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      Product(s):
      Salicylic acid ≥99%
      MSDS
       
ortho-salicylic acid
Notes :
a compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. it has bacteriostatic, fungicidal, and keratolytic actions. its salts, the salicylates, are used as analgesics. (from dorland's, 28th ed)
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  • Organoleptics
      • Organoleptic Properties
        Odor Type :nutty
        Odor Strength :low
        Odor Description:
        at 100.00 %. 
        faint phenolic nutty
  • Properties
      • Physical Properties
        Appearance :white powder (est)
        Assay : 99.00 to 100.00 % 
        Food Chemicals Codex Listed :No
        Melting Point : 158.00 to  161.00 °C. @ 760.00 mm Hg
        Boiling Point : 211.00 °C. @ 20.00 mm Hg
        Boiling Point : 336.00 to  337.00 °C. @ 760.00 mm Hg
        Vapor Pressure :1.000000 mm/Hg @ 114.00 °C.
        Vapor Density :4.8 ( Air = 1 )
        Flash Point :> 212.00 °F. TCC ( > 100.00 °C. )
        logP (o/w) : 2.260
  • Safety
      • Safety Information
        Most important hazard(s) :Xn - Harmful.
          R 22 - Harmful if swallowed.
        R 36/38 - Irritating to skin and eyes.
        R 41 - Risk of serious damage to eyes.
        S 02 - Keep out of the reach of children.
        S 20/21 - When using do not eat, drink or smoke.
        S 22 - Do not breath dust.
        S 24/25 - Avoid contact with skin and eyes.
        S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
        S 37/39 - Wear suitable gloves and eye/face protection.
        Oral/Parenteral Toxicity : 
          oral-rat LD50  891 mg/kg
        BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
        BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971

        oral-mouse LD50  480 mg/kg
        "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959.

        oral-rabbit LD50  1300 mg/kg
        Drugs in Japan Vol. 6, Pg. 291, 1982.

        intraperitoneal-rat LD50  157 mg/kg
        BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
        Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 31, 1992.

        oral-mouse LD50  908 mg/kg
        (Sado, 1973)

        gavage-rat LD50  1050 mg/kg
        (Hasegawa et al., 1989)

        oral-cat LD50  400 mg/kg
        "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959.

        intraperitoneal-mouse LD50  300 mg/kg
        LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
        Gendai no Rinsho. Vol. 3, Pg. 675, 1969.

        intravenous-mouse LD50  184 mg/kg
        BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
        Yakugaku Zasshi. Journal of Pharmacy. Vol. 91, Pg. 550, 1971.

        Dermal Toxicity : 
          skin-rabbit LD50 > 10000 mg/kg
        BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971

        skin-rat LD50 > 2000 mg/kg
        LIVER: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER
        Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 15(Suppl

        subcutaneous-mouse LD50 520 mg/kg
        BEHAVIORAL: MUSCLE WEAKNESS CARDIAC: CHANGE IN RATE
        Archives Internationales de Pharmacodynamie et de Therapie. Vol. 38, Pg. 9, 1930.

        subcutaneous-rabbit LDLo 6000 mg/kg
        "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.

        skin-man TDLo 57 mg/kg
        SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR
        JAMA, Journal of the American Medical Association. Vol. 244, Pg. 660, 1980.

        Inhalation Toxicity : 
          inhalation-rat LC50 > 900 mg/m3/1H
        BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971

        inhalation-mammal (species unspecified) LC50 > 300 mg/m3
        Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 31, 1992.

  • Safety in Use
      • Safety in Use Information
        Category :stabilizing agents
        Maximised Survey-derived Daily Intakes (MSDI-EU) :0.024 (μg/capita/day)
        Maximised Survey-derived Daily Intakes (MSDI-USA) :0.03 (μg/capita/day)
        Structure Class :I
        Recommendation for ortho-salicylic acid fragrance usage levels up to :
         not for fragrance use.
         
        Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
        The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA on the "Resources" link.
        publication number : 20
         average usual ppmaverage maximum ppm
        baked goods : --
        beverages(nonalcoholic) : 5.0000050.00000
        beverages(alcoholic) : 10.00000100.00000
        breakfast cereal : --
        cheese : --
        chewing gum : --
        condiments / relishes : --
        confectionery froastings : --
        egg products : --
        fats / oils : --
        fish products : --
        frozen dairy : 10.00000100.00000
        fruit ices : 10.00000100.00000
        gelatins / puddings : --
        granulated sugar : --
        gravies : --
        hard candy : --
        imitation dairy : --
        instant coffee / tea : --
        jams / jellies : 10.00000100.00000
        meat products : --
        milk products : 5.0000050.00000
        nut products : --
        other grains : --
        poultry : --
        processed fruits : --
        processed vegetables : --
        reconstituted vegetables : --
        seasonings / flavors : --
        snack foods : --
        soft candy : --
        soups : --
        sugar substitutes : --
        sweet sauces : --
  • Safety References
      • Safety References
        European Food Safety Athority(efsa) :Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
        European Food Safety Authority (EFSA) reference(s) :
        Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23:page or pdf
        Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC):page or pdf
        Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food:page or pdf
        Flavouring Group Evaluation 9, Revision 1: (FGE.09 Rev1)[1] - Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical groups 8 and 30, and an ester of a phenol carboxylic acid from chemical group 25 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food:page or pdf
        Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23:page or pdf
        Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009):page or pdf
        Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1]:page or pdf
        Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30:page or pdf
        Flavouring Group Evaluation 9, Revision 2 (FGE.09Rev2): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25:page or pdf
        Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30:page or pdf
        EPI System :View
        Chemicalize.org :Calculate predicted properties
        IUCLID Chemical Data Sheet :View
        ClinicalTrials.gov :search
        Daily Med :search
        NIOSH International Chemical Safety Cards :search
        NLM Hazardous Substances Data Bank :Search
        Chemical Carcinogenesis Research Information System :Search
        AIDS Citations :Search
        Cancer Citations :Search
        Toxicology Citations :Search
        EPA GENetic TOXicology :Search
        Env. Mutagen Info. Center :Search
        NLM Developmental and Reproductive Toxicity :Search
        National Toxicology Program :Search
        EPA Substance Registry Services (TSCA) :69-72-7
        EPA ACToR :Toxicology Data
        SCCNFP :opinion
        WGK Germany :1
         2-hydroxybenzoic acid
        DTP/NCI :180
        Chemidplus :0000069727
        EPA/NOAA CAMEO :hazardous materials
        RTECS :69-72-7
  • Articles
  • References
      • References
         2- hydroxybenzoic acid
        NIST Chemistry WebBook :379013429
        Canada Domestic Sub. List :69-72-7
        Pubchem (cid):338
        Pubchem (sid):135269852
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      • Other Information
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        CHEMBL :View
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        UM BBD :Search
        HMDB (Comprehensive Metabolomic Database) :Search
        Export Tariff Code :2918.21.5000
        Haz-Map : View
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        MedlinePlusSupp : View
        VCF-Online: VCF Volatile Compounds in Food
        ChemSpider : View
        Wikipedia : View
        RSC Learn Chemistry : View
        Formulations/Preparations :
        salicylic acid formulations: salicylic acid formulations: preparation dose (%) product manufacturer fostex medicated cleansing bar bristol-myers salicylic acid cleansing bar stiefel cream fostex medicated cleansing cream bristol-myers deep cleansing shower gel glaxosmithkline neutrogena clear pore treatment neutrogena propa ph peel-off acne mask stri-dex clear gel maximum strength (with sd alcohol 9.3%) blistex hydrisalic (with sd alcohol 40b and propylene glycol) pedinol clear away gel (with alcohol 57.6% ww, ether 16.4% ww in flexible collodion) schering-plough compound w gel (with alcohol 57.6% and ether 16.42% in flexible collodion) medtech duoplant gel (with alcohol 67.5% in flexible collodion) schering-plough lotion salac acne medication-cleanser (with benzyl alcohol) bioglan sebasorb (with attapulgite activated 10%) summers ointment mg 217 sal-acid triton plaster trans-ver-sal (with propylene glycol) clear away schering-plough clear away plantar system schering-plough compound w one step pads medtech freezone pads medtech mediplast beiersdorf sal-acid pedinol pledgets (saturated with solution) oxy balance daily cleansing pads (with sd alcohol 40b 40% and propylene glycol) glaxosmithkline stri-dex regular strength pads (with sd alcohol 28%) blistex stri-dex sensitive skin pads (with sd alcohol 28% and aloe) blistex noxzema 2-in-1 pads extra strength procter & gamble oxy balance maximum daily cleansing pads (with sd alcohol 40b 50% and propylene glycol) glaxosmithkline stayclear deep cleaning pads boots stri-dex pads maximum strength (with sd alcohol 40 44%) blistex stri-dex super scrub pads (with sd alcohol 54%) blistex shampoo ionil plus (with sd alcohol 40 12%) healthpoint dhs sal shampoo person & covey neutrogena tsal maximum strength neutrogena solution propa ph cleanser (with sd alcohol 40 25% and aloe) propa ph normalsensitive astringent cleanser sebucare lotion (with alcohol 61%) bristol-myers squibb multi-action astringent (with alcohol 38.8%) glaxosmithkline noxzema 2-in-1 astringent procter & gamble propa ph foaming face wash propa ph maximum strength astringent cleanser stayclear zone-controlled clearstick boots gordofilm (in flexible collodian) gordon clear away liquid (with 17% sd alcohol 32, ether 52% in flexible collodion) schering-plough compound w solution (with alcohol 21.2% and ether 63.5% in flexible collodion) medtech duofilm (with alcohol sd 32 17% and ether 52% in flexible collodion) schering-plough occlusal-hp (with isopropyl alcohol 63% in a polyacrylic vehicle) bioglan off-ezy wart remover (with alcohol 21% and ether 65% in flexible collodion) salactic film (with isopropyl alcohol 2.7% in a flexible collodion) pedinol sal-plant gel (with isopropyl alcohol 2.5% in flexible collodion) pedinol wart-off (with alcohol 26.35% in flexible collodion) pfizer freezone (with alcohol 20.5% and ether 65.5% in flexible collodion) medtech
  • Blenders
      • Potential Blenders and core components note
        None Found
  • Uses
      • Potential Uses
         antidandruff agents   bacteriostatic 
         castoreumFR  fungicide 
         hair conditioning   keratolytics 
         preservatives   skin conditioning 
  • Occurrence
  • Search
      • Search for Name, Cas,
        Enics, Fema, Flavis
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        Odor
2-hydroxybenzoic acid (Click)
CAS Number : 69-72-7
ESIS EC# (EINECS) :200-712-3
Beilstein Number :0774890
MDL :MFCD00002439
CoE Number :10165
XlogP3 :2.30 (est)
Molecular Weight :138.12242000
Formula :C7 H6 O3
BioActivity Summary :listing
NMR Predictor :Predict
Category :stabilizing agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information :
Google Scholar : Search Google Books : Search
Google Scholar : with word "volatile"Search Google Scholar : with word "flavor"Search
Google Scholar : with word "odor"SearchPerfumer and Flavorist : Search
Google Patents : Search US Patents : Search
EU Patents : Search IBM Patents : Obtain
Pubchem Patents:Search
PubMed : SearchNCBI : Search
JECFA Food Flavoring :958  2-hydroxybenzoic acid
Flavis Number :08.112 (Old site)
EU SANCO Food Flavourings :08.112  o-salicylic acid

FEMA Number :3985  2-hydroxybenzoic acid
FDA Mainterm : SALICYLIC ACID
FDA Regulation :FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2600 Rubber articles intended for repeated use.
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Picture of molecule
2-hydroxybenzoic acid
Synonyms :
 acidum salicylicum
 amiperfect
 amipreserve
 benzoic acid, 2-hydroxy-
 benzoic acid, o-hydroxy-
2-carboxyphenol
o-carboxyphenol
ortho-carboxyphenol
 compound W
 domerine
 duofilm
 duoplant
 fostex
 freezone
2-hydroxy-benzoic acid
2-hydroxybenzene carboxylic acid
2-hydroxybenzenecarboxylic acid
2-hydroxybenzoic acid
o-hydroxybenzoic acid
ortho-hydroxybenzoic acid
 phenol-2-carboxylic acid
 retarder W
2-salicylic acid
o-salicylic acid
 salicylic acid crystalline/powder
 salicylic acid natural
 salicylic acid USP crystal
 salicylic acid USP powder
 saligel
 salonil
 sebucare
 verrugon
Soluble in :
 alcohol
 water, 3808 mg/L @ 25 °C (est)
 water, 2240 mg/L @ 25 °C (exp)
Insoluble in :
 water
Stability :
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