CAS Number: 99-89-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:202-798-8
FDA UNII:9F59JOO816
Nikkaji Web:J43.396I
Beilstein Number:1363564
MDL:MFCD00002372
XlogP3:2.90 (est)
Molecular Weight:136.19384000
Formula:C9 H12 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FLAVIS Number:04.073 (Old)
DG SANTE Food Flavourings:04.073 4-isopropylphenol
 
Physical Properties:
Appearance:white to tan powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 60.00 to 64.00 °C. @ 760.00 mm Hg
Boiling Point: 222.00 to 223.00 °C. @ 760.00 mm Hg
Boiling Point: 112.00 to 115.00 °C. @ 12.00 mm Hg
Vapor Pressure:0.147000 mm/Hg @ 25.00 °C. (est)
Flash Point: 203.00 °F. TCC ( 95.30 °C. ) (est)
logP (o/w): 2.900
Soluble in:
 alcohol
 water, 1102 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: woody
Odor Strength:medium ,
recommend smelling in a 1.00 % solution or less
woody warm spicy medicinal
Odor Description:at 1.00 % in dipropylene glycol. woody warm spicy medicinal
Flavor Type: burnt
">burnt phenolic
Taste Description: burnt phenolic
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
Penta International
4-isoPROPYLPHENOL
Santa Cruz Biotechnology
For experimental / research use only.
4-isoPropylphenol
Sigma-Aldrich: Aldrich
For experimental / research use only.
4-Isopropylphenol 98%
TCI AMERICA
For experimental / research use only.
4-isoPropylphenol >99.0%(GC)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
C N - Corrosive, Dangerous for the environment.
R 22 - Harmful if swallowed.
R 34 - Causes burns.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
R 43 - May cause sensitisation by skin contact.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 28 - After contact with skin, wash immediately with plenty of water.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 40 mg/kg
BEHAVIORAL: SLEEP
Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.

oral-mouse LD50 875 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(1), Pg. 94, 1981.

intraperitoneal-mouse LDLo 250 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 5, Pg. 339, 1953.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.24 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 420 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.500002.50000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.200001.00000
Edible ices, including sherbet and sorbet (03.0): 0.500002.50000
Processed fruit (04.1): 0.400002.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 1.000005.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 2.0000010.00000
Meat and meat products, including poultry and game (08.0): 0.200001.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.200001.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.300001.50000
Foodstuffs intended for particular nutritional uses (13.0): 0.500002.50000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 0.200001.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 1.000005.00000
Ready-to-eat savouries (15.0): 2.0000010.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.400002.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 22 (FGE.22): Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 58 (FGE.58) Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25
View page or View pdf
EPI System: View
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):99-89-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7465
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2430
WGK Germany:2
4-propan-2-ylphenol
Chemidplus:0000099898
RTECS:SL5950000 for cas# 99-89-8
 
