(R)-(+)-pulegone
pulegone
 
Notes:
Occurs in oils of Mentha spp., Hedeoma pulegioides and many other essential oils. Fragrance and flavour ingredient
  • Fleurchem
    • Fleurchem, Inc.
      Have A Flavorful Day
      A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.
      Operating out of the 200,000 sq. ft., former Hercules/PFW facility in Middletown, NY; Fleurchem produces a full range of natural isolates, synthetic chemicals & specialities, essential oils and flavors. Additionally, the company performs toll manufacturing, as well as custom chemical synthesis for a wide range of clients.
      Email: Information
      US Voice: 845-341-2100
      US Fax: 845-341-2121
      Product(s):
      pulegone natural
       
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
      Email: Info
      Voice: 34 93 379 38 49
      Fax: 34 93 370 65 04
      Linkedin
      Product(s):
      PULEGONE NATURAL 95%
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      Product(s):
      16-87600 d-PULEGONE, Kosher
      16-87605 d-PULEGONE, NATURAL, Kosher
       
  • Prodasynth
    • Prodasynth
      Made in Grasse
      Chemical specialist in manufacturing, distributing and sourcing of tailor-made ingredients for the Flavour & Fragrance industry.
      Today we are also proud to say, we have created an important range of Natural Molecules which can be found in our Raw Material Compendium. The versatility of our small but efficient structure is one of our main strengths when trying to fulfill our clients' requirements.
      Email: Info:
      Email: Karine Cohen
      Voice: (33) 4 93 09 00 11
      Fax: (33) 4 22 13 07 38
      New Catalog
      Products List: View
      Product(s):
      PULEGONE NATURAL > 90
       
  • Sigma-Aldrich
    • Sigma-Aldrich
      Complete Supply Chain
      The perfect blend of products and services that bring your creativity to life.
      Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards.
      Email: Information
      US Email: Sales
      US Voice: 800-244-1173
      US Fax: 800-368-4661
      Facebook
      Twitter
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      Linkedin
      Certified Food Grade Products
      Product(s):
      W296309 (R)-(+)-Pulegone ≥90%
      SDS
       
Synonyms   Articles   Notes   Search
(5R)-5-methyl-2-propan-2-ylidenecyclohexan-1-one (Click)
CAS Number: 89-82-7Picture of molecule
ECHA EINECS - REACH Pre-Reg: 201-943-2
FDA UNII: 4LF2673R3G
Nikkaji Web: J3.216F
Beilstein Number: 2040703
MDL: MFCD00063000
CoE Number: 2050
XlogP3-AA: 2.80 (est)
Molecular Weight: 152.23672000
Formula: C10 H16 O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 753  pulegone
FEMA Number: 2963  pulegone
FDA Mainterm: PULEGONE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: colorless clear oily liquid (est)
Assay: 85.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 220.00 to  222.00 °C. @ 760.00 mm Hg
Boiling Point: 132.00 to  133.00 °C. @ 50.00 mm Hg
Vapor Pressure: 0.093000 mm/Hg @ 25.00 °C. (est)
Flash Point: 180.00 °F. TCC ( 82.22 °C. )
logP (o/w): 3.080
Soluble in:
 alcohol
 water, 173.7 mg/L @ 25 °C (est)
Insoluble in:
 water
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: minty
Odor Strength: medium
 peppermint  camphoreous  fresh  herbal  buchu  
Odor Description:
at 100.00 %. 
peppermint camphor fresh herbal buchu
Luebke, William tgsc, (1985)
 minty  sulfurous  sweet  metallic  buchu  
Odor Description:
Minty, sulfuraceous, sweet with metallic buchu nuances
Mosciano, Gerard P&F 16, No. 1, 31, (1991)
 minty  sulfurous  fruity  currant black currant  raspberry  fresh  green  leafy  
Taste Description:
at 20.00 ppm.  
Minty sulfuraceous, fruity blackcurrant and raspberry, with fresh green leafy nuances
Mosciano, Gerard P&F 16, No. 1, 31, (1991)
Substantivity: 8 Hour(s)
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
Synonyms   Articles   Notes   Search   Top
Suppliers:
Aurochemicals
PULEGONE, Natural
EMD Millipore
For experimental / research use only.
(R)-(+)-Pulegone
Ernesto Ventós
PULEGONE NATURAL (EX PENNYROYAL)
Odor: MINTY, FRESH
ExtraSynthese
For experimental / research use only.
(R)-(+)-Pulegone (GC) ≥98% (sum of enantiomers)
Fleurchem
pulegone natural
Lluch Essence
PULEGONE NATURAL 95%
Odor: CAMPHORACEOUS, FRESH, MINTY
Mane
pulegone (ex Pennyroyal)
Nippon Terpene Chemicals
d-Pulegone 98% up
Parchem
(R)-(+)-pulegone
Penta International
d-PULEGONE, Kosher
Penta International
d-PULEGONE, NATURAL, Kosher
Prodasynth
PULEGONE NATURAL > 90
Odor: MINTY, FRESH
Reincke & Fichtner
D-Pulegone
Reincke & Fichtner
Pulegone natural
Santa Cruz Biotechnology
For experimental / research use only.
(+)-Pulegone
Sigma-Aldrich
(R)-(+)-Pulegone ≥90%
Certified Food Grade Products
TCI AMERICA
For experimental / research use only.
(+)-Pulegone >95.0%(GC)
Vigon International
Pulegone Dextro Natural ex Pennyroyal Oil
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
10 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
intravenous-dog LDLo  330 mg/kg
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION CARDIAC: CHANGE IN RATE
Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 236, Pg. 633, 1953.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for (R)-(+)-pulegone usage levels up to:
  5.0000 % in the fragrance concentrate.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: 24.0000025.00000
beverages(nonalcoholic): 5.000008.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 5.0000032.00000
fruit ices: 5.0000032.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -17.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of alicyclic substances used as flavor ingredients.View pdf
European Food Safety Authority (EFSA) reference(s):
Pulegone and Menthofuran in flavourings - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 57 (FGE.57)[1]: Consideration of two structurally related pulegone metabolites and one ester thereof evaluated by JECFA (55th meeting)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 213, Revision 2 (FGE.213Rev2): Consideration of genotoxic potential for a,▀-unsaturated alicyclic ketones and precursors from chemical subgroup 2.7 of FGE.19
View page or View pdf
EPI System: View
Chemical Carcinogenesis Research Information System: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 89-82-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 442495
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 (5R)-5-methyl-2-propan-2-ylidenecyclohexan-1-one
Chemidplus: 0000089827
RTECS: OT0261000 for cas# 89-82-7
Synonyms   Articles   Notes   Search   Top
References:
 (5R)-5-methyl-2-propan-2-ylidenecyclohexan-1-one
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 89-82-7
Pubchem (cid): 442495
Pubchem (sid): 134972995
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C09893
HMDB (The Human Metabolome Database): HMDB35604
FooDB: FDB014298
Export Tariff Code: 2914.29.5000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
For Odor
citrus
 bergamot acetoacetateFR
 thiogeraniolFL/FR
herbal
 buchu oximeFR
mentholic
 cornmint oil terpenelessFL/FR
dextro,laevo-mentholFL/FR
laevo-mentholFL/FR
 peppermint cyclohexanoneFL/FR
dextro-piperitoneFL/FR
isopulegyl acetateFL/FR
minty
 diosphenolFL/FR
(-)-menthoneFL/FR
 pennyroyal oilFL/FR
 peppermint oil idahoFL/FR
 peppermint oil terpenelessFL/FR
isopulegoneFL/FR
(R)-(+)-pulegoneFL/FR
sulfurous
 buchu mercaptanFL/FR
 mango thiolFL/FR
 passiflora acetateFL/FR
 
