tea tree oil australia
 
Notes:
Melaleuca Alternifolia is one of the smaller tea trees from southeastern Australia. Its leaves are collected and water or steam distilled locally. essential oil extracted from melaleuca alternifolia (tea tree). it is used as a topical antimicrobial due to the presence of terpineol. tsca definition 2008: extractives and their physically modified derivatives. melaleuca alternifolia, myrtaceae.
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Name: melaleuca alternifolia leaf oil
CAS Number: 68647-73-4 
MDL: MFCD00132409
Also Contains: melaleuca alternifolia leaf extract
Name: melaleuca alternifolia oil
CAS Number: 8022-72-8 
Category: antimicrobial agents
 
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FEMA Number: 3902  tea tree oil
FDA Mainterm: TEA TREE OIL (MELALEUCA ALTERNIFOLIA)
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Physical Properties:
Appearance: pale yellow to yellow clear liquid (est)
Food Chemicals Codex Listed: No
Specific Gravity: 0.88800 to 0.90900 @  25.00 °C.
Pounds per Gallon - (est).: 7.389 to  7.564
Refractive Index: 1.47500 to 1.48200 @  20.00 °C.
Optical Rotation: +5.00 to +15.00
Flash Point: 122.00 °F. TCC ( 50.00 °C. )
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage: store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 alcohol
 fixed oils
 paraffin oil
 water, 332.1 mg/L @ 25 °C (est)
Insoluble in:
 water
 glycerin
Stability:
 alkali
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Organoleptic Properties:
Odor Type: spicy
Odor Strength: medium
Odor Description:
at 100.00 %. 
spicy nutmeg pine warm terpene
Substantivity: 44 Hour(s)
  
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Cosmetic Information:
None found
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Safety Information:
Most important hazard(s):
Xn N - Harmful, Dangerous for the environment.
  R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
R 43 - May cause sensitisation by skin contact.
R 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R 65 - Harmful: may cause lung damage if swallowed.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
S 62 - If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label.
Oral/Parenteral Toxicity:
  oral-rat LD50  1900 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 407, 1988.

oral-child TDLo  500 uL/kg
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: ATAXIA
Journal of Toxicology, Clinical Toxicology. Vol. 32, Pg. 461, 1994.

oral-child TDLo  500 uL/kg
BEHAVIORAL: SLEEP BEHAVIORAL: ATAXIA
Veterinary and Human Toxicology. Vol. 37, Pg. 557, 1995.

oral-man TDLo  21 uL/kg
BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Medical Journal of Australia. Vol. 159, Pg. 830, 1993.

Dermal Toxicity:
  skin-rabbit LDLo 5000 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 407, 1988.

Inhalation Toxicity:
  Not determined
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Safety in Use Information:
Category: antimicrobial agents
Recommendation for tea tree oil australia usage levels up to:
  3.0000 % in the fragrance concentrate.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 18
Click here to view publication 18
 average usual ppmaverage maximum ppm
baked goods: 10.0000030.00000
beverages(nonalcoholic): 10.0000030.00000
beverages(alcoholic): 10.0000050.00000
breakfast cereal: 10.0000030.00000
cheese: 10.0000030.00000
chewing gum: 10.0000050.00000
condiments / relishes: 10.0000050.00000
confectionery froastings: 10.0000030.00000
egg products: 10.0000030.00000
fats / oils: 10.0000030.00000
fish products: 10.0000050.00000
frozen dairy: 10.0000030.00000
fruit ices: 10.0000030.00000
gelatins / puddings: 10.0000030.00000
granulated sugar: --
gravies: 10.0000050.00000
hard candy: 10.0000050.00000
imitation dairy: 10.0000030.00000
instant coffee / tea: 10.0000030.00000
jams / jellies: 10.0000030.00000
meat products: 10.0000050.00000
milk products: 10.0000030.00000
nut products: 10.0000030.00000
other grains: 10.0000030.00000
poultry: 10.0000030.00000
processed fruits: 10.0000030.00000
processed vegetables: 10.0000050.00000
reconstituted vegetables: 10.0000050.00000
seasonings / flavors: 10.0000030.00000
snack foods: 10.0000050.00000
soft candy: 10.0000030.00000
soups: 10.0000050.00000
sugar substitutes: 10.0000030.00000
sweet sauces: 10.0000030.00000
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 68647-73-4
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
SCCNFP: opinion
WISER: UN 1993
WGK Germany:3
 melaleuca alternifolia leaf oil
Chemidplus: 0068647734
RTECS: RJ3697600 for cas# 68647-73-4
 melaleuca alternifolia oil
Chemidplus: 0008022728
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References:
 melaleuca alternifolia leaf oil
Canada Domestic Sub. List: 68647-73-4
Pubchem (sid): 135349900
 melaleuca alternifolia oil
Canada Domestic Sub. List: 8022-72-8
Pubchem (sid): 135325475
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Other Information:
FDA Everything Added to Food in the United States (EAFUS): View
Export Tariff Code: 3301.29.5050
Household Products: Search
MedlinePlusSupp: View
Wikipedia: View
FAO: BASIC PRINCIPLES OF STEAM DISTILLATION
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Potential Blenders and core components note
 