References:
 4-propan-2-ylphenol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:99-89-8
Pubchem (cid):7465
Pubchem (sid):134972064
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
UM BBD:Search
HMDB (The Human Metabolome Database):HMDB29667
FooDB:FDB005302
Export Tariff Code:2907.19.8000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
amber
amber carane
FR
animal
musk indenofuran
FR
anise
estragon absolute
FR
balsamic
croton glabellus bark extract
FL/FR
frankincense absolute
FL/FR
guaiyl acetate
FL/FR
khella oil
FR
myrrh resinoid
FR
opoponax absolute (balsamodendron kafal)
FL/FR
valeriana wallichii root oil
FR
earthy
3-
octanol
FL/FR
floral
cassis specialty
FR
dihydrojasmone
FL/FR
mimosa absolute
FL/FR
mimosa absolute france
FL/FR
mimosa absolute india
FL/FR
rose concrete (rosa centifolia)
FR
green
octanal diethyl acetal
FL/FR
herbal
acorus calamus rhizome oil
FR
ajowan seed oil
FL/FR
anthemis nobilis flower oil roman
FL/FR
sweet
basil absolute
FL/FR
calamintha clinopodium oil
FR
canarium luzonicum oil
FL/FR
clary sage oil france
FL/FR
dill seed oil
FL/FR
dill seed oil CO2 extract
FL/FR
linalyl acetate
FL/FR
nonisyl acetate
FR
curled
parsley seed oil
FL/FR
petroselinum crispum seed oil CO2 extract
FL/FR
common
tansy flower oil
FR
common
tansy flower oil dutch
FR
theaspirane
FL/FR
thyme absolute
FL/FR
licorice
(E)-
anethol
FL/FR
medicinal
2-
hydroxybenzaldehyde
FL/FR
summer
savory oil
FL/FR
minty
(-)-iso
pulegol
FL/FR
musk
musk indanone
FR
orris
eugenyl formate
FL/FR
para-iso
propyl acetophenone
FL/FR
peppery
asarum europaeum oil
FR
phenolic
meta-
cresol
FR
ortho-
guaiacol
FL/FR
4-
methyl-2,6-dimethoxyphenol
FL/FR
saffron
saffron stigmates absolute
FR
spicy
allspice berry absolute
FL/FR
anona squamosa leaf oil
FR
artemisia dracunculus herb oil
FL/FR
atractylis root oil
FR
ayou wood oil
FR
carvacrol
FL/FR
beta-
caryophyllene
FL/FR
caryophyllene
FL/FR
alpha-
caryophyllene alcohol
FL/FR
cascarilla oil replacer
FL/FR
cassia bark oil china
FL/FR
cassia leaf oil
FL/FR
cinnamon bark oil
FL/FR
cinnamon bark oil (cinnamomum zeylanicum) india
FL/FR
cinnamon bark oil ceylon
FL/FR
cinnamon leaf oil ceylon
FL/FR
cinnamon oleoresin ceylon
FL/FR
clove bud absolute
FL/FR
clove bud oil CO2 extract
FL/FR
croton eluteria bark oil
FL/FR
eugenyl acetate
FL/FR
galangal root oil
FL/FR
ginger oleoresin africa
FL/FR
ginger root oil brazil
FL/FR
ginger root oil china
FL/FR
grains of paradise oil
FL/FR
green oxane
FR
mace absolute
FL/FR
mace oil
FL/FR
machilus kusanoi leaf oil
FR
machilus kusanoi wood oil
FR
maja fragrance
FR
methyl heptadienone
FL/FR
myristica fragrans fruit extract
FL/FR
myristica fragrans seed tincture
FL/FR
nutmeg oil
FL/FR
ocimum gratissimum herb oil india
FR
black
pepper absolute
FL/FR
pepper hexanone
FR
black
pepper oil CO2 extract
FL/FR
pepper tree berry absolute
FL/FR
pepper tree berry oil
FL/FR
piper longum fruit oil
FL/FR
piper longum fruit oil CO2 extract
FL/FR
safrole
CS
spicy carbonate
FR
sugandha kokila berry oil
FR
(E)-
tiglic acid
FL/FR
turmeric root absolute
FL/FR
zingiber officinale root extract
FL/FR
zingiber officinale root tincture
FL/FR
terpenic
para-
cymene
FL/FR
juniper branch oil
FR
(R)-(-)-alpha-
phellandrene
FL/FR
pine needle oil dwarf
FL/FR
thujonic
common
tansy oil canada
FR
vanilla
vanilla cresol
FR
vanillin propylene glycol acetal
FL/FR
woody
iso
caryophyllene
CS
caryophyllene alcohol acetate
FR
caryophyllene formate
FL/FR
beta-
caryophyllene oxide
FL/FR
atlas
cedarwood oil
FR
curcuma zedoaria bark extract
FL/FR
dacrydium franklinii wood oil
FR
frankincense resinoid
FL/FR
(E)-
germacrene D
FL/FR
guaiacwood oil
FL/FR
guaiacwood oil 20% in gurjun balsam oil
FR
guaiacyl acetate
FL/FR
hedychium spicatum root oil
FR
jatamansi root oil
FR
juniper berry oleoresin
FL/FR
methyl methylene tricyclodecanol
FR
patchouli absolute
FR
rhubarb oxirane
FR
sabinene
FL/FR
santal penten-2-ol
