heliotropin
Notes:
Blend with 7 parts anisyl alcohol and 5 parts heliotropin to remove the custard note. Imparts a lasting sweetness whenever used. sandalwood enhancer - santall and heliotropin. has been used as a pediculicide.
Synonyms   Articles   Notes   Search
Fragrance Demo Formulas    Flavor Demo Formulas
1,3-benzodioxole-5-carbaldehyde (Click)
CAS Number: 120-57-0 30024-74-9
ECHA EINECS - REACH Pre-Reg: 204-409-7
FDA UNII:KE109YAK00
Beilstein Number: 131691
MDL: MFCD00005828
FEMA Number: 2911
CoE Number: 104
XlogP3: 1.10 (est)
Molecular Weight: 150.13342000
Formula: C8 H6 O3
BioActivity Summary: listing
NMR Predictor: Predict
EFSA/JECFA Comments: ADI: 0-2.5 (JECFA, 1968).
Category: cosmetic, flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
JECFA Food Flavoring: 896  piperonal
Flavis Number: 05.016 (Old)
EU SANCO Food Flavourings: 05.016  piperonal

FEMA Number: 2911  piperonal
FDA Mainterm: PIPERONAL
FDA Regulation:
FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart A--General Provisions
Sec. 182.60 Synthetic flavoring substances and adjuvants.
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Physical Properties:
Appearance: white crystalline powder (est)
Assay: 98.00 to 100.00 % 
Heavey Metals: <40.00 ppm
Food Chemicals Codex Listed: Yes
Melting Point: 37.00 to  39.00 °C. @ 760.00 mm Hg
Boiling Point: 263.00 to  265.00 °C. @ 760.00 mm Hg
Boiling Point: 144.00 to  145.00 °C. @ 15.00 mm Hg
Congealing Point: 35.30 °C.
Acid Value: 3.00 max. KOH/g
Vapor Pressure: 0.003000 mm/Hg @ 25.00 °C.
Flash Point: > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 1.050
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage: store in cool, dry place in tightly sealed containers, protected from heat and light.
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Organoleptic Properties:
Odor Type: floral
Odor Strength: medium
Odor Description:
at 100.00 %. 
heliotrope flower sweet powdery coconut vanilla
Substantivity: 212 Hour(s)
  
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: masking agents
perfuming agents
skin conditioning
Synonyms   Articles   Notes   Search   Top
Safety Information:
Most important hazard(s):
Xi - Irritant
  R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Human Experience: 6 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
  gavage-rat LD50  [sex: M,F] 2700 mg/kg
(Jenner et al., 1964)

gavage-rat LD50  [sex: M,F] 2700 mg/kg
(Taylor et al., 1964)

gavage-rat LD50  [sex: M,F] 2700 mg/kg
(Hagan et al., 1965)

intraperitoneal-mouse LD50  480 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 370, 1954.

oral-rat LD50  2700 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 6, Pg. 378, 1964.

intraperitoneal-rat LDLo  1500 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Revue Medicale de la Suisse Romande. Vol. 16, Pg. 449, 1896.

