EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

(3alpha,5alpha)-androst-16-en-3-ol
3a-hydroxyandrost-16-ene

Supplier Sponsors

Name:(3R,5S,8R,9S,10S,13R,14S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
CAS Number: 1153-51-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:214-573-1
FDA UNII: 48K9VAM062
Nikkaji Web:J109.628A
MDL:MFCD00051224
XlogP3-AA:5.30 (est)
Molecular Weight:274.44730000
Formula:C19 H30 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white powder (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 141.00 to 143.00 °C. @ 760.00 mm Hg
Boiling Point: 374.07 °C. @ 760.00 mm Hg (est)
Flash Point:> 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w): 6.030 (est)
Soluble in:
 alcohol
 water, 3.642 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Type: musk
animal musk natural
Odor Description:at 100.00 %. animal musk natural
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Androst-16-en-3-ol, (3a,5a)- 95%
Carbosynth
For experimental / research use only.
5a-Androst-16-en-3a-ol
Sigma-Aldrich: Sigma
For experimental / research use only.
5a-Androst-16-en-3a-ol
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for (3alpha,5alpha)-androst-16-en-3-ol usage levels up to:
  1.0000 % in the fragrance concentrate.
 
Recommendation for (3alpha,5alpha)-androst-16-en-3-ol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):1153-51-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :101989
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(3R,5S,8R,9S,10S,13R,14S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Chemidplus:0001153511
 
References:
 (3R,5S,8R,9S,10S,13R,14S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:1153-51-1
Pubchem (cid):101989
Pubchem (sid):135143040
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB05935
FooDB:FDB012828
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
(Z)-
oleyl alcohol
FR
amber
amber
amber furan
FR
ambergris naphthol
FR
ambrinol
FR
alpha-
ambrinol
FL/FR
animal
animal carbolactone
FR
iso
butyl quinoline
FR
iso
butyl quinoline
FR
civet absolute
FL/FR
costus valerolactone
FR
para-
cresyl caprylate
FL/FR
para-
cresyl isobutyrate
FL/FR
para-
cresyl phenyl acetate
FL/FR
indolall
FR
indole
FL/FR
indoletal
FR
para-
methyl tetrahydroquinoline
FL/FR
piperidine
FL/FR
skatole
FL/FR
1-oxa
spiro-4,7-dodecane
FR
balsamic
amyl phenyl acetate
FL/FR
guaiyl butyrate
FR
opoponax oil (balsamodendron kafal)
FL/FR
opoponax resinoid (balsamodendron kafal)
FR
chocolate
iso
amyl phenyl acetate
FL/FR
earthy
muscogene
FR
ethereal
propyl valerate
FL/FR
fatty
delta-
juniper lactone
FL/FR
floral
para-
cresyl acetate
FL/FR
(E)-2,5,9-
trimethyl-4,9-decadien-1-al
FR
fruity
linalyl hexanoate
FL/FR
green
valerian rhizome oil CO2 extract china
FL/FR
herbal
petitgrain heptane
FR
valerian rhizome oil
FL/FR
valerian rhizome oil china
FL/FR
leathery
castoreum absolute
FL/FR
marine
marine pyridine
FR
musk
(Z)-
civet decenone
FL/FR
ethylene dodecanoate
FR
exaltone (Firmenich)
FR
juniper lactone
FL/FR
delta-
muscenone
FR
dextro,laevo-
muscone
FL/FR
musk dimethyl indane
FL/FR
musk lactone
FR
musk nonane
FR
(Z)-
musk pentane
FR
omega-
pentadecalactone
FL/FR
spicy
(E,E)-
piperine
FL/FR
tobacco
para-
cresyl isovalerate
FL/FR
woody
spikenard oil
FL/FR
For Flavor
No flavor group found for these
amyl phenyl acetate
FL/FR
2,6-
dimethoxy-4-vinyl phenol
FL
linalyl hexanoate
FL/FR
4-
methyl cyclohexanone
FL
para-
methyl tetrahydroquinoline
FL/FR
piperidine
FL/FR
propyl valerate
FL/FR
skatole
FL/FR
spikenard oil
FL/FR
amber
amber
alpha-
ambrinol
FL/FR
ammoniacal
pyrrolidine
FL
animal
civet absolute
FL/FR
para-
cresyl caprylate
FL/FR
indole
FL/FR
aromatic
para-
cresyl acetate
FL/FR
para-
cresyl isobutyrate
FL/FR
balsamic
opoponax oil (balsamodendron kafal)
FL/FR
fatty
delta-
juniper lactone
FL/FR
floral
iso
amyl phenyl acetate
FL/FR
fruity
valerian rhizome oil
FL/FR
valerian rhizome oil china
FL/FR
valerian rhizome oil CO2 extract china
FL/FR
leathery
castoreum absolute
FL/FR
musk
(Z)-
civet decenone
FL/FR
juniper lactone
FL/FR
dextro,laevo-
muscone
FL/FR
musk dimethyl indane
FL/FR
phenolic
para-
cresyl isovalerate
FL/FR
para-
cresyl phenyl acetate
FL/FR
roasted
ethyl 3-(furfuryl thio) propionate
FL
sour
3-
methyl valeric acid
FL
spicy
(E,E)-
piperine
FL/FR
vanilla
omega-
pentadecalactone
FL/FR
 
Potential Uses:
FRamber
FRanimal
FRmusk
 
Occurrence (nature, food, other):note
 swine testes
Search Picture
 
Synonyms:
5-a-androst-16-en-3-a-ol
 androst-16-en-3-ol
(3a,5a)-androst-16-en-3-ol
 androst-16-en-3-ol, (3a,5a)-
5alpha-androst-16-en-3,alpha-ol
 androst-16-en-3a-ol
5a-androst-16-en-3a-ol
5alpha-androst-16-en-3alpha-ol
alpha-delta-16-androsten-3-ol
16,17-androstene-3-ol
3-a-androstenol
(3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1H-cyclopenta(a)phenanthren-3-ol
(3R,5S,8R,9S,10S,13R,14S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
3a-hydroxyandrost-16-ene
3alpha-hydroxyandrost-16-ene
 
 
Notes:
Aroma substance from the Perigord truffle tuber Androstenol is a steroidal compound belonging to the group of odorous 16-androstenes, first isolated from boar testes and also found in humans. Androstenol has pheromone-like properties in both animals and humans, but the molecular targets of its pheromonal activity are unknown. Androstenol as a pheromone is well suited because of high volatility and lipophilicity. (PMID: 1419890, 8142319, 16415088); ; 3a-Hydroxyandrost-16-ene is a steroidal compound belonging to the group of odorous 16-androstenes, first isolated from boar testes and also found in humans. 3a-Hydroxyandrost-16-ene has pheromone-like properties in both animals and humans, but the molecular targets of its pheromonal activity are unknown. 3a-Hydroxyandrost-16-ene is structurally similar to endogenous A-ring reduced neurosteroids that act as positive modulators of GABAA receptors. 3a-Hydroxyandrost-16-ene has neurosteroid-like activity as a GABAA receptor modulator. The various actions of 3a-Hydroxyandrost-16-ene in the whole-animal models are consistent with its activity as a GABAA receptor modulator. GABAA receptors could represent a target for 3a-Hydroxyandrost-16-ene as a pheromone, for which it is well suited because of high volatility and lipophilicity, or as a conventional hormonal neurosteroid. (PMID: 1419890, 8142319, 16415088); Androstenol is an sex pheromone in pigs, possessing a musk-like odor.; The Pheromone Androstenol (5{alpha}-Androst-16-en-3{alpha}-ol) Is a Neurosteroid Positive Modulator of GABAA Receptors -- Kaminski RM, Marini H, Ortinski PI, Vicini S, Rogawski MA 317 (2): 694 -- Journal of Pharmacology and Experimental Therapeutics; The pheromone androstenol (5?-androst-16-en-3?-ol) is a neurosteroid positive modulator of GABAA receptors
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