|
Category:flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless solid (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 133.00 to 135.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 314.00 to 315.00 °C. @ 760.00 mm Hg
|
| Vapor Pressure: | 0.002000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 259.00 °F. TCC ( 126.11 °C. )
|
| logP (o/w): | 2.606 (est) |
| Soluble in: |
| | alcohol | | | water, 947.8 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor Type: animal |
| phenolic animal leathery |
| Odor Description:at 10.00 % in dipropylene glycol. phenolic animal leather |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | flavoring agents |
| Recommendation for 2,6-dimethoxy-4-vinyl phenol usage levels up to: | | | not for fragrance use.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 1.20 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 420 (μg/person/day) |
| Threshold of Concern: | 1800 (μg/person/day) |
| Structure Class: | I |
| |
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| | average usage mg/kg | maximum usage mg/kg |
| Dairy products, excluding products of category 02.0 (01.0): | 0.50000 | 2.50000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 0.20000 | 1.00000 |
| Edible ices, including sherbet and sorbet (03.0): | 0.50000 | 2.50000 |
| Processed fruit (04.1): | 0.40000 | 2.00000 |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
| Confectionery (05.0): | 1.00000 | 5.00000 |
| Chewing gum (05.3): | - | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 0.20000 | 1.00000 |
| Bakery wares (07.0): | 2.00000 | 10.00000 |
| Meat and meat products, including poultry and game (08.0): | 0.20000 | 1.00000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 0.20000 | 1.00000 |
| Eggs and egg products (10.0): | - | - |
| Sweeteners, including honey (11.0): | - | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 0.30000 | 1.50000 |
| Foodstuffs intended for particular nutritional uses (13.0): | 0.50000 | 2.50000 |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 0.20000 | 1.00000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 1.00000 | 5.00000 |
| Ready-to-eat savouries (15.0): | 2.00000 | 10.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 0.40000 | 2.00000 |
Safety References:
References:
Other Information:
Potential Blenders and core components note
| For Odor |
| amber |
ambrette seed oil CO2 extract
FL/FR |
alpha- ambrinol
FL/FR |
| animal |
6-tert- butyl-meta-cresol
FL/FR |
castoreum liquid
FL/FR |
castoreum resinoid
FL/FR |
castoreum tincture
FL/FR |
civet absolute
FL/FR |
para- cresyl caprylate
FL/FR |
para- cresyl isobutyrate
FL/FR |
para- cresyl phenyl acetate
FL/FR |
indole
FL/FR |
6- methyl quinoline
FL/FR |
para- methyl tetrahydroquinoline
FL/FR |
piperidine
FL/FR |
skatole
FL/FR |
1-oxa spiro-4,7-dodecane
FR |
| anisic |
ortho- acetanisole
FL/FR |
| balsamic |
amyl phenyl acetate
FL/FR |
sumatra benzoin absolute
FL/FR |
opoponax oil (balsamodendron kafal)
FL/FR |
| camphoreous |
dextro- camphor
FL/FR |
| chocolate |
iso amyl phenyl acetate
FL/FR |
vanillyl ethyl ether
FL/FR |
| coumarinic |
phthalide
FL/FR |
| creamy |
para- vanillyl alcohol
FL/FR |
| ethereal |
propyl valerate
FL/FR |
| fatty |
delta- juniper lactone
FL/FR |
| floral |
alpha- amyl cinnamyl acetate
FL/FR |
benzyl alcohol
FL/FR |
cananga oil
FL/FR |
citronellol
FL/FR |
para- cresyl acetate
FL/FR |
dimethyl anthranilate
FL/FR |
dimethyl octanol
FL/FR |
ortho- methyl acetophenone
FL/FR |
(E)-2,5,9- trimethyl-4,9-decadien-1-al
FR |
| fruity |
ethyl 3-hydroxyhexanoate
FL/FR |
linalyl hexanoate
FL/FR |
osmanthus flower absolute
FL/FR |
para- tolualdehyde
FL/FR |
meta- tolualdehyde
FL/FR |
| green |
diphenyl oxide
FL/FR |
phenoxyacetaldehyde 50% in benzyl alcohol
FR |
seaweed absolute (fucus vesiculosus et serratus)
FL/FR |
valerian rhizome oil CO2 extract china
FL/FR |
| herbal |
saffron indenone
FL/FR |
valerian rhizome oil
FL/FR |
valerian rhizome oil china
FL/FR |
yerba mate absolute
FL/FR |
| honey |
phenyl pyruvic acid
FL/FR |
| leathery |
castoreum absolute
FL/FR |
| medicinal |
2,6- xylenol
FL/FR |
| minty |
piperitenone
FL/FR |
| mossy |
sea resorcylate
FR |
veramoss (IFF)
FR |
| musk |
(Z)- civet decenone
FL/FR |
juniper lactone
FL/FR |
dextro,laevo- muscone
FL/FR |
musk dimethyl indane
FL/FR |
omega- pentadecalactone
FL/FR |
| nutty |
2,3- dimethyl pyrazine
FL/FR |
nutty cyclohexenone
FL/FR |
| phenolic |
para- cresol
FL/FR |
ortho- cresyl isobutyrate
FL/FR |
2,3- dimethyl benzofuran
FL/FR |
para-alpha- dimethyl styrene
FL/FR |
ortho- guaiacol
FL/FR |
2'- hydroxyacetophenone
FL/FR |
methyl benzoate
FL/FR |
4- methyl-2,6-dimethoxyphenol
FL/FR |
2- propyl phenol
FL/FR |
4- propyl phenol
FL/FR |
4- vinyl phenol
FL/FR |
2,3- xylenol
FL/FR |
2,5- xylenol
FL/FR |
| smoky |
4- ethyl phenol
FL/FR |
pyroligneous acids
FL/FR |
| spicy |
clove bud absolute
FL/FR |
cuminyl alcohol
FL/FR |
4- ethyl guaiacol
FL/FR |
4- methyl guaiacol
FL/FR |
(E,E)- piperine
FL/FR |
zingerone
FL/FR |
| tobacco |
para- cresyl isovalerate
FL/FR |
3- ethyl pyridine
FL/FR |
methyl benzoxole
FL/FR |
| tropical |
genet absolute
FL/FR |
| vanilla |
ortho- dimethyl hydroquinone
FL/FR |
| woody |
cistus twig/leaf oil molecular distilled
FL/FR |
guaiacyl acetate
FL/FR |
methyl cedryl ketone
FL/FR |
spikenard oil
FL/FR |
beta- thujaplicin
FR |
| For Flavor |
| No flavor group found for these |
amyl phenyl acetate
FL/FR |
para- anisic acid
FL |
6-tert- butyl-meta-cresol
FL/FR |
ortho- cresyl isobutyrate
FL/FR |
2,4- dihydroxybenzoic acid
FL |
ortho- dimethyl hydroquinone
FL/FR |
2- furfurylidene butyraldehyde
FL |
linalyl hexanoate
FL/FR |
3- methyl crotonic acid
FL |
4- methyl cyclohexanone
FL |
4- methyl salicylaldehyde
FL |
para- methyl tetrahydroquinoline
FL/FR |
piperidine
FL/FR |
piperitenone
FL/FR |
4- propyl phenol
FL/FR |
2- propyl phenol
FL/FR |
propyl valerate
FL/FR |
para- salicylic acid
FL |
seaweed absolute (fucus vesiculosus et serratus)
FL/FR |
skatole
FL/FR |
spikenard oil
FL/FR |
| amber |
| amber |
ambrette seed oil CO2 extract
FL/FR |
alpha- ambrinol
FL/FR |
| animal |
castoreum liquid
FL/FR |
castoreum resinoid
FL/FR |
castoreum tincture
FL/FR |
civet absolute
FL/FR |
para- cresyl caprylate
FL/FR |
indole
FL/FR |
6- methyl quinoline
FL/FR |
| anisic |
ortho- methyl acetophenone
FL/FR |
| aromatic |
para- cresyl acetate
FL/FR |
para- cresyl isobutyrate
FL/FR |
| balsamic |
opoponax oil (balsamodendron kafal)
FL/FR |
| burnt |
2,6- xylenol
FL/FR |
| caramellic |
3- ethyl pyridine
FL/FR |
| chemical |
2,3- dimethyl benzofuran
FL/FR |
| coumarinic |
phthalide
FL/FR |
| creamy |
para- vanillyl alcohol
FL/FR |
| earthy |
alpha- amyl cinnamyl acetate
FL/FR |
| fatty |
dimethyl octanol
FL/FR |
delta- juniper lactone
FL/FR |
| fishy |
3- penten-2-one
FL |
| floral |
iso amyl phenyl acetate
FL/FR |
cananga oil
FL/FR |
citronellol
FL/FR |
| fruity |
benzyl alcohol
FL/FR |
dimethyl anthranilate
FL/FR |
ethyl 3-hydroxyhexanoate
FL/FR |
osmanthus flower absolute
FL/FR |
meta- tolualdehyde
FL/FR |
valerian rhizome oil
FL/FR |
valerian rhizome oil china
FL/FR |
valerian rhizome oil CO2 extract china
FL/FR |
| green |
diphenyl oxide
FL/FR |
| hay |
genet absolute
FL/FR |
| herbal |
saffron indenone
FL/FR |
yerba mate absolute
FL/FR |
| leathery |
castoreum absolute
FL/FR |
| meaty |
2,6- dimethyl thiophenol
FL |
ortho- thioguaiacol
FL |
| medicinal |
dextro- camphor
FL/FR |
| musk |
(Z)- civet decenone
FL/FR |
juniper lactone
FL/FR |
dextro,laevo- muscone
FL/FR |
musk dimethyl indane
FL/FR |
| musty |
2- ethoxythiazole
FL |
2,5- xylenol
FL/FR |
| naphthyl |
2'- hydroxyacetophenone
FL/FR |
| nutty |
2,3- dimethyl pyrazine
FL/FR |
methyl benzoxole
FL/FR |
nutty cyclohexenone
FL/FR |
| phenolic |
para- cresol
FL/FR |
para- cresyl isovalerate
FL/FR |
para- cresyl phenyl acetate
FL/FR |
methyl benzoate
FL/FR |
4- methyl-2,6-dimethoxyphenol
FL/FR |
phenyl pyruvic acid
FL/FR |
4- vinyl phenol
FL/FR |
2,3- xylenol
FL/FR |
| powdery |
ortho- acetanisole
FL/FR |
| roasted |
ethyl 3-(furfuryl thio) propionate
FL |
| rummy |
vanillyl ethyl ether
FL/FR |
| smoky |
4- ethyl phenol
FL/FR |
pyroligneous acids
FL/FR |
| sour |
3- methyl valeric acid
FL |
| spicy |
sumatra benzoin absolute
FL/FR |
clove bud absolute
FL/FR |
cuminyl alcohol
FL/FR |
para-alpha- dimethyl styrene
FL/FR |
4- methyl guaiacol
FL/FR |
(E,E)- piperine
FL/FR |
para- tolualdehyde
FL/FR |
zingerone
FL/FR |
| vanilla |
omega- pentadecalactone
FL/FR |
| woody |
cistus twig/leaf oil molecular distilled
FL/FR |
4- ethyl guaiacol
FL/FR |
ortho- guaiacol
FL/FR |
guaiacyl acetate
FL/FR |
methyl cedryl ketone
FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | canolol | | 2,6- | dimethoxy-4-vinylphenol | | 4- | ethenyl-2,6-dimethoxyphenol | | | phenol, 4-ethenyl-2,6-dimethoxy- |
Articles:
| PubMed:Cold-pressed and hot-pressed rapeseed oil: The effects of roasting and seed moisture on the antioxi- dant activity, canolol, and tocopherol level. |
| PubMed:Dehulling and microwave pretreatment effects on the physicochemical composition and antioxidant capacity of virgin rapeseed oil. |
| PubMed:Mechanical hulling and thermal pre-treatment effects on rapeseed oil antioxidant capacity and related lipophilic and hydrophilic bioactive compounds. |
| PubMed:Antioxidant (Tocopherol and Canolol) Content in Rapeseed Oil Obtained from Roasted Yellow-Seeded Brassica napus. |
| PubMed:The effect of microwave pretreatment of seeds on the stability and degradation kinetics of phenolic compounds in rapeseed oil during long-term storage. |
| PubMed:Potential of endophytic fungus Phomopsis liquidambari for transformation and degradation of recalcitrant pollutant sinapic acid. |
| PubMed:Flavoromics approach in monitoring changes in volatile compounds of virgin rapeseed oil caused by seed roasting. |
| PubMed:Changes in 4-vinylsyringol and other phenolics during rapeseed oil refining. |
| PubMed:Canolol inhibits gastric tumors initiation and progression through COX-2/PGE2 pathway in K19-C2mE transgenic mice. |
| PubMed:Value-added potential of expeller-pressed canola oil refining: characterization of sinapic acid derivatives and tocopherols from byproducts. |
| PubMed:Effect of seed roasting on canolol, tocopherol, and phospholipid contents, Maillard type reactions, and oxidative stability of mustard and rapeseed oils. |
| PubMed:Influence of microwaves treatment of rapeseed on phenolic compounds and canolol content. |
| PubMed:Endogenous Phenolics in Hulls and Cotyledons of Mustard and Canola: A Comparative Study on Its Sinapates and Antioxidant Capacity. |
| PubMed:Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involves suppression of oxidative stress and inflammatory cytokines. |
| PubMed:Anticancer effects of 4-vinyl-2,6-dimethoxyphenol (canolol) against SGC-7901 human gastric carcinoma cells. |
| PubMed:Isolation and identification of a potent radical scavenger (canolol) from roasted high erucic mustard seed oil from Nepal and its formation during roasting. |
| PubMed:Protective effect of canolol from oxidative stress-induced cell damage in ARPE-19 cells via an ERK mediated antioxidative pathway. |
| PubMed:Canolol: a promising chemical agent against oxidative stress. |
| PubMed:Therapeutic strategies by modulating oxygen stress in cancer and inflammation. |
| PubMed:4-Vinyl-2,6-dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori-infected carcinogen-treated Mongolian gerbils. |
| PubMed:Isolation, identification, and structure of a potent alkyl-peroxyl radical scavenger in crude canola oil, canolol. |
| PubMed:Antioxidative and antimutagenic activities of 4-vinyl-2,6-dimethoxyphenol (canolol) isolated from canola oil. |
|
3D/inchi