Dermal Toxicity:
  skin-rabbit LD50 > 5000 mg/kg
National Technical Information Service. Vol. OTS0535062

skin-rat LD50 > 5 mg/kg
National Technical Information Service. Vol. OTS0535062

Inhalation Toxicity:
  Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: cosmetic, flavor and fragrance agents
Recommendation for heliotropin usage levels up to:
  8.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 1500.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 3200.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -18.00000
beverages(nonalcoholic): -6.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -36.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -7.00000
fruit ices: -7.00000
gelatins / puddings: -5.80000
granulated sugar: --
gravies: --
hard candy: -7.40000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of hydroxyl- and alkoxy-substituted benzyl derivatives used as flavor ingredients.View pdf
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23
View page or View pdf
Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23
View page or View pdf
Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf
EPI System: View
Chemicalize.org: Calculate predicted properties
ECHA Data Sheet: View
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
National Toxicology Program: Search
EPA Substance Registry Services (TSCA): 120-57-0
EPA ACToR: Toxicology Data
National Institute of Allergy and Infectious Diseases: Data
WGK Germany:2
 1,3-benzodioxole-5-carbaldehyde
DTP/NCI: 26826
Chemidplus: 0000120570
EPA/NOAA CAMEO:hazardous materials
RTECS: TO1575000 for cas# 120-57-0
Synonyms   Articles   Notes   Search   Top
References:
 1,3-benzodioxole-5-carbaldehyde
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 120-57-0
Pubchem (cid): 8438
Pubchem (sid): 134975051
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C10812
HMDB (The Human Metabolome Database): HMDB32612
YMDB (Yeast Metabolome Database): YMDB01776
Export Tariff Code: 2932.93.0000
Haz-Map: View
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
grades: technical; fcc
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
ortho-acetanisoleFL/FR
para-acetanisoleFL/FR
 acetophenoneFL/FR
2-acetyl furanFL/FR
 acetyl methyl anthranilateFL/FR
 allspice oilFL/FR
 amber formateFR
 ambrette seed oilFL/FR
isoamyl benzoateFL/FR
alpha-amyl cinnamaldehydeFL/FR
 amyl isoeugenolFR
isoamyl phenyl acetateFL/FR
isoamyl salicylateFL/FR
 amyris wood oilFL/FR
 animal carbolactoneFR
ortho-anisaldehydeFL/FR
para-anisaldehydeFL/FR
para-anisaldehyde / methyl anthranilate schiff's baseFR
 anise seed oil colombiaFL/FR
para-anisyl acetateFL/FR
para-anisyl alcoholFL/FR
 anisyl propanal / methyl anthranilate schiff's baseFR
 anthocephalus cadamba oilFR
 beeswax absoluteFL/FR
 benzaldehydeFL/FR
siam benzoin resinoidFL/FR
 benzophenoneFL/FR
 benzyl acetateFL/FR
 benzyl alcoholFL/FR
 benzyl cinnamateFL/FR
 benzyl isoeugenolFL/FR
 benzyl salicylateFL/FR
 bergamot oilFL/FR
blood orange oil italyFL/FR
isobutyl benzoateFL/FR
isobutyl cinnamateFL/FR
 caramel furanoneFL
 cardamom seed oilFL/FR
 cassia bark oil chinaFL/FR
 cherry oxyacetateFL/FR
 cinnamyl alcoholFL/FR
 citronellolFL/FR
 clary sage oil franceFL/FR
 clove bud oilFL/FR
 clover nitrileFR
 cocoa butenalFL/FR
 cocoa oleoresinFL/FR
 cocoa pentenalFL/FR
 copaiba balsam oilFL/FR
 costus valerolactoneFR
 coumarinFR
para-cresyl propionaldehydeCS
 cyclohexadecanoneFR
 cyclohexyl acetic acidFL/FR
 cyclohexyl ethyl alcoholFL/FR
 cycloteneFL/FR
alpha-damasconeFL/FR
beta-damasconeFL/FR
gamma-decalactoneFL/FR
 decanal (aldehyde C-10)FL/FR
 decanolFL/FR
 decyl acetateFL/FR
 deertongue absoluteFR
 dihydrojasmoneFL/FR