FR
spicy pentanone
FL/FR
spikenard oil
FL/FR
spikenard oil CO2 extract
FL/FR
zedoary bark oil
FL/FR
zedoary root oil
FL/FR
zedoary root oil CO2 extract
FL/FR
For Flavor
No flavor group found for these
alpha-
caryophyllene alcohol
FL/FR
caryophyllene formate
FL/FR
croton glabellus bark extract
FL/FR
eugenyl formate
FL/FR
(E)-
germacrene D
FL/FR
grains of paradise oil
FL/FR
guaiyl acetate
FL/FR
(R)-(-)-alpha-
phellandrene
FL/FR
piper longum fruit oil CO2 extract
FL/FR
spikenard oil
FL/FR
spikenard oil CO2 extract
FL/FR
anise
anise
(E)-
anethol
FL/FR
balsamic
opoponax absolute (balsamodendron kafal)
FL/FR
brown
(E)-
tiglic acid
FL/FR
cooling
theaspirane
FL/FR
floral
dihydrojasmone
FL/FR
linalyl acetate
FL/FR
fruity
spicy pentanone
FL/FR
green
canarium luzonicum oil
FL/FR
methyl heptadienone
FL/FR
octanal diethyl acetal
FL/FR
herbal
ajowan seed oil
FL/FR
anthemis nobilis flower oil roman
FL/FR
sweet
basil absolute
FL/FR
clary sage oil france
FL/FR
dill seed oil
FL/FR
dill seed oil CO2 extract
FL/FR
curled
parsley seed oil
FL/FR
petroselinum crispum seed oil CO2 extract
FL/FR
thyme absolute
FL/FR
meaty
phenyl mercaptan
FL
medicinal
frankincense absolute
FL/FR
summer
savory oil
FL/FR
minty
(-)-iso
pulegol
FL/FR
musty
3-
octanol
FL/FR
phenolic
4-
methyl-2,6-dimethoxyphenol
FL/FR
propyl 2-furoate
FL
pine
pine needle oil dwarf
FL/FR
smoky
prosopis juliflora wood extract
FL
solvent
methyl phenyl sulfide
FL
spicy
allspice berry absolute
FL/FR
artemisia dracunculus herb oil
FL/FR
carvacrol
FL/FR
beta-
caryophyllene
FL/FR
caryophyllene
FL/FR
cascarilla oil replacer
FL/FR
cassia bark oil china
FL/FR
cassia leaf oil
FL/FR
cinnamon bark oil
FL/FR
cinnamon bark oil (cinnamomum zeylanicum) india
FL/FR
cinnamon bark oil ceylon
FL/FR
cinnamon leaf oil ceylon
FL/FR
cinnamon oleoresin ceylon
FL/FR
clove bud absolute
FL/FR
clove bud oil CO2 extract
FL/FR
croton eluteria bark oil
FL/FR
eugenyl acetate
FL/FR
galangal root oil
FL/FR
ginger oleoresin africa
FL/FR
ginger root oil brazil
FL/FR
ginger root oil china
FL/FR
2-
hydroxybenzaldehyde
FL/FR
mace absolute
FL/FR
mace oil
FL/FR
myristica fragrans fruit extract
FL/FR
myristica fragrans seed tincture
FL/FR
nutmeg oil
FL/FR
black
pepper absolute
FL/FR
black
pepper oil CO2 extract
FL/FR
white
pepper oleoresin
FL
pepper tree berry absolute
FL/FR
pepper tree berry oil
FL/FR
piper longum fruit oil
FL/FR
para-iso
propyl acetophenone
FL/FR
winter
savory oil
FL
turmeric oleoresin
FL
turmeric root absolute
FL/FR
zingiber officinale root extract
FL/FR
zingiber officinale root tincture
FL/FR
terpenic
para-
cymene
FL/FR
vanilla
vanillin propylene glycol acetal
FL/FR
waxy
mimosa absolute
FL/FR
mimosa absolute france
FL/FR
mimosa absolute india
FL/FR
woody
beta-
caryophyllene oxide
FL/FR
curcuma zedoaria bark extract
FL/FR
frankincense resinoid
FL/FR
ortho-
guaiacol
FL/FR
guaiacwood oil
FL/FR
guaiacyl acetate
FL/FR
juniper berry oleoresin
FL/FR
sabinene
FL/FR
zedoary bark oil
FL/FR
zedoary root oil
FL/FR
zedoary root oil CO2 extract
FL/FR
 
Potential Uses:
FLspice
 
Occurrence (nature, food, other):note
 cumin seed - up to 1900 mg/kg
Search Trop Picture
 cumin seed oil
Search Trop Picture
 eucalyptus polybractea
Search Trop Picture
 potato fried potato
Search Trop Picture
 
Synonyms:
 australol
p-cumenol
para-cumenol
1-hydroxy-4-isopropyl benzene
1-hydroxy-4-isopropylbenzene
4-hydroxycumene
p-hydroxycumene
para-hydroxycumene
4-(1-methyl ethyl) phenol
4-(methylethyl)phenol
4-(1-methylethyl)phenol
 phenol, (1-methylethyl)-
 phenol, 4-(1-methylethyl)-
 phenol, 4-isopropyl-
 phenol, p-isopropyl-
 prodox 133
4-(prop-2-yl)phenol
4-(propan-2-yl)phenol
4-propan-2-ylphenol
4-isopropyl phenol
p-isopropyl phenol
para-isopropyl phenol
4-isopropylphenol
p-isopropylphenol
para-isopropylphenol
 
 
Notes:
Occurs in oil of Eucalyptus sp. [CCD]
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