|
Category:flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Organoleptic Properties:
| Odor Type: meaty |
| garlic |
| Odor Description:at 0.10 % in propylene glycol. repulsive penetrating garlic |
| meaty phenolic sulfurous rubbery alliaceous |
Odor Description:Meaty, phenolic, sulfuraceous, with a rubbery allicious backnote
Mosciano, Gerard P&F 16, No. 2, 49, (1991) |
| Flavor Type: meaty |
| meaty phenolic burnt rubbery sulfurous |
Taste Description: at 20.00 ppm. Meaty, phenolic, with a burnt rubber sulfureous nuance
Mosciano, Gerard P&F 16, No. 2, 49, (1991) |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | T+ - Very toxic. |
R 10 - Flammable.
R 24/25 - Toxic in contact with skin and if swallowed.
R 26 - Very toxic by inhalation.
R 41 - Risk of serious damage to eyes.
S 01/02 - Keep locked up and out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 28 - After contact with skin, wash immediately with plenty of water.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
|
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
gavage-rat LD50 46 mg/kg
(Fairchild & Stokinger, 1958)
oral-bird - wild LD50 24 mg/kg
Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
intraperitoneal-mouse LD50 25 mg/kg
National Technical Information Service. Vol. AD277-689
oral-mouse LD50 267 mg/kg
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Technical Information Service. Vol. OTS0557376
intraperitoneal-rat LD50 9800 ug/kg
BEHAVIORAL: COMA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
American Industrial Hygiene Association Journal. Vol. 19, Pg. 171, 1958.
oral-rat LD50 46200 ug/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: COMA
American Industrial Hygiene Association Journal. Vol. 19, Pg. 171, 1958.
|
| Dermal Toxicity: |
skin-rabbit LD50 134 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
BEHAVIORAL: ATAXIA
American Industrial Hygiene Association Journal. Vol. 19, Pg. 171, 1958.
skin-rat LD50 300 mg/kg
BEHAVIORAL: TREMOR
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE
American Industrial Hygiene Association Journal. Vol. 19, Pg. 171, 1958.
|
| Inhalation Toxicity: |
inhalation-mouse LC50 28 ppm/4H
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
American Industrial Hygiene Association Journal. Vol. 19, Pg. 171, 1958.
inhalation-rat LC50 33 ppm/4H
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
American Industrial Hygiene Association Journal. Vol. 19, Pg. 171, 1958.
|
Safety in Use Information:
| Category: | | flavoring agents |
| Recommendation for phenyl mercaptan usage levels up to: | | | not for fragrance use.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.73 (μg/capita/day) |
| Structure Class: | II |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 12 |
| Click here to view publication 12 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 5.30000 |
| beverages(nonalcoholic): | - | 1.50000 |
| beverages(alcoholic): | - | 3.70000 |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | 0.20000 |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 5.50000 |
| fruit ices: | - | - |
| gelatins / puddings: | - | 2.50000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | 3.10000 |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | 5.50000 |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
|
European Food Safety Authority (EFSA) reference(s):
|
Flavouring Group Evaluation 8 (FGE.08)[1]: Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20
View page or View pdf
|
Flavouring Group Evaluation 74 (FGE.74)[1]: Consideration of Simple Aliphatic Sulphides and Thiols evaluated by JECFA (61st meeting) Structurally related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or without Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08 (2008)
View page or View pdf
|
Flavouring Group Evaluation 8, Revision 1 (FGE.08Rev1): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf
|
Flavouring Group Evaluation 91 (FGE.91): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev1 (2009)
View page or View pdf
|
Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf
|
Scientific Opinion on Flavouring Group Evaluation 08, Revision 4 (FGE.08Rev4): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf
|
| EPI System: View |
| NIOSH International Chemical Safety Cards:search |
| NIOSH Pocket Guide:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):108-98-5 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :7969 |
| National Institute of Allergy and Infectious Diseases:Data |
| WISER:UN 2337 |
| WGK Germany:3 |
| benzenethiol |
| Chemidplus:0000108985 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:108-98-5 |
References:
Other Information:
Potential Blenders and core components note
| For Odor |
| alliaceous |
dimethyl trisulfide
FL/FR |
dipropyl disulfide
FL/FR |
| burnt |
rum ether
FL/FR |
| caramellic |
coffee dione
FL/FR |
iso propenyl pyrazine
FL/FR |
shoyu furanone
FL/FR |
| coffee |
coffee difuran
FL/FR |
furfuryl mercaptan
FL/FR |
| floral |
ortho- methyl acetophenone
FL/FR |
| fruity |
tropical trithiane
FL/FR |
| meaty |
meaty dithiane
FL/FR |
4- methyl nonanoic acid
FL/FR |
sulfuryl acetate
FL/FR |
| minty |
agathosma crenulata leaf oil
FL/FR |
| musty |
hazelnut pyrazine
FL/FR |
| nutty |
3,5- cocoa pyrazine
FL/FR |
4,5- dimethyl-2-ethyl-3-thiazoline
FL/FR |
2- methyl pyrazine
FL/FR |
5- methyl quinoxaline
FL/FR |
2- methyl-3-(methyl thio) pyrazine
FL/FR |
2,3,5,6- tetramethyl pyrazine
FL/FR |
| phenolic |
2-iso propyl phenol
FL/FR |
| smoky |
birch tar oil
FL/FR |
| sulfurous |
benzothiazole
FL/FR |
ethyl 3-mercaptopropionate
FL/FR |
fish thiol
FL/FR |
furfuryl thioacetate
FL/FR |
2- mercaptopropionic acid
FL/FR |
4- methyl 4-mercaptopentan-2-one 1% solution
FL/FR |
1- phenethyl mercaptan
FL/FR |
| tobacco |
methyl benzoxole
FL/FR |
| tonka |
whiskey lactone
FL/FR |
| woody |
4-iso propyl phenol
FL/FR |
| For Flavor |
| No flavor group found for these |
acetaldehyde diethyl mercaptal
FL |
4- acetyl-2-methyl pyrimidine
FL |
gamma- aminobutyric acid
FL |
amyl mercaptan
FL |
benzyl disulfide
FL |
benzyl methyl sulfide
FL |
birch tar oil
FL/FR |
2- butenoic acid
FL |
2-iso butyl-4,5-dimethyl oxazole
FL |
2-(2- butyl)-4,5-dimethyl-3-thiazoline
FL |
cyclopropyl (E,Z)-2,6-nonadienamide
FL |
2,5- diethyl thiazole
FL |
dimethyl dihydrocyclopentapyrazine
FL |
dimethyl tetrasulfide
FL |
4,5- dimethyl-2-ethyl thiazole
FL |
2,6- dimethyl-3-((2-methyl-3-furyl)thio)-4-heptanone
FL |
bis(2,5- dimethyl-3-furyl) disulfide
FL |
2,5- dimethyl-3-thiofuroyl furan
FL |
ethyl (E,Z)-2,6-nonadienamide
FL |
S- ethyl 2-acetyl aminoethane thioate
FL |
ethyl 3-mercaptopropionate
FL/FR |
ethyl 4-(acetyl thio) butyrate
FL |
ethyl dimethyl pyrazine
FL |
(Z+E)-5- ethyl-4-methyl-2-(2-butyl) thiazoline
FL |
(Z+E)-5- ethyl-4-methyl-2-(2-methyl propyl) thiazoline
FL |
4- methyl 4-mercaptopentan-2-one 1% solution
FL/FR |
methyl dihydrofuran thiol
FL |
2- methyl thiazolidine
FL |
2-( methyl thio) ethanol
FL |
2-( methyl thio) methyl-2-butenal
FL |
2- methyl-3-(methyl thio) pyrazine
FL/FR |
2- methyl-3-furyl tetrasulfide
FL |
3-((2- methyl-3-furyl)thio)-4-heptanone
FL |
4-((2- methyl-3-furyl)thio)-5-nonanone
FL |
1,9- nonane dithiol
FL |
peanut dithiazine
FL |
1- phenethyl mercaptan
FL/FR |
1,3- propane dithiol
FL |
iso propyl disulfide
FL |
3- thienyl mercaptan
FL |
|
N-(2-(3,4- dimethoxyphenyl)ethyl)-3,4-dimethoxycinnamic acid amide
FL |
3,7- dimethyl-2,6-octadien-1-yl cyclopropyl carboxamide
FL |
4- mercapto-2-pentanone 1% in acetoin
FL |
2- methyl-1-methyl thio-2-butene
FL |
pyrrolidino-(1,2E)-4H-2,4-dimethyl-1,3,5-dithiazine
FL |
1-(2- thienyl) butanone
FL |
| alliaceous |
| alliaceous |
1,3- butane dithiol
FL |
dimethyl trisulfide
FL/FR |
dipropyl disulfide
FL/FR |
3- tetrahydrothiophenone
FL |
| anisic |
ortho- methyl acetophenone
FL/FR |
| burnt |
bacon dithiazine
FL |
1,6- hexane dithiol
FL |
iso propenyl pyrazine
FL/FR |
4-iso propyl phenol
FL/FR |
rum ether
FL/FR |
| caramellic |
caramel furanone
FL |
shoyu furanone
FL/FR |
| chemical |
2,5- dimethyl furan
FL |
| cocoa |
butyraldehyde
FL |
| coffee |
coffee difuran
FL/FR |
coffee dione
FL/FR |
furfuryl mercaptan
FL/FR |
2- thiophene thiol
FL |
| earthy |
difurfuryl sulfide
FL |
1,8- octane dithiol
FL |
| eggy |
iso propyl mercaptan
FL |
| fatty |
4,5- dimethyl-2-propyl oxazole
FL |
4- methyl nonanoic acid
FL/FR |
| fruity |
tropical trithiane
FL/FR |
| green |
2,5- dimethyl-4-ethyl oxazole
FL |
| malty |
yeast thiazoline
FL |
| meaty |
4- allyl-2,6-dimethoxyphenol
FL |
benzothiazole
FL/FR |
2,6- dimethyl thiophenol
FL |
2,5- dimethyl-3-furan thiol
FL |
1,1- ethane dithiol 1% in ethanol 94.5% / ethyl acetate 4%
FL |
4- furfuryl thio-2-pentanone
FL |
meaty dithiane
FL/FR |
2- mercaptomethyl pyrazine
FL |
2- mercaptopropionic acid
FL/FR |
2- methyl 3-(methyl thio) furan
FL |
12- methyl tridecanal
FL |
bis(2- methyl-3-furyl) disulfide
FL |
S-(2- methyl-3-furyl) ethane thioate
FL |
2- methyl-3-tetrahydrofuran thiol
FL |
propyl 2-mercaptopropionate
FL |
propyl 2-methyl-3-furyl disulfide
FL |
pyrazinyl ethane thiol
FL |
2- pyridinyl methane thiol
FL |
sulfuryl acetate
FL/FR |
thialdine
FL |
ortho- thiocresol
FL |
ortho- thioguaiacol
FL |
| metallic |
2,5- dihydroxy-1,4-dithiane
FL |
| minty |
agathosma crenulata leaf oil
FL/FR |
| musty |
2- ethoxythiazole
FL |
hazelnut pyrazine
FL/FR |
| nutty |
3- acetyl-2,5-dimethyl thiophene
FL |
3,5- cocoa pyrazine
FL/FR |
3,5(6)- cocoa pyrazine
FL |
3,5- diethyl-2-methyl pyrazine
FL |
2,5- diethyl-3-methyl pyrazine
FL |
4,5- dimethyl-2-ethyl-3-thiazoline
FL/FR |
methyl benzoxole
FL/FR |
2- methyl pyrazine
FL/FR |
5- methyl quinoxaline
FL/FR |
nutty thiazole
FL |
2,3,5,6- tetramethyl pyrazine
FL/FR |
| onion |
furfuryl isopropyl sulfide
FL |
| phenolic |
2- hydroxyisophorone
FL |
propyl 2-furoate
FL |
| popcorn |
2- propionyl-2-thiazoline
FL |
| roasted |
furfuryl thioacetate
FL/FR |
hexyl mercaptan
FL |
| savory |
N-(2,4- dimethoxybenzyl)-N2-(2-(pyridin-2-yl)ethyl) oxalamide
FL |
N-( heptan-4-yl)benzo(D)(1,3)dioxole-5-carboxamide
FL |
N1-(2- methoxy-4-methyl benzyl)-N2-(2-(pyridin-2-yl)ethyl) oxalamide
FL |
N1-(2- methoxy-4-methyl benzyl)-N2-2(2-(5-methyl pyridin-2-yl)ethyl) oxalamide
FL |
| solvent |
2- ethyl furan
FL |
2-iso propyl phenol
FL/FR |
| sulfurous |
2,3- butane dithiol
FL |
diphenyl disulfide
FL |
S- ethyl thioacetate
FL |
fish thiol
FL/FR |
methyl 2-methyl-3-furyl disulfide
FL |
3- methyl-2-butane thiol
FL |
2- naphthyl mercaptan
FL |
roasted butanol
FL |
| vegetable |
tyramine
FL |
| woody |
whiskey lactone
FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzene thiol | | | benzenethiol | | | mercaptobenzene | | | phenol, thio- | | | phenyl thiol | | | phenylmercaptan | | | phenylsulfide | | | thiophenol |
Articles:
|
3D/inchi