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sorbitan oleate
sorbitan monooleate

Supplier Sponsors

Name:[2-[(2R,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (Z)-octadec-9-enoate
CAS Number: 1338-43-8Picture of molecule3D/inchi
Other(deleted CASRN):122303-50-8
ECHA EINECS - REACH Pre-Reg:215-665-4
Beilstein Number:8172514
XlogP3-AA:6.00 (est)
Molecular Weight:428.60988000
Formula:C24 H44 O6
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:emulsifiers, stabilizers
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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JECFA Food Additive: Sorbitan Monooleate
GSFA Codex: Sorbitan monooleate (494)
DG SANTE Food Additives:sorbitan monooleate
DG SANTE Food Contact Materials:sorbitan monooleate
FDA Regulation:
Subpart A--Polymer Substances and Polymer Adjuvants for Food Treatment
Sec. 173.75 Sorbitan monooleate.

Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.

Subpart D--Certain Adjuvants and Production Aids
Sec. 178.3400 Emulsifiers and/or surface-active agents.

Subpart B--Drugs
Sec. 73.1001 Diluents in color additive mixtures for drug use exempt from certification.
Physical Properties:
Appearance:amber viscous liquid to solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 579.00 to 580.00 °C. @ 760.00 mm Hg (est)
Saponification Value:145.00 to 160.00
Flash Point: 367.00 °F. TCC ( 186.20 °C. ) (est)
logP (o/w): 6.014 (est)
Soluble in:
 water, hot
 water, 0.01914 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor Type: fatty
Odor Strength:low
Substantivity:400 Hour(s)
fatty oily waxy
Odor Description:at 100.00 %. fatty oily waxy
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: surfactant - emulsifying
BOC Sciences
For experimental / research use only.
Span80 95%
Chemical-navi - Nikkol
Odor: characteristic
Use: Special narrow distribution sorbitan oleate for anti-rust / corrosion prevention.
Chemical-navi - Nikkol
Odor: characteristic
Use: W/O emulsifier; anti-rust; plant-derived
Arlacel™ 1689
Odor: bland
Use: W/O emulsifier for a wide range of oils, for soft creams and milks. Used in baby care, body care, facial care, sun care, colour cosmetics and lip products.
Arlacel™ 481
Odor: bland
Use: Waxy W/O emulsifier preparations for high viscosity creams such as baby creams with ZnO. Used in baby care, facial care and sun care.
ECSA Chemicals
Graham Chemical
Sorbitan Monooleate
Kao Corporation
Odor: characteristic
Use: Emulsifier and conditioning agent (low substantive effect)
Kao Corporation
Odor: characteristic
Use: Emulsifiers for pharmaceuticals and cosmetics, Emulsifiers for agrochemicals.
Kao Corporation
Odor: characteristic
Use: Emulsifier for pharmaceuticals and cosmetics, Emulsifiers and dispersants for pigments, Emulsifiers for lubricants
Lipo Chemicals
Liposorb® O
Odor: characteristic
Use: Liposorb® O is primarily used in oil-in-water emulsions in combination with a high HLB emulsifier.The emulsifier pair produces smooth lotions and creams in skin and hair care and make-up bases. Liposorb® O is a spreading aid for bath oils and adds water-dispersibility to anhydrous systems.
Lonza Group
Glycomul™ O KFG
Lonza Group
Lonzest™ SMO
Mohini Organics
Odor: characteristic
Use: MONEMUL® - 80 is Non-ionic, lipophillic (Oil loving) surfactant. Used for preparing excellent water in oil emulsifier for neutral and mildly alkaline and acidic pH system. It is also used as stabilizer, softener, bodying agent, Opacifiers in cosmetic and pharmaceutical cream and lotions, coupling agent for medicants, Petroleum oils as a friction modifier and rust preventives. It also acts as a textile and leather lubricant. Widely used emulsifier for making Emulsion Explosives and used as co-surfactant with MOLESAN™ 909 and MOLESAN™ DG6 (Polymerized emulsifiers) for the packaged explosives.