 dimethyl alpha-iononeFR
 dimethyl anthranilateFL/FR
 dimethyl benzyl carbinolFL/FR
 dimethyl benzyl carbinyl butyrateFL/FR
ortho-dimethyl hydroquinoneFL/FR
 dodecanal (aldehyde C-12 lauric)FL/FR
1-dodecanolFL/FR
 ethyl cinnamateFL/FR
 ethyl maltolFL/FR
 ethyl methyl-para-tolyl glycidateFL/FR
 ethyl phenyl acetateFL/FR
 ethyl vanillinFL/FR
 ethyl vanillin isobutyrateFL/FR
 ethyl vanillin propylene glycol acetalFL/FR
 ethylene brassylateFL/FR
isoeugenyl acetateFL/FR
 fir balsam absoluteFR
 floral pyranolFR
 frankincense oilFL/FR
 geraniolFL/FR
(E)-geranyl acetoneFL/FR
 geranyl phenyl acetateFL/FR
 guaiacwood oilFL/FR
 gurjun balsam oilFR
 hay absoluteFR
 heliotrope absoluteFR
 heliotropyl acetateFL/FR
 heliotropyl acetoneFL/FR
 heliotropyl alcoholFL/FR
 heliotropyl diethyl acetalFR
gamma-heptalactoneFL/FR
gamma-hexalactoneFL/FR
(Z)-3-hexen-1-yl acetateFL/FR
(Z)-3-hexen-1-yl butyrateFL/FR
(Z)-3-hexen-1-yl propionateFL/FR
alpha-hexyl cinnamaldehydeFL/FR
 hexyl isovalerateFL/FR
 hyacinth etherFR
 hydroxycitronellalFL/FR
 immortelle absoluteFL/FR
 indoleFL/FR
(E)-beta-iononeFL/FR
alpha-ironeFL/FR
 labdanum resinoidFR
 lavender absolute bulgariaFL/FR
 linalool oxideFL/FR
 maltolFL/FR
para-methyl acetophenoneFL/FR
para-methyl anisoleFL/FR
alpha-methyl cinnamaldehydeFL/FR
 methyl cinnamateFL/FR
6-methyl coumarinFL
 methyl dihydrojasmonateFL/FR
para-methyl hydratropaldehydeFL/FR
alpha-methyl iononeFL/FR
beta-isomethyl iononeFL/FR
alpha-isomethyl ionone (50% min.)FL/FR
alpha-isomethyl ionone (90% min.)FL/FR
 methyl ionyl acetateFL/FR
 methyl isoeugenolFL/FR
 mint lactoneFL/FR
dextro,laevo-musconeFL/FR
 exaltoneFR
 musk amberolFR
 musk indaneFR
 musk tetralinFR
 myrrh oilFL/FR
beta-naphthyl ethyl etherFL/FR
 neroli oil bigardeFL/FR
 nerolidolFL/FR
gamma-nonalactone (aldehyde C-18 (so-called))FL/FR
gamma-octalactoneFL/FR
 orris pyridine 25% IPMFR
 orris rhizome resinoid (iris pallida)FL/FR
 patchouli ethanoneFR
 patchouli oilFL/FR
 peach pivalateFR
omega-pentadecalactoneFL/FR
 peony alcoholFR
 peru balsam oilFL/FR
 phenethyl alcoholFL/FR
 phenethyl phenyl acetateFL/FR
 phenoxyethyl isobutyrateFL/FR
 phenyl acetic acidFL/FR
3-phenyl propionaldehydeFL/FR
3-phenyl propyl alcoholFL/FR
4-phenyl-2-butanolFL/FR
 phthalideFL/FR
 powdery ketoneFL
 prenyl acetateFL/FR
isopropyl phenyl acetateFL/FR
 raspberry ketoneFL/FR
 rhodinolFL/FR
 rhodinyl phenyl acetateFL/FR
 rose absolute (rosa damascena) bulgariaFL/FR
 rose butanoateFL/FR
 santallFR
(+)-alpha-santalyl acetateFL/FR
 strawberry furanoneFL/FR
alpha-terpineolFL/FR
ortho-thioguaiacolFL
 timber propanolFR
 tobacarolFR
 tolu balsamFL/FR
 tolualdehydes (mixed o,m,p)FL/FR
 tonka bean absoluteFR
2,3,5-trimethyl pyrazineFL/FR
(E)-2,5,9-trimethyl-4,9-decadien-1-alFR
 tuberose absolute (from pommade)FL/FR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
10-undecen-1-al (aldehyde C-11 undecylenic)FL/FR
10-undecen-1-yl acetateFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanilla oleoresin baliFL/FR
para-vanillic acidFL/FR
 vanillinFL/FR
 vanillyl acetateFL/FR
para-vanillyl alcoholFL/FR
 vanillyl isobutyrateFL/FR
 vanillylidene acetoneFL/FR
 veramossFR
 vetiveryl acetateFL/FR
 watermelon ketoneFR
 woody acetateFR
(Z)-woody amyleneFR
 woody epoxideFR
 woody propanolFR
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 abroniaFR
 acacia cassie farnesianaFR
 aimant 
 aldehydicFR
 amberFR
 ambrene 
 amour-amour 
 angel 
 apple blossomFR
 arpege 
 arrack 
 baby powderFR
 balsamFR
 bananaFR
 bayberryFR
 blackberryFR
 bluebell 
 blueberryFR
 bouquetFR
 carnation dianthus oeilletFR
 cherryFR
 cherry blossomFR
 clover trefle le'trefle incarnatFR
 coconutFR
 coconut tropicalFR
 crabapple blossomFR
 creamFR
 decumaria 
 dilleniaFR
 fern fougereFR
 fetesFR
 fir needle pine needleFL/FR
 fixer 
 floralFR
 florida breeze 
 forest pine forestFR
 fresh & cleanFR
 gardeniaFR
 genet genista broomFR
 ginger whiteFR
 gingerbreadFR
 habubaFR
 hawthornFR
 hay new mown hay foin coupeFR
 heliotropeFR
 honeysuckle chevrefeuilleFR
 hops houblonFL/FR
 hugonia 
 hyacinth jacintheFR
 japan flowers 
 je reviens 
 leather russianFR
 lemonFR
 lilac lilas syringaFR
 lilyFR
 linden blossom limeflower tilleulFR
 lotusFR
 magnoliaFR
 meadow countryFR
 mimosaFR
 mintFR
 monimia 
 muguet lily of the valleyFR
 muskFR
 my sin 
 narcissus narcisseFR
 nemesia 
 neroliFR
 nut pistachioFL
 ophira 
 orchidFR
 orientalFR
 orris irisFR
 passion blossomFR
 patchouliFR
 peachFR
 pina coladaFR
 powderFR
 pumpkin pieFR
 rainFR
 roseFR
 sandalwoodFR
 scandal 
 spiceFR
 sweet peaFR
 tide 
 tobaccoFR
 tonka beanFR
 tuberoseFR
 vanillaFR
 violetFR
 wallflowerFR
 wisteria wistaria glycineFR
 woodyFR
Synonyms   Articles   Notes   Search   Top
Natural Occurrence in: note
 blueberry
 camphor wood
 chicken
 dill
GRIN Trop Picture
 melon
 pepper black pepper
GRIN Trop Picture
 sherry
 spirea ulmaria
GRIN Trop Picture
 tobacco burley tobacco
GRIN Trop Picture
 vanilla tahiti vanilla
GRIN Trop Picture
 violet flower
GRIN Trop Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
 benzo[1,3]dioxole-5-carbaldehyde
 benzo[d][1,3]dioxole-5-carbaldehyde
2H-benzo[d]1,3-dioxolene-5-carbaldehyde
1,3-benzodioxole-5-carbaldehyde
2H-1,3-benzodioxole-5-carbaldehyde
1,3-benzodioxole-5-carboxaldehyde
3,4-dihydroxybenzaldehyde methylene ketal
3,4-dimethylene dioxybenzaldehyde
 dioxymethylene procatechuic aldehyde
 dioxymethylene protocatechuic aldehyde
 formaldehyde protechualdehyde-3,4-cyclic acetal
5-formyl-1,3-benzodioxole
 geliotropin
 heliobase
 heliotropin natural
 heliotropin recrystallized extra FCC
 heliotropine
 heliotropine crystals
 heliotropine crystals FCC
 heliotropine natural
 heliotropine synthetic
3,4-methylene dioxy) benzaldehyde
3,4-bis(methylene dioxy) benzaldehyde
3,4-(methylene dioxy)-1,3-benzodioxole-5-benzaldehyde
3,4-methylene dioxybenzaldehyde
3,4-methylene protocatechuic aldehyde
3,4-(methylenedioxy)benzaldehyde
3,4-methylenedioxybenzaldehyde
 piperonal
 piperonal nat.
 piperonaldehyde
 piperonyl aldehyde
 piperonylaldehyde
 protocatechuic aldehyde methylene ether
Synonyms   Articles   Notes   Search   Top
Articles:
Google Patents: Process for preparing piperonal
PubMed: Can head louse repellents really work? Field studies of piperonal 2% spray.
J-Stage: First Total Synthesis of Justicidone, a p-Quinone-Lignan Derivative from Justicia hyssopifolia
PubMed: Piperonal prevents high-fat diet-induced hepatic steatosis and insulin resistance in mice via activation of adiponectin/AMPK pathway.
J-Stage: Synthesis of Optically Active Olivil Type of Lignan from L-Arabinose Using threo-Selective Aldol Condensation as a Key Reaction
PubMed: Forensic profiling of sassafras oils based on comprehensive two-dimensional gas chromatography.
PubMed: Anticancer activity and biophysical reactivity of copper complexes of 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-alkylhydrazinecarbothioamides.
PubMed: Enantiomeric HPLC resolution and absolute stereochemistry assignment of a new poligamain derivative.
PubMed: Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli.
PubMed: Synthesis and impurity profiling of MDMA prepared from commonly available starting materials.
PubMed: Synthesis and GC-MS analysis of a series of homologs and regioisomers of 3,4-methylenedioxypyrovalerone (MDPV).
PubMed: Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells.
PubMed: Selective recognition of sesamol using molecularly imprinted polymers containing magnetic wollastonite.
PubMed: Simultaneous determination of bioactive compounds in Piper nigrum L. and a species comparison study using HPLC-PDA.
PubMed: Availability of target odor compounds from seized ecstasy tablets for canine detection.
PubMed: Half-sandwich ruthenium–arene complexes with thiosemicarbazones: synthesis and biological evaluation of [(η⁶-p-cymene)Ru(piperonal thiosemicarbazones)Cl]Cl complexes.
PubMed: Synthesis and characterization of mixed-ligand diimine-piperonal thiosemicarbazone complexes of ruthenium(II): Biophysical investigations and biological evaluation as anticancer and antibacterial agents.
PubMed: S-selective hydroxynitrile lyase from a plant Baliospermum montanum: molecular characterization of recombinant enzyme.
PubMed: Total synthesis of (+)-virgatusin via AlCl3-catalyzed [3+2] cycloaddition.
PubMed: In vitro biological studies and structural elucidation of fluoro-substituted phenyl acrylic acids.
PubMed: Enhancement in sample collection for the detection of MDMA using a novel planar SPME (PSPME) device coupled to ion mobility spectrometry (IMS).
PubMed: Toxicological methods for tracing drug abuse: chromatographic, spectroscopic and biological characterisation of ecstasy derivatives.
PubMed: Dynamic planar solid phase microextraction-ion mobility spectrometry for rapid field air sampling and analysis of illicit drugs and explosives.
PubMed: Detection of piperonal emitted from polymer controlled odor mimic permeation systems utilizing Canis familiaris and solid phase microextraction-ion mobility spectrometry.
PubMed: N-[(E)-1,3-Benzodioxol-5-yl-methyl-idene]-4-methyl-aniline.
PubMed: Titanium imido complexes utilizing orthometallated derivatized acetophenone and piperonal imine ligands: synthesis, isolation, and characterization.
PubMed: A combined experimental and theoretical study of the polar [3 + 2] cycloaddition of electrophilically activated carbonyl ylides with aldehydes and imines.
PubMed: Adsorbed resin phase spectrophotometric determination of vanillin or/and its derivatives.
PubMed: [Synthesis of pyridine-containing diacylhydrazones and study on their spectral properties].
PubMed: Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity.
PubMed: Headspace sampling and detection of cocaine, MDMA, and marijuana via volatile markers in the presence of potential interferences by solid phase microextraction-ion mobility spectrometry (SPME-IMS).
PubMed: Synthesis and use of 4-peptidylhydrazido-N-hexyl-1,8-naphthalimides as fluorogenic histochemical substrates for dipeptidyl peptidase IV and tripeptidyl peptidase I.
PubMed: Silenes in organic synthesis: a concise synthesis of (+/-) -epi-picropodophyllin.
PubMed: Electrochemical and spectroscopic characterisation of amphetamine-like drugs: application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors.
PubMed: Alpha-phenyl-N-tert-butyl nitrone (PBN) derivatives: synthesis and protective action against microvascular damages induced by ischemia/reperfusion.
PubMed: Development and validation of an RP-HPLC method for quantitative determination of vanillin and related phenolic compounds in Vanilla planifolia.
PubMed: The fumigant and repellent activity of aliphatic lactones against Pediculus humanus capitis (Anoplura: Pediculidae).
PubMed: Synthesis of 7-deoxypancratistatin from carbohydrates by the use of olefin metathesis.
PubMed: A study of impurities in intermediates and 3,4-methylenedioxymethamphetamine (MDMA) samples produced via reductive amination routes.
PubMed: First total synthesis of justicidone, a p-quinone-lignan derivative from Justicia hyssopifolia.
PubMed: Determination of synthesis method of ecstasy based on the basic impurities.
PubMed: Chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets seized in Hong Kong.
PubMed: [Succivil efficacy in endogenous intoxication].
PubMed: [Study on the spectrophotometric determination of vanadium with piperonal fluorone by atomic absorption spectrophotometer].
PubMed: [Study on the determination of iron by silica gel H phase-diffuse reflectance spectrometry].
PubMed: Bhc-diol as a photolabile protecting group for aldehydes and ketones.
PubMed: Microbiologic oxidation of isosafrole into piperonal.
PubMed: Concentrations of nine alkenylbenzenes, coumarin, piperonal and pulegone in Indian bidi cigarette tobacco.
