Occurs in a variety of foods and flavours and in food pyrolysis products [DFC] Flavourant with chicken aroma. Volatile component of roasted shrimp [DFC]
  • Alfrebro
    • Alfrebro LLC
      Let's get reacquainted
      Building great taste with aroma chemicals, extracts, and distillates
      The Alfrebro brand was established in the early 1900s by Alex Fries & Brothers, a Cincinnati Flavor Company. In 1980, the brand was re-launched as an aroma chemical manufacturer. Since its inception, Alfrebro’s primary focus has been to provide quality natural and high value synthetic chemicals.
      Email: Sarah Forbis
      Email: Sales
      Voice: 513-539-3021
      Fax: 513-539-7372
      US Voice: 513-539-7373
      Thialdine 0.1% in ETOH, Natural
  • Apiscent Labs
    • Apiscent Labs, LLC
      Delivery of Quality
      Custom manufacturer and international supplier of fine ingredients.
      We believe inspired chemistry enriches lives. That's why our team is guided by a mission to provide fine ingredients to the worldwide pharmaceutical, flavor and fragrance markets with a primary focus on the manufacturing of value-added, research-based molecules. We're innovative problem solvers committed to excellence at every phase. Our work builds the foundation for our clients' continued success.
      Email: Info
      Email: Carl Sheeley
      Email: Customer Service
      Voice: +1 (414) 744 3993
      Fax: +1 (414) 744 7111
  • Axxence Aromatic
    • Axxence Aromatic GmbH
      We bring nature to your flavour
      Dedicated to provide the best possible quality and supply service of natural aroma ingredients.
      Axxence Aromatic is entirely dedicated to provide the best possible quality and supply service of natural aroma ingredients to the Flavour & Fragrance Industry worldwide.
      Email: Service
      Voice: +49.2822.68561.0
      Fax: +49.2822.68561.39
      Products List: View
      401800 THIALDINE Natural
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
      Email: Mr. Jia
      Email: Mr. Guo
      Voice: 86-10-68418738
      Fax: 86-10-68418739
      Mr. Guo86-10-68483445
      Mr. Guo86-10-68418739
      10287 Dihydro-2,4,6-trimethyl-1,3,5-(2H)dithiazine
  • CTC Organics
    • CTC Organics
      For More Than 40 Year
      Your source for rare aroma chemicals for the flavor and fragrance industy.
      “The world is run by middle men.” The number of times I have heard Dr. Liu utter those words are innumerable. He loved reciting and recording famous quotes and had many of his own. Among his many talents, Dr. Liu had a unique genius in the area of chemistry. He had an uncanny understanding of the pulse of the chemical industry and was a superb salesman.
      US Email: Customer Service
      US Voice: (404) 524-6744
      US Fax: (404) 577-1651
      W2017 thialdine
  • DeLong Chemicals America
    • DeLong Chemicals America
      Custom Manufacturing
      Supplier of aroma chemicals, pharmaceutical and specialty chemical intermediates.
      DeLong Chemicals America, LLC is an extension of Shijiazhuang Lida Chemical Co, Ltd to North America, a leading supplier and manufacturer of aroma chemicals, serving the industries of food, tobacco and perfume, while also providing intermediates, custom synthesis and custom manufacturing for pharmaceutical and specialty chemical industries.
      US Email: Customer Service
      US Email: Sales
      US Voice: (203) 271-9017
      New products
      9862 Dihydro-2,4,6-Trimethyl-1,3,5-(4H)dithiazine, Kosher
  • Excellentia International
    • Excellentia International
      Ingredients by Nature
      Exceptional quality and excellence in meeting our customers requirements.
      Excellentia International was founded in 2010 through the merger of Excellentia Flavors LLC and Polarome International. Collectively, these companies account for more than one hundred years of industry experience, and are recognized for exceptional quality and excellence in meeting our customers’ requirements.
      Email: Info
      Email: Sales
      Email: Regulatory
      Voice: 732.749.9840
      Our Services
      Thialdine Natural
    • FCI SAS
      Inspired by Nature
      At FCI customer service is not a department it’s an attitude.
      Our team is composed of motivated professionals with great experience in the flavours and fragrances market. Our company has been serving this industry for more than 40 years and is ISO 9001 certified since 2009 . Whatever your question on flavour and fragrance ingredients: commercial, technical or regulatory – we will answer it very quickly.
      Email: Info
      Email: Philippe Faucher
      Voice: +33 (0)1 34 25 58 10
      Fax: + 33 1 34 25 58 18
      18038 THIALDINE
  • Natural Advantage
    • Natural Advantage
      Manufacturer of natural flavor ingredients
      With over 25 years experience in the flavor and food ingredient industries.
      Natural Advantage was formed over seventeen years ago to supply the growing demand for natural food and flavor ingredients. We employ a wide range of multi-disciplined scientists who are dedicated to high quality service, customer satisfaction and creating an outstanding value for our clients.
      Email: Info
      Email: Customer service
      Voice: 318-215-1456
      Fax: 318-335-1579
      What We Do
      Products List: View
      Thialdine Nat, 50% in Triacetin
  • Penta International
  • Treatt
    • Treatt PLC
      Innovative ingredient solutions
      World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.
      We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products.
      Email: Enquiries
      US Email: Enquiries
      Voice: +44 (0) 1284 702500
      Fax: +44 (0) 1284 703809
      US Voice: +1 863 668 9500
      US Fax: +1 863 668 3388
      5,6-Dihydro-2,4,6-Trimethyl-4H-1,3,5-Dithiazine Halal, Kosher

      Used flavours for oils and fats at 0.35-3.5ppm; in meat and dairy flavours for snack foods and sauces at 3-6ppm; and in soups and seasonings, at 4-8ppm.
Synonyms   Articles   Notes   Search
(4R,6S)-2,4,6-trimethyl-1,3,5-dithiazinane (Click)
CAS Number: 638-17-5Picture of molecule
ECHA EINECS - REACH Pre-Reg: 211-323-3
Nikkaji Web: J6.921C
XlogP3-AA: 2.50 (est)
Molecular Weight: 163.30661000
Formula: C6 H13 N S2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Also(can) Contains: 2,4,6-trimethyl dihydro-1,3,5-dithiazine
EFSA/JECFA Comments: JECFA evaluated 2,4,6-trimethyldihydro-4H-1,3,5-dithiazine (CASrn as in Register). (R)- or (S)- enantiomer not specified by CASrn in Register. Mixture of diastereoisomers, each of them racemic (EFFA, 2013b).
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 1049  2,4,6-trimethyldihydro-4H-1,3,5-dithiazine
Flavis Number: 15.109 (Old)
DG SANTE Food Flavourings: 15.109  2,4,6-trimethyldihydro-4H-1,3,5-dithiazine
FEMA Number: 4018  2,4,6-trimethyldihydro-4H-1,3,5-dithiazine
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Physical Properties:
Appearance: pale brownish yellow crystals (est)
Assay: 99.00 to 100.00 % sum of isomers
Food Chemicals Codex Listed: No
Melting Point: 46.00 to  48.00 °C. @ 760.00 mm Hg
Boiling Point: 260.00 to  261.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.012000 mm/Hg @ 25.00 °C. (est)
Flash Point: 232.00 °F. TCC ( 111.11 °C. )
logP (o/w): 0.523 (est)
Soluble in:
 water, 7000 mg/L @ 20 °C (exp)
Insoluble in:
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Organoleptic Properties:
Odor Type: meaty
Odor Strength: high ,
recommend smelling in a 0.10 % solution or less
 roasted  meaty  beefy  meaty roasted meaty  
Odor Description:
at 0.10 % in propylene glycol. 
roasted meaty beefy
 meaty  roasted  meaty roasted meaty  
Taste Description:
meaty roasted
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Cosmetic Information:
None found
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Thialdine 0.1% in ETOH, Natural
Odor: Roasty Meaty Beefy
Anhui Suzhou Jinli Aromatic Chemicals
2,4,6-Trimethyl dihydro-4H-1,3,5-dithazinane
Odor: sulfur, baked meat, roast nut
Apiscent Labs
Odor: Heated meat, roasted beef-like
Axxence Aromatic
Beijing Lys Chemicals
BOC Sciences
For experimental / research use only.
CTC Organics
DeLong Chemicals America
Dihydro-2,4,6-Trimethyl-1,3,5-(4H)dithiazine, Kosher
Excellentia International
Thialdine Natural
Odor: Very rich and powerful earthy sulfurous
Jinan Enlighten Chemical Technology(Wutong Aroma )
2,4,6-Trimethyl dihydro-4H-1,3,5- dithazinane, Kosherk
Natural Advantage
Thialdine Nat, 50% in Triacetin
Penta International
Penta International
Halal, Kosher
Odor: Roast beef-like, typical of heated meat, cooked shrimp
Flavor: rich, meat flavour
Used flavours for oils and fats at 0.35-3.5ppm; in meat and dairy flavours for snack foods and sauces at 3-6ppm; and in soups and seasonings, at 4-8ppm.
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  265 mg/kg
Radiation Research. Vol. 7, Pg. 22, 1957.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavoring agents
Recommendation for thialdine usage levels up to:
 not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 1.10 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 3.30 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 20
Click here to view publication 20
 average usual ppmaverage maximum ppm
baked goods: 8.0000016.00000
beverages(nonalcoholic): 3.000006.00000
beverages(alcoholic): --
breakfast cereal: 0.070000.35000
cheese: --
chewing gum: 10.0000020.00000
condiments / relishes: 3.000006.00000
confectionery froastings: --
egg products: 4.000008.00000
fats / oils: 0.350003.50000
fish products: 0.350003.50000
frozen dairy: 4.000008.00000
fruit ices: 3.000006.00000
gelatins / puddings: 3.000006.00000
granulated sugar: --
gravies: 4.000008.00000
hard candy: 5.0000010.00000
imitation dairy: 3.000006.00000
instant coffee / tea: --
jams / jellies: --
meat products: 3.000006.00000
milk products: 3.000006.00000
nut products: --
other grains: --
poultry: 0.200002.00000
processed fruits: --
processed vegetables: 0.200002.00000
reconstituted vegetables: 0.200002.00000
seasonings / flavors: 200.00000500.00000
snack foods: 3.000006.00000
soft candy: 4.000008.00000
soups: 4.000008.00000
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3
View page or View pdf
EPI System: View
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 12518
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0000638175
RTECS: JO6430000 for cas# 638-17-5
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NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 12518
Pubchem (sid): 134978715
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
HMDB (The Human Metabolome Database): HMDB31187
FooDB: FDB020393
Export Tariff Code: 2934.10.0090
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
For Odor
 dimethyl trisulfideFL/FR
 methyl furfuryl disulfideFL/FR
 rum etherFL/FR
2,6-dimethyl pyrazineFL/FR
 coffee difuranFL/FR
2-methyl-3-,5 or 6-(furfuryl thio) pyrazineFL/FR
 nutty pyrazineFL/FR
 ethyl crotonateFL/FR
 tropical thiazoleFL/FR
 tropical trithianeFL/FR
2-heptyl furanFL/FR
 meaty dithianeFL/FR
4-methyl nonanoic acidFL/FR
 sulfuryl acetateFL/FR
 hazelnut pyrazineFL/FR
 strawberry furanone methyl etherFL/FR
2-ethyl pyrazineFL/FR
2-ethyl-4-methyl thiazoleFL/FR
2-methyl-3-(methyl thio) pyrazineFL/FR
2,3-dimethyl benzofuranFL/FR
4-vinyl phenolFL/FR
 pyroligneous acidsFL/FR
 ethyl 2-mercaptopropionateFL/FR
 ethyl 3-mercaptopropionateFL/FR
 fish thiolFL/FR
2-mercaptopropionic acidFL/FR
4-methyl 4-mercaptopentan-2-one 1% solutionFL/FR
2-(methyl thio) phenolFL/FR
 methyl benzoxoleFL/FR
For Flavor
No flavor group found for these
4-acetyl-2-methyl pyrimidineFL
 amyl mercaptanFL
1,2-butane dithiolFL
2,5-diethyl thiazoleFL
 dimethyl tetrasulfideFL
bis(2,5-dimethyl-3-furyl) disulfideFL
(Z+E)-2,5-dimethyl-3-tetrahydrofuran thiolFL
2,5-dimethyl-3-thiofuroyl furanFL
S-ethyl 2-acetyl aminoethane thioateFL
 ethyl 3-mercaptopropionateFL/FR
2-ethyl-3-methyl thiopyrazineFL
(Z+E)-5-ethyl-4-methyl-2-(2-butyl) thiazolineFL
