EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

4-acetyl-2,5-dimethyl-3(2H)-furanone
4-acetyl-2,5-dimethylfuran-3-one

Supplier Sponsors

CAS Number: 36871-78-0Picture of molecule3D/inchi
FDA UNII:Y1BRB2IA9F
XlogP3-AA:0.70 (est)
Molecular Weight:154.16530000
Formula:C8 H10 O3
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
Racemate (EFFA, 2015). CASrn 36871-78-0 to be introduced in the Register Safety evaluation not completed; mp: 34-35
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
JECFA Food Flavoring:2234 4-acetyl-2,5-dimethyl-3(2H)-furanone
FLAVIS Number:13.175 (Old)
DG SANTE Food Flavourings:13.175 4-acetyl-2,5-dimethylfuran-3(2H)-one
FEMA Number:4070 4-acetyl-2,5-dimethyl-3(2H)-furanone
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):36871-78-0 ; 4-ACETYL-2,5-DIMETHYL-3(2H)-FURANONE
 
Physical Properties:
Appearance:colourless solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 34.00 to 35.00 °C. @ 760.00 mm Hg
Boiling Point: 283.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.009000 mmHg @ 25.00 °C. (est)
Flash Point: 238.00 °F. TCC ( 114.50 °C. ) (est)
logP (o/w): 0.115 (est)
Soluble in:
 alcohol
 water, 7.443e+004 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: caramellic
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
caramellic fruity
Odor Description:at 0.10 % in propylene glycol. caramellic fruity rasberry
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Axsyn
For experimental / research use only.
4-ACETYL-2,5-DIMETHYL-3(2H)-FURANONE
BOC Sciences
For experimental / research use only.
4-Acetyl-2,5-dimethyl-3(2H)-furanone
Parchem
4-acetyl-2,5-dimethyl-3(2H)-furanone
Penta International
4-ACETYL-2,5-DIMETHYL-3(2H)-FURANONE
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for 4-acetyl-2,5-dimethyl-3(2H)-furanone usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 1.30 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 1000 (μg/person/day)
Threshold of Concern:90 (μg/person/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 22
Click here to view publication 22
 average usual ppmaverage maximum ppm
baked goods: 0.5000025.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: 2.0000010.00000
cheese: 3.0000015.00000
chewing gum: 4.0000020.00000
condiments / relishes: --
confectionery froastings: 4.0000020.00000
egg products: --
fats / oils: 2.0000010.00000
fish products: 1.000005.00000
frozen dairy: 3.0000015.00000
fruit ices: 3.0000015.00000
gelatins / puddings: 3.0000015.00000
granulated sugar: --
gravies: 2.0000010.00000
hard candy: 4.0000020.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: 2.0000010.00000
meat products: 1.000005.00000
milk products: 3.0000015.00000
nut products: --
other grains: --
poultry: 1.000005.00000
processed fruits: 2.0000010.00000
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 2.0000010.00000
snack foods: 5.0000025.00000
soft candy: 4.0000020.00000
soups: 2.0000010.00000
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

List of apha, beta-Unsaturated Aldehydes and Ketones representative of FGE.19 substances for Genotoxicity Testing [1] - Statement of the Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
View page or View pdf

Flavouring Group Evaluation 220: alpha,beta-Unsaturated ketones and precursors from chemical subgroup 4.4 of FGE.19: 3(2H)-Furanones
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 220, Revision 1 (FGE.220Rev1): alpha,beta-Unsaturated ketones and precursors from chemical subgroup 4.4 of FGE.19: 3(2H)-Furanones
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 220, Revision 2 (FGE.220Rev1): a,-Unsaturated ketones and precursors from chemical subgroup 4.4 of FGE.19: 3(2H)-Furanones
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 220 Revision 3 (FGE.220Rev3): Consideration of genotoxic potential for a,-unsaturated 3(2H)-Furanones from subgroup 4.4 of FGE.19
View page or View pdf

Scientific opinion on Flavouring Group Evaluation 313, (FGE.313): a,-unsaturated 3(2H)-furanone derivatives from chemical group 13
View page or View pdf

EPI System: View
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :53426546
National Institute of Allergy and Infectious Diseases:Data
4-acetyl-2,5-dimethylfuran-3-one
Chemidplus:0036871780
 
References:
 4-acetyl-2,5-dimethylfuran-3-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):53426546
Pubchem (sid):135336403
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):Search
FooDB:FDB008892
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
For Odor
acidic
cyclohexyl acetic acid
FL/FR
balsamic
2-
acetyl furan
FL/FR
iso
amyl pyruvate
FL/FR
bready
furfural
FL/FR
burnt
rum ether
FL/FR
buttery
acetoin
FL/FR
acetyl butyryl
FL/FR
acetyl propionyl
FL/FR
3,4-
hexane dione
FL/FR
caramellic
2-oxo
butyric acid
FL/FR
caramel furanone solution
FL/FR
caramel pentadione
FL/FR
cyclotene
FL/FR
cyclotene hydrate
FL/FR
alpha,alpha-
dimethyl anisyl acetone
FL/FR
ethyl 2-hydroxy-2-methyl butyrate
FL/FR
ethyl cyclopentenolone
FL/FR
ethyl furaneol
FL/FR
ethyl maltol
FL/FR
5-
ethyl-2,3,4,5-tetramethyl-2-cyclohexen-1-one
FL/FR
fenugreek absolute
FL/FR
immortelle absolute
FL/FR
levulinic acid
FL/FR
maltol
FL/FR
maltyl isobutyrate
FL/FR
maltyl propionate
FL/FR
maple furanone
FL/FR
menthone lactone
FL/FR
5-
methyl furfural
FL/FR
iso
propenyl pyrazine
FL/FR
rosefuran
FL/FR
shoyu furanone
FL/FR
strawberry furanone
FL/FR
strawberry furanone acetate
FL/FR
strawberry furanone solution
FL/FR
toffee furanone
FL/FR
chocolate
2-
methyl butyraldehyde
FL/FR
coconut
gamma-
heptalactone
FL/FR
creamy
gamma-
butyrolactone
FL/FR
ethereal
ethyl 4-pentenoate
FL/FR
ethyl pyruvate
FL/FR
fermented
butyl laevo-lactate
FL/FR
ethyl (E)-2-crotonate
FL/FR
ethyl crotonate
FL/FR
fruity
iso
butyl 2-butenoate
FL/FR
ethyl lactate
FL/FR
(E)-
ethyl tiglate
FL/FR
hexyl (E)-tiglate
FL/FR
methyl nonane dione
FL/FR
2-
pentyl furan
FL/FR
tetrahydrofurfuryl acetate
FL/FR
green
iso
amyl 3-(2-furan) propionate
FL/FR
herbal
butyl levulinate
FL/FR
nutty
2-
acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR
3,5-
cocoa pyrazine
FL/FR
1,2-
cyclohexane dione
FL/FR
2,3-
dimethyl pyrazine
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
nutty cyclohexenone
FL/FR
phenolic
4-
methyl-2,6-dimethoxyphenol
FL/FR
spicy
(E)-
propyl 2-furan acrylate
FL/FR
spicy acetoacetate
FL/FR
(E)-
tiglic acid
FL/FR
sweet
vanilla oleoresin bali
FL/FR
vanilla oleoresin bourbon
FL/FR
vanilla
ethyl vanillin
FL/FR
vanillin
FL/FR
vanillyl isobutyrate
FL/FR
vegetable
tetrahydrofurfuryl alcohol
FL/FR
For Flavor
No flavor group found for these
2-
acetyl-3,4,5,6-tetrahydropyridine
FL
(E)-
aconitic acid
FL
allyl 2-furoate
FL
iso
amyl pyruvate
FL/FR
benzyl disulfide
FL
1,2-
cyclohexane dione
FL/FR
2,5-
diethyl tetrahydrofuran
FL
alpha,alpha-
dimethyl anisyl acetone
FL/FR
ethyl 2-hydroxy-2-methyl butyrate
FL/FR
ethyl 4-pentenoate
FL/FR
5-
ethyl-2,3,4,5-tetramethyl-2-cyclohexen-1-one
FL/FR
furfuryl acetone
FL
menthone lactone
FL/FR
methyl nonane dione
FL/FR
rosa canina seed extract
FL
rosefuran
FL/FR
strawberry furanone ethyl ether
FL
iso
amyl 3-(2-furan) propionate
FL/FR
acidic
acidic
levulinic acid
FL/FR
dextro,laevo-
tartaric acid
FL
bready
mango furanone
FL
brown
2-oxo
butyric acid
FL/FR
furfural
FL/FR
5-
methyl furfural
FL/FR
tetrahydrofurfuryl acetate
FL/FR
(E)-
tiglic acid
FL/FR
burnt
furfuryl alcohol
FL
iso
propenyl pyrazine
FL/FR
rum ether
FL/FR
buttery
butyl laevo-lactate
FL/FR
diacetyl
FL
3,4-
hexane dione
FL/FR
caramellic
caramel furanone
FL
caramel furanone solution
FL/FR
caramel pentadione
FL/FR
cyclotene
FL/FR
cyclotene hydrate
FL/FR
ethyl furaneol
FL/FR
ethyl maltol
FL/FR
5-
ethyl-3,4,5,6-tetramethyl cyclohexen-2-one
FL
fenugreek absolute
FL/FR
maltol
FL/FR
maltyl propionate
FL/FR
maple furanone
FL/FR
3-
methyl butyl 2-furyl butyrate
FL
pyruvaldehyde
FL
shoyu furanone
FL/FR
strawberry furanone
FL/FR
strawberry furanone acetate
FL/FR
strawberry furanone solution
FL/FR
toffee furanone
FL/FR
coffee
2-
thiophene thiol
FL
creamy
acetoin
FL/FR
acetyl butyryl
FL/FR
2-
propanoyl thiophene
FL
fatty
diacetyl trimer
FL
2,4-
undecadienal
FL
(E,E)-2,4-
undecadienal
FL
fruity
ethyl lactate
FL/FR
(E)-
ethyl tiglate
FL/FR
furfuryl valerate
FL
2-
pentanoyl furan
FL
(E)-
propyl 2-furan acrylate
FL/FR
fusel
2-
methyl butyraldehyde
FL/FR
green
iso
butyl 2-butenoate
FL/FR
hexyl (E)-tiglate
FL/FR
immortelle absolute
FL/FR
2-
pentyl furan
FL/FR
herbal
butyl levulinate
FL/FR
5-
hydroxymethyl furfural
FL
jammy
ethyl cyclopentenolone
FL/FR
maltyl isobutyrate
FL/FR
lactonic
gamma-
heptalactone
FL/FR
malty
hordeum vulgare extract (cereal grass)
FL
milky
gamma-
butyrolactone
FL/FR
musty
ethyl (E)-2-crotonate
FL/FR
nutty
2-
acetyl furan
FL/FR
2-
acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR
aconitic acid
FL
3,5-
cocoa pyrazine
FL/FR
2,3-
dimethyl pyrazine
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
nutty cyclohexenone
FL/FR
peanut oxazole
FL
tetrahydrofurfuryl alcohol
FL/FR
phenolic
4-
methyl-2,6-dimethoxyphenol
FL/FR
roasted
acer spicatum bark extract
FL
rummy
ethyl crotonate
FL/FR
ethyl pyruvate
FL/FR
smoky
dextro-
xylose
FL
spicy
spicy acetoacetate
FL/FR
sweet
acetone alcohol
FL
caramel dione
FL
cyclohexyl acetic acid
FL/FR
honey distillates
FL
vanilla oleoresin bali
FL/FR
vanilla oleoresin bourbon
FL/FR
toasted
acetyl propionyl
FL/FR
vanilla
ethyl vanillin
FL/FR
vanillin
FL/FR
vanillyl isobutyrate
FL/FR
waxy
furfuryl octanoate
FL
octyl 2-furoate
FL
 
Potential Uses:
FRfruit
FRpineapple
FRstrawberry
 
Occurrence (nature, food, other):note
 pineapple fruit
Search Trop Picture
 strawberry wild strawberry fruit
Search Trop Picture
 
Synonyms:
4-acetyl-2,5-dimethylfuran-3-one
4-acetyl-2,5-dimethylfuran-3(2H)-one
3(2H)-furanone, 4-acetyl-2,5-dimethyl-
 

Articles:

 None found yet.
 
Notes:
Used as a food additive [EAFUS]
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2018 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy