EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

homomenthol
3,3,5-trimethylcyclohexanol

Supplier Sponsors

Name:3,3,5-trimethylcyclohexan-1-ol
CAS Number: 116-02-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-122-7
FDA UNII:08CL3G94GH
Nikkaji Web:J46.555K
Beilstein Number:2203314
MDL:MFCD00019378
XlogP3-AA:2.60 (est)
Molecular Weight:142.24166000
Formula:C9 H18 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
JECFA name: 3,3,5-Trimethyl cyclohexanol. Racemate (EFFA, 2010a).
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1099 3,3,5-trimethyl cyclohexanol
FLAVIS Number:02.209 (Old)
DG SANTE Food Flavourings:02.209 3,3,5-trimethylcyclohexan-1-ol
FEMA Number:3962 3,3,5-trimethylcyclohexanol
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):116-02-9 ; 3,3,5-TRIMETHYLCYCLOHEXANOL
 
Physical Properties:
Appearance:white crystals (est)
Assay: 98.00 to 100.00 sum of isomers
Food Chemicals Codex Listed: No
Melting Point: 30.00 to 34.00 °C. @ 760.00 mm Hg
Boiling Point: 80.00 °C. @ 20.00 mm Hg
Boiling Point: 193.00 to 196.00 °C. @ 760.00 mm Hg
Acid Value: 1.00 max. KOH/g
Vapor Pressure:0.173000 mmHg @ 25.00 °C. (est)
Flash Point: 180.00 °F. TCC ( 82.22 °C. )
logP (o/w): 2.734 (est)
Soluble in:
 water, 840.8 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Type: minty
Odor Strength:medium
Substantivity:20 hour(s) at 100.00 %
minty cooling mentholic musty spicy
Odor Description:at 100.00 %. mint cool mentholic musty spicy
Luebke, William tgsc, (1986)
Odor sample from: Berje Inc.
Flavor Type: minty
mentholic cooling minty spicy
Taste Description: mentholic cooling minty spicy
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
EMD Millipore
For experimental / research use only.
3,3,5-Trimethylcyclohexanol
Inoue Perfumery
3,3,5-TRIMETHYLCYCLOHEXANOL
Lluch Essence
TRIMETHYLCYCLOHEXANOL MIX
Moellhausen
3,3,5-TRIMETHYLCYCLOHEXANOL
Penta International
3,3,5-TRIMETHYLCYCLOHEXANOL
Santa Cruz Biotechnology
For experimental / research use only.
3,3,5-Trimethylcyclohexanol
Sigma-Aldrich: Aldrich
For experimental / research use only.
3,3,5-Trimethylcyclohexanol
TCI AMERICA
For experimental / research use only.
3,3,5-Trimethylcyclohexanol (cis- and trans- mixture) >90.0%(GC)
Vigon International
Trimethyl-3,3,5 Cyclohexanol (Homomenthol)
Odor: Mint cool mentholic musty spicy
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 37/38 - Irritating to respiratory system and skin.
R 41 - Risk of serious damage to eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 [sex: M,F] 3250 mg/kg
(Smyth & Carpenter, 1948)

oral-rat LD50 3250 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 60, 1949.

Dermal Toxicity:
skin-rabbit LD50 2800 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 60, 1949.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for homomenthol usage levels up to:
  4.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.12 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.10 (μg/capita/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 19
 average usual ppmaverage maximum ppm
baked goods: 0.100000.20000
beverages(nonalcoholic): 0.400001.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: 0.500001.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 1.000002.00000
fruit ices: --
gelatins / puddings: 0.500001.00000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 2.000005.00000
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 51, (FGE.51)[1] - Consideration of alicyclic ketones and secondary alcohols and related esters evaluated by JECFA (59th meeting) and structurally related to alicyclic ketones, secondary alcohols and related esters evaluated by EFSA in FGE.09 (2004) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 9, Revision 1: (FGE.09 Rev1)[1] - Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical groups 8 and 30, and an ester of a phenol carboxylic acid from chemical group 25 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 9, Revision 2 (FGE.09Rev2): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 51, Revision 1 (FGE.51Rev1): Consideration of alicyclic ketones and secondary alcohols and related esters evaluated by the JECFA (59th meeting) structurally related to alicyclic ketones secondary alcohols and related esters in FGE.09Rev3 (2011)
View page or View pdf