Mohini Organics
Odor: characteristic
Use: MONEMUL® - 80Hi is Non-ionic, lipophillic (Oil loving) surfactant. The High Oleic content of this product makes it to use the special applications and world over this grade of product is used. The Low toxicity and low skin Irritation makes it to use as Emulsifier and Stabilizer for Oil based Lotions, Ointments and personal care formulations. MONEMUL® - 80Hi, is finding applications in Textiles as Antistat, Softeners and Lubricant for fabric softener and in Oil field Chemicals as Dispersant and Corrosion Inhibitor. The product is extensively used in the Emulsion Explosives as Mineral Oil (Fuel) Emulsifier.
Sorbitan Mono Oleate 20 EO
Sorbitan Mono Oleate N
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
Sorbitan Oleate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Sorbitan monooleate
SysKem Chemie
Sorbitan Monooleate
Sorbitan monoleate
Zschimmer & Schwarz
Lubricit SMO-H
Zschimmer & Schwarz
Lubricit SMO-VEG
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
emulsifiers, stabilizers
Recommendation for sorbitan oleate usage levels up to:
 not for fragrance use.
Recommendation for sorbitan oleate flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Re-evaluation of sorbitan monostearate (E 491), sorbitan tristearate (E 492), sorbitan monolaurate (E 493), sorbitan monooleate (E 494) and sorbitan monopalmitate (E 495) when used as food additives
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):1338-43-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6433271
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
[2-[(2R,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (Z)-octadec-9-enoate
RTECS:WG2932400 for cas# 1338-43-8
 [2-[(2R,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (Z)-octadec-9-enoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:1338-43-8
Pubchem (cid):6433271
Pubchem (sid):134979650
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):HMDB29886
Export Tariff Code:2916.15.5000
FDA Listing of Food Additive Status:View
Potential Blenders and core components note
None Found
Potential Uses:
 emulsifying agents
Occurrence (nature, food, other):note
 not found in nature
 alkamuls S/80
 alkamuls SMO
1,4-anhydro-D-glucitol 6-(9-octadecanoate)
1,4-anhydro-D-glucitol, 6-(9-octadecenoate)
1,4-anhydro-dextro-glucitol 6-(9-octadecanoate)
 anhydrosorbitol monooleate
 arlacel 1689
 arlacel 481
 arlacel 80
 armotan MO
 crill 4
 dehymuls SMO
[2-[(2R,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (Z)-octadec-9-enoate
 emasol 410
D-glucitol, 1,4-anhydro-, 6-(9-octadecenoate)
 glycomul O
 glycomul O KFG
 ionet S-80
 kaopan SP-O-10
 kemmat S 80
 liposorb O
 lonzest SMO
 lubricit SMO-H
 lubricit SMO-VEG
 monemul - 80
 monemul - 80Hi
 montan 80
 montane 80
 montane 80 VGA
 newcol 80
 nikkol SO-10NR
 nikkol SO-10V
 nissan nonion OP 80R
 nonion OP80R
 radiasurf 7155
 rheodol AO-10V
 rheodol SP-O10V
 S-MAX 80
 sorban AO
 sorbirol O
 sorbitan mono-(9Z)-9-octadecenoate
 sorbitan mono-(Z)-9-octadecenoate
 sorbitan mono-oleate
 sorbitan monooleate
 sorbitan monooleic acid ester
 sorbitan O
 sorbitan, mono-(9Z)-9-octadecenoate
 sorbitan, mono-9-octadecenoate, (Z)-
 sorbon S 80


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PubMed:Interface composition of multiple emulsions: rheology as a probe.
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PubMed:Solubilizing excipients in oral and injectable formulations.
PubMed:Polymeric nanoparticles composed of fatty acids and polyvinylalcohol for topical application of sunscreens.
