EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

pyrazinyl methyl sulfide
2-methyl mercaptopyrazine

Supplier Sponsors

Name:2-methylsulfanylpyrazine
CAS Number: 21948-70-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:244-675-1
FDA UNII:R1C97E3A4F
Nikkaji Web:J225.488C
MDL:MFCD00041024
CoE Number:2288
XlogP3:1.20 (est)
Molecular Weight:126.18182000
Formula:C5 H6 N2 S
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:796 pyrazinyl methyl sulfide
FLAVIS Number:14.034 (Old)
DG SANTE Food Flavourings:14.034 pyrazinyl methyl sulfide
FEMA Number:3231 pyrazinyl methyl sulfide
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: PYRAZINYL METHYL SULFIDE
 
Physical Properties:
Appearance:pale yellow to yellow solid or liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 42.00 to 47.00 °C. @ 760.00 mm Hg
Boiling Point: 75.00 °C. @ 5.00 mm Hg
Vapor Pressure:0.161000 mm/Hg @ 25.00 °C. (est)
Flash Point:> 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w): 1.170
Soluble in:
 propylene glycol
 water, 9533 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: sulfurous
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
corn chip nutty sulfurous ethereal
Odor Description:at 0.10 % in propylene glycol. corn chip nutty sulfurous ether
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Advanced Biotech
2 METHYLTHIO PYRAZINE
Ambles Nature et Chimie
2-METHYL THIO PYRAZINE
Berjé
2-Methyl Thio Pyrazine
Happening at Berje
BOC Sciences
For experimental / research use only.
2-Methylthiopyrazine
Carbosynth
For experimental / research use only.
2-(Methylthio)pyrazine
Jiangyin Healthway
2-Methylthio pyrazine
New functional food ingredients
Jinan Enlighten Chemical Technology(Wutong Aroma )
2-Methylthio pyrazine, Kosherk
M&U International
2-METHYLTHIO PYRAZINE, Kosher
Penta International
PYRAZINYL METHYL SULFIDE, Kosher
Sigma-Aldrich
2-(Methylthio)pyrazine, ≥98%, FG
Certified Food Grade Products
Sunaux International
2-Methylthio Pyrazine
Synerzine
Pyrazinylmethyl Sulfide
also named 2-Methylthiopyrazine
TCI AMERICA
For experimental / research use only.
2-(Methylthio)pyrazine >98.0%(GC)
Tengzhou Jitian Aroma Chemiclal
2-Methylthio Pyrazine
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 37/38 - Irritating to respiratory system and skin.
R 41 - Risk of serious damage to eyes.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-rat LD50 [sex: M,F] 2500 mg/kg
(Posternak et al., 1975)

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for pyrazinyl methyl sulfide usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.0061 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.01 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
 average usual ppmaverage maximum ppm
baked goods: -1.00000
beverages(nonalcoholic): -1.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -1.00000
fruit ices: -1.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):21948-70-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :519907
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-methylsulfanylpyrazine
Chemidplus:0021948709
 
References:
 2-methylsulfanylpyrazine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:21948-70-9
Pubchem (cid):519907
Pubchem (sid):135263445
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB33152
FooDB:FDB011157
Export Tariff Code:2933.99.8290
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
caramellic
geranyl crotonate
FR
corn chip
popcorn pyrimidine
FL/FR
floral
autumn carboxylate
FR
green
tiglaldehyde
FL/FR
herbal
acorn acetate
FR
nutty
3-
acetyl pyridine
FL/FR
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR
filbert pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
nutty quinoxaline
FL/FR
popcorn
2-
acetyl pyrazine
FL/FR
2-
acetyl pyridine
FL/FR
2-
acetyl thiazole
FL/FR
sulfurous
2-
acetyl thiophene
FL/FR
dimethyl sulfide
FL/FR
For Flavor
No flavor group found for these
2-
acetyl-5-methyl pyrazine
FL
2-
acetyl-6-methyl pyrazine
FL
diethyl sulfide
FL
ethyl dimethyl pyrazine
FL
2-
propionyl pyrrole
FL
pyrazine
FL
pyrrole
FL
ammoniacal
ammoniacal
2-
methyl piperidine
FL
bready
2-
propionyl thiazole
FL
corn
2-
acetyl pyridine
FL/FR
2-
acetyl thiazole
FL/FR
2-
acetyl-2-thiazoline
FL
popcorn pyrimidine
FL/FR
fruity
tiglaldehyde
FL/FR
green
2,5-
dimethyl thiophene
FL
2-
ethyl-5-methyl thiophene
FL
malty
yeast thiazoline
FL
meaty
thialdine
FL
nutty
3-
acetyl pyridine
FL/FR
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR
filbert pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
nutty quinoxaline
FL/FR
nutty thiazole
FL
onion
2-
acetyl thiophene
FL/FR
roasted
2-
acetyl pyrazine
FL/FR
sulfurous
dimethyl sulfide
FL/FR
 
Potential Uses:
FLcauliflower
FLgarlic
FLleek
FLonion
 
Occurrence (nature, food, other):note
 hazelnut
Search Trop Picture
 
Synonyms:
2-methyl mercaptopyrazine
2-methyl thio pyrazine
(methyl thio) pyrazine
2-(methyl thio) pyrazine
2-methyl thiopyrazine
2-(methylmercapto)pyrazine
2-methylsulfanyl-pyrazine
2-(methylsulfanyl)pyrazine
2-methylsulfanylpyrazine
2-methylthio pyrazine
(methylthio)pyrazine
2-(methylthio)pyrazine
2-methylthiopyrazine
 pyrazine, 2-(methylthio)-
 pyrazinylmethyl sulfide
 
 
Notes:
Flavouring ingredient
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