leerall
 
Notes:
Gives good body. waxy floral fruity accord: 0.05 - leerall 0.01 - aldehyde C-14 0.05 - aldehyde C18 10% 0.01 - musk gx 0.01 - raspberry ketone 10% 0.01 - aldehyde C-16 10%
Synonyms   Articles   Notes   Search
Fragrance Demo Formulas
4-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde (Click)
CAS Number: 31906-04-4Picture of molecule
Other: 56493-02-8
ECHA EINECS - REACH Pre-Reg: 250-863-4
FDA UNII:QUE43B9Z2Q
Nikkaji Web: J68.877K
Beilstein Number: 2046455
MDL: MFCD00019423
XlogP3-AA: 1.70 (est)
Molecular Weight: 210.31674000
Formula: C13 H22 O2
NMR Predictor: Predict (works with chrome or firefox)
Also(can) Contains: 3,4-leerall 20.00% to 34.00%
Category: fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
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Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Appearance: colorless to pale yellow clear viscous liquid (est)
Assay: 97.00 to 100.00 % sum of isomers
Food Chemicals Codex Listed: No
Specific Gravity: 0.98900 to 0.99700 @  25.00 °C.
Pounds per Gallon - (est).: 8.229 to  8.296
Refractive Index: 1.48600 to 1.49300 @  20.00 °C.
Acid Value: 5.00 max. KOH/g
Vapor Pressure: 0.000029 mm/Hg @ 25.00 °C. (est)
Flash Point: 200.00 °F. TCC ( 93.33 °C. )
logP (o/w): 2.080
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage: store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 alcohol
 water, very slightly
 water, 184.6 mg/L @ 25 °C (est)
Insoluble in:
 paraffin oil
 water
Stability:
 alcoholic fine fragrance, good
 alcoholic lotion
 antiperspirant, good
 deo stick
 detergent perborate
 fabric softener, good
 hard surface cleaner
 liquid detergent
 shampoo
 soap, good
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: floral
Odor Strength: medium
Odor Description:
at 100.00 %. 
floral muguet cyclamen rhubarb woody
Substantivity: 400 Hour(s)
  
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: masking agents
perfuming agents
Synonyms   Articles   Notes   Search   Top
Safety Information:
Most important hazard(s):
Xi - Irritant
  R 43 - May cause sensitisation by skin contact.
S 02 - Keep out of the reach of children.
S 36 - Wear suitable protective clothing.
Oral/Parenteral Toxicity:
  oral-rat LD50  3250 ul/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: TREMOR
National Technical Information Service. Vol. OTS0535072

Dermal Toxicity:
  skin-rabbit LD50 11300 ul/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
National Technical Information Service. Vol. OTS0535072

Inhalation Toxicity:
  Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: fragrance agents
IFRA Critical Effect: Sensitization
IFRA: View Standard
Fragrance usage is IFRA RESTRICTED. View Standard for complete information.
Please review all IFRA documents for complete information.
IFRA categories: limits in the finished product: (For a description of the categories, refer to the IFRA QRA Information Booklet.)
Category 1:
See Note (1)
0.11 % (1)
Category 2:  0.15 %
Category 3:  0.60 %
Category 4:  1.50 %
Category 5:  1.00 %
Category 6:
See Note (1)
2.90 % (1)
Category 7:  0.30 %
Category 8:  1.50 %
Category 9:  1.50 %
Category 10:  1.50 %
Category 11: See Note (2)
 Notes:
 

For this material, for pragmatic reasons, restrictive levels allowed by the QRA for certain categories but actually being higher than those already in place before applying the QRA, will temporarily not be implemented until the end of a 5 year monitoring phase. At the end of the 5 years the position will be reevaluated again.

 

(1) IFRA would recommend that any material used to impart perfume or flavour in products intended for human ingestion should consist of ingredients that are in compliance with appropriate regulations for foods and food flavourings in the countries of planned distribution and, where these are lacking, with the recommendations laid down in the Code of Practice of IOFI (International Organisation of the Flavor Industry). Further information about IOFI can be found on its website (www.iofi.org).

 

(2) Category 11 includes all non-skin contact or incidental skin contact products. Due to the negligible skin contact from these types of products there is no justification for a restriction of the concentration of this fragrance ingredient in the finished product.

 
Recommendation for leerall flavor usage levels up to:
 not for flavor use.