For Flavor
 
No flavor group found for these
 diosphenolFL/FR
dextro-piperitoneFL/FR
isopulegoneFL/FR
cooling
laevo-mentholFL/FR
dextro,laevo-mentholFL/FR
green
 potato butyraldehydeFL
mentholic
 cornmint oil terpenelessFL/FR
 peppermint cyclohexanoneFL/FR
minty
(-)-menthoneFL/FR
 pennyroyal oilFL/FR
 peppermint oil idahoFL/FR
 peppermint oil terpenelessFL/FR
(R)-(+)-pulegoneFL/FR
 thiogeraniolFL/FR
sulfurous
 buchu mercaptanFL/FR
 mango thiolFL/FR
tropical
 passiflora acetateFL/FR
woody
isopulegyl acetateFL/FR
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 currant blackFR
 grapeFR
 herbalFR
 mintFR
 peachFR
 pennyroyalFL/FR
 peppermintFR
 raspberryFR
 strawberryFR
 tropicalFL
 woodyFR
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 agathosma crenulata oil @ 53.75%
Data  GC  Search Trop  Picture
 bergamot plant wild
Search Trop  Picture
 blackberry fruit
Search  Picture
 blueberry plant
Search  Picture
 buchu leaf oil @ 0.94%
Data  GC  Search Trop  Picture
 calamintha nepeta (l.) savi subsp. glandulosa oil greece @ 41.00%
Data  GC  Search Trop  Picture
 cayenne fruit
Search Trop  Picture
 chamomile roman chamomile
Search Trop  Picture
 cornmint oil india @ 0.13%
Data  GC  Search Trop  Picture
 cornmint plant
Search Trop  Picture
 currant black currant bud
Search Trop  Picture
 currant black currant fruit
Search Trop  Picture
 horsemint shoot
Search Trop  Picture
 lemon balm
Search Trop  Picture
 lemongrass oil morocco @ 0.90%
Data  GC  Search Trop  Picture
 mint
Search Trop  Picture
 origanum
Search  Picture
 pennyroyal
Search Trop  Picture
 pennyroyal oil @ 86.70%
Data  GC  Search Trop  Picture
 pennyroyal oil cuba @ 25.14%
Data  GC  Search Trop  Picture
 pennyroyal oil uruguay @ 26.8-41.10%
Data  GC  Search Trop  Picture
 pepper bell pepper fruit
Search Trop  Picture
 peppermint leaf
Search Trop  Picture
 peppermint oil america @ 1.38%
Data  GC  Search Trop  Picture
 peppermint oil CO2 extract @ 0.30%
Data  GC  Search Trop  Picture
 peppermint oil mongolia @ 0.22%
Data  GC  Search Trop  Picture
 peppermint oil russia @ 0.99%
Data  GC  Search Trop  Picture
 rosemary
Search Trop  Picture
 rue oil cuba @ 0.10%
Data  GC  Search Trop  Picture
 sage oil cuba @ 0.86%
Data  GC  Search Trop  Picture
 satureja viminea l. oil costa rica @ 35.30%
Data  GC  Search Trop  Picture
 spearmint
Search  Picture
 spearmint leaf
Search Trop  Picture
 spearmint oil
Search Trop  Picture
 tea black tea
Search  Picture
 thyme oil wild or creeping pakistan @ 0.21%
Data  GC  Search Trop  Picture
 water mint leaf
Search Trop  Picture
 water mint shoot
Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
 cyclohexanone, 5-methyl-2- (1-methylethylidene)-, (R)-
 cyclohexanone, 5-methyl-2-(1-methylethylidene)-, (5R)-
 cyclohexanone, 5-methyl-2-(1-methylethylidene)-, (R)-
(1R)-(+)-p-menth-4,8-en-3-one
(1R)-(+)-para-menth-4,8-en-3-one
(1R)-(+)-p-menth-4(8)-en-3-one
(1R)-(+)-para-menth-4(8)-en-3-one
(R)-(+)-p-menth-4(8)-en-3-one
(R)-(+)-para-menth-4(8)-en-3-one
(R)-p-menth-4(8)-en-3-one
(R)-para-menth-4(8)-en-3-one
R-(+)-p-menth-4(8)-en-3-one
delta-4,8-p-menthen-3-one
delta-4,8-para-menthen-3-one
(R)-5-methyl-2-(1-methyl ethylidene) cyclohexanone
(R)-5-methyl-2-(1-methylethylidene)cyclohexanone
(5R)-5-methyl-2-(2-propanyliden)cyclohexanon
(5R)-5-methyl-2-(methylethylidene)cyclohexan-1-one
(5R)-5-methyl-2-(propan-2-ylidene)cyclohexan-1-one
(5R)-5-methyl-2-(propan-2-ylidene)cyclohexanone
(R)-5-methyl-2-(propan-2-ylidene)cyclohexanone
(5R)-5-methyl-2-propan-2-ylidenecyclohexan-1-one
(R)-1-methyl-4-isopropylidene-3-cyclohexanone
(R)-3-methyl-6-isopropylidene cyclohexanone
(R)-3-methyl-6-isopropylidenecyclohexanone
(R)-1-isopropylidene-4-methyl-2-cyclohexanone
(R)-2-isopropylidene-5-methyl-cyclohexanone
(5R)-2-isopropylidene-5-methylcyclohexanone
(R)-2-isopropylidene-5-methylcyclohexanone
 pulegone
(+)-pulegone
(+)-(R)-pulegone
(R)-pulegone
(R)-(+)-pulegone
delta-pulegone
 pulegone (ex Pennyroyal)
 pulegone dextro natural ex pennyroyal oil
D-pulegone, natural
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Divergent total synthesis of the Lycopodium alkaloids huperzine A, huperzine B, and huperzine U.
PubMed: Synthesis of (R)-(+)-4-methylcyclohex-2-ene-1-one.
PubMed: Synthesis of (R)-(+)-4-methylcyclohex-2-ene-1-one.
PubMed: An efficient total synthesis of (-)-huperzine A.
PubMed: R(+)-pulegone impairs Ca┬▓+ homeostasis and causes negative inotropism in mammalian myocardium.
PubMed: Pharmacological activity of (R)-(+)-pulegone, a chemical constituent of essential oils.
PubMed: Fungicidal properties of the essential oil of Hesperozygis marifolia on Aspergillus flavus link.
PubMed: IR-Raman-VCD study of R-(+)-pulegone: influence of the solvent.
PubMed: A trapping method for semi-quantitative assessment of reactive metabolite formation using [35S]cysteine and [14C]cyanide.
PubMed: Defense on the rocks: low monoterpenoid levels in plants on pillars without mammalian herbivores.
PubMed: Total synthesis and structural confirmation of ent-galbanic acid and marneral.
PubMed: Enantiospecific effect of pulegone and pulegone-derived lactones on Myzus persicae (Sulz.) settling and feeding.
PubMed: Acaricidal activities of paeonol and benzoic acid from Paeonia suffruticosa root bark and monoterpenoids against Tyrophagus putrescentiae (Acari: Acaridae).
PubMed: Dansyl glutathione as a trapping agent for the quantitative estimation and identification of reactive metabolites.
PubMed: Synthesis of a highly hindered hydrindanone via alpha-carