EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

laevo-menthol
L-menthol

Supplier Sponsors

Fragrance Demo Formulas
Flavor Demo Formulas
Name:(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol
CAS Number: 2216-51-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:218-690-9
FDA UNII:BZ1R15MTK7
Nikkaji Web:J9.251G
Beilstein Number:1902293
MDL:MFCD00062979
XlogP3-AA:3.00 (est)
Molecular Weight:156.26860000
Formula:C10 H20 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FEMA Number:2665 L-menthol
FDA:No longer provide for the use of these seven synthetic flavoring substances
 
Physical Properties:
Appearance:colorless crystals (est)
Assay: 99.00 to 100.00
Heavey Metals:<1.00ppm
Food Chemicals Codex Listed: Yes
Optical Rotation:-1.00 to +2.00
Melting Point: 41.00 to 44.00 °C. @ 760.00 mm Hg
Boiling Point: 212.00 to 216.00 °C. @ 760.00 mm Hg
Boiling Point: 111.00 to 112.00 °C. @ 20.00 mm Hg
Vapor Pressure:0.032000 mm/Hg @ 25.00 °C. (est)
Flash Point: 190.00 °F. TCC ( 87.78 °C. )
logP (o/w): 3.400
Soluble in:
 alcohol
 water, 434.5 mg/L @ 25 °C (est)
 water, 490 mg/L @ 25 °C (exp)
Insoluble in:
 water
Stability:
 bath foam
 cream
 hair spray
 lipstick
 lotion
 non-discoloring in most media
 