Synonyms   Articles   Notes   Search   Top
Safety References:
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 31906-04-4
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 91604
National Institute of Allergy and Infectious Diseases: Data
SCCNFP: opinion
WGK Germany:2
 4-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde
Chemidplus: 0031906044
RTECS: GW2850000 for cas# 31906-04-4
Synonyms   Articles   Notes   Search   Top
References:
 4-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 31906-04-4
Pubchem (cid): 91604
Pubchem (sid): 135048904
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2912.30.0000
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
For Odor
aldehydic
 citrus carbaldehydeFR
 decanal (aldehyde C-10)FL/FR
 dodecanal (aldehyde C-12 lauric)FL/FR
2-methyl undecanal (aldehyde C-12 mna)FL/FR
 nonanal (aldehyde C-9)FL/FR
10-undecenal (aldehyde C-11 undecylenic)FL/FR
amber
 ambroxanFL/FR
 angelica root oilFL/FR
 cistus ladaniferus resinoidFR
animal
para-cresyl caprylateFL/FR
anise
 anise seed oilFL/FR
sweet fennel seed oilFL/FR
balsamic
isoamyl benzoateFL/FR
 amyris wood oilFL/FR
siam benzoin resinoidFL/FR
 benzophenoneFL/FR
 benzyl cinnamateFL/FR
 benzyl salicylateFL/FR
laevo-bornyl acetateFL/FR
isobornyl acetateFL/FR
isobutyl cinnamateFL/FR
 cinnamyl alcoholFL/FR
 clover nitrileFR
 ethyl cinnamateFL/FR
 fir balsam absoluteFR
 fir needle oil siberiaFL/FR
 fir tree fragranceFR
 methyl (E)-cinnamateFL/FR
3-phenyl propyl alcoholFL/FR
berry
 raspberry ketoneFL/FR
 raspberry ketone acetateFL/FR
 raspberry ketone methyl etherFL/FR
buttery
 acetoinFL/FR
caramellic
 strawberry furanoneFL/FR
citrus
 bergamot oil bergaptene reduced italyFL/FR
 dihydromyrcenolFL/FR
 grapefruit oil c.p. californiaFL/FR
 grapefruit pentanolFR
alpha-methylene citronellalFR
blood orange oil italyFL/FR
sweet orange peel oil c.p. brazilFL/FR
 tangerine oil americaFL/FR
 tetrahydromyrcenolFR
coconut
gamma-heptalactoneFL/FR
gamma-nonalactone (aldehyde C-18 (so-called))FL/FR
gamma-octalactoneFL/FR
fatty
 decanolFL/FR
floral
alpha-amyl cinnamaldehydeFL/FR
isoamyl salicylateFL/FR
 benzyl acetateFL/FR
 benzyl alcoholFL/FR
 bois de rose oil brazilFL/FR
4-isobutyl cyclohexane propanalFR
 cilantro herb oil egyptFL/FR
 citronellolFL/FR
 citronellyl acetateFL/FR
 coriander seed oilFL/FR
 corps popinalFR
 cuminyl acetaldehydeFL/FR
 cyclamen aldehydeFL/FR
 cyclamen homoaldehydeFR
 cyclohexyl ethyl alcoholFL/FR
9-decen-1-olFL/FR
 dihydrojasmoneFL/FR
 dimethyl anthranilateFL/FR
 dimethyl benzyl carbinolFL/FR
 dimethyl benzyl carbinyl acetateFL/FR
 dimethyl benzyl carbinyl butyrateFL/FR
2,5-dimethyl-2-indan methanolFR
4-ethyl cyclohexane propanalFR
(E,E)-farnesolFL/FR
 floral pyranolFR
 floral specialtyFR
 gardenia oxideFR
 geraniolFL/FR
 geranium oil bourbonFL/FR
 geranyl acetateFL/FR
 heliotropinFL/FR
 heliotropyl acetateFL/FR
 heliotropyl acetoneFL/FR
 heliotropyl diethyl acetalFR
(Z)-3-hexen-1-yl salicylateFL/FR
alpha-hexyl cinnamaldehydeFL/FR
 ho leaf oilFR
 hyacinth etherFR
 hydroxycitronellalFL/FR
calla lily fragranceFR
 lily of the valley specialtyFR
 lilyallFR
 lilyall / methyl anthranilate schiff's baseFR
 lilyall substituteFR
 linaloolFL/FR
laevo-linaloolFL/FR
 linalool oxideFL/FR
 magnolia cyclohexanolFR
 methoxycitronellalFR
para-methyl acetophenoneFL/FR
4-methyl cyclohexane propanalFR
 methyl dihydrojasmonateFL/FR
 mimosa absolute franceFL/FR
 muguet butanolFR
 muguet carboxaldehydeFR
 muguet ethanolFR
 muguet octadienolFR
 nerolFL/FR
 nerolidolFL/FR
 neryl acetateFL/FR
 nonanolFL/FR
 ocean propanalFL/FR
 octahydro-4,7-methano-1H-indene-5-acetaldehydeFR
 octahydro-4,7-methano-1H-indene-5-acetaldehyde + 6-methyl-octahydro-4,7-methano-indene-5-carbaldehydFR
 orris pyridine 25% IPMFR
 peony alcoholFR
 petitgrain oil paraguayFL/FR
 phenethyl acetateFL/FR
 phenethyl alcoholFL/FR
 phenethyl isobutyrateFL/FR
 phenethyl isovalerateFL/FR
 phenethyl phenyl acetateFL/FR
 phenethyl propionateFL/FR
4-propyl cyclohexane propanalFR
 rhodinolFL/FR
 rose butanoateFL/FR
 tetrahydrolinaloolFL/FR
 violet methyl carbonateFR
 ylang ylang flower oilFL/FR
fruity
 allyl amyl glycolateFR
 allyl cyclohexyl propionateFL/FR
 benzyl propionateFL/FR
2-cyclopentyl cyclopentanoneFL/FR
(E)-alpha-damasconeFL/FR
(E)-beta-damasconeFL/FR
gamma-decalactoneFL/FR
 dimethyl benzyl carbinyl isobutyrateFR
(R)-gamma-dodecalactoneFL/FR
 green acetateFR
 methyl anthranilateFL/FR
 strawberry glycidate 1 (aldehyde C-16 (so-called))FL/FR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
green
 acetaldehyde ethyl phenethyl acetalFL/FR
 diphenyl oxideFL/FR
 galbanum oilFL/FR
(Z)-3-hexen-1-yl acetateFL/FR
(Z)-3-hexen-1-yl benzoateFL/FR
(Z)-3-hexen-1-yl propionateFL/FR
(Z)-3-hexen-1-yl tiglateFL/FR
 hexyl 2-methyl butyrateFL/FR
 hexyl tiglateFL/FR
(Z)-leaf acetalFL/FR
 melon nonenoateFL/FR
 methyl heptine carbonateFL/FR
 methyl octine carbonateFL/FR
(Z)-5-octen-1-olFL/FR
 phenyl acetaldehydeFL/FR
 phenyl acetaldehyde dimethyl acetalFL/FR
3-phenyl propionaldehydeFL/FR
 styralyl acetateFL/FR
 violet leaf absoluteFL/FR
hay
 beeswax absoluteFL/FR
 hay absoluteFR
herbal
 carum carvi fruit oilFL/FR
 clary sage oil franceFL/FR
 daucus carota fruit oilFL/FR
 lavender absolute bulgariaFL/FR
 linalyl acetateFL/FR
 nopyl acetateFR
alpha-terpinyl acetateFL/FR
honey
 methyl phenyl acetateFL/FR
marine
green algae absoluteFL/FR
melon
 melon heptenalFL/FR
 watermelon ketoneFR
minty
 spearmint oil americaFL/FR
mossy
 oakmoss absoluteFL/FR
 veramoss (IFF)FR
naphthyl
beta-naphthyl ethyl etherFL/FR
powdery
para-anisyl acetateFL/FR
para-anisyl alcoholFL/FR
spicy
 benzyl isoeugenolFL/FR
 carnation absoluteFR
 cassia bark oil chinaFL/FR
 clove bud oilFL/FR
black currant bud absoluteFL/FR
 elettaria cardamomum seed oilFL/FR
 eugenolFL/FR
isoeugenyl acetateFL/FR
alpha-methyl cinnamaldehydeFL/FR
 methyl isoeugenolFL/FR
 nutmeg oilFL/FR
black pepper oilFL/FR
 pimenta acris leaf oilFL/FR
terpenic
 frankincense oilFL/FR
 juniperus communis fruit oilFL/FR
alpha-terpineolFL/FR
thujonic
 armoise oilFR
tonka
gamma-hexalactoneFL/FR
 tonka bean absoluteFR
vanilla
 ethyl vanillinFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanillyl acetateFL/FR
waxy
 decyl acetateFL/FR
1-dodecanolFL/FR
 ethyl laurateFL/FR
1-undecanolFL/FR
woody
 amber carbinolFR
 frankincense resinoid replacerFR
 guaiacwood oilFL/FR
 gurjun balsam oilFR
 methyl cedryl ketoneFL/FR
 patchouli ethanoneFR
 patchouli oilFL/FR
 santallFR
 spruce needle oil canadaFL/FR
 tobacarol (IFF)FR
 vetiver oil haitiFL/FR
 woody acetateFR
(Z)-woody amyleneFR
 
For Flavor
 
No flavor group found for these
green algae absoluteFL/FR
2-cyclopentyl cyclopentanoneFL/FR
(R)-gamma-dodecalactoneFL/FR
(E,E)-farnesolFL/FR
 methyl (E)-cinnamateFL/FR
aldehydic
 nonanal (aldehyde C-9)FL/FR
1-undecanolFL/FR
animal
para-cresyl caprylateFL/FR
anise
 anise seed oilFL/FR
sweet fennel seed oilFL/FR
balsamic
siam benzoin resinoidFL/FR
 benzyl salicylateFL/FR
laevo-bornyl acetateFL/FR
isobutyl cinnamateFL/FR
 ethyl cinnamateFL/FR
 fir needle oil siberiaFL/FR
berry
 heliotropyl acetoneFL/FR
 raspberry ketoneFL/FR
 raspberry ketone acetateFL/FR
 raspberry ketone methyl etherFL/FR
brown
 beeswax absoluteFL/FR
caramellic
 strawberry furanoneFL/FR
cherry
 heliotropinFL/FR
citrus
 bergamot oil bergaptene reduced italyFL/FR
 grapefruit oil c.p. californiaFL/FR
laevo-linaloolFL/FR
 linaloolFL/FR
 nerolFL/FR
blood orange oil italyFL/FR
sweet orange peel oil c.p. brazilFL/FR
 petitgrain oil paraguayFL/FR
 tangerine oil americaFL/FR
alpha-terpineolFL/FR
coconut
gamma-nonalactone (aldehyde C-18 (so-called))FL/FR
creamy
 acetoinFL/FR
gamma-hexalactoneFL/FR
para-methyl acetophenoneFL/FR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
fatty
(Z)-3-hexen-1-yl benzoateFL/FR
10-undecenal (aldehyde C-11 undecylenic)FL/FR
floral
 bois de rose oil brazilFL/FR
 citronellolFL/FR
 citronellyl acetateFL/FR
 dihydrojasmoneFL/FR
 dimethyl benzyl carbinyl acetateFL/FR
 dimethyl benzyl carbinyl butyrateFL/FR
 geraniolFL/FR
 geranium oil bourbonFL/FR
 heliotropyl acetateFL/FR
 linalyl acetateFL/FR
 methyl dihydrojasmonateFL/FR
 methyl phenyl acetateFL/FR
 neryl acetateFL/FR
 ocean propanalFL/FR
 phenethyl alcoholFL/FR
 phenethyl propionateFL/FR
 rhodinolFL/FR
 tetrahydrolinaloolFL/FR
 ylang ylang flower oilFL/FR
fruity
 allyl cyclohexyl propionateFL/FR
isoamyl benzoateFL/FR
para-anisyl acetateFL/FR
para-anisyl alcoholFL/FR
 benzyl acetateFL/FR
 benzyl alcoholFL/FR
 benzyl propionateFL/FR
(E)-alpha-damasconeFL/FR
(E)-beta-damasconeFL/FR
gamma-decalactoneFL/FR
 dimethyl anthranilateFL/FR
 methyl anthranilateFL/FR
 phenethyl isovalerateFL/FR
 rose butanoateFL/FR
 strawberry glycidate 1 (aldehyde C-16 (so-called))FL/FR
 styralyl acetateFL/FR
geranium
 benzophenoneFL/FR
green
 acetaldehyde ethyl phenethyl acetalFL/FR
isoamyl salicylateFL/FR
 angelica root oilFL/FR
 cinnamyl alcoholFL/FR
 cuminyl acetaldehydeFL/FR
 cyclamen aldehydeFL/FR
 cyclohexyl ethyl alcoholFL/FR
 dihydromyrcenolFL/FR
 diphenyl oxideFL/FR
 galbanum oilFL/FR
 geranyl acetateFL/FR
(Z)-3-hexen-1-yl acetateFL/FR
(Z)-3-hexen-1-yl propionateFL/FR
(Z)-3-hexen-1-yl salicylateFL/FR
(Z)-3-hexen-1-yl tiglateFL/FR
 hexyl 2-methyl butyrateFL/FR
 hexyl tiglateFL/FR
(Z)-leaf acetalFL/FR
 linalool oxideFL/FR
 melon heptenalFL/FR
 melon nonenoateFL/FR
 methyl heptine carbonateFL/FR
