EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

ortho-salicylic acid
2-hydroxybenzoic acid

Supplier Sponsors

Name:2-hydroxybenzoic acid
CAS Number: 69-72-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-712-3
FDA UNII: O414PZ4LPZ
Nikkaji Web:J2.370A
Beilstein Number:0774890
MDL:MFCD00002439
CoE Number:10165
XlogP3:2.30 (est)
Molecular Weight:138.12242000
Formula:C7 H6 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:stabilizing agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:958 2-hydroxybenzoic acid
DG SANTE Food Flavourings:08.112 o-salicylic acid
DG SANTE Food Contact Materials:o-salicylic acid
FEMA Number:3985 2-hydroxybenzoic acid
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):69-72-7 ; SALICYLIC ACID
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2600 Rubber articles intended for repeated use.
 
Physical Properties:
Appearance:white powder (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 158.00 to 161.00 °C. @ 760.00 mm Hg
Boiling Point: 211.00 °C. @ 20.00 mm Hg
Boiling Point: 336.00 to 337.00 °C. @ 760.00 mm Hg
Vapor Pressure:1.000000 mmHg @ 114.00 °C.
Vapor Density:4.8 ( Air = 1 )
Flash Point:> 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w): 2.260
Soluble in:
 alcohol
 water, 3808 mg/L @ 25 °C (est)
 water, 2240 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor Type: nutty
phenolic nutty
Odor Description:at 100.00 %. faint phenolic nutty
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antidandruff agents
fragrance
hair conditioning
keratolytics
preservatives
skin conditioning
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Salicylic acid 98%
American International Chemical, LLC.
Salicylic Acid from Wintergreen
Aurochemicals
SALICYLIC ACID, Natural
BOC Sciences
For experimental / research use only.
Salicylic Acid >98%
Charkit Chemical
SALICYLIC ACID PHARMA/USP
Charkit Chemical
SALICYLIC ACID TECH GRADE
Charkit Chemical
SALICYLIC ACID USP
ECSA Chemicals
SALICYLIC ACID RPH- FU, KG 1
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
SALICYLIC ACID
EMD Millipore
For experimental / research use only.
Salicylic Acid
Glentham Life Sciences
Salicylic acid, 99%
Glentham Life Sciences
Salicylic acid, BP, Ph. Eur grade
Global Essence
Salicylic Acid Natural
Graham Chemical
Salicylic Acid
Lipo Chemicals
Lipo® CD-SA
Odor: characteristic
Use: Lipo® CD-SA is an aqueous solution of cyclodextrin-encapsulated salicylic acid. Salicylic acid is a topical keratolytic agent. This compound is used in many personal care products to enhance exfoliation of the surface stratum corneum and in acne treatment products.
Penta International
SALICYLIC ACID FOOD GRADE
Penta International
SALICYLIC ACID NATURAL
Penta International
SALICYLIC ACID USP CRYSTAL
Penta International
SALICYLIC ACID USP POWDER
Santa Cruz Biotechnology
For experimental / research use only.
Salicylic Acid ≥99%
Sigma-Aldrich
Salicylic acid, ≥99%, FG
Certified Food Grade Products
Silver Fern Chemical
Salicylic Acid
Odor: characteristic
Use: Salicylic Acid is widely used in the cosmetics, personal care, and pharmaceutical industries. It is also used in the manufacture of aspirin and salicylates, resins, as a food preservative, and a fungicide.
TCI AMERICA
For experimental / research use only.
2-Hydroxybenzoic Acid >99.5%(T)
Ungerer & Company
Salicylic Acid Natural
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/38 - Irritating to skin and eyes.
R 41 - Risk of serious damage to eyes.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 891 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971

oral-mouse LD50 480 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959.

oral-rabbit LD50 1300 mg/kg
Drugs in Japan Vol. 6, Pg. 291, 1982.

intraperitoneal-rat LD50 157 mg/kg
BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 31, 1992.

oral-mouse LD50 908 mg/kg
(Sado, 1973)

gavage-rat LD50 1050 mg/kg
(Hasegawa et al., 1989)

oral-cat LD50 400 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959.

intraperitoneal-mouse LD50 300 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gendai no Rinsho. Vol. 3, Pg. 675, 1969.

intravenous-mouse LD50 184 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakugaku Zasshi. Journal of Pharmacy. Vol. 91, Pg. 550, 1971.

Dermal Toxicity:
skin-rabbit LD50 > 10000 mg/kg
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971

skin-rat LD50 > 2000 mg/kg
LIVER: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 15(Suppl

subcutaneous-mouse LD50 520 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS CARDIAC: CHANGE IN RATE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 38, Pg. 9, 1930.

subcutaneous-rabbit LDLo 6000 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.

skin-man TDLo 57 mg/kg
SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR
JAMA, Journal of the American Medical Association. Vol. 244, Pg. 660, 1980.

Inhalation Toxicity:
inhalation-rat LC50 > 900 mg/m3/1H
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971

inhalation-mammal (species unspecified) LC50 > 300 mg/m3
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 31, 1992.

 
Safety in Use Information:
Category:
stabilizing agents
Recommendation for ortho-salicylic acid usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.024 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.03 (μg/capita/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 20
Click here to view publication 20
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): 5.0000050.00000
beverages(alcoholic): 10.00000100.00000
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 10.00000100.00000
fruit ices: 10.00000100.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: 10.00000100.00000
meat products: --
milk products: 5.0000050.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23
View page or View pdf

Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 9, Revision 1: (FGE.09 Rev1)[1] - Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical groups 8 and 30, and an ester of a phenol carboxylic acid from chemical group 25 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23
View page or View pdf

Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009)
View page or View pdf

Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1]
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

Flavouring Group Evaluation 9, Revision 2 (FGE.09Rev2): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):69-72-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :338
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:1
2-hydroxybenzoic acid
Chemidplus:0000069727
EPA/NOAA CAMEO:hazardous materials
RTECS:69-72-7
 
References:
 2-hydroxybenzoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:69-72-7
Pubchem (cid):338
Pubchem (sid):135269852
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C00805
HMDB (The Human Metabolome Database):HMDB01895
FooDB:FDB000882
YMDB (Yeast Metabolome Database):YMDB01322
Export Tariff Code:2918.29.0800
MedlinePlusSupp:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
salicylic acid formulations: salicylic acid formulations: preparation dose (%) product manufacturer fostex medicated cleansing bar bristol-myers salicylic acid cleansing bar stiefel cream fostex medicated cleansing cream bristol-myers deep cleansing shower gel glaxosmithkline neutrogena clear pore treatment neutrogena propa ph peel-off acne mask stri-dex clear gel maximum strength (with sd alcohol 9.3%) blistex hydrisalic (with sd alcohol 40b and propylene glycol) pedinol clear away gel (with alcohol 57.6% ww, ether 16.4% ww in flexible collodion) schering-plough compound w gel (with alcohol 57.6% and ether 16.42% in flexible collodion) medtech duoplant gel (with alcohol 67.5% in flexible collodion) schering-plough lotion salac acne medication-cleanser (with benzyl alcohol) bioglan sebasorb (with attapulgite activated 10%) summers ointment mg 217 sal-acid triton plaster trans-ver-sal (with propylene glycol) clear away schering-plough clear away plantar system schering-plough compound w one step pads medtech freezone pads medtech mediplast beiersdorf sal-acid pedinol pledgets (saturated with solution) oxy balance daily cleansing pads (with sd alcohol 40b 40% and propylene glycol) glaxosmithkline stri-dex regular strength pads (with sd alcohol 28%) blistex stri-dex sensitive skin pads (with sd alcohol 28% and aloe) blistex noxzema 2-in-1 pads extra strength procter & gamble oxy balance maximum daily cleansing pads (with sd alcohol 40b 50% and propylene glycol) glaxosmithkline stayclear deep cleaning pads boots stri-dex pads maximum strength (with sd alcohol 40 44%) blistex stri-dex super scrub pads (with sd alcohol 54%) blistex shampoo ionil plus (with sd alcohol 40 12%) healthpoint dhs sal shampoo person & covey neutrogena tsal maximum strength neutrogena solution propa ph cleanser (with sd alcohol 40 25% and aloe) propa ph normalsensitive astringent cleanser sebucare lotion (with alcohol 61%) bristol-myers squibb multi-action astringent (with alcohol 38.8%) glaxosmithkline noxzema 2-in-1 astringent procter & gamble propa ph foaming face wash propa ph maximum strength astringent cleanser stayclear zone-controlled clearstick boots gordofilm (in flexible collodian) gordon clear away liquid (with 17% sd alcohol 32, ether 52% in flexible collodion) schering-plough compound w solution (with alcohol 21.2% and ether 63.5% in flexible collodion) medtech duofilm (with alcohol sd 32 17% and ether 52% in flexible collodion) schering-plough occlusal-hp (with isopropyl alcohol 63% in a polyacrylic vehicle) bioglan off-ezy wart remover (with alcohol 21% and ether 65% in flexible collodion) salactic film (with isopropyl alcohol 2.7% in a flexible collodion) pedinol sal-plant gel (with isopropyl alcohol 2.5% in flexible collodion) pedinol wart-off (with alcohol 26.35% in flexible collodion) pfizer freezone (with alcohol 20.5% and ether 65.5% in flexible collodion) medtech
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 antidandruff agents
 bacteriostatic
FRcastoreum
 fungicide
 hair conditioning
 keratolytics
 preservatives
 skin conditioning
 
Occurrence (nature, food, other):note
 anise seed
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 barley shoot
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 beet root
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 bilberry leaf
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 broccoli asparagus broccoli leaf
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 cashew fruit
Search Trop Picture
 cassia plant
Search Trop Picture
 chamomile sweet false chamomile plant
Search Trop Picture
 cotton root
Search Trop Picture
 currant red currant fruit
Search Trop Picture
 evening-primrose plant
Search Trop Picture
 garlic bulb
Search Trop Picture
 grape hull husk
Search Trop Picture
 grape leaf
Search Trop Picture
 grape root
Search Trop Picture
 meadow sweet
Search Trop Picture
 pea plant
Search Trop Picture
 peanut seed
Search Trop Picture
 pennyroyal
Search Trop Picture
 raspberry red raspberry fruit
Search Trop Picture
 raspberry red raspberry plant
Search Trop Picture
 sage plant
Search Trop Picture
 soybean seed
Search Trop Picture
 sunflower seed
Search Trop Picture
 tarragon leaf
Search Trop Picture
 tea leaf
Search Trop Picture
 wheat seed
Search Trop Picture
 ylang ylang
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Synonyms:
 acidum salicylicum
 amiperfect
 amipreserve
 benzoic acid, 2-hydroxy-
 benzoic acid, o-hydroxy-
2-carboxyphenol
o-carboxyphenol
ortho-carboxyphenol
 compound W
 domerine
 duofilm
 duoplant
 fostex
 freezone
2-hydroxy-benzoic acid
2-hydroxybenzene carboxylic acid
2-hydroxybenzenecarboxylic acid
2-hydroxybenzoic acid
o-hydroxybenzoic acid
ortho-hydroxybenzoic acid
 phenol-2-carboxylic acid
 retarder W
2-salicylic acid
o-salicylic acid
 salicylic acid crystalline/powder
 salicylic acid natural
 salicylic acid USP crystal
 salicylic acid USP powder
 saligel
 salonil
 sebucare
 verrugon
 

Articles:

PubMed:Effects of salicylic acid and putrescine on storability, quality attributes and antioxidant activity of plum cv. 'Santa Rosa'.
J-Stage:Cellulase Applied to the Leaves of Sweet Pepper (Capsicum annuum L. var. grossum) Upregulates the Production of Salicylic and Azelaic Acids
PubMed:Effects of postharvest salicylic acid dipping on Alternaria rot and disease resistance of jujube fruit during storage.
PubMed:After-ripening induced transcriptional changes of hormonal genes in wheat seeds: the cases of brassinosteroids, ethylene, cytokinin and salicylic acid.
PubMed:Evaluation of the pharmacological properties of salicylic acid-derivative organoselenium: 2-hydroxy-5-selenocyanatobenzoic acid as an anti-inflammatory and antinociceptive compound.
PubMed:Toxicology of isoproturon to the food crop wheat as affected by salicylic acid.
PubMed:Eugenol enhances the resistance of tomato against tomato yellow leaf curl virus.
PubMed:Reciprocal crosstalk between jasmonate and salicylate defence-signalling pathways modulates plant volatile emission and herbivore host-selection behaviour.
PubMed:Application of Tb(4)O(7) nanoparticles for lasalocid and salicylate determination in food analysis.
PubMed:A systemic response of geophytes is demonstrated by patterns of protein expression and the accumulation of signal molecules in Zantedeschia aethiopica.
PubMed:Biotic elicitors effectively increase the glucosinolates content in Brassicaceae sprouts.
PubMed:Opening of Iris flowers is regulated by endogenous auxins.
PubMed:The effects of host defence elicitors on betacyanin accumulation in Amaranthus mangostanus seedlings.
PubMed:Two centrosymmetric dinuclear phenanthroline-copper(II) complexes with 3,5-dichloro-2-hydroxybenzoic acid and 5-chloro-2-hydroxybenzoic acid.
PubMed:Influence of elicitation with H₂O₂ on phenolics content, antioxidant potential and nutritional quality of Lens culinaris sprouts.
PubMed:Novel interrelationship between salicylic acid, abscisic acid, and PIP2-specific phospholipase C in heat acclimation-induced thermotolerance in pea leaves.
PubMed:[Changes in H2O2 and salicylic acid contents as well as plasma membrane H+-ATPase activity and their relations in pea leaves during thermotolerance induction].
PubMed:Phenolic Compounds from Halimodendron halodendron (Pall.) Voss and Their Antimicrobial and Antioxidant Activities.
PubMed:Hydrogen peroxide scavenging, antioxidant and anti-radical activity of some phenolic acids.
PubMed:Nematicidal activity of mint aqueous extracts against the root-knot nematode Meloidogyne incognita.
PubMed:Anti-inflammatory drugs selectively target sporangium development in Mucor.
PubMed:New CE-ESI-MS analytical method for the separation, identification and quantification of seven phenolic acids including three isomer compounds in virgin olive oil.
PubMed:Effect of chemical systemic acquired resistance elicitors on avenanthramide biosynthesis in oat (Avena sativa).
PubMed:Determination of the antioxidant capacity of active food packagings by in situ gas-phase hydroxyl radical generation and high-performance liquid chromatography-fluorescence detection.
PubMed:Effect of external stress on density and size of glandular trichomes in full-grown Artemisia annua, the source of anti-malarial artemisinin.
PubMed:Pleiotropic changes in Arabidopsis f5h and sct mutants revealed by large-scale gene expression and metabolite analysis.
PubMed:Aspirin inhibits secretagogue-stimulated and postprandial pancreatic exocrine secretion in conscious rats.
PubMed:Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle.
PubMed:Benzothiadiazole induces the accumulation of phenolics and improves resistance to powdery mildew in strawberries.
PubMed:Phenolic acid profiles in some small berries.
PubMed:Salicylate activity. 3. Structure relationship to systemic acquired resistance.
PubMed:Chemical marker for ALS-inhibitor herbicides: 2-aminobutyric acid proportional in sub-lethal applications.
PubMed:Development of a yeast bio-assay to screen anti-mitochondrial drugs.
PubMed:Inhibition of pancreatic lipase by phenolic acids--examination in vitro.
PubMed:Valine pathway is more crucial than phenyl propanoid pathway in regulating capsaicin biosynthesis in Capsicum frutescens mill.
PubMed:Metabolic profiling of root exudates of Arabidopsis thaliana.
PubMed:Adsorption and Chemical Modification of Phenols on a Silver Surface.
PubMed:Is there a role for dietary salicylates in health?
 
Notes:
a compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. it has bacteriostatic, fungicidal, and keratolytic actions. its salts, the salicylates, are used as analgesics. (from dorland's, 28th ed) Preservative, fungicide (superseded), prohibited in milk and wine Salicylic acid is a colorless, crystalline organic carboxylic acid. Salicylic acid is toxic if ingested in large quantities, but in small quantities is used as a food preservative and antiseptic in toothpaste. It is also the key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts. The carboxyl group (COOH) can react with alcohols, forming several useful esters. The name derives from the latin word for the willow tree (Salix), from whose bark it can be obtained.; --Wikipedia; Salicylic acid treats acne by causing skin cells to slough off more readily, preventing pores from clogging up. This effect on skin cells also makes salicylic acid an active ingredient in several shampoos meant to treat dandruff. Use of straight salicylic solution may cause hyperpigmentation on unpretreated skin for those with darker skin types (Fitzpatrick phototypes IV, V, VI), as well as with the lack of use of a broad spectrum sunblock. Subsalicylate in combination with bismuth form the popular stomach relief aid known commonly as Pepto-Bismol. When combined the two key ingredients help control diarrhea, nausea, heartburn, and even gas. It is also very mildly anti-biotic.
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