PubMed:Effects of ethanol addition on micellar solubilization and plume migration during surfactant enhanced recovery of tetrachloroethene.
PubMed:Solubilization of cyclosporin A.
PubMed:Formation and characterization of three-component-sorbitan monoester surfactant, oil and water-creams.
PubMed:Enzymatic activity and stability of D-fructose dehydrogenase and sarcosine dehydrogenase immobilized onto giant vesicles.
PubMed:Comparison of oil-in-water emulsions manufactured by microfluidization and homogenization.
PubMed:Oral bioavailability of the antioxidant astaxanthin in humans is enhanced by incorporation of lipid based formulations.
PubMed:Aerobic biological treatment of synthetic municipal wastewater in membrane-coupled bioreactors.
PubMed:The effects of pressure-sensitive adhesives and solubilizers on the skin permeation of testosterone from a matrix-type transdermal delivery system.
PubMed:Rheological properties of three component creams containing sorbitan monoesters as surfactants.
PubMed:Co-surfactant of ethoxylated sorbitan ester and sorbitan monooleate for enhanced flushing of tetrachloroethylene.
PubMed:[Lipase-catalyzed enantioselective ammonolysis of racemic phenylglycine methyl ester in organic solvent].
PubMed:Medium-chain fatty acids but not L-carnitine accelerate the kinetics of [14C]triacylglycerol utilization by colostrum-deprived newborn pigs.
PubMed:Naphthalene, phenanthrene and surfactant biodegradation.
PubMed:Final report on the safety assessment of sorbitan caprylate, sorbitan cocoate, sorbitan diisostearate, sorbitan dioleate, sorbitan distearate, sorbitan isostearate, sorbitan olivate, sorbitan sesquiisostearate, sorbitan sesquistearate, and sorbitan triisostearate.
PubMed:Marking of nonpalpable breast lesions using a custom carbon suspension.
PubMed:Reduction of linoleic acid inhibition in production of conjugated linoleic acid by Propionibacterium freudenreichii ssp. shermanii.
PubMed:Effect of hydrophilic substances on liberation of quinidine from starch - alginate sphere.
PubMed:The Behavior of Sorbitan Surfactants at the Water-Oil Interface: Straight-Chained Hydrocarbons from Pentane to Dodecane as an Oil Phase.
PubMed:Rheological properties of creams with four different surfactant combinations - effect of storage time and conditions.
PubMed:The Effect of Temperature on Sorbitan Surfactant Monolayers.
PubMed:Topical transport of hydrophilic compounds using water-in-oil nanoemulsions.
PubMed:Surfactant enhanced recovery of tetrachloroethylene from a porous medium containing low permeability lenses. 1. Experimental studies.
PubMed:Characterizing colloidal structures of pseudoternary phase diagrams formed by oil/water/amphiphile systems.
PubMed:Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres.
PubMed:Controlled Growth of Gold Nanoparticles in Aerosol-OT/Sorbitan Monooleate/Isooctane Mixed Reverse Micelles.
PubMed:Determination of optimal combination of surfactants in creams using rheology measurements.
PubMed:Influence of surfactants in aqueous-based polymeric dispersions on the thermomechanical and adhesive properties of acrylic films.
PubMed:Oestradiol skin delivery from ultradeformable liposomes: refinement of surfactant concentration.
PubMed:Separation of aniline from aqueous solutions using emulsion liquid membranes.
PubMed:Mixed Micelles of Sodium Deoxycholate and Polyoxyethylene Sorbitan Monooleate (Tween 80).
PubMed:Patch testing in contact cheilitis.
PubMed:Effects of surfactant on release characteristics of clonidine hydrochloride from ethylcellulose film.
PubMed:The composition of NF-defined emulsifiers: sorbitan monolaurate, monopalmitate, monostearate, monooleate, polysorbate 20, polysorbate 40, polysorbate 60, and polysorbate 80.
PubMed:Formulation of a protein with propellant HFA 134a for aerosol delivery.
PubMed:The effect of core-to-wall ratio and Span 80 concentration on the properties of ascorbic acid microcapsules.
PubMed:Influence of interfacial rheological properties of mixed emulsifier films on the stability of water-in-oil-in-water emulsions.
PubMed:Synthesis of bioadhesive poly(acrylic acid) nano- and microparticles using an inverse emulsion polymerization method for the entrapment of hydrophilic drug candidates.
PubMed:Effects of Tween 80 and sucrose on acute short-term stability and long-term storage at -20 degrees C of a recombinant hemoglobin.
PubMed:A study on the in-vitro percutaneous absorption of propranolol from disperse systems.
PubMed:Preparation and evaluation of sustained release cross-linked chitosan microspheres containing phenobarbitone.
PubMed:Effect of Neck Formation on the Measurement of Dynamic Interfacial Tension in a Drop Volume Tensiometer
PubMed:MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM197 conjugate vaccine.
PubMed:Stability and stabilization of recombinant peroxidase in reversed micelles.
PubMed:Contact dermatitis due to emulsifiers.
PubMed:Studies on the Mutagenicity of Mild Gasification Products of Coal and Their Subfractions by the Salmonella/Microsomal Assay
PubMed:Studies on the mutagenicity of mild gasification products of coal and their subfractions by the Salmonella/microsomal assay.
PubMed:Sorbitan mono-oleate: a potential allergen in paste bandages.
PubMed:Microencapsulation of ovalbumin in poly(lactide-co-glycolide) by an oil-in-oil (o/o) solvent evaporation method.
PubMed:The effect of surfactant and solid phase concentration on drug aggregates in model aerosol propellent suspensions.
PubMed:Characterization of surfactant effect on aggregates in model aerosol propellent suspensions.
PubMed:Characterization of the lipase activity of Malassezia furfur.
PubMed:Geodesic surfactant structures.
PubMed:Enhancement of humoral response against human influenza vaccine with the simple submicron oil/water emulsion adjuvant MF59.
PubMed:Multiple emulsion-based systems carrying insulin: development and characterization.
PubMed:Prolonged release of rifampicin from multiple w/o/w emulsion systems.
PubMed:Effect of surfactants on the physical stability of recombinant human growth hormone.
PubMed:Some preparative variables influencing the properties of W/O/W multiple emulsions.
PubMed:High sensitization rate to emulsifiers in patients with chronic leg ulcers.
PubMed:Evaluation of solubilizers in the drug release testing of hydrophilic matrix extended-release tablets of felodipine.
PubMed:The influence of surface properties on uptake of oil into complex coacervate microcapsules.
PubMed:Stability and activity of hydrogenases of Methanobacterium thermoautotrophicum and Alcaligenes eutrophus in reversed micellar systems.
PubMed:Penicillin G extraction from model media using an emulsion liquid membrane: determination of optimum extraction conditions.
PubMed:Emulsification and fatty acid chain length affect the kinetics of [14C]-medium-chain triacylglycerol utilization by neonatal piglets.
PubMed:Emulsification and fatty-acid chain length affect the utilization of medium-chain triglycerides by neonatal pigs.
PubMed:Utilization of medium-chain triglycerides by neonatal pigs: effects of emulsification and dose delivered.
PubMed:Effects of nonionic surfactants on the solubilization and mineralization of phenanthrene in soil-water systems.
PubMed:Extraction and enrichment of cadmium and manganese from aqueous solution using a liquid membrane.
PubMed:Effects of polyoxyethylene (20) sorbitan monooleate on the acute toxicity of linear alkylbenzenesulfonate (C12LAS) to fish.
PubMed:Preparation of multi-phase microspheres of poly(D,L-lactic acid) and poly(D,L-lactic-co-glycolic acid) containing a W/O emulsion by a multiple emulsion solvent evaporation technique.
PubMed:Phase diagram studies for microencapsulation of pharmaceuticals using cellulose acetate trimellitate.
PubMed:Prevalence and sources of sensitization to emulsifiers: a clinical study.
PubMed:Excitatory potential of artificial membrane in response to current pulse stimulation.
PubMed:Comparison of enrichment and plating media for isolation of Yersinia.
PubMed:A pharmacokinetic model for the percutaneous absorption of indomethacin and the prediction of drug disposition kinetics.
PubMed:[Extraction of cholesterol from the blood using multiple emulsions].
PubMed:Effect of proteins on the assessment of surfactant cytotoxicity by an in vitro test: Possible correlations with in vivo data.
PubMed:Absorption of indomethacin and its calcium salt through rat skin: effect of penetration enhancers and relationship between in vivo and in vitro penetration.
PubMed:Some factors affecting the microencapsulation of pharmaceuticals with cellulose acetate phthalate.
PubMed:Intestinal calcium absorption in the rat after oral Tween 80 administration.
PubMed:Stable oil-in-water emulsions: preparation and use as vaccine vehicles for lipophilic adjuvants.
PubMed:Polysorbate 80: a pharmacological study.
PubMed:Self-excitation in a porous membrane doped with sorbitan monooleate (Span-80) induced by an Na+/K+ concentration gradient.
PubMed:Spectrophotometric method for quantitation of peroxides in sorbitan monooleate and monostearate.
PubMed:Influence of surface-active food additives on the integrity and permeability of rat intestinal mucosa.
PubMed:Experimental Corynebacterium pseudotuberculosis infection in lambs.
PubMed:Purification and characterization of the tween-hydrolyzing esterase of Mycobacterium smegmatis.
PubMed:Mycobacteriocins produced by rapidly growing mycobacteria are Tween-hydrolyzing esterases.
PubMed:Allergic contact dermatitis to sorbitan monooleate (Span 80).
PubMed:Viscosity change after dilution with solutions of water--oil--water emulsions and solute permeability through the oil layer.
PubMed:Arthritis-inducing ability of a synthetic adjuvant, N-acetylmuramyl peptides, and bacterial disaccharide peptides related to different oil vehicles and their composition.
PubMed:[Ointments on an emulsified base with pentol and sorbitanoleate in the prevention of skine lesions in furniture manufacture workers].
PubMed:Possible involvement of a calcium-stimulated ATP-hydrolyzing activity associated with mycobacteriophage I3 in the DNA injection process.
PubMed:An esterase on the outer membrane of Pseudomonas aeruginosa for the hydrolysis of long chain acyl esters.
PubMed:[Studies on the parmacodynamic activity of several drug solvents. 3. 1,2-Propanediol, tetrahydrofurfuryl alcohol-polyethylene glycol ether (THFP), olyoxyethylene sorbitan monooleate (PSM)].
PubMed:Stability of lactic Acid bacteria to freezing as related to their Fatty Acid composition.
PubMed:The use of d-limonene preparation as a dissolving agent of gallstones.
PubMed:Release of cell-bound polygalacturonase and cellulase from mycelium of Rhizoctonia solani.
PubMed:Death of Lactobacillus bulgaricus Resulting from Liquid Nitrogen Freezing.
PubMed:Physical properties of a polyoxyethylene sorbitan monooleate micelle.
PubMed:Leptospiral selection, growth, and virulence in synthetic medium.
PubMed:[Effects of polyoxyethylene sorbitan monooleate (tween 80) on digestion & on intestinal absorption of fats].
PubMed:Interaction of preservatives with macromolecules. I. Binding of parahydroxybenzoic acid esters by polyoxyethylene 20 sorbitan monooleate (tween 80).
PubMed:Celiac disease treated with polyoxyethylene sorbitan monooleate.
PubMed:The effect of wetting agents on the growth of tubercle bacilli.
PubMed:The preparation and stability of fatty acid-free polyoxethylene sorbitan monooleate (tween 80).
Emulsifier and clarification agent in food preparations (sugar liquor or juice)
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