(Z+E)-5-ethyl-4-methyl-2-(2-methyl propyl) thiazolineFL
2-hexyl thiopheneFL
1-(3-hydroxy-5-methyl-2-thienyl) ethanoneFL
3-mercapto-3-methyl butyl formateFL
4-methyl 4-mercaptopentan-2-one 1% solutionFL/FR
 methyl benzoxoleFL/FR
 methyl dihydrofuran thiolFL
2-methyl thiazolidineFL
2-methyl-1-butane thiolFL
4-methyl-2-(methyl thiomethyl)-2-hexenalFL
2-methyl-3-,5 or 6-(furfuryl thio) pyrazineFL/FR
2-methyl-3-(methyl thio) pyrazineFL/FR
1,9-nonane dithiolFL
2-pentyl thiopheneFL
1-phenethyl mercaptanFL
isopropyl disulfideFL
2-isopropyl-3-(methyl thio) pyrazineFL
3-thienyl mercaptanFL
 thioacetic acidFL
3,7-dimethyl-2,6-octadien-1-yl cyclopropyl carboxamideFL
4-mercapto-2-pentanone 1% in acetoinFL
2-methyl-1-methyl thio-2-buteneFL
1-(2-thienyl) butanoneFL
 allyl disulfideFL
 allyl mercaptanFL
1,3-butane dithiolFL
 cyclopentyl mercaptanFL
 dimethyl trisulfideFL/FR
 tropical thiazoleFL/FR
 bacon dithiazineFL
1,6-hexane dithiolFL
 rum etherFL/FR
2,3-dimethyl benzofuranFL/FR
2,5-dimethyl furanFL
 coffee difuranFL/FR
2-ethyl-4-methyl thiazoleFL/FR
 methyl furfuryl disulfideFL/FR
 difurfuryl sulfideFL
1,8-octane dithiolFL
isopropyl mercaptanFL
2-heptyl furanFL/FR
4-methyl nonanoic acidFL/FR
 tropical trithianeFL/FR
4-methyl thiazoleFL
4-penten-1-yl acetateFL
2,6-dimethyl thiophenolFL
2,5-dimethyl-3-furan thiolFL
1,1-ethane dithiol 1% in ethanol 94.5% / ethyl acetate 4%FL
 furfuryl 2-methyl-3-furyl disulfideFL
 meaty dithianeFL/FR
2-mercaptomethyl pyrazineFL
2-mercaptopropionic acidFL/FR
2-methyl 3-(methyl thio) furanFL
2-(methyl thio) phenolFL/FR
 methyl thiofuryl butanalFL
12-methyl tridecanalFL
bis(2-methyl-3-furyl) disulfideFL
S-(2-methyl-3-furyl) ethane thioateFL
2-methyl-3-tetrahydrofuran thiolFL
 phenyl mercaptanFL
 propyl 2-mercaptopropionateFL
 pyrazinyl ethane thiolFL
2-pyridinyl methane thiolFL
 sulfuryl acetateFL/FR
 hazelnut pyrazineFL/FR
 strawberry furanone methyl etherFL/FR
3-acetyl-2,5-dimethyl thiopheneFL
2-acetyl-4-methyl thiazoleFL
3,5-diethyl-2-methyl pyrazineFL
2,5-diethyl-3-methyl pyrazineFL
2,6-dimethyl pyrazineFL/FR
2-ethyl pyrazineFL/FR
 nutty pyrazineFL/FR
 nutty thiazoleFL
 ethyl 2-mercaptopropionateFL/FR
 furfuryl isopropyl sulfideFL
2-ethyl benzene thiolFL
4-vinyl phenolFL/FR
3-(methyl thio) propyl mercaptoacetateFL
 hexyl mercaptanFL
 ethyl crotonateFL/FR
 prosopis juliflora wood extractFL
 pyroligneous acidsFL/FR
2,3-butane dithiolFL
 ethyl methyl sulfideFL
S-ethyl thioacetateFL
 fish thiolFL/FR
 methyl 2-methyl-3-furyl disulfideFL
3-methyl-2-butane thiolFL
2-naphthyl mercaptanFL
 roasted butanolFL
2-(methyl thio) ethyl acetateFL
 faex extractsFL
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Potential Uses:
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Occurrence (nature, food, other): note
Search  Picture
 chicken fried chicken
Search  Picture
Search  Picture
 peanut butter
Search  Picture
 shrimp cooked shrimp
Search  Picture
Search  Picture
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4H-1,3,5-dithiazine, (R,S)-dihydro-2,4,6-trimethyl-
(R,S)-1,3,5-dithiazine, perhydro-2,4,6-trimethyl
(R,S)-2,4,6-trimethyl dihydro-1,3,5(4H)-dithiazine
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