(±)-N,N-dimethyl menthyl succinamide
(1R,2S,5R)-N,N-dimethyl menthyl succinamide

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Name: [(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl] 4-(dimethylamino)-4-oxo-butanoate CAS Number: 544714-08-1 3D/inchi FDA UNII: 8O850QYR5T XlogP3-AA: 3.00 (est) Molecular Weight: 282.42750000 Formula: C16 H30 N2 O2 NMR Predictor: Predict (works with chrome, Edge or firefox) EFSA/JECFA Comments: Register name to be changed to (1R,2S,5R) N,NDimethyl menthyl succinamide. Category:flavoring agents   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Perfumer and Flavorist: Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search JECFA Food Flavoring: 1602 (+/-)-N,N-dimethyl menthyl succinamide DG SANTE Food Flavourings: 16.092 (1R,2S,5R)-N,N-dimethyl menthyl succinamide FEMA Number: 4230 (+/-)-N,N-dimethyl menthyl succinamide FDA: No longer provide for the use of these seven synthetic flavoring substances FDA Mainterm (SATF): 544714-08-1 ; (+/-)-N,N-DIMETHYL MENTHYL SUCCINAMIDE   Physical Properties: Appearance: yellow to orange clear liquid (est) Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Specific Gravity: 0.96500 to 0.97500 @ 25.00 °C. Pounds per Gallon - (est).: 8.030 to 8.113 Refractive Index: 1.52200 to 1.53000 @ 20.00 °C. Boiling Point: 380.00 °C. @ 760.00 mm Hg Acid Value: 3.00 max. KOH/g Flash Point: > 212.00 °F. TCC ( > 100.00 °C. ) logP (o/w): 3.633 (est) Soluble in:   alcohol   water, slightly   water, 13.96 mg/L @ 25 °C (est) Insoluble in:   water   Organoleptic Properties: Odor Description:cool minty Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: Axsyn For experimental / research use only. N,N-DIMETHYLMENTHYLSUCCINAMIDE Parchem (±)-N,N-Dimethyl Menthyl Succinamide Chemical Sources Association Need This Item for Flavor/Food?: You can contact the Chemical Sources Association   Safety Information:   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: Not determined Dermal Toxicity: Not determined Inhalation Toxicity: Not determined   Safety in Use Information: Category: flavoring agents Recommendation for (±)-N,N-dimethyl menthyl succinamide usage levels up to:   not for fragrance use.   Maximised Survey-derived Daily Intakes (MSDI-EU): 61.00 (μg/capita/day) Maximised Survey-derived Daily Intakes (MSDI-USA): 88.00 (μg/capita/day) Modified Theoretical Added Maximum Daily Intake (mTAMDI): 15000 (μg/person/day) Threshold of Concern: 1800 (μg/person/day) Structure Class: I Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library publication number: 22 Click here to view publication 22   average usual ppm average maximum ppm baked goods: - - beverages(nonalcoholic): 100.00000 300.00000 beverages(alcoholic): 100.00000 300.00000 breakfast cereal: - - cheese: - - chewing gum: 4000.00000 8000.00000 condiments / relishes: - - confectionery froastings: 400.00000 1000.00000 egg products: - - fats / oils: - - fish products: - - frozen dairy: - - fruit ices: 20.00000 50.00000 gelatins / puddings: 20.00000 100.00000 granulated sugar: - - gravies: - - hard candy: 800.00000 2000.00000 imitation dairy: - - instant coffee / tea: - - jams / jellies: - - meat products: - - milk products: - - nut products: - - other grains: - - poultry: - - processed fruits: - - processed vegetables: - - reconstituted vegetables: - - seasonings / flavors: 100.00000 500.00000 snack foods: 30.00000 200.00000 soft candy: 800.00000 2000.00000 soups: - - sugar substitutes: - - sweet sauces: - -   Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.   