For Odor
balsamic
 croton glabellus bark extractFL/FR
 mastic oilFL/FR
camphoreous
 clary alcoholFR
citrus
 oriental citrus fragranceFR
floral
 cananga oilFL/FR
 coriander seed oilFL/FR
 dihydrocarvyl acetateFL/FR
abrialis lavandin oilFL/FR
 neroli oil bigardeFL/FR
 rhodinyl acetateFL/FR
 rose absolute (rosa damascena) bulgariaFL/FR
herbal
 acorus calamus rhizome oilFR
1,4-cineoleFL/FR
6-hydroxydihydrotheaspirane (mixture of isomers)FL/FR
 lavender absolute bulgariaFL/FR
 myrtenolFL/FR
 piperitoneFL/FR
 sabinene hydrateFL/FR
 theaspiraneFL/FR
mentholic
 cornmint oil chinaFL/FR
(±)-isomenthoneFL/FR
 peppermint cyclohexanoneFL/FR
dextro-piperitoneFL/FR
minty
 pennyroyal oil fractionsFL/FR
 peppermint absoluteFL/FR
isopulegolFL/FR
(-)-isopulegolFL/FR
mossy
 oakmoss absoluteFL/FR
spicy
 allspice berry oil terpenelessFL/FR
 angelica oilFL/FR
 clove bud oilFL/FR
 cubeb oil CO2 extract (piper cubeba)FL/FR
 ginger oil terpenesFR
 ginger root oilFL/FR
 ginger root oil chinaFL/FR
 ginger root oil cochinFL/FR
 nutmeg oilFL/FR
 nutmeg oleoresinFL/FR
terpeneless black pepper oilFL/FR
black pepper oilFL/FR
terpenic
 cassis bud oilFL/FR
(R)-(-)-alpha-phellandreneFL/FR
tonka
 tonka bean absoluteFR
woody
(+)-campheneFL/FR
 campheneFL/FR
 sabineneFL/FR
 
For Flavor
 
No flavor group found for these
(+)-campheneFL/FR
 croton glabellus bark extractFL/FR
(R)-(-)-alpha-phellandreneFL/FR
 rose absolute (rosa damascena) bulgariaFL/FR
balsamic
 mastic oilFL/FR
camphoreous
 campheneFL/FR
6-hydroxydihydrotheaspirane (mixture of isomers)FL/FR
cooling
1,4-cineoleFL/FR
 sabinene hydrateFL/FR
 theaspiraneFL/FR
floral
 cananga oilFL/FR
 dihydrocarvyl acetateFL/FR
 neroli oil bigardeFL/FR
 rhodinyl acetateFL/FR
fruity
 cassis bud oilFL/FR
green
 oakmoss absoluteFL/FR
herbal
 coriander seed oilFL/FR
abrialis lavandin oilFL/FR
 lavender absolute bulgariaFL/FR
mentholic
 peppermint cyclohexanoneFL/FR
minty
 cornmint oil chinaFL/FR
(±)-isomenthoneFL/FR
 myrtenolFL/FR
 pennyroyal oil fractionsFL/FR
 peppermint absoluteFL/FR
 piperitoneFL/FR
dextro-piperitoneFL/FR
(-)-isopulegolFL/FR
isopulegolFL/FR
spicy
 allspice berry oil terpenelessFL/FR
 angelica oilFL/FR
 clove bud oilFL/FR
 cubeb oil CO2 extract (piper cubeba)FL/FR
 ginger root oilFL/FR
 ginger root oil chinaFL/FR
 ginger root oil cochinFL/FR
 nutmeg oilFL/FR
 nutmeg oleoresinFL/FR
black pepper oilFL/FR
terpeneless black pepper oilFL/FR
woody
 sabineneFL/FR
 
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Potential Uses:
 herbalFR
 mintFR
 nutmegFR
 pineFR
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Occurrence (nature, food, other): note
 tea tree
Search Trop  Picture
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Synonyms:
 melaleuca alternifolia leaf oil
 melasol (melaleuca alternifolia)
 oil distilled from the leaves of the tea tree, melaleuca alternifolia, myrtaceae
 tea tree EO
 tea tree ess. oil (for fragrance) (Robertet)
 tea tree essential oil
 tea tree oil
 tea tree oil australia organic
 tea tree oil natural
 tea tree oil organic
 teatree oil
 ti tree oil (melaleuca alternifolia)
 ti-trol (melaleuca alternifolia)
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Articles:
PubMed: Effect of a cooling gel on pain sensitivity and healing of hot-iron cattle brands.
PubMed: Spray-by-spray in situ cross-linking alginate hydrogels delivering a tea tree oil microemulsion.
PubMed: The effect of thyme and tea tree oils on morphology and metabolism of Candida albicans.
PubMed: Effect of a tea tree oil and organic acid footbath solution on digital dermatitis in dairy cows.
PubMed: Mosquitocidal essential oils: are they safe against non-target aquatic organisms?
PubMed: Antimicrobial activity of essential oils and five terpenoid compounds against Campylobacter jejuni in pure and mixed culture experiments.
PubMed: The possible mechanism of antifungal action of tea tree oil on Botrytis cinerea.
PubMed: α-Terpineol induces fatty liver in mice mediated by the AMP-activated kinase and sterol response element binding protein pathway.
PubMed: Fungal decay and shelf life of oranges coated with chitosan and bergamot, thyme, and tea tree essential oils.
PubMed: Plant essential oils and mastitis disease: their potential inhibitory effects on pro-inflammatory cytokine production in response to bacteria related inflammation.
PubMed: Characterization, antibiofilm, and mechanism of action of novel PEG-stabilized lipid nanoparticles loaded with terpinen-4-ol.
PubMed: Dipping and jetting with tea tree (Melaleuca alternifolia) oil formulations control lice (Bovicola ovis) on sheep.
PubMed: Bioactivity of tea tree oil from Melaleuca alternifolia against sheep lice (Bovicola ovis Schrank) in vitro.
PubMed: Insecticidal and repellent effects of tea tree (Melaleuca alternifolia) oil against Lucilia cuprina.
PubMed: Antimicrobial activity of two essential oils.
PubMed: Essential oils as biopreservatives: different methods for the technological application in lettuce leaves.
PubMed: MRSA colonisation (eradicating colonisation in people without active/invasive infection).
PubMed: Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex.
PubMed: Botanicals in dermatology: an evidence-based review.
PubMed: Alternative therapies for common dermatologic disorders, part 1.
PubMed: Candidiasis (vulvovaginal).
PubMed: Growth inhibition of pathogenic bacteria and some yeasts by selected essential oils and survival of L. monocytogenes and C. albicans in apple-carrot juice.
PubMed: Changes in antibiotic susceptibility in staphylococci habituated to sub-lethal concentrations of tea tree oil (Melaleuca alternifolia).
PubMed: Candidiasis (vulvovaginal).
PubMed: Habituation to sub-lethal concentrations of tea tree oil (Melaleuca alternifolia) is associated with reduced susceptibility to antibiotics in human pathogens.
PubMed: Melaleuca alternifolia essential oil possesses potent anti-staphylococcal activity extended to strains resistant to antibiotics.
PubMed: A review of the toxicity of Melaleuca alternifolia (tea tree) oil.
PubMed: The antimutagenic activity of Lavandula angustifolia (lavender) essential oil in the bacterial reverse mutation assay.
PubMed: Evaluation of antioxidant activity of Australian tea tree (Melaleuca alternifolia) oil and its components.
PubMed: Preferred age for assessment of qualitative and quantitative characteristics of the essential oil of tea tree (Melaleuca alternifolia) seedlings prior to plantation establishment.
PubMed: Bioactivity of Backhousia citriodora: antibacterial and antifungal activity.
PubMed: Comparison of oil recovered from tea tree leaf by ethanol extraction and steam distillation.
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