PubMed: [Comparative evaluation of antioxidant properties of neoselen and berberin in chronic heliotrinal hepatitis].
PubMed: [Morphological features of the thymus in heliotrin hepatitis upon administration of immunostimulators].
PubMed: A short synthesis of (+/-)-epiasarinin.
PubMed: Antioxidant properties of 8.0.4'-neolignans.
PubMed: Asymmetric Synthesis of Sesaminone: Confirmation of Its Structure and Determination of Its Absolute Configuration.
PubMed: Synthesis of optically active olivil type of lignan from L-arabinose using threo-selective aldol condensation as a key reaction.
PubMed: Histochemical method for dipeptidyl aminopeptidase II with a new anthraquinonyl hydrazide substrate.
PubMed: [The effect of perftoran on the biochemical detoxication parameters in rats with an acute toxic lesion of the liver].
PubMed: Enzyme-assisted asymmetric total synthesis of (-)-podophyllotoxin and (-)-picropodophyllin.
PubMed: Quantitation of flavor-related alkenylbenzenes in tobacco smoke particulate by selected ion monitoring gas chromatography-mass spectrometry.
PubMed: [The effect of immunomudulin on the structural-functional status of the organs of the immune and hematopoietic systems in chronic toxic hepatitis].
PubMed: Solid phase microextraction of alkenylbenzenes and other flavor-related compounds from tobacco for analysis by selected ion monitoring gas chromatography-mass spectrometry.
PubMed: Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus Laevis oocytes.
PubMed: Cloning, functional expression and characterization of a human olfactory receptor.
PubMed: An Asymmetric Synthesis of L-694,458, a Human Leukocyte Elastase Inhibitor, via Novel Enzyme Resolution of beta-Lactam Esters.
PubMed: Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids.
PubMed: Synthesis, anti-GABA activity and preferred conformation of bicuculline and norbicuculline enantiomers.
PubMed: Fragrance administration to reduce anxiety during MR imaging.
PubMed: Head louse repellents.
PubMed: Arena tests with piperonal, a new louse repellent.
PubMed: New head louse repellent.
PubMed: [Contamination in illegal amphetamine. Contaminants resulting from the synthesis of 3,4-(methylenedioxy)amphetamine (MDA) via condensation between nitroethane and piperonal].
PubMed: [Synthesis of derivatives of 2,4-bis(arylmethino)-8-butyl-8- azabicyclo[3.2.1]octan-3-one].
PubMed: Determination of coumarin as an adulterant in vanilla flavoring products by high-performance liquid chromatography.
PubMed: Metabolic disposition of piperine in the rat.
PubMed: Inhibition of rabbit nasal and hepatic cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase by methylenedioxyphenyl compounds.
PubMed: Chemosensitivity of lobster,Homarus americanus, to secondary plant compounds: Unused receptor capabilities.
PubMed: Metabolism of piperonal and piperonyl alcohol in the rat with special reference to the scission of the methylenedioxy group.
PubMed: The inhibition of rat nasal cytochrome P-450-dependent mono-oxygenase by the essence heliotropin (piperonal).
PubMed: Genotoxicity of safrole-related chemicals in microbial test systems.
PubMed: The metabolism of some food additives related to piperonal in the rabbit.
PubMed: Quantitative determination of chlorpromazine. HCl in tablets, spansules, injectables, and bulk chemical by nuclear magnetic resonance spectroscopy.
PubMed: [The mechanism of centrolobular hepatic necrosis in acute heliotropin poisoning].
PubMed: [Changes in the antigenic composition of the rat liver in acute and chronic heliotropin poisoning].
PubMed: [AUTOANTIGENICITY IN EXPERIMENTAL LIVER DISEASES (ANTIGENIC PROPERTIES OFTHE SERUM IN HELIOTROPIN-INDUCED HEPATITIS)].
PubMed: Correlation of piperonal test values for aromatic compounds with the atmospheric concentration of benzo(A)pyrene.
PubMed: [ON THE SYNTHESIS OF PIPERONAL].
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Soluble in:
 alcohol
 benzyl benzoate
 dipropylene glycol
 fixed oils
 isopropyl myristate
 propylene glycol
 water, 3500 mg/L @ 25 °C (exp)
Insoluble in:
 paraffin oil
 water
 glycerin
Stability:
 bath foam
 hair spray
 powder
 soap
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