 methyl octine carbonateFL/FR
 nerolidolFL/FR
 oakmoss absoluteFL/FR
(Z)-5-octen-1-olFL/FR
 phenyl acetaldehyde dimethyl acetalFL/FR
3-phenyl propionaldehydeFL/FR
 violet leaf absoluteFL/FR
herbal
 carum carvi fruit oilFL/FR
 cilantro herb oil egyptFL/FR
 clary sage oil franceFL/FR
 coriander seed oilFL/FR
 daucus carota fruit oilFL/FR
 lavender absolute bulgariaFL/FR
honey
 phenethyl acetateFL/FR
 phenethyl isobutyrateFL/FR
 phenethyl phenyl acetateFL/FR
 phenyl acetaldehydeFL/FR
lactonic
gamma-heptalactoneFL/FR
gamma-octalactoneFL/FR
medicinal
 dimethyl benzyl carbinolFL/FR
minty
 spearmint oil americaFL/FR
powdery
beta-naphthyl ethyl etherFL/FR
soapy
 dodecanal (aldehyde C-12 lauric)FL/FR
1-dodecanolFL/FR
spicy
 benzyl cinnamateFL/FR
 benzyl isoeugenolFL/FR
 cassia bark oil chinaFL/FR
 clove bud oilFL/FR
black currant bud absoluteFL/FR
 elettaria cardamomum seed oilFL/FR
 eugenolFL/FR
isoeugenyl acetateFL/FR
alpha-methyl cinnamaldehydeFL/FR
 methyl isoeugenolFL/FR
 nutmeg oilFL/FR
black pepper oilFL/FR
3-phenyl propyl alcoholFL/FR
 pimenta acris leaf oilFL/FR
terpenic
 juniperus communis fruit oilFL/FR
tropical
alpha-amyl cinnamaldehydeFL/FR
vanilla
 ethyl vanillinFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanillyl acetateFL/FR
waxy
 decanal (aldehyde C-10)FL/FR
 decanolFL/FR
9-decen-1-olFL/FR
 decyl acetateFL/FR
 ethyl laurateFL/FR
alpha-hexyl cinnamaldehydeFL/FR
 hydroxycitronellalFL/FR
2-methyl undecanal (aldehyde C-12 mna)FL/FR
 mimosa absolute franceFL/FR
 nonanolFL/FR
woody
 ambroxanFL/FR
 amyris wood oilFL/FR
isobornyl acetateFL/FR
 frankincense oilFL/FR
 guaiacwood oilFL/FR
 methyl cedryl ketoneFL/FR
 patchouli oilFL/FR
 spruce needle oil canadaFL/FR
alpha-terpinyl acetateFL/FR
 vetiver oil haitiFL/FR
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 acacia cassie farnesianaFR
 agrumen 
 aldehydicFR
 almondFR
 almond blossom 
 alpine bouquet 
 amberFR
 ambergrisFR
 ambretteFL/FR
 angel 
 angelicaFL/FR
 animalFR
 appleFR
 apple blossomFR
 apple crabapple 
 apple greenFR
 apple redFR
 ash mountain ash berry 
 balsamFR
 bananaFR
 bark 
 bay rumFR
 bayberryFR
 bergamotFR
 blackberryFR
 blueberryFR
 blueberry whortleberry red whortleberry 
 bois de rose rosewoodFR
 botanical 
 bouquetFR
 boxwood blossom 
 boysenberryFR
 bramble arctic bramble blackberry 
 bubble gumFR
 burberry 
 butterscotchFR
 calamusFR
 caramel 
 carnation dianthus oeilletFR
 cassia blossom 
 cedar forestFR
 cedarleafFL/FR
 cherryFR
 cherry blossomFR
 chypreFR
 citrusFR
 civetFR
 clematisFR
 cloth clean cloths 
 cloudberry bakeapple 
 clove blossom 
 clover trefle le'trefle incarnatFR
 coloniaFR
 costusFL
 crabapple blossomFR
 cranberryFR
 cucumberFR
 curacaoFL/FR
 currantFR
 cyclamenFR
 daffodil narcissusFR
 dilleniaFR
 eglantine sweet briarFR
 elder berryFR
 elder flowerFR
 fagoniaFR
 fantasy blends 
 fern fougereFR
 fetesFR
 fidji 
 figFR
 fir balsamFR
 fir needle pine needleFL/FR
 floralFR
 florida breeze 
 foliage 
 forestFR
 frangipanni plumeriaFR
 freesiaFR
 galbanumFL/FR
 gardeniaFR
 genet genista broomFR
 geraniumFR
 gingerFR
 ginger whiteFR
 gingergrassFR
 gooseberryFR
 grapeFR
 grapefruitFR
 greenhouseFR
 guaiacwoodFL/FR
 guavaFR
 heatherFR
 herbalFR
 hibiscusFR
 hollyberryFR
 honeysuckle chevrefeuilleFR
 huckleberry bilberryFR
 hyacinth jacintheFR
 hydrangeaFR
 iris blossom 
 ivyFR
 jackfruit 
 jasminFR
 jonquil narcissus jonquillaFR
 joop 
 juniper berryFR
 kewda 
 kiwiFR
 kiwi blossom 
 kumquatFR
 lavandinFL/FR
 lavenderFR
 leatherFR
 lemonFR
 lemongrassFR
 lilac lilas syringaFR
 lilyFR
 limeFR
 linaloe woodFL/FR
 linden blossom limeflower tilleulFR
 loganberry dewberryFR
 lotusFR
 lycheeFR
 magnoliaFR
 mangoFR
 mango flowerFR
 meadow countryFR
 melon watermelon muskmelon cantaloupe 
 millefleurs 
 mimosaFR
 mintFR
 muguet lily of the valleyFR
 mulberryFR
 muskFR
 narcissus narcisseFR
 neroliFR
 new car 
 ocean sea 
 orangeFR
 orange blossomFR
 orchidFR
 outdoors freshFR
 pansyFR
 papayaFR
 passion blossomFR
 passion fruitFR
 peachFR
 peach blossomFR
 pearFR
 pear blossomFR
 pear prickly pear 
 peonyFR
 pert plus 
 petal flower petal 
 petitgrain bergamotFL/FR
 petitgrain limeFL/FR
 petuniaFR
 phloxFR
 pina coladaFR
 pineappleFR
 plumFR
 plum blossom 
 plum mirabille blossom 
 pomegranateFR
 poppy 
 potpourriFR
 praline 
 privet 
 privet blossom 
 quinceFR
 raspberryFR
 rhubarbFR
 roseFR
 rose tea roseFR
 rose whiteFR
 rose wild rose 
 saffronFR
 sandalwoodFR
 spiceFR
 starfruit 
 stock evening scentedFR
 strawberryFR
 sweet peaFR
 tangerineFR
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 tropical 
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 violet leafFL/FR
 wallflowerFR
 wintergreenFR
 wisteria wistaria glycineFR
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Occurrence (nature, food, other): note
 not found in nature
 salvia officinalis oil england @ 0.10%
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Synonyms:
 cyclohexal
3-cyclohexene-1-carboxaldehyde, 4-(4-hydroxy-4-methylpentyl)-
3 and 4-(4-hydroxy-4-methyl pentyl) cyclohex-3-ene-1-carbaldehyde
4-(4-hydroxy-4-methyl pentyl) cyclohex-3-ene-1-carbaldehyde
3 and 4-(4-hydroxy-4-methyl pentyl)-3-cyclohexene-1-carboxaldehyde
4-(4-hydroxy-4-methyl pentyl)-3-cyclohexene-1-carboxaldehyde
4-(4-hydroxy-4-methylpentyl)-1-cyclohex-3-enecarboxaldehyde
4-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-carbaldehyde
3 and 4-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-carboxaldehyde
4-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-carboxaldehyde
4-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-carboxaldehye
4-(4-hydroxy-4-methylpentyl)cyclohex-3-ene carbaldehyde
3 and 4-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde
4-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde
4-(4-hydroxy-4-methylpentyl)cyclohex-3-enecarbaldehyde
 hydroxyisohexyl 3-cyclohexene carboxaldehyde
4,4-hydroxymethyl pentyl cyclohexene carbaldehyde
 kovanol (Takasago)
 kovyral
 landolal
 lanyral
 leerall
 lydoucal (A.C.S. International)
 lyral (IFF)
 lysinal
 mugonal
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Articles:
PubMed: Baseline series fragrance markers fail to predict contact allergy.
PubMed: Postnatal odorant exposure induces peripheral olfactory plasticity at the cellular level.
PubMed: Multicentre patch testing with fragrance mix II and hydroxyisohexyl 3-cyclohexene carboxaldehyde by the Swedish Contact Dermatitis Research Group.
PubMed: Application of Purpald® for determination of 3-cyclohexene-1-carboxaldehyde and hydroxyisohexyl 3-cyclohexene carboxaldehyde.
PubMed: Hydroxyisohexyl 3-cyclohexene carboxaldehyde (lyral) in patch test preparations under varied storage conditions.
PubMed: Categorization of fragrance contact allergens for prioritization of preventive measures: clinical and experimental data and consideration of structure-activity relationships.
PubMed: Risk factors associated with sensitization to hydroxyisohexyl 3-cyclohexene carboxaldehyde.
PubMed: Odorant responsiveness of embryonic mouse olfactory sensory neurons expressing the odorant receptors S1 or MOR23.
PubMed: Results of patch testing with fragrance mix 1, fragrance mix 2, and their ingredients, and Myroxylon pereirae and colophonium, over a 21-year period.
PubMed: Two fragrance chemicals may act as toxicants via TRPA1 stimulation rather than via direct mitochondrial action.
PubMed: Fragrance chemicals lyral and lilial decrease viability of HaCat cells' by increasing free radical production and lowering intracellular ATP level: protection by antioxidants.
PubMed: Allergic contact dermatitis to fragrances: part 2.
PubMed: Prevalence of allergic contact dermatitis caused by hydroxyisohexyl 3-cyclohexene carboxaldehyde has not changed in Denmark.
PubMed: Is hydroxyisohexyl 3-cyclohexene carboxaldehyde sensitization declining in central Europe?
PubMed: Patch tests with fragrance mix II and its components.
PubMed: An odor-specific threshold deficit implicates abnormal cAMP signaling in youths at clinical risk for psychosis.
PubMed: Contact allergy to the 26 specific fragrance ingredients to be declared on cosmetic products in accordance with the EU cosmetics directive.
PubMed: [Current contact allergens].
PubMed: Enhanced sensitization and elicitation responses caused by mixtures of common fragrance allergens.
PubMed: Patch-testing with fragrance mix II.
PubMed: Can exposure limitations for well-known contact allergens be simplified? An analysis of dose-response patch test data.
PubMed: Deodorants are the leading cause of allergic contact dermatitis to fragrance ingredients.
PubMed: Fragrance allergens in 'specific' cosmetic products.
PubMed: Hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral®) as allergen: experience from a contact dermatitis unit.
PubMed: Fragrance mix II in the baseline series contributes significantly to detection of fragrance allergy.
PubMed: Patch testing with fragrance mix II: results of the IVDK 2005-2008.
PubMed: Olfactory sensitivity for sperm-attractant aromatic aldehydes: a comparative study in human subjects and spider monkeys.
PubMed: Fragrance contact allergy: a 4-year retrospective study.
PubMed: Fragrance allergy: assessing the safety of washed fabrics.
PubMed: Determination of suspected allergens in cosmetic products by headspace-programmed temperature vaporization-fast gas chromatography-quadrupole mass spectrometry.
PubMed: A new IFRA Standard on the fragrance ingredient, hydroxyisohexyl 3-cyclohexene carboxaldehyde.
PubMed: Fragrance contact allergy in Iran.
PubMed: Clinical relevance of positive patch test reactions to the 26 EU-labelled fragrances.
PubMed: The dose-response relationship between the patch test and ROAT and the potential use for regulatory purposes.
PubMed: Quantitative patch and repeated open application testing in hydroxyisohexyl 3-cyclohexene carboxaldehyde sensitive-patients.
PubMed: Expression patterns of odorant receptors and response properties of olfactory sensory neurons in aged mice.
PubMed: Hydroxyisohexyl 3-cyclohexene carboxaldehyde allergy: relationship between patch test and repeated open application test thresholds.
PubMed: Polyvalent type IV sensitizations to multiple fragrances and a skin protection cream in a metal worker.
PubMed: [Facial allergic contact dermatitis. Data from the IVDK and review of literature].
PubMed: An odor-specific threshold deficit implicates abnormal intracellular cyclic AMP signaling in schizophrenia.
PubMed: Hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral) is still a frequent allergen.
PubMed: Allergic contact dermatitis from lyral in an aerosol deodorant.
PubMed: Allergic contact dermatitis to a perfume containing lyral.
PubMed: Contact allergy in patients with rosacea: a clinic-based, prospective epidemiological study.
PubMed: Frequency of and trends in fragrance allergy over a 15-year period.
PubMed: Recommendation to include fragrance mix 2 and hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral) in the European baseline patch test series.
PubMed: Fragrance ingredient labelling in products on sale in the U.K.
PubMed: High-performance liquid chromatographic method for the simultaneous determination of 24 fragrance allergens to study scented products.
PubMed: Selected important fragrance sensitizers in perfumes--current exposures.
PubMed: Patch test results with patients' own perfumes, deodorants and shaving lotions: results of the IVDK 1998-2002.
PubMed: Experimental elicitation with hydroxyisohexyl-3-cyclohexene carboxaldehyde-containing deodorants.
PubMed: [Sensitization to Lyral].
PubMed: Delayed-type hypersensitivity to fragrance materials in a select North American population.
PubMed: Odorant responses of olfactory sensory neurons expressing the odorant receptor MOR23: a patch clamp analysis in gene-targeted mice.
PubMed: Fragrance contact dermatitis in Korea: a joint study.
PubMed: Clinical update on contact allergy.
PubMed: Lyral: a fragrance allergen.
PubMed: Patch testing with a new fragrance mix - reactivity to the individual constituents and chemical detection in relevant cosmetic products.
PubMed: Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix.
PubMed: Rosacea and contact allergy to cosmetics and topical medicaments--retrospective analysis of multicentre surveillance data 1995-2002.
PubMed: Cosmetic allergy: incidence, diagnosis, and management.
PubMed: [Allergy to cosmetics. I. Fragrances].
PubMed: Functional characterization of a mouse testicular olfactory receptor and its role in chemosensing and in regulation of sperm motility.
PubMed: The fragrance hand immersion study - an experimental model simulating real-life exposure for allergic contact dermatitis on the hands.
PubMed: Fragrance allergy in patients with hand eczema - a clinical study.
PubMed: Hydroxyisohexyl 3-cyclohexene carboxaldehyde- known as Lyral: quantitative aspects and risk assessment of an important fragrance allergen.
PubMed: [Epidemiologic surveillance of contact allergens. The "monitoring series" of IVDK (Information Network ofDermatologic Clinics for Detection and Scientific Evaluation of Contact Allergy].
PubMed: Cross-adaptation between olfactory responses induced by two subgroups of odorant molecules.
PubMed: Hydroxymethyl pentylcyclohexene- carboxaldehyde (Lyral) as a fragrance allergen in the UK.
PubMed: Principles and methodology for identification of fragrance allergens in consumer products.
PubMed: Further important sensitizers in patients sensitive to fragrances.
PubMed: Lyral has been included in the patch test standard series in Germany.
PubMed: Blocking adenylyl cyclase inhibits olfactory generator currents induced by "IP(3)-odors".
PubMed: Regulation of cutaneous allergic reaction by odorant inhalation.
PubMed: Lyral is an important sensitizer in patients sensitive to fragrances.
PubMed: Allergic contact dermatitis from the fragrance ingredient Lyral in underarm deodorant.
PubMed: Odorants selectively activate distinct G protein subtypes in olfactory cilia.
PubMed: Towards structural models of molecular recognition in olfactory receptors.
PubMed: Existence of multiple receptors in single neurons: responses of single bullfrog olfactory neurons to many cAMP-dependent and independent odorants.
PubMed: Patch testing with fragrances: results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes.
PubMed: Chemosensitivity of the osphradium of the pond snail Lymnaea stagnalis
PubMed: Allergic contact dermatitis from the synthetic fragrances Lyral and acetyl cedrene in separate underarm deodorant preparations.
PubMed: Molecular modeling of ligand-receptor interactions in the OR5 olfactory receptor.
PubMed: A quantitative in vitro assay for the evaluation of phototoxic potential of topically applied materials.
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