Flavouring Group Evaluation 51, Revision 2 (FGE.51Rev2): Consideration of alicyclic ketones and secondary alcohols and related esters evaluated by JECFA (59th meeting) structurally related to alicyclic ketones secondary alcohols and related esters in FGE.09Rev6 (2015)
View page or View pdf

EPI System: View
NLM Hazardous Substances Data Bank:Search
EPA Substance Registry Services (TSCA):116-02-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8298
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
3,3,5-trimethylcyclohexan-1-ol
Chemidplus:0000116029
RTECS:GW0875000 for cas# 116-02-9
 
References:
 3,3,5-trimethylcyclohexan-1-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:116-02-9
Pubchem (cid):8298
Pubchem (sid):134975364
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB29557
FooDB:FDB000708
Export Tariff Code:2906.12.0000
Haz-Map:View
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
fenchone
FL/FR
laurel leaf concrete
FR
yarrow oil greece
FL/FR
yarrow oil hungary
FL/FR
laurel leaf absolute
FL/FR
laevo-mono
menthyl glutarate
FL/FR
2-
methyl-3-butanone
FL/FR
yarrow oil
FL/FR
anisic
anisic
bitter
fennel seed oil spain
FR
balsamic
dextro,laevo-
borneol
FL/FR
dextro,laevo-iso
borneol
FL/FR
dextro-
borneol
FL/FR
laevo-
borneol
FL/FR
iso
bornyl acetate
FL/FR
iso
bornyl formate
FL/FR
iso
bornyl methyl ether
FL/FR
iso
bornyl propionate
FL/FR
dextro-
fenchone
FL/FR
camphoreous
3-
benzylidene-2-butanone
FL/FR
bornyl isobutyrate
FL/FR
butyrophenone
FL/FR
alpha-
campholenic alcohol
FL/FR
dextro-
camphor
FL/FR
(±)-
camphor
FL/FR
camphor tree bark oil
FL/FR
beta-homo
cyclocitral
FL/FR
fenchol
FL/FR
laevo-
fenchone
FL/FR
herbal ethanone
FR
hinoki leaf oil
FR
thujyl alcohol
FL/FR
verbenone
FL/FR
citrus
ocimene quintoxide
FL/FR
earthy
2-
ethyl fenchol
FL/FR
ethereal
methyl ethyl ketone
FL/FR
floral
dihydrocarvyl acetate
FL/FR
dihydrolinalool
FL/FR
linalool oxide (furanoid)
FL/FR
fruity
cherry propanol
FL/FR
herbal
1-
allyl-2,2,7,7-tetramethyl cycloheptanol
FR
barosma betulina leaf oil
FL/FR
(-)-
bornyl isovalerate
FL/FR
chamomile oil morocco
FR
1,8-
cineole
FL/FR
1,4-
cineole
FL/FR
dehydroxylinalool oxide
FL/FR
dimethyl cyclormol (IFF)
FR
2,10-
epoxypinane
FR
eucalyptus globulus oil
FL/FR
geranic oxide
FL/FR
herbal dioxane
FR
herbal undecanol
FR
6-
hydroxydihydrotheaspirane (mixture of isomers)
FL/FR
hyssop oil
FL/FR
lavandin concrete
FL/FR
abrialis
lavandin oil
FL/FR
spike
lavender absolute
FL/FR
spike
lavender oil
FL/FR
spike
lavender oil spain
FL/FR
melaleuca leucadendron var. cajuputi leaf oil
FL/FR
methyl cyclogeranate (Firmenich)
FR
myrtenol
FL/FR
myrtle oil
FL/FR
niaouli oil
FR
origanum oil
FL/FR
origanum oil greece
FL/FR
pine hexanol
FR
alpha-
pinene
FL/FR
pinocarveol
FL/FR
piperitone
FL/FR
rosemary absolute
FL/FR
rosemary oil egypt
FL/FR
rosemary oil morocco
FL/FR
rosemary oil spain
FL/FR
sabinene hydrate
FL/FR
sage absolute spain
FL/FR
theaspirane
FL/FR
white
thyme oil
FL/FR
thyme oil (thymus zygis gracillis) spain
FL/FR
thymol
FL/FR
mentholic
cornmint oil china
FL/FR
cornmint oil terpeneless
FL/FR
dextro,laevo-
menthol
FL/FR
dextro-neo
menthol
FL/FR
(±)-
menthol
FL/FR
(±)-iso
menthone
FL/FR
laevo-
menthyl acetate
FL/FR
menthyl acetate racemic
FL/FR
peppermint cyclohexanone
FL/FR
dextro-
piperitone
FL/FR
minty
dextro-
carvone
FL/FR
cis-
carvone-5,6-oxide
FL/FR
cornmint oil japan
FL/FR
dextro-
dihydrocarvone
FL/FR
(-)-
menthone
FL/FR
(±)-
menthone
FL/FR
laevo-
menthyl lactate
FL/FR
pennyroyal oil fractions
FL/FR
peppermint absolute
FL/FR
peppermint oil america
FL/FR
peppermint oil idaho
FL/FR
iso
propyl tiglate
FL/FR
(-)-iso
pulegol
FL/FR
iso
pulegol
FL/FR
(R)-(+)-
pulegone
FR
naphthyl
ortho-
methyl anisole
FL/FR
1-
methyl naphthalene
FL/FR
spicy
carvacrol
FL/FR
elettaria cardamomum seed oil
FL/FR
galangal root oil
FL/FR
laurel berry absolute
FL/FR
laurus nobilis fruit oil
FL/FR
laurus nobilis leaf oil
FL/FR
laurus nobilis leaf oil turkey
FL/FR
marjoram oil (thymus mastichina) spain
FL/FR
myrtenal
FL/FR
origanum majorana oil
FL/FR
origanum majorana oil cuba
FL/FR
white
sassafras oil
FL/FR
sugandha kokila berry oil
FR
tea tree oil
FR
laevo-
verbenone
FL/FR
zvoulimba leaf oil
FR
thujonic
armoise oil
FR
cedarleaf oil terpeneless
FR
sage oil (salvia lavandulifolia vahl.) spain
FL/FR
woody
iso
bornyl isovalerate
FL/FR
bornyl valerate
FL/FR
2-tert-
butyl cyclohexanone
FR
camphene
FL/FR
(+)-
camphene
FL/FR
hinoki root oil
FR
orris hexanone
FR
patchouli ethanol
FR
patchouli hexanol
FR
sandal glycol acetal
FR
zedoary bark oil
FL/FR
For Flavor
No flavor group found for these
3-
benzylidene-2-butanone
FL/FR
dextro-
borneol
FL/FR
dextro,laevo-
borneol
FL/FR
bornyl isobutyrate
FL/FR
(-)-
bornyl isovalerate
FL/FR
iso
bornyl methyl ether
FL/FR
butyrophenone
FL/FR
(+)-
camphene
FL/FR
alpha-
campholenic alcohol
FL/FR
capsicum oleoresin CO2 extract
FL
epoxyoxophorone
FL
fenchone
FL/FR
laurel berry absolute
FL/FR
laurus nobilis fruit oil
FL/FR
laurus nobilis leaf oil
FL/FR
laurus nobilis leaf oil turkey
FL/FR
linalool oxide (furanoid)
FL/FR
melaleuca leucadendron var. cajuputi leaf oil
FL/FR
menthyl acetate racemic
FL/FR
laevo-mono
menthyl glutarate
FL/FR
menthyl propylene glycol carbonate
FL
3-
methyl cyclohexanone
FL
2-
methyl-3-butanone
FL/FR
(Z,Z)-
photocitral A
FL
white
sassafras oil
FL/FR
laevo-
verbenone
FL/FR
verbenone
FL/FR
yarrow oil
FL/FR
yarrow oil greece
FL/FR
yarrow oil hungary
FL/FR
laurel leaf absolute
FL/FR
thujyl alcohol
FL/FR
balsamic
balsamic
iso
bornyl propionate
FL/FR
camphoreous
dextro,laevo-iso
borneol
FL/FR
laevo-
borneol
FL/FR
camphene
FL/FR
(±)-
camphor
FL/FR
camphor tree bark oil
FL/FR
fenchol
FL/FR
laevo-
fenchone
FL/FR
geranic oxide
FL/FR
6-
hydroxydihydrotheaspirane (mixture of isomers)
FL/FR
ortho-
methyl anisole
FL/FR
pinocarveol
FL/FR
chemical
methyl ethyl ketone
FL/FR
cooling
1,4-
cineole
FL/FR
beta-homo
cyclocitral
FL/FR
dextro-
fenchone
FL/FR
spike
lavender oil
FL/FR
dextro,laevo-
menthol
FL/FR
iso
menthol
FL
laevo-
menthyl lactate
FL/FR
peppermint oil america
FL/FR
sabinene hydrate
FL/FR
theaspirane
FL/FR
WS-3
FL
WS-5
FL
earthy
2-
ethyl fenchol
FL/FR
floral
dihydrocarvyl acetate
FL/FR
dihydrolinalool
FL/FR
fruity
cherry propanol
FL/FR
green
dextro-
dihydrocarvone
FL/FR
ocimene quintoxide
FL/FR
iso
propyl tiglate
FL/FR
herbal
barosma betulina leaf oil
FL/FR
eucalyptus globulus oil
FL/FR
hyssop oil
FL/FR
lavandin concrete
FL/FR
abrialis
lavandin oil
FL/FR
spike
lavender absolute
FL/FR
spike
lavender oil spain
FL/FR
origanum majorana oil
FL/FR
origanum oil
FL/FR
origanum oil greece
FL/FR
rosemary absolute
FL/FR
rosemary oil egypt
FL/FR
rosemary oil morocco
FL/FR
rosemary oil spain
FL/FR
sage absolute spain
FL/FR
sage oil (salvia lavandulifolia vahl.) spain
FL/FR
white
thyme oil
FL/FR
thyme oil (thymus zygis gracillis) spain
FL/FR
medicinal
dextro-
camphor
FL/FR
mentholic
cornmint oil terpeneless
FL/FR
dextro-neo
menthol
FL/FR
(±)-
menthol
FL/FR
peppermint cyclohexanone
FL/FR
minty
dextro-
carvone
FL/FR
cis-
carvone-5,6-oxide
FL/FR
1,8-
cineole
FL/FR
cornmint oil china
FL/FR
cornmint oil japan
FL/FR
(-)-
menthone
FL/FR
(±)-iso
menthone
FL/FR
(±)-
menthone
FL/FR
laevo-
menthyl acetate
FL/FR
myrtenal
FL/FR
myrtenol
FL/FR
pennyroyal oil fractions
FL/FR
peppermint absolute
FL/FR
peppermint oil idaho
FL/FR
piperitone
FL/FR
dextro-
piperitone
FL/FR
(-)-iso
pulegol
FL/FR
iso
pulegol
FL/FR
naphthyl
1-
methyl naphthalene
FL/FR
phenolic
thymol
FL/FR
spicy
carvacrol
FL/FR
cubeb oleoresin
FL
elettaria cardamomum seed oil
FL/FR
galangal root oil
FL/FR
marjoram oil (thymus mastichina) spain
FL/FR
myrtle oil
FL/FR
origanum majorana oil cuba
FL/FR
woody
iso
bornyl acetate
FL/FR
iso
bornyl formate
FL/FR
iso
bornyl isovalerate
FL/FR
bornyl valerate
FL/FR
dehydroxylinalool oxide
FL/FR
alpha-
pinene
FL/FR
zedoary bark oil
FL/FR
 
Potential Uses:
FL/FRcamphor tree bark
FL/FRcistus
FLcooling
FReucalyptus oil replacer
FRhay new mown hay
FRherbal
FRmint
FL/FRpennyroyal
FRpeppermint
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 cyclohexanol, 3,3,5-trimethyl-
 cyclonol
 dihydroisophorol
homomenthol
1-methyl-3-dimethyl cyclohexanol-5
 TMCH
3,3,5-trimethyl cyclohexan-1-ol
3,3,5-trimethyl cyclohexanol
3,3,5-trimethyl-1-cyclohexanol
 trimethyl-3 3 5 cyclohexanol
3,3,5-trimethyl-cyclohexanol
3,3,5-trimethylcyclohexan-1-ol
3,3,5-trimethylcyclohexanol
3,5,5-trimethylcyclohexanol
 
 
Notes:
Menthol replacer. Flavouring ingredient
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