average usage mg/kg maximum usage mg/kg Dairy products, excluding products of category 02.0 (01.0): 0.40000 4.00000 Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.40000 4.00000 Edible ices, including sherbet and sorbet (03.0): 0.40000 4.00000 Processed fruit (04.1): - - Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): - - Confectionery (05.0): 40.00000 400.00000 Chewing gum (05.3): - - Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): - - Bakery wares (07.0): 4.00000 40.00000 Meat and meat products, including poultry and game (08.0): 0.40000 4.00000 Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.40000 4.00000 Eggs and egg products (10.0): - - Sweeteners, including honey (11.0): - - Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.40000 4.00000 Foodstuffs intended for particular nutritional uses (13.0): - - Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 40.00000 400.00000 Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 40.00000 400.00000 Ready-to-eat savouries (15.0): 0.40000 4.00000 Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.40000 4.00000   Safety References: European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... European Food Safety Authority (EFSA) reference(s): Flavouring Group Evaluation 86, (FGE.86)[1] - Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) - Scientific Opinion of the Panel on Food Additives - Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) View page or View pdf Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting) View page or View pdf EPI System: View AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :71049629 National Institute of Allergy and Infectious Diseases:Data [(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl] 4-(dimethylamino)-4-oxo-butanoate Chemidplus:0544714081   References: Leffingwell: Chirality or Article   [(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl] 4-(dimethylamino)-4-oxo-butanoate NIST Chemistry WebBook: Search Inchi Pubchem (cid): 71049629 Pubchem (sid): 163642448   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements FDA Substances Added to Food (formerly EAFUS): View HMDB (The Human Metabolome Database): HMDB32236 FooDB: FDB009318 ChemSpider: View   Potential Blenders and core components note For Odor No odor group found for these camel grass oil FR cyclopentanone FL/FR laevo-mono menthyl glutarate FL/FR laevo- menthyl methyl ether FL/FR pinocarvone FL/FR aldehydic aldehydic iso butyraldehyde FL/FR anisic estragole FL/FR camphoreous dextro- camphor FL/FR camphor tree bark oil FL/FR herbal ethanone FR thujyl alcohol FL/FR citrus ocimene quintoxide FL/FR earthy 3- octanol FL/FR patchouli cyclohexanol FR floral citronellal diisotridecyl acetal FR cyclohexyl ethyl acetate FL/FR cyclohexyl propanol FR 2- decalinol FR dihydrocarvyl acetate FL/FR 2',4'- dimethyl acetophenone FL/FR earthy indane FR floral methanol FR geranium oil china FL/FR menthadienyl formate FR muguet butanol FR ylang ylang flower oil CO2 extract FL/FR ylang ylang flower oil I FL/FR ylang ylang flower oil II FL/FR ylang ylang flower oil III FL/FR fruity 2- cyclopentyl cyclopentanone FL/FR lilac lactone FL/FR green geranium absolute FL/FR thiogeraniol FL/FR herbal barosma betulina leaf oil FL/FR 1,4- cineole FL/FR dehydroxylinalool oxide FL/FR iso dihydrolavandulol FR (Z)-iso dihydrolavandulyl acetate FR herbal undecanol FR hyssop oil FL/FR para- menthane-3,8-diol FL/FR myrtenol FL/FR perillaldehyde FL/FR pine hexanol FR D-(+)-alpha- pinene FL/FR piperitone FL/FR rosemary absolute FL/FR rosemary oil morocco FL/FR sabinene hydrate FL/FR viridiflorol FL/FR licorice sweet basil oleoresin FL/FR mentholic cornmint oil FL/FR cornmint oil terpeneless FL/FR laevo- menthol FL/FR dextro,laevo- menthol FL/FR dextro-neo menthol FL/FR (±)- menthol FL/FR (±)-iso menthone FL/FR menthyl acetate FL/FR laevo- menthyl acetate FL/FR menthyl acetate racemic FL/FR peppermint cyclohexanone FL/FR dextro- piperitone FL/FR minty agathosma crenulata leaf oil FL/FR laevo- carveol FL/FR laevo- carvone FL/FR carvone FL/FR carvyl propionate FL/FR cyclohexanone FR dihydrocarveol FL/FR diosphenol FL/FR bitter fennel seed oil FR mentha longifolia oil FR dextro-2,8-para- menthadien-1-ol FL/FR trans-para-2,8-1- menthadienol FL/FR trans-para- menthan-2-one FL/FR homo menthol FL/FR (-)- menthone FL/FR menthoxypropane diol FL/FR homo menthyl acetate FL/FR 2- methyl cyclohexanone FL/FR pennyroyal oil FL/FR peppermint oil CO2 extract FL/FR peppermint oil idaho FL/FR peppermint oil terpeneless FL/FR beta- phellandrene FL/FR piperitenone FL/FR laevo- piperitone FL/FR iso propyl tiglate FL/FR (-)-iso pulegol FL/FR iso pulegone FL/FR (R)-(+)- pulegone FR iso pulegyl formate FL/FR spearmint absolute FL/FR spearmint oil america FL/FR spearmint oil terpeneless FL/FR tetrahydrocarvone FL/FR wintergreen oil FL/FR WS-23 FL/FR spicy N,N- diethyl octanamide FR laevo- verbenone FL/FR sulfurous buchu mercaptan FL/FR thujonic armoise oil FR tropical beta- cyclocitral FL/FR woody para-tert- butyl cyclohexanone FR For Flavor No flavor group found for these carvone FL/FR cyclopentanone FL/FR 2- cyclopentyl cyclopentanone FL/FR 2',4'- dimethyl acetophenone FL/FR lilac lactone FL/FR limonen-10-yl acetate FL dextro-2,8-para- menthadien-1-ol FL/FR cis+trans-para-1(7)8- menthadien-2-yl acetate FL trans-para-2,8-1- menthadienol FL/FR para- menthane-3,8-diol FL/FR 3-laevo- menthoxy-2-methyl propane-1,2-diol FL menthyl acetate racemic FL/FR laevo-mono menthyl glutarate FL/FR laevo- menthyl methyl ether FL/FR menthyl propylene glycol carbonate FL 2- methyl cyclohexanone FL/FR beta- phellandrene FL/FR (Z,Z)- photocitral A FL D-(+)-alpha- pinene FL/FR pinocarvone FL/FR piperitenone FL/FR piperitenone oxide FL iso pulegone FL/FR iso pulegyl formate FL/FR laevo- verbenone FL/FR viridiflorol FL/FR thujyl alcohol FL/FR aldehydic aldehydic iso butyraldehyde FL/FR camphoreous camphor tree bark oil FL/FR coffee 2-iso propyl pyrazine FL cooling 1,4- cineole FL/FR laevo- menthol FL/FR dextro,laevo- menthol FL/FR menthoxypropane diol FL/FR homo menthyl acetate FL/FR menthyl acetate FL/FR sabinene hydrate FL/FR WS-5 FL floral dihydrocarvyl acetate FL/FR geranium oil china FL/FR ylang ylang flower oil CO2 extract FL/FR ylang ylang flower oil I FL/FR ylang ylang flower oil II FL/FR ylang ylang flower oil III FL/FR green cyclohexyl ethyl acetate FL/FR dihydrocarveol FL/FR geranium absolute FL/FR ocimene quintoxide FL/FR iso propyl tiglate FL/FR thiogeraniol FL/FR herbal 2- acetoxy-1,8-cineole FL barosma betulina leaf oil FL/FR hyssop oil FL/FR rosemary absolute FL/FR rosemary oil morocco FL/FR licorice sweet basil oleoresin FL/FR estragole FL/FR meaty 2- methyl 3-(methyl thio) furan FL medicinal dextro- camphor FL/FR mentholic cornmint oil FL/FR cornmint oil terpeneless FL/FR (±)- menthol FL/FR dextro-neo menthol FL/FR peppermint cyclohexanone FL/FR minty agathosma crenulata leaf oil FL/FR laevo- carveol FL/FR laevo- carvone FL/FR carvyl propionate FL/FR diosphenol FL/FR trans-para- menthan-2-one FL/FR homo menthol FL/FR (-)- menthone FL/FR (±)-iso menthone FL/FR laevo- menthyl acetate FL/FR myrtenol FL/FR pennyroyal oil FL/FR peppermint oil CO2 extract FL/FR peppermint oil idaho FL/FR peppermint oil terpeneless FL/FR piperitone FL/FR laevo- piperitone FL/FR dextro- piperitone FL/FR (-)-iso pulegol FL/FR spearmint absolute FL/FR spearmint oil america FL/FR spearmint oil terpeneless FL/FR tetrahydrocarvone FL/FR wintergreen oil FL/FR WS-23 FL/FR musty 3- octanol FL/FR spicy perillaldehyde FL/FR sulfurous buchu mercaptan FL/FR tropical beta- cyclocitral FL/FR woody dehydroxylinalool oxide FL/FR   Potential Uses: FR fruit FL mint   Occurrence (nature, food, other):note   not found in nature   Synonyms:   butanoic acid, 4-(dimethylamino)-4-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester (+/-)-N,N- dimethyl menthyl succinamide (1R,2S,5R)-N,N- dimethyl menthyl succinamide N,N- dimethyl menthyl succinamide N,N- dimethyl N'-(3-menthyl) succinamide 4-( dimethylamino-4-oxo-butanioc acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester 4-( dimethylamino)-4-oxo-butanoic acid [1R-(1a,2b,5a)]-5-methyl-2-(1-methylethyl)cyclohexyl ester N,N- dimethylmenthylsuccinamide [(1R,2S,5R)-2-iso propyl-5-methyl-cyclohexyl] 4-(dimethylamino)-4-oxo-butanoate (1R,2S,5R)-2-iso propyl-5-methylcyclohexyl 4-(dimethylamino)-4-oxobutanoate   Articles: Info:aliphatic and aromatic amines and amides

Notes: Used as a food additive [EAFUS]