Category:flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless to pale yellow clear oily liquid (est) |
Assay: | 96.00 to 100.00
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.19500 to 1.20400 @ 25.00 °C.
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Pounds per Gallon - (est).: | 9.944 to 10.018
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Refractive Index: | 1.47900 to 1.48400 @ 20.00 °C.
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Melting Point: | 10.00 to 14.00 °C. @ 760.00 mm Hg
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Boiling Point: | 117.00 °C. @ 16.00 mm Hg
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Boiling Point: | 98.00 to 99.00 °C. @ 14.00 mm Hg
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Vapor Pressure: | 0.103000 mm/Hg @ 25.00 °C. (est) |
Vapor Density: | 3.6 ( Air = 1 ) |
Flash Point: | 190.00 °F. TCC ( 87.78 °C. )
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logP (o/w): | 0.492 (est) |
Soluble in: |
| acetone | | alcohol | | water | | water, 1.152e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
Odor Type: sulfurous |
Odor Strength:very high |
Substantivity:400 hour(s) at 100.00 % |
meaty sulfurous roasted |
Odor Description:at 0.01 % in propylene glycol. meaty sulfurous roasted |
sulfurous meaty savory brown roasted |
Odor Description:Sulfury, meaty savory, brown with roasted brown nuances Mosciano, Gerard P&F 17, No. 5, 127, (1992) |
Flavor Type: meaty |
meaty sulfurous brothy brown |
Taste Description: at 15.00 ppm. Meaty, sulfurous, brothy, brown Mosciano, Gerard P&F 17, No. 5, 127, (1992) |
Odor and/or flavor descriptions from others (if found). |
Frutarom |
2-MERCAPTOPROPIONIC ACID |
Odor Description:Cheese, Sour Suggested Uses: Cheese, Dairy Products, Meat |
Taste Description:meaty sulfury broth brown |
R C Treatt & Co Ltd |
Thiolactic Acid Halal, Kosher |
Odor Description:Meaty, sulphurous, brothy, brown notes |
Taste Description:meaty, sulphurous, brothy, brown Used in smoke, meat and bacon flavours. Normal use levels in finished consumer product: 0.5-50 ppm. |
Cosmetic Information:
Suppliers:
Beijing Lys Chemicals |
2-Mercaptopropionic acid
|
BRUNO BOCK |
Thiolactic Acid
Odor: characteristic Use: TLA's unique reducing properties make it acceptable for use in a wide variety of chemical reactions including addition, elimination, or cyclization reactions. TGA's sulfur group (-SH) will react in the presence of bases, acids, ketone groups or organic halogens. In the presence of alcohols or amines, the carboxylic group will react preferentially. |
Charkit Chemical |
MERCAPTOPROPIONIC ACID, 2- M0250 FEMA 3180
|
EMD Millipore |
For experimental / research use only. |
2-Mercaptopropionic Acid
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Endeavour Specialty Chemicals |
2-Mercaptopropionic acid 98% F&F
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Speciality Chemical Product Groups |
Frutarom |
2-MERCAPTOPROPIONIC ACID
Odor: Cheese, Sour Use: Suggested Uses: Cheese, Dairy Products, Meat |
Inoue Perfumery |
ALPHA-MERCAPTOPROPIONIC ACID
|
M&U International |
THIOLACTIC ACID, Kosher
|
Penta International |
THIOLACTIC ACID, Kosher
|
R C Treatt & Co Ltd |
Thiolactic Acid
Halal, Kosher Odor: Meaty, sulphurous, brothy, brown notes Flavor: meaty, sulphurous, brothy, brown Used in smoke, meat and bacon flavours. Normal use levels in finished consumer product: 0.5-50 ppm. |
Robinson Brothers |
2-Mercaptopropionic acid F&F
|
https://www.robinsonbrothers.uk/chemistry-competences |
Santa Cruz Biotechnology |
For experimental / research use only. |
Thiolactic acid
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Sigma-Aldrich |
2-Mercaptopropionic acid, ≥95%, FG
Odor: meaty |
Certified Food Grade Products |
Sunaux International |
Thiolactic Acid
|
Synerzine |
2-Mercaptopropionic Acid
|
Taytonn |
2-Mercaptopropionic Acid
Odor: Cheese, Sour |
TCI AMERICA |
For experimental / research use only. |
Thiolactic Acid >97.0%(GC)
|
WholeChem |
2-Mercaptopropionic acid
|
Wujiang CIYUN Flavor & Fragrance |
Thiolactic Acid ≥98.0%
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Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | C - Corrosive. |
R 25 - Toxic if swallowed. R 34 - Causes burns. S 01/02 - Keep locked up and out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
inhalation-rat TCLo 700 ppm Kodak Company Reports. Vol. 21MAY1971
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Safety in Use Information:
Category: | flavor and fragrance agents |
|
Maximised Survey-derived Daily Intakes (MSDI-EU): | 2.10 (μg/capita/day) |
Structure Class: | I |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 4 |
| average usual ppm | average maximum ppm |
baked goods: | - | - |
beverages(nonalcoholic): | - | - |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | - |
fruit ices: | - | - |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | 50.00000 |
hard candy: | - | - |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | 50.00000 |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | 50.00000 |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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European Food Safety Authority (EFSA) reference(s):
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Flavouring Group Evaluation 8 (FGE.08)[1]: Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20 View page or View pdf
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Flavouring Group Evaluation 74 (FGE.74)[1]: Consideration of Simple Aliphatic Sulphides and Thiols evaluated by JECFA (61st meeting) Structurally related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or without Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08 (2008) View page or View pdf
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Flavouring Group Evaluation 8, Revision 1 (FGE.08Rev1): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf
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Flavouring Group Evaluation 91 (FGE.91): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev1 (2009) View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 08, Revision 4 (FGE.08Rev4): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf
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EPI System: View |
Cancer Citations:Search |
Toxicology Citations:Search |
Env. Mutagen Info. Center:Search |
EPA Substance Registry Services (TSCA):79-42-5 |
EPA ACToR:Toxicology Data |
EPA Substance Registry Services (SRS):Registry |
Laboratory Chemical Safety Summary :62326 |
National Institute of Allergy and Infectious Diseases:Data |
WISER:UN 2936 |
WGK Germany:1 |
2-sulfanylpropanoic acid |
Chemidplus:0000079425 |
EPA/NOAA CAMEO:hazardous materials |
RTECS:UF5250000 for cas# 79-42-5 |
References:
Other Information:
Potential Blenders and core components note
For Odor |
alliaceous |
dimethyl trisulfide FL/FR |
coffee |
furfuryl mercaptan FL/FR |
2- methyl-3-,5 or 6-(furfuryl thio) pyrazine FL/FR |
meaty |
meaty dithiane FL/FR |
nutty |
2- ethyl-4-methyl thiazole FL/FR |
sulfurous |
ethyl 2-mercaptopropionate FL/FR |
fish thiol FL/FR |
4- methyl 4-mercaptopentan-2-one 1% solution FL/FR |
For Flavor |
No flavor group found for these |
1,2- butane dithiol FL |
(Z+E)-2,5- dimethyl-3-tetrahydrofuran thiol FL |
(Z+E)-2,5- dimethyl-3-thioacetoxytetrahydrofuran FL |
ethyl 4-(acetyl thio) butyrate FL |
4- mercapto-3-methyl-2-butanol FL |
4- methoxybenzoyl oxyacetic acid FL |
4- methyl 4-mercaptopentan-2-one 1% solution FL/FR |
methyl dihydrofuran thiol FL |
2- methyl-1-butane thiol FL |
2- methyl-3-,5 or 6-(furfuryl thio) pyrazine FL/FR |
2- methyl-3-furyl tetrasulfide FL |
1,9- nonane dithiol FL |
1,3- propane dithiol FL |
iso propyl disulfide FL |
sodium methoxybenzoyl oxyacetate FL |
|
3,7- dimethyl-2,6-octadien-1-yl cyclopropyl carboxamide FL |
alliaceous |
alliaceous |
1,3- butane dithiol FL |
dimethyl trisulfide FL/FR |
coffee |
2- ethyl-4-methyl thiazole FL/FR |
furfuryl mercaptan FL/FR |
earthy |
difurfuryl sulfide FL |
1,8- octane dithiol FL |
eggy |
iso propyl mercaptan FL |
green |
4- penten-1-yl acetate FL |
herbal |
celery seed oleoresin FL |
meaty |
2,6- dimethyl thiophenol FL |
2,5- dimethyl-3-furan thiol FL |
furfuryl 2-methyl-3-furyl disulfide FL |
meaty dithiane FL/FR |
(R,S)-2- mercapto-3-butanol FL |
2- methyl 3-(methyl thio) furan FL |
12- methyl tridecanal FL |
bis(2- methyl-3-furyl) disulfide FL |
S-(2- methyl-3-furyl) ethane thioate FL |
2- methyl-3-tetrahydrofuran thiol FL |
pyrazinyl ethane thiol FL |
ortho- thiocresol FL |
metallic |
2,5- dihydroxy-1,4-dithiane FL |
nutty |
nutty thiazole FL |
onion |
ethyl 2-mercaptopropionate FL/FR |
furfuryl isopropyl sulfide FL |
phenolic |
2- ethyl benzene thiol FL |
roasted |
hexyl mercaptan FL |
sulfurous |
2,3- butane dithiol FL |
fish thiol FL/FR |
methyl 2-methyl-3-furyl disulfide FL |
3- methyl-2-butane thiol FL |
2- naphthyl mercaptan FL |
3- pentane thiol FL |
roasted butanol FL |
waxy |
octyl 2-furoate FL |
Potential Uses:
| antioxidants |
FL | coffee |
| depilatories |
FL | egg |
| hair straightening agents |
| hair waving agents |
FL | meat |
| reducing agents |
FL | savory |
| soup |
Occurrence (nature, food, other): note
Synonyms:
2- | mercaptopropanoic acid | a- | mercaptopropanoic acid | alpha- | mercaptopropanoic acid | 2- | mercaptopropionic acid | alpha- | mercaptopropionic acid | 2- | mercaptopropionicacid | | propanoic acid, 2-mercapto- | | propionic acid, 2-mercapto- | 2- | sulfanylpropanoic acid | 2- | thiol propionic acid | | thiolactic acid | 2- | thiolactic acid | 2- | thiolpropionic acid |
Articles:
PubMed:Small but powerful: co-assembly of polyether-based triblock terpolymers into sub-30 nm micelles and synergistic effects on cellular interactions. |
PubMed:Synthesis of high-quality water-soluble near-infrared-emitting CdTe quantum dots capped with 3-mercaptobutyric acid. |
PubMed:Oxidation of dissolved elemental mercury by thiol compounds under anoxic conditions. |
PubMed:Development of Fe/Fe3O4 core-shell nanocubes as a promising magnetic resonance imaging contrast agent. |
PubMed:Effect of freeze dried bovine amniotic membrane extract on full thickness wound healing. |
PubMed:Quantum dots-based fluorescent probes for turn-on and turn-off sensing of butyrylcholinesterase. |
PubMed:A simple screening test for the detection of metallo-β-lactamase-producing Pseudomonas aeruginosa and Acinetobacter in a tertiary care hospital. |
PubMed:Adhesion of quantum dots-induced membrane damage of Escherichia coli. |
PubMed:Sequestering ability of some chelating agents towards methylmercury(II). |
PubMed:Ligand-controlled growth of ZnSe quantum dots in water during Ostwald ripening. |
PubMed:Characterization of the modified Hodge test-positive isolates of Enterobacteriaceae in Taiwan. |
PubMed:Magic sized ZnS quantum dots as a highly sensitive and selective fluorescence sensor probe for Ag+ ions. |
PubMed:S-nitrosocysteine-decorated PbS QDs/TiO2 nanotubes for enhanced production of singlet oxygen. |
PubMed:Synthesis of gold nanoclusters: a fluorescent marker for water-soluble TiO2 nanotubes. |
PubMed:Evaluation of different methods for detection of metallo-beta-lactamases in Pseudomonas aeruginosa clinical isolates. |
PubMed:Metallo-beta-lactamase-producing Pseudomonas aeruginosa in two hospitals from southern Brazil. |
PubMed:Evidence for the formation of a mononuclear ferric-hydroperoxo complex via the reaction of dioxygen with an (N4S(thiolate))iron(II) complex. |
PubMed:Synthesis and biological evaluation of new 4-thiazolidinone derivatives. |
PubMed:Fabrication of PbS quantum dot doped TiO2 nanotubes. |
PubMed:Synthesis, antibacterial and antifungal activities of 3-(1,2,4-triazol-3-yl)-4-thiazolidinones. |
PubMed:Electrocatalytic response of norepinephrine at a thiolactic acid self-assembled gold electrode. |
PubMed:Highly stereoselective iodolactonization of 4,5-allenoic acids--an efficient synthesis of 5-(1'-iodo-1'(Z)-alkenyl)-4,5-dihydro-2(3H)-furanones. |
PubMed:Synthesis and biological activity of functionalized indole-2-carboxylates, triazino- and pyridazino-indoles. |
PubMed:Metallo-beta-lactamase detection: comparative evaluation of double-disk synergy versus combined disk tests for IMP-, GIM-, SIM-, SPM-, or VIM-producing isolates. |
PubMed:Identification of bismuth-thiolate-carboxylate clusters by electrospray ionization mass spectrometry. |
PubMed:Convenient test using a combination of chelating agents for detection of metallo-beta-lactamases in the clinical laboratory. |
PubMed:Quantitative analysis of thiols in consumer products on a microfluidic CE chip with fluorescence detection. |
PubMed:[Analysis of the metallo-beta-lactamase gene in multidrug-resistant Pseudomonas aeruginosa isolated at Showa University Hospital]. |
PubMed:Heterogeneity of metallo-beta-lactamases in clinical isolates of Chryseobacterium meningosepticum from Hangzhou, China. |
PubMed:Effects of bismuth contamination on the growth and activity of soil microorganisms using thiols as model compounds. |
PubMed:Synthesis, stereochemistry and biological activity of some novel long alkyl chain substituted thiazolidin-4-ones and thiazan-4-one from 10-undecenoic acid hydrazide. |
PubMed:Metallo-beta-lactamase-producing gram-negative bacilli: laboratory-based surveillance in cooperation with 13 clinical laboratories in the Kinki region of Japan. |
PubMed:Identification, isolation, and characterization of cysteinate and thiolactate complexes of bismuth. |
PubMed:Dissociation dynamics of thiolactic acid at 193 nm: detection of the nascent OH product by laser-induced fluorescence. |
PubMed:Comparison of the double-disk, combined disk, and Etest methods for detecting metallo-beta-lactamases in gram-negative bacilli. |
PubMed:Synthesis and fungicidal activity of novel 4,4'-bis(2' '-aryl-5' '-methyl/unsubstituted-4' '-oxo-thiazolidin-3' '-yl) bibenzyl. |
PubMed:Synthesis of some newer derivatives of 2-amino benzoic acid as potent anti-inflammatory and analgesic agents. |
PubMed:Metabolism of fungicide diethofencarb in grape (Vitis vinifera L.): definitive identification of thiolactic acid conjugated metabolites. |
PubMed:Prevalence of metallo-beta-lactamase among Pseudomonas aeruginosa and Acinetobacter baumannii in a Korean university hospital and comparison of screening methods for detecting metallo-beta-lactamase. |
PubMed:Ligand-exchangeability of 2-coordinate phosphinegold(I) complexes with AuSP and AuNP cores showing selective antimicrobial activities against Gram-positive bacteria. Crystal structures of [Au(2-Hmpa)(PPh(3))] and [Au(6-Hmna)(PPh(3))] (2-H(2)mpa=2-mercaptopropionic acid, 6-H(2)mna=6-mercaptonicotinic acid). |
PubMed:Production of CTX-M-3 extended-spectrum beta-lactamase and IMP-1 metallo beta-lactamase by five Gram-negative bacilli: survey of clinical isolates from seven laboratories collected in 1998 and 2000, in the Kinki region of Japan. |
PubMed:Synthesis and antituberculosis activity of cycloalkylidenehydrazide and 4-aza-1-thiaspiro[4.5]decan-3-one derivatives of imidazo[2,1-b]thiazole. |
PubMed:Evaluation of a new Etest for detecting metallo-beta-lactamases in routine clinical testing. |
PubMed:[Antimicrobial activities and mechanisms of carbapenem resistance in clinical isolates of carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter spp]. |
PubMed:Fluorescence quenching properties and chemiluminescence responses of alpha-ketothiols derivatized with o-phthalaldehyde and primary amino compounds. |
PubMed:[Gene examination methods (detection and genotyping of resistant genes)--metallo-beta-lactamase]. |
PubMed:DNA as an important target in radiation-induced apoptosis of MYC and MYC plus RAS transfected rat embryo fibroblasts. |
PubMed:Simultaneous determination of tiopronin and its metabolites in rat blood by LC-ESI-MS-MS using methyl acrylate for stabilization of thiol group. |
PubMed:Convenient test for screening metallo-beta-lactamase-producing gram-negative bacteria by using thiol compounds. |
PubMed:Disposition of 1,2-[14C]Dibromoethane in male Wistar rats. |
PubMed:Inhibition of the metallo-beta-lactamase produced from Serratia marcescens by thiol compounds. |
PubMed:Amperometric detection of organic thiols at a tungsten wire electrode following their separation by liquid chromatography. |
PubMed:Synthesis and pharmacology of novel analogues of oxytocin and deaminooxytocin: directed methods for the construction of disulfide and trisulfide bridges in peptides. |
PubMed:Chemiluminescent determination of tiopronin and its metabolite, 2-mercaptopropionic acid, in urine by HPLC coupled with a flow injection set-up. |
PubMed:1H-NMR and 13C-NMR investigation of complexes of Mn2+ with ocytocin analogues in (2H6)dimethylsulfoxide. |
PubMed:Separation of urinary thiols as tributyltinmercaptides and determination using capillary isotachophoresis. |
PubMed:Specificity studies of 3-Mercaptopyruvate sulfurtransferase. |
PubMed:Pharmacokinetics of tiopronin after repeated oral administration in rheumatoid arthritis. |
PubMed:Isolation of S-[2-carboxy-1-(1H-imidazol-4-yl)ethyl]-3-thiolactic acid, a new metabolite of histidine, from normal human urine and its formation from S-[2-carboxy-1-(1H-imidazol-4-yl)ethyl]cysteine. |
PubMed:Rapid determination of glutamine in biological samples by high-performance liquid chromatography. |
PubMed:Purification and characterization of 3-mercaptolactic acid S-conjugate oxidases. |
PubMed:Hydroosmotic activities of arginine-vasopressins modified either in positions 1, 2 and 4 or at N-terminal extensions. |
PubMed:Inhibition by thiols of copper(II)-induced oxidation of oxyhemoglobin. |
PubMed:The pharmacokinetics of tiopronin and its principal metabolite (2-mercaptopropionic acid) after oral administration to healthy volunteers. |
PubMed:Determination of 2-mercaptopropionylglycine and its metabolite, 2-mercaptopropionic acid, in plasma by ion-pair reversed-phase high-performance liquid chromatography with post-column derivatization. |
PubMed:Studies on heterocyclic compounds: spiro [indole-3,2'-thiazolidine] derivatives. II. Antimicrobial activity of halogenated 3'-phenylspiro 3H-indole-3,2'-thiazolidine -2,4 (1H)-diones. |
PubMed:Suppression of natriferic activity of the vasopressin molecule by modifications in positions 1, 2 and 4. |
PubMed:Synthesis and biological activity profiles of atrial natriuretic factor (ANF) analogs. |
PubMed:Studies of MR 889, a new synthetic proteinase inhibitor. |
PubMed:Oxidation of thiols by sodium N-haloarylsulphonamides. |
PubMed:Studies on heterocyclic compounds: 1,3-thiazolidin-4-one derivatives. III. Biological activity of halogenated 2,3-diaryl-1,3-thiazolidin-4-ones. |
PubMed:Studies on heterocyclic compounds: 1,3-thiazolidin-4-ones from Schiff bases. |
PubMed:High-performance liquid chromatography of 2-mercaptopropionylglycine and its metabolite 2-mercaptopropionic acid in plasma and urine after treatment with thiopronine. |
PubMed:Binding of [3H]muscimol to calf cerebrocortical synaptic membranes and the effects of sulphur-containing convulsant and non-convulsant compounds. |
PubMed:2-Mercaptopropionate, a novel metabolite formed during treatment with 2-mercaptopropionyl-glycine in cystinuria. |
PubMed:3-Mercaptopropionic acid, a potent inhibitor of fatty acid oxidation in rat heart mitochondria. |
PubMed:Reduction of beta-thiopyruvic acid by lactate dehydrogenase: a kinetic study. |
PubMed:Sodium ion/L-lactate co-transport in rabbit small-intestinal brush-border-membrane vesicles. |
PubMed:Titrimetric determination of mercaptans with chloramine-T. |
PubMed:EFFECT OF 2-MERCAPTOETHYLAMINE ON THE PEROXIDATION IN MICROSOMES OF UNSATURATED LIPIDS CATALYZED BY CYSTEINE OR THIOLACTIC ACID AND ULTRAVIOLET LIGHT. |
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