Organoleptic Properties:
Odor Type: mentholic
Odor Strength:high ,
recommend smelling in a 10.00 % solution or less
Substantivity:32 hour(s) at 20.00 % in dipropylene glycol
peppermint cooling mentholic minty
Odor Description:at 10.00 % in dipropylene glycol. peppermint cooling mentholic minty
Flavor Type: cooling
cooling camphoreous minty clean spicy
Taste Description: cooling camphoreous minty clean spicy
Odor and/or flavor descriptions from others (if found).
Symrise
Menthol-l dist.
Odor Description:typical-minty, fresh, cool
Taste Description:cool, fresh, peppermint-like
Useful in: mint.
Takasago
l-Menthol Biobased 100%
Odor Description:Mint-like odor with cooling feel
Used in perfumery to give power, lift, and freshness. Widely used in flavors, cosmetics, pharmaceutical dentifrices, and tobacco flavors.
Moellhausen
MENTHOL L- NATURAL 99%
Odor Description:cool, peppermint
Taste Description:cold, sweet, mint
Symrise
Menthol-l Freeflow®
Odor Description:typical minty, fresh, cool
Taste Description:cool, fresh, peppermint-like
Useful in: mint.
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
A.C.S. International
L-Menthol Cryst. Nat.
Operational Capabilities
Anhui Haibei
Menthol Crystal natural
Odor: Peppermint cooling minty
Apple Flavor & Fragrance
l-Menthol crystal, Natural, Chinese
Aromatic and Allied Chemicals
Melted Menthol
Aromatic and Allied Chemicals
Menthol Crystals
Aromatic and Allied Chemicals
Menthol Flakes
Aromatic and Allied Chemicals
Organic Menthol Crystals
Aromatic and Allied Chemicals
Organic Menthol Flake
Arora Aromatics
Menthol Crystals, I.P., BP, USP/EP ( Natural Menthol Crystals )
Atlantic Chemicals
Menthol Natural Or Synthetic
Augustus Oils
Menthol Crystals
Services
Berjé
Menthol Crystals Natural Chinese
Happening at Berje
Berjé
Menthol Crystals Natural Indian
BOC Sciences
For experimental / research use only.
L-Menthol
Bontoux
MENTHOL CRYSTALS
Camden-Grey Essential Oils
Menthol Crystals
Odor: characteristic
Use: Menthol is the chief constituent of peppermint oil; it is responsible for its odor and taste and the "cooling sensation" when applied to the skin and mucosal surfaces. Mentha piperita contains up to 50% menthol and Mentha arvensis contains 70-80% menthol. Menthol crystals should be kept in a cool place in a well-capped container. Menthol is the solid constituent of oil of peppermint, to which its characteristic odor is due, and was formerly known as peppermint camphor. Menthol is obtained by subjecting the distilled oil of peppermint to a temperature of -22 C, (-7.6 F.) by the aid of a freezing mixture. The menthol crystallizes out in satiny crystals and the mother liquor is removed while the low temperature is maintained.
Charabot
Menthol nat
100% Pure & Natural, Kosher
Odor: Aromatic, minty, fresh
Charkit Chemical
MENTHOL CRYSTALS FCC NATURAL
Charkit Chemical
MENTHOL CRYSTALS, USP
Citrus and Allied Essences
laevo-Menthol Crystals USP Select FCC (natural)
Market Report
De Monchy Aromatics
Menthol Crystals, Natural
ECSA Chemicals
Menthol Crystal, Natural
Company Profile
EMD Millipore
For experimental / research use only.
(-)-Menthol
Ernesto Ventós
MENTHOL CRYSTALS, NATURAL
Odor: COOL, MENTHOLIC
Ernesto Ventós
MENTHOL-L BASF FLAKES
Odor: MINTY, FRESH, COOL
Flavor: COOL, FRESH, PEPPERMINT
Ernesto Ventós
MENTHOL-L BASF SOLID MASS
Odor: MINTY, FRESH, COOL
Flavor: COOL, FRESH, PEPPERMINT
Ernesto Ventós
MENTHOL, SYNTHETIC
Odor: MINTY, FRESH, COOL
Excellentia International
Menthol, l- Natural
ExtraSynthese
For experimental / research use only.
(-)-Menthol (GC) ≥99% (sum of enantiomers)
Fleurchem
l-menthol natural
Frey + Lau
Menthol Ph. Eur.
Odor: Fresh, cool, mint
Frutarom
MENTHOL CRYSTALS INDIAN BP2013 25KG KEG
Global Essence
Menthol Crystals Chinese
Global Essence
Menthol Crystals Indian
Global Essence
Menthol Crystals Organic
Global Essence
Menthol FCC Synthetic
Global Essence
Menthol Flakes FCC Synthetic
Ind-Swift Laboratories
Menthol Crystals (ep/usp/bp/ip/jp)
Ind-Swift Laboratories
Menthol Powder
Indo World Trading
Menthol Crystals
Indukern F&F
MENTHOL 42/44 CRYSTALS NATURAL
Odor: MENTHOLATED, FRESH
Indukern F&F
MENTHOL CRYSTAL SYNTHETIC
Jiangyin Healthway
Menthol crystal
New functional food ingredients
Kraft Chemical
Natural Menthol
Kunshan Sainty
Menthol Crystals, Kosher
Liberty Natural Products
MENTHOL LARGE CRYSTALS INDIA
Liberty Natural Products
MENTHOL SMALL CRYSTALS INDIA
Lluch Essence
MENTHOL LARGE CRYST. NAT.
Lluch Essence
MENTHOL SMALL CRYST. NAT.
M&U International
Menthol Crystals, Kosher
M&U International
Nat. Methyl Crystals
Mane
Menthol Crystals
Isolate ex Mint
Odor: Aromatic Minty Fresh
Mentha & Allied Products
laevo-Menthol (Molten 99.5%)
Mentha & Allied Products
Menthol Crystal Ip/Bp/Usp/Ep/Jp
99.40% Min. (L-Menthol Content)
Mentha & Allied Products
Menthol Melted
97.00 % Min (L-Menthol Content)
Mentha & Allied Products
Menthol Powder 97.00%.min
Moellhausen
MENTHOL L- 99.7% SYNTH.
Odor: cool, peppermint
Flavor: cold, sweet, mint
Moellhausen
MENTHOL L- NATURAL 99%
Odor: cool, peppermint
Flavor: cold, sweet, mint
Moellhausen
MENTHOL L- POLAR BEAR
Moellhausen
MENTHOL L-PHARMA
Nectar Lifesciences
Menthol Crystals
Nectar Lifesciences
Menthol Flakes
Nippon Terpene Chemicals
l-Menthol 98% up, Japan Pharmacopeia grade
Pearlchem Corporation
Menthol Crystal Natural Chinese
Penta International
L-MENTHOL (PELLETS) SYNTH. FCC, Kosher
Penta International
L-MENTHOL CRYSTALS USP NATURAL, Kosher
Penta International
L-MENTHOL CRYSTALS USP SYNTHETIC, Kosher
Penta International
L-MENTHOL CRYSTALS USP/BP/EP/JP NATURAL, Kosher
PerfumersWorld
Menthol Crystals 50% in DPG
PerfumersWorld
Menthol Crystals
Odor: cool fresh mint
Phoenix Aromas & Essential Oils
Menthol Crystals (Chinese, Indian)
Reincke & Fichtner
L-Menthol natural
Reincke & Fichtner
L-Menthol
Robertet
Menthol nat
100% Pure & Natural, Kosher
Odor: Aromatic, minty, fresh
Santa Cruz Biotechnology
For experimental / research use only.
(-)-Menthol >98%
Sigma-Aldrich
L-Menthol, ≥99%, FCC, FG
Odor: minty; camphoraceous; woody; tobacco
Certified Food Grade Products
Sigma-Aldrich
L-Menthol, natural, ≥99%, FCC, FG
Odor: minty; camphoraceous; woody; tobacco
Silver Fern Chemical
Natural Mentol Crystal Essential Oil
Silverline Chemicals
laevo-menthol(USP/BP/NF)
Silverline Chemicals
Menthol flakes
Silverline Chemicals
Menthol Powder
Silverline Chemicals
Natural Menthol Medium Crystals
Silverline Chemicals
Natural Menthol Small Crystals
Sinofi Food Ingredients
Menthol Crystals
Flavor: characteristic
Flavoring Agent, Vape, Cigarette, Fragrance, Beverages, Ice Cream, Confectionery, Baked Food, Cookies, Chewing Gum, Hard Candy, Toothpaste, Mouthwashing, Alcoholic Beverages, Cosmetic, Pharmaceutical.
Sunaux International
Menthol Crystals
Symrise
Menthol-l dist.
Odor: typical-minty, fresh, cool
Flavor: cool, fresh, peppermint-like
Useful in: mint.
Symrise
Menthol-l Freeflow®
Odor: typical minty, fresh, cool
Flavor: cool, fresh, peppermint-like
Useful in: mint.
Symrise
Menthol-l pellets PH
Symrise
Menthol-l pellets
Odor: typical-minty, fresh, cool
Flavor: cool, fresh, peppermint-like
Useful in: mint.
Takasago
l-Menthol
Biobased 100%
Odor: Mint-like odor with cooling feel
Use: Used in perfumery to give power, lift, and freshness. Widely used in flavors, cosmetics, pharmaceutical dentifrices, and tobacco flavors.
The Fragrance Museum
Taytonn
Menthol Natural
Odor: Cool , Menthol/ Mentholic
TCI AMERICA
For experimental / research use only.
(-)-Menthol >99.0%(GC)
Tengzhou Xiang Yuan Aroma Chemicals
L-Menthol
The Good Scents Company
L-menthol 96%
The John D. Walsh Company
Menthol, Natural Crystals
The Lebermuth Company
Menthol Crystals Organic FFL
Odor: Menthol mint
The Lebermuth Company
Menthol Crystals Organic
Odor: Menthol, mint
The Lermond Company
Menthol, Natural Crystals USP
The Perfumers Apprentice
Menthol Liquid (PG)
Ungerer & Company
menthol crystals
Vigon International
Menthol Pellets Synthetic
Wanxiang International
Menthol Crystals Natural
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 37/38 - Irritating to respiratory system and skin.
R 41 - Risk of serious damage to eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3300 mg/kg
FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 58, 1967.

intraperitoneal-rat LD50 700 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: GENERAL ANESTHETIC
Journal of Pharmacy and Pharmacology. Vol. 35, Pg. 110, 1983.

oral-mouse LD50 3400 mg/kg
Quarterly Journal of Pharmacy & Pharmacology. Vol. 5, Pg. 233, 1932.

intraperitoneal-mouse LD50 6600 mg/kg
Farmatsevtichnii Zhurnal Vol. 17(3), Pg. 53, 1962.

intraperitoneal-cat LD50 800 mg/kg
FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 58, 1967.

oral-cat LD50 800 mg/kg
FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 58, 1967.

intravenous-cat LDLo 34 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 63, Pg. 43, 1939.

intraperitoneal-guinea pig LDLo 4000 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 63, Pg. 43, 1939.

intraperitoneal-rabbit LDLo 2000 mg/kg
FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 58, 1967.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 14, Pg. 471, 1976.

subcutaneous-rat LD50 1000 mg/kg
FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 58, 1967.

subcutaneous-mouse LD50 5000 mg/kg
FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 58, 1967.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
maximum skin levels for fine fragrances:
  0.5800 % and are based on the assumption that the fragrance mixture is used at 20% in a consumer product (IFRA Use Level Survey). (IFRA, 2006)
Recommendation for laevo-menthol usage levels up to:
  8.0000 % in the fragrance concentrate.
use level in formulae for use in cosmetics:
  0.4000 %
Dermal Systemic Exposure in Cosmetic Products:
 0.0102 mg/kg/day (IFRA, 2006)
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -130.00000
beverages(nonalcoholic): -35.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -1100.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -68.00000
fruit ices: -68.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -400.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
EPI System: View
Daily Med:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):2216-51-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :16666
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol
Chemidplus:0002216515
RTECS:OT0700000 for cas# 2216-51-5
 
References:
Leffingwell:Chirality or Article
 (1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:2216-51-5
Pubchem (cid):16666
Pubchem (sid):134983024
Flavornet:2216-51-5
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
UM BBD:Search
KEGG (GenomeNet):C00400
HMDB (The Human Metabolome Database):HMDB03352
FooDB:FDB014499
YMDB (Yeast Metabolome Database):YMDB01740
Export Tariff Code:2906.11.0000
Household Products:Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
corn oil
CS
anise
anise
anise seed oil colombia
FL/FR
anisic
dihydroanethol
FL/FR
balsamic
amyris wood oil
FL/FR
benzyl salicylate
FL/FR
laevo-
bornyl acetate
FL/FR
iso
bornyl acetate
FL/FR
iso
bornyl formate
FL/FR
clover nitrile
FR
dextro-
fenchone
FL/FR
camphoreous
camphor tree bark oil
FL/FR
fenchol
FL/FR
laevo-
fenchone
FL/FR
citrus
limonene oxide
FL/FR
earthy
(-)-alpha-
fenchol
FL/FR
fatty
decanol
FL/FR
floral
iso
amyl salicylate
FL/FR
bois de rose oil brazil
FL/FR
cyclohexyl ethyl alcohol
FL/FR
geranium oil bourbon
FL/FR
heliotropyl diethyl acetal
FR
alpha-
hexyl cinnamaldehyde
FL/FR
ho leaf oil
FR
hyacinth ether
FR
laevo-
linalool
FL/FR
linalool
FL/FR
linalool oxide
FL/FR
methyl dihydrojasmonate
FL/FR
nerol
FL/FR
ocean propanal
FL/FR
fruity
menthyl isovalerate
FL/FR
green
chrysanthemum carbaldehyde
FR
herbal
dill seed oil CO2 extract indian
FL/FR
dill seed oil indian
FL/FR
eucalyptus globulus oil
FL/FR
abrialis
lavandin oil
FL/FR
lavender absolute bulgaria
FL/FR
linalyl acetate
FL/FR
myrtenol
FL/FR
nopyl acetate
FR
beta-
pinene
FL/FR
rosemary oil spain
FL/FR
sabinene hydrate
FL/FR
theaspirane
FL/FR
mentholic
cornmint oil
FL/FR
cornmint oil china
FL/FR
cornmint oil india
FL/FR
cornmint oil terpeneless
FL/FR
dextro-neo
menthol
FL/FR
dextro,laevo-
menthol
FL/FR
neoiso
menthol
FL/FR
dextro,laevo-neo
menthol
FL/FR
(±)-
menthol
FL/FR
(±)-iso
menthone
FL/FR
(+)-
menthone
FL/FR
menthyl acetate
FL/FR
laevo-
menthyl acetate
FL/FR
menthyl acetate racemic
FL/FR
peppermint cyclohexanone
FL/FR
dextro-
piperitone
FL/FR
iso
pulegyl acetate
FL/FR
minty
laevo-
carveol
FL/FR
(4R,6R)-
carveol
FL/FR
laevo-
carvone
FL/FR
cis-
carvone-5,6-oxide
FL/FR
carvyl acetate
FL/FR
cornmint oil japan
FL/FR
cornmint oil terpenes
FR
dihydrocarveol
FL/FR
(+)-
dihydrocarvone
FL/FR
mentha arvensis flower/leaf/stem extract
FL/FR
mentha arvensis flower/leaf/stem water
FL/FR
mentha arvensis herb extract
FR
mentha piperita extract
FL/FR
mentha piperita flower/leaf/stem extract
FL/FR
mentha piperita flower/leaf/stem water
FR
mentha piperita herb extract america
FR
mentha piperita leaf water
FR
mentha piperita tincture
FL/FR
mentha spicata herb extract
FL/FR
mentha spicata herb tincture
FL/FR
mentha spicata herb water
FL/FR
mentha spicata leaf extract
FL/FR
trans-para-
menthan-2-one
FL/FR
homo
menthol
FL/FR
(-)-
menthone
FL/FR
(±)-
menthone
FL/FR
laevo-
menthyl lactate
FL/FR
2-
methyl cyclohexanone
FL/FR
methyl salicylate
FL/FR
pennyroyal oil
FL/FR
peppermint absolute
FL/FR
peppermint distillates
FL/FR
peppermint fragrance
FR
peppermint leaf
CS
peppermint oil
FL/FR
peppermint oil america
FL/FR
peppermint oil brazil
FL/FR
peppermint oil china
FL/FR
peppermint oil CO2 extract
FL/FR
peppermint oil dementholized
FL/FR
peppermint oil england
FL/FR
peppermint oil france
FL/FR
peppermint oil hungary
FL/FR
peppermint oil idaho
FL/FR
peppermint oil india
FL/FR
peppermint oil mongolia
FL/FR
peppermint oil montana
FL/FR
peppermint oil morocco
FL/FR
peppermint oil russia
FL/FR
peppermint oil special fractions
FL/FR
peppermint oil tasmania
FL/FR
peppermint oil terpeneless
FL/FR
peppermint oil terpenes
FR
peppermint oil willamette
FL/FR
peppermint oil yakima
FL/FR
peppermint water
FL/FR
laevo-
piperitone
FL/FR
iso
pulegol
FL/FR
(-)-iso
pulegol
FL/FR
iso
pulegone
FL/FR
(R)-(+)-
pulegone
FR
spearmint absolute
FL/FR
spearmint essence
FL/FR
spearmint fragrance
FR
spearmint oil
FL/FR
spearmint oil america
FL/FR
spearmint oil china
FL/FR
spearmint oil scotch
FL/FR
spearmint oil terpeneless
FL/FR
spearmint oil terpenes
FR
tetrahydrocarvone
FL/FR
wintergreen oil
FL/FR
WS-23
FL/FR
musty
3-
acetyl-2,5-dimethyl furan
FL/FR
naphthyl
para-
methyl anisole
FL/FR
nutty
2-
acetyl-3-ethyl pyrazine
FL/FR
3,5-
cocoa pyrazine
FL/FR
filbert pyrazine
FL/FR
phenolic
methyl benzoate
FL/FR
popcorn
2-
acetyl pyridine
FL/FR
powdery
para-
anisyl alcohol
FL/FR
spicy
carvacrol
FL/FR
trans-
carveol
FL/FR
elettaria cardamomum seed oil
FL/FR
marjoram oil (thymus mastichina) spain
FL/FR
black
pepper oil CO2 extract
FL/FR
pepper tree berry oil
FL/FR
pimenta acris leaf oil
FL/FR
sulfurous
dimethyl sulfide
FL/FR
4-
methoxy-2-methyl butane thiol
FL/FR
terpenic
alpha-
terpineol
FL/FR
tonka
mint lactone
FL/FR
waxy
decyl acetate
FL/FR
woody
camphene
FL/FR
1,4-
dimethyl bicyclo(3.2.1)octan-3-one
FR
(Z)-
woody amylene
FR
For Flavor
No flavor group found for these
(4R,6R)-
carveol
FL/FR
trans-
carveol
FL/FR
laevo-
carveol
FL/FR
(+)-
dihydrocarvone
FL/FR
(±)-N,N-
dimethyl menthyl succinamide
FL
limonene oxide
FL/FR
mentha arvensis flower/leaf/stem extract
FL/FR
mentha arvensis flower/leaf/stem water
FL/FR
cis+trans-para-1(7)8-
menthadien-2-yl acetate
FL
dextro,laevo-neo
menthol
FL/FR
neoiso
menthol
FL/FR
3-laevo-
menthoxy-2-methyl propane-1,2-diol
FL
menthyl acetate racemic
FL/FR
2-
methyl cyclohexanone
FL/FR
iso
pulegone
FL/FR
menthyl methyl lactate
FL
anise
anise
anise seed oil colombia
FL/FR
balsamic
benzyl salicylate
FL/FR
laevo-
bornyl acetate
FL/FR
camphoreous
camphene
FL/FR
camphor tree bark oil
FL/FR
fenchol
FL/FR
(-)-alpha-
fenchol
FL/FR
laevo-
fenchone
FL/FR
citrus
laevo-
linalool
FL/FR
linalool
FL/FR
nerol
FL/FR
alpha-
terpineol
FL/FR
cooling
dextro-
fenchone
FL/FR
dextro,laevo-
menthol
FL/FR
iso
menthol
FL
menthyl acetate
FL/FR
laevo-
menthyl lactate
FL/FR
peppermint oil america
FL/FR
sabinene hydrate
FL/FR
theaspirane
FL/FR
WS-3
FL
corn
2-
acetyl pyridine
FL/FR
corn flavor
FL
white
corn flavor
FL
yellow
corn flavor
FL
sweet
corn flavor
FL
creamy
mint lactone
FL/FR
fatty
dimethyl sulfoxide
FL
floral
bois de rose oil brazil
FL/FR
geranium oil bourbon
FL/FR
linalyl acetate
FL/FR
methyl dihydrojasmonate
FL/FR
ocean propanal
FL/FR
fruity
para-
anisyl alcohol
FL/FR
menthyl isovalerate
FL/FR
green
iso
amyl salicylate
FL/FR
cyclohexyl ethyl alcohol
FL/FR
dihydrocarveol
FL/FR
linalool oxide
FL/FR
herbal
dihydroanethol
FL/FR
eucalyptus globulus oil
FL/FR
abrialis
lavandin oil
FL/FR
lavender absolute bulgaria
FL/FR
rosemary oil spain
FL/FR
malty
yeast thiazoline
FL
mentholic
cornmint oil
FL/FR
cornmint oil terpeneless
FL/FR
(±)-
menthol
FL/FR
dextro-neo
menthol
FL/FR
(+)-
menthone
FL/FR
peppermint cyclohexanone
FL/FR
minty
laevo-
carvone
FL/FR
cis-
carvone-5,6-oxide
FL/FR
carvyl acetate
FL/FR
cornmint oil china
FL/FR
cornmint oil india
FL/FR
cornmint oil japan
FL/FR
mentha piperita extract
FL/FR
mentha piperita flower/leaf/stem extract
FL/FR
mentha piperita tincture
FL/FR
mentha spicata herb extract
FL/FR
mentha spicata herb tincture
FL/FR
mentha spicata herb water
FL/FR
mentha spicata leaf extract
FL/FR
trans-para-
menthan-2-one
FL/FR
homo
menthol
FL/FR
(±)-
menthone
FL/FR
(-)-
menthone
FL/FR
(±)-iso
menthone
FL/FR
laevo-
menthyl acetate
FL/FR
methyl salicylate
FL/FR
myrtenol
FL/FR
pennyroyal oil
FL/FR
peppermint absolute
FL/FR
peppermint distillates
FL/FR
peppermint flavor
FL
peppermint oil
FL/FR
peppermint oil brazil
FL/FR
peppermint oil china
FL/FR
peppermint oil CO2 extract
FL/FR
peppermint oil dementholized
FL/FR
peppermint oil england
FL/FR
peppermint oil france
FL/FR
peppermint oil hungary
FL/FR
peppermint oil idaho
FL/FR
peppermint oil india
FL/FR
peppermint oil mongolia
FL/FR
peppermint oil montana
FL/FR
peppermint oil morocco
FL/FR
peppermint oil russia
FL/FR
peppermint oil special fractions
FL/FR
peppermint oil tasmania
FL/FR
peppermint oil terpeneless
FL/FR
peppermint oil willamette
FL/FR
peppermint oil yakima
FL/FR
peppermint water
FL/FR
dextro-
piperitone
FL/FR
laevo-
piperitone
FL/FR
(-)-iso
pulegol
FL/FR
iso
pulegol
FL/FR
spearmint absolute
FL/FR
spearmint distillates
FL
spearmint essence
FL/FR
spearmint flavor
FL
spearmint herb
FL
spearmint oil
FL/FR
spearmint oil america
FL/FR
spearmint oil china
FL/FR
spearmint oil scotch
FL/FR
spearmint oil terpeneless
FL/FR
tetrahydrocarvone
FL/FR
wintergreen oil
FL/FR
WS-23
FL/FR
naphthyl
para-
methyl anisole
FL/FR
nutty
3-
acetyl-2,5-dimethyl furan
FL/FR
2-
acetyl-3-ethyl pyrazine
FL/FR
3,5-
cocoa pyrazine
FL/FR
filbert pyrazine
FL/FR
phenolic
methyl benzoate
FL/FR
pine
beta-
pinene
FL/FR
sour
corn apple cider vinegar flavor
FL
spicy
carvacrol
FL/FR
dill seed oil CO2 extract indian
FL/FR
dill seed oil indian
FL/FR
elettaria cardamomum seed oil
FL/FR
marjoram oil (thymus mastichina) spain
FL/FR
black
pepper oil CO2 extract
FL/FR
pepper tree berry oil
FL/FR
pimenta acris leaf oil
FL/FR
sulfurous
dimethyl sulfide
FL/FR
ethyl methyl sulfide
FL
4-
methoxy-2-methyl butane thiol
FL/FR
tea
white
tea peach spearmint flavor
FL
terpenic
para-
menthatriene
FL
waxy
decanol
FL/FR
decyl acetate
FL/FR
alpha-
hexyl cinnamaldehyde
FL/FR
woody
amyris wood oil
FL/FR
iso
bornyl acetate
FL/FR
iso
bornyl formate
FL/FR
iso
pulegyl acetate
FL/FR
 
Potential Uses:
FLcooling
FRfern
FRgeranium
FRherbal
FRlavender
 lifter
FRlime
FRmint
FL/FRpennyroyal
FRpeppermint
FRrose
FRspice
FRspring rain
FRwintergreen
 
Occurrence (nature, food, other):note
 basil oil
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 basil plant
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 cabbage leaf
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 coconut fruit
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 coriander leaf
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 corn silk
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 cornmint leaf
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 cornmint oil
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 cornmint plant
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 elder black elder flower oil
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 guava leaf oil
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 horsemint shoot
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 lovage root
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 marjoram oil
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 melon bitter melon seed oil
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 mint plant
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 pennyroyal oil
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 peppermint leaf
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 peppermint oil
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 sage leaf
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 sage plant
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 spearmint leaf
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 spearmint oil
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 sunflower flower oil
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 tarragon oil
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 tarragon shoot
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 tea leaf
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 water mint leaf
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 water mint shoot
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Synonyms:
 cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-
 cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,3R,4S)-
L-hexahydrothymol
laevo-hexahydrothymol
 levomenthol
L-menthacamphor
laevo-menthacamphor
(1R,3R,4S)-4-menthan-3-ol
(-)-trans-p-menthan-cis-ol
(-)-trans-para-menthan-cis-ol
(1R,3R,4S)-4-menthane-3-ol
(-)-trans-p-menthane-cis-ol
(-)-trans-para-menthane-cis-ol
(-)-(1R,2S,5R)-menthol
(1R,2S,5R)-(-)-menthol
D-(-)-menthol
L-menthol
L-(-)-menthol
nat.L-menthol
(-)-menthol (GC) ≥99% (sum of enantiomers)
laevo-menthol (molten 99.5%)
laevo-menthol (natural)
L-menthol (pellets) synth. FCC
L-menthol 98% up, japan pharmacopeia grade
L-menthol cryst. nat.
 menthol crystal Ip/Bp/Usp/Ep/Jp
L-menthol crystal, natural, chinese
L-menthol crystals
organic menthol crystals
 menthol crystals (codex) (ex mint)
 menthol crystals chinese
 menthol crystals indian
L-menthol crystals USP natural
laevo-menthol crystals USP select FCC (natural)
L-menthol crystals USP synthetic
L-menthol crystals USP/BP/EP/JP natural
 menthol ex mint arvensis india
organic menthol flake
 menthol flakes FCC synthetic
 menthol L- 99.7% synth.
 menthol L- natural
natural menthol large crystals BP/USP
natural menthol medium crystals
L-menthol natural
spray dried menthol natural
 menthol powder 97.00%.min
 menthol powder dry BP/USP
natural menthol small crystals
natural menthol small crystals BP/USP
laevo-menthol USP/NF/FCC natural
 menthol-L dist.
 menthol-L freeflow
 menthol-L pellets (US production)
 menthol-L pellets PH
 menthol, (1R,3R,4S)-(-)-
 menthol, natural crystals USP
laevo-menthol(USP/BP/NF)
(-)-trans-p-methan-cis-3-ol
(-)-trans-p-methane-cis-3-ol
(1R-(1-alpha,2-beta,5-alpha))-5-methyl-2-(1-methyl ethyl) cyclohexanol
(1R-(1-alpha,2-beta,5-alpha))-5-methyl-2-(1-methylethyl)cyclohexanol
(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexanol
[1R-(1a,2b,5a)]-5-methyl-2-(1-methylethyl)cyclohexanol
(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol
(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexanol
(1R-(1alpha,2beta,5alpha))-5-methyl-2-isopropyl cyclohexanol
(1R,2S,5R)-5-methyl-2-propan-2-yl-cyclohexan-1-ol
(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol
L-peppermint camphor
1-isopropyl-4-methyl cyclohexan-2-ol
(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanol
(1R,2S,5R)-2-isopropyl-5-methylcyclohexanol
 

Articles:

Info:menthol
PubMed:Influence of repeated daily menthol exposure on human temperature regulation and perception.
PubMed:A Green and Sustainable Approach: Celebrating the 30th Anniversary of the Asymmetric l-Menthol Process.
PubMed:Formulation and evaluation of floating tablet of H2-receptor antagonist.
PubMed:Spraying with 0.20% L-menthol does not enhance 5 km running performance in the heat in untrained runners.
PubMed:A continuous tri-phase transition effect for HIFU-mediated intravenous drug delivery.
PubMed:Somatosensory and vasomotor manifestations of individual and combined stimulation of TRPM8 and TRPA1 using topical L-menthol and trans-cinnamaldehyde in healthy volunteers.
PubMed:Prevention of colonic spasm using L-menthol in colonoscopic examination.
PubMed:L-menthol improves adenoma detection rate during colonoscopy: a randomized trial.
PubMed:Mechanistic investigation and reversible effect of 2-isopropyl-5-methylcyclohexyl heptanoate on the in vitro percutaneous absorption of indomethacin.
PubMed:Synthesis and quantitative analysis of diastereomeric linked ester conjugates with remote stereocenters using high-field NMR and chiral HPLC.
PubMed:A combination of site-directed mutagenesis and chemical modification to improve diastereopreference of Pseudomonas alcaligenes lipase.
PubMed:A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia.
PubMed:Structure-activity relationships of monoterpenes and acetyl derivatives against Aedes aegypti (Diptera: Culicidae) larvae.
PubMed:A novel animal model of dysphagia following stroke.
PubMed:TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain.
PubMed:Enantioselective hydrolysis of dl-menthyl benzoate by cell-free extract of newly isolated Acinetobacter sp. ECU2040.
PubMed:Efficacy of spraying l-menthol solution during endoscopic treatment of early gastric cancer: a phase III, multicenter, randomized, double-blind, placebo-controlled study.
PubMed:The effect of inhaled menthol on upper airway resistance in humans: a randomized controlled crossover study.
PubMed:The effects of menthol on cold allodynia and wind-up-like pain in upper limb amputees with different levels of phantom limb pain.
PubMed:Thermal grill-evoked sensations of heat correlate with cold pain threshold and are enhanced by menthol and cinnamaldehyde.
PubMed:Menthosomes, novel ultradeformable vesicles for transdermal drug delivery: optimization and characterization.
PubMed:Topical hindpaw application of L-menthol decreases responsiveness to heat with biphasic effects on cold sensitivity of rat lumbar dorsal horn neurons.
PubMed:Lack of effect of menthol level and type on smokers' estimated mouth level exposures to tar and nicotine and perceived sensory characteristics of cigarette smoke.
PubMed:Multicenter phase II randomized study evaluating dose-response of antiperistaltic effect of L-menthol sprayed onto the gastric mucosa for upper gastrointestinal endoscopy.
PubMed:A dual catalyst system provides the shortest pathway for L-menthol synthesis.
PubMed:Reduction of misleading ("false") positive results in mammalian cell genotoxicity assays. I. Choice of cell type.
PubMed:Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation.
PubMed:Body regional influences of L-menthol application on the alleviation of heat strain while wearing firefighter's protective clothing.
PubMed:Properties of gastroretentive sustained release tablets prepared by combination of melt/sublimation actions of L-menthol and penetration of molten polymers into tablets.
PubMed:Direct GC analysis of the fatty acid compositions of conjugated linoleic acid and its L-menthyl esters.
PubMed:An open-label, single-arm study assessing the efficacy and safety of L: -menthol sprayed onto the gastric mucosa during upper gastrointestinal endoscopy.
PubMed:A phase I study evaluating tolerability, pharmacokinetics, and preliminary efficacy of L-menthol in upper gastrointestinal endoscopy.
PubMed:Proteomics indicates modulation of tubulin polymerization by L-menthol inhibiting human epithelial colorectal adenocarcinoma cell proliferation.
PubMed:Topical high-concentration (40%) menthol-somatosensory profile of a human surrogate pain model.
PubMed:The stereoisomers of menthol in selected tobacco products. A brief report.
PubMed:Antiperistaltic effect and safety of L-menthol sprayed on the gastric mucosa for upper GI endoscopy: a phase III, multicenter, randomized, double-blind, placebo-controlled study.
PubMed:Effect of (E)-2-isopropyl-5-methylcyclohexyl octadec-9-enoate on transdermal delivery of Aconitum alkaloids.
PubMed:Different effects of l- and d-menthol on the microstructure of ceramide 5/cholesterol/palmitic acid bilayers.
PubMed:A statistical approach to the development of a transdermal delivery system for ondansetron.
PubMed:Feasibility of transdermal delivery of prochlorperazine.
PubMed:An efficient bioprocess for enzymatic production of L-menthol with high ratio of substrate to catalyst using whole cells of recombinant E. coli.
PubMed:The influence of menthol on thermoregulation and perception during exercise in warm, humid conditions.
PubMed:Topical application of L-menthol induces heat analgesia, mechanical allodynia, and a biphasic effect on cold sensitivity in rats.
PubMed:Lidocaine/L-menthol binary system: cocrystallization versus solid-state immiscibility.
PubMed:Efficacy and safety profile of a topical methyl salicylate and menthol patch in adult patients with mild to moderate muscle strain: a randomized, double-blind, parallel-group, placebo-controlled, multicenter study.
PubMed:Infrared spectroscopic study of lipid interaction in stratum corneum treated with transdermal absorption enhancers.
PubMed:Dual response surface-optimized synthesis of L-menthyl conjugated linoleate in solvent-free system by Candida rugosa lipase.
PubMed:Erythema multiforme-like generalized contact dermatitis to l-menthol contained in anti-inflammatory medical compresses as an ingredient.
PubMed:The effects of swilling an L(-)-menthol solution during exercise in the heat.
PubMed:Skin disposition of d-camphor and l-menthol alone and together.
PubMed:Effect of l-menthol on the thermotropic behavior of ceramide 2/cholesterol mixtures as a model for the intercellular lipids in stratum corneum.
PubMed:Transdermal delivery of tolterodine by O-acylmenthol: In vitro/in vivo correlation.
PubMed:Effect of penetration enhancers on transdermal delivery of propofol.
PubMed:Menthol and geraniol biotransformation and glycosylation capacity of Levisticum officinale hairy roots.
PubMed:Design and in vivo evaluation of an indapamide transdermal patch.
PubMed:Formulation optimization of an indomethacin-containing photocrosslinked polyacrylic acid hydrogel as an anti-inflammatory patch.
PubMed:Identification of degradation products in loxoprofen sodium adhesive tapes by liquid chromatography-mass spectrometry and dynamic pressurized liquid extraction-solid-phase extraction coupled to liquid chromatography-nuclear magnetic resonance spectroscopy.
PubMed:[Advantages of the L-menthol test in assessing chronic nasal obstruction].
PubMed:Impact of menthol inhalation on nasal mucosal temperature and nasal patency.
PubMed:Fragrance material review on l-menthol.
PubMed:Fragrance material review on d,l-menthol.
PubMed:Essential oil of lavender inhibited the decreased attention during a long-term task in humans.
PubMed:Differential transfer of dietary flavour compounds into human breast milk.
PubMed:Transdermal delivery of valsartan: I. Effect of various terpenes.
PubMed:Enhancement in skin permeation of 5-aminolevulinic acid using l-menthol and its derivatives.
PubMed:Esters of pyromellitic acid. Part II. Esters of chiral alcohols: para pyromellitate diesters as a novel class of resolving agents and use of pyromellitates as duplicands for chiral purification.
PubMed:Expression of Fos protein in brainstem after application of l-menthol to the rat nasal mucosa.
PubMed:Insecticidal activity of menthol derivatives against mosquitoes.
PubMed:Transdermal delivery of penetrants with differing lipophilicities using O-acylmenthol derivatives as penetration enhancers.
PubMed:Effect of O-acylmenthol on transdermal delivery of drugs with different lipophilicity.
PubMed:Fragrance release from the surface of branched poly (amide)s.
PubMed:Effects of dimethylformamide and L-menthol permeation enhancers on transdermal delivery of quercetin.
PubMed:Effects of ethanol/l-menthol on the dynamics and partitioning of spin-labeled lipids in the stratum corneum.
PubMed:Characteristic component odors emerge from mixtures after selective adaptation.
PubMed:Thermal and nociceptive sensations from menthol and their suppression by dynamic contact.
PubMed:Efficient asymmetric synthesis of novel gastrin receptor antagonist AG-041R via highly stereoselective alkylation of oxindole enolates.
PubMed:Combined effects of ethanol and L-menthol on hairless rat stratum corneum investigated by synchrotron X-ray diffraction.
PubMed:Enhanced skin permeation of salicylate by ion-pair formation in non-aqueous vehicle and further enhancement by ethanol and l-menthol.
PubMed:Psychophysical study of the effects of topical application of menthol in healthy volunteers.
PubMed:Formulation and evaluation of ethylene-vinyl acetate copolymer matrix patches containing formoterol fumarate.
PubMed:Effects of solvents on skin permeation of formoterol fumarate.
PubMed:Cold sensitivity in axotomized fibers of experimental neuromas in mice.
PubMed:Effects of upper airway anaesthesia on respiratory-related evoked potentials in humans.
PubMed:Enzymatic synthesis of l-menthyl alpha-maltoside and l-menthyl alpha-maltooligosides from l-menthyl alpha-glucoside by cyclodextrin glucanotransferase.
PubMed:Alpha-anomer-selective glucosylation of menthol with high yield through a crystal accumulation reaction using lyophilized cells of Xanthomonas campestris WU-9701.
PubMed:TRPM8 protein localization in trigeminal ganglion and taste papillae.
PubMed:Psychophysical isolation of the modality responsible for detecting multimodal stimuli: a chemosensory example.
PubMed:[Synthetical evaluation of promoting effect of some kinds of transdermal enhancers with grey relational cluster method].
PubMed:The effect of solvent interactions on alpha-, beta-, and gamma-cyclodextrin/flavor molecular inclusion complexes.
PubMed:Effect of L-menthol and 1,8-cineole on phase behavior and molecular organization of SC lipids and skin permeation of zidovudine.
PubMed:Synthesis and characterization of fluorescent poly(aromatic amide) dendrimers.
PubMed:Evaluation of percutaneous absorption of midazolam by terpenes.
PubMed:Synthesis, absolute configuration and biological activities of both enantiomers of 2-(5,7-Dichloro-3-indolyl)propionic acid: a novel dichloroindole auxin and antiauxin.
PubMed:Flavor release and perception in hard candy: influence of flavor compound-flavor solvent interactions.
PubMed:Flavor release and perception in hard candy: influence of flavor compound-compound interactions.
PubMed:Origin of chiral induction in radical reactions with the diastereoisomers (5R)- and (5S)-5-l-menthyloxyfuran-2[5H]-one.
PubMed:Topical menthol--a human model for cold pain by activation and sensitization of C nociceptors.
PubMed:Effect of mixed micelle formulations including terpenes on the transdermal delivery of diclofenac.
PubMed:Comparison of skin permeation enhancement by 3-l-menthoxypropane-1,2-diol and l-menthol: the permeation of indomethacin and antipyrine through Yucatan micropig skin and changes in infrared spectra and X-ray diffraction patterns of stratum corneum.
PubMed:Lytic activity of l-menthol derivatives against the snow blight disease fungus, Micronectriella nivalis.
PubMed:Autonomic nervous system responses to odours: the role of pleasantness and arousal.
PubMed:Elevation of plasma levels of L-dopa in transdermal administration of L-dopa-butylester in rats.
PubMed:In vitro skin permeation of morphine hydrochloride during the finite application of penetration-enhancing system containing water, ethanol and l-menthol.
PubMed:Molecular-imprinted, polymer-coated quartz crystal microbalances for the detection of terpenes.
PubMed:Effect of pH on skin permeation enhancement of acidic drugs by l-menthol-ethanol system.
PubMed:Oral irritant properties of menthol: sensitizing and desensitizing effects of repeated application and cross-desensitization to nicotine.
PubMed:[Does the inhalation of a 1% L-menthol solution in the premedication of fiberoptic bronchoscopy affect coughing and the sensation of dyspnea?].
PubMed:Preparation of griseofulvin for topical application using N-methyl-2-pyrrolidone.
PubMed:Physicochemical studies of lidocaine-menthol binary systems for enhanced membrane transport.
PubMed:Effect of l-menthol-ethanol-water system on the systemic absorption of flurbiprofen after repeated topical applications in rabbits.
PubMed:Cyclodextrin encapsulation to prevent the loss of l-menthol and its retention during drying.
PubMed:Whisker growth of l-menthol in coexistence with various excipients.
PubMed:l-Menthol-induced [Ca2+]i increase and impulses in cultured sensory neurons.
PubMed:Effects of branched cyclodextrins on the solubility and stability of terpenes.
PubMed:Effect of synthesized cyclohexanol derivatives using L-menthol as a lead compound on the percutaneous absorption of ketoprofen.
PubMed:Transbuccal permeation of a nucleoside analog, dideoxycytidine: effects of menthol as a permeation enhancer.
PubMed:Analysis of skin disposition of flurbiprofen after topical application in hairless rats.
PubMed:Disposition kinetics and effects of menthol.
PubMed:Effect of chiral enhancers on the permeability of optically active and racemic metoprolol across hairless mouse skin.
PubMed:The posterior nasal nerve plays an important role on cardiopulmonary reflexes to nasal application of capsaicin, distilled water and l-menthol in anesthetized dogs.
PubMed:Effects of removal of stratum corneum, delipidization and addition of enhancers, ethanol and l-menthol, on skin permeation of benzoic acid and its 4-n-alkyl substituents in excised guinea pig dorsal skin.
PubMed:The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes in vitro: a novel perspective for its therapeutic use in inflammatory diseases.
PubMed:Transdermal absorption of L-dopa from hydrogel in rats.
PubMed:Development and in vitro evaluation of nimodipine transdermal formulations using factorial design.
PubMed:Determination of l-menthol in pharmaceutical products by high performance liquid chromatography with polarized photometric detection.
PubMed:Anomer-selective glucosylation of l-menthol by yeast alpha-glucosidase.
PubMed:Racemate and enantiomers of ketoprofen: phase diagram, thermodynamic studies, skin permeability, and use of chiral permeation enhancers.
PubMed:Effect of several hydrophilic polymers on the permeation of morphine and salicylic acid through excised hairless rat skin.
PubMed:Identification of the L-menthol binding site in guinea-pig lung membranes.
PubMed:Effect of menthol and related terpenes on the percutaneous absorption of propranolol across excised hairless mouse skin.
PubMed:Skin permeation of parabens in excised guinea pig dorsal skin, its modification by penetration enhancers and their relationship with n-octanol/water partition coefficients.
PubMed:13-week inhalation toxicity study of menthol cigarette smoke.
PubMed:Nasal inhalation of l-menthol reduces respiratory discomfort associated with loaded breathing.
PubMed:The effect of L-menthol stimulation of the major palatine nerve on subjective and objective nasal patency.
PubMed:Nasal receptors responding to cold and l-menthol airflow in the guinea pig.
PubMed:Sensitization and desensitization to capsaicin and menthol in the oral cavity: interactions and individual differences.
PubMed:l-Menthol, oleic acid and lauricidin in absorption enhancement of free and sodium salt of diclofenac using ethanol treated silicone membrane as model for skin.
PubMed:Preparation and stability testing of a hydrogel for topical analgesia.
PubMed:[Antinociceptive effects of counterirritants].
PubMed:Metabolic fate of [3H]-l-menthol in the rat.
PubMed:The antitussive effects of menthol, camphor and cineole in conscious guinea-pigs.
PubMed:Determination of menthol in honey by gas chromatography.
PubMed:Influence of composition of l-menthol-ethanol-water ternary solvent system on the transdermal delivery of morphine hydrochloride.
PubMed:Effect of pretreatment of skin with cyclic monoterpenes on permeation of diclofenac in hairless rat.
PubMed:Feasibility of use of several cardiovascular agents in transdermal therapeutic systems with l-menthol-ethanol system on hairless rat and human skin.
PubMed:Effect of l-menthol on the permeation of indomethacin, mannitol and cortisone through excised hairless mouse skin.
PubMed:Menthol in the upper airway depresses ventilation in newborn dogs.
PubMed:The sensory effects of l-menthol on human skin.
PubMed:Effects of l-menthol and dl-camphor on the penetration and hydrolysis of methyl salicylate in hairless mouse skin.
PubMed:Combined effect of cyclic monoterpenes and ethanol on percutaneous absorption of diclofenac sodium.
PubMed:Upper airway cooling and l-menthol reduce ventilation in the guinea pig.
PubMed:Effect of l-menthol on laryngeal receptors.
PubMed:The effect of L-menthol stimulation of the major palatine nerve on nasal patency.
PubMed:Effect of cyclic monoterpenes on percutaneous absorption in the case of a water-soluble drug (diclofenac sodium).
PubMed:Immobilization of lipase from Candida cylindraceae and its use in the synthesis of menthol esters by transesterification.
PubMed:Percutaneous absorption enhancing effect and skin irritation of monocyclic monoterpenes.
PubMed:Two-phase system membrane reactor with cofactor recycling.
PubMed:The effects of menthol on reaction time and nasal sensation of airflow in subjects suffering from the common cold.
PubMed:Olfactory and trigeminal thresholds and nasal resistance to airflow.
PubMed:Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals.
PubMed:Studies on the metabolism of l-menthol in rats.
PubMed:The effects of D and L isomers of menthol upon nasal sensation of airflow.
PubMed:The effects of menthol isomers on nasal sensation of airflow.
PubMed:Menthol inhibits the perception of warmth.
PubMed:Menthol modulates oral sensations of warmth and cold.
PubMed:Metabolism of Monoterpenes : Early Steps in the Metabolism of d-Neomenthyl-beta-d-Glucoside in Peppermint (Mentha piperita) Rhizomes.
PubMed:Receptor cell responses to odorants: similarities and differences among odorants.
PubMed:Demonstration that limonene is the first cyclic intermediate in the biosynthesis of oxygenated p-menthane monoterpenes in Mentha piperita and other Mentha species.
PubMed:Metabolism of Monoterpenes: Conversion of l-Menthone to l-Menthol and d-Neomenthol by Stereospecific Dehydrogenases from Peppermint (Mentha piperita) Leaves.
PubMed:Demonstration of the Intercellular Compartmentation of l-Menthone Metabolism in Peppermint (Mentha piperita) Leaves.
PubMed:Metabolism of Monoterpenes : EVIDENCE FOR COMPARTMENTATION OF l-MENTHONE METABOLISM IN PEPPERMINT (MENTHA PIPERITA) LEAVES.
PubMed:Electronic properties of the nitrosamine function.
PubMed:Separation of l-menthol from racemic menthol U.S.P.
 
Notes:
Present in large amts. in peppermint oil (Mentha piperita), also in other Mentha spp.. Used in confectionery and perfumery. Flavouring agent (-)-menthol is the major occuring menthol stereoisomer in nature. (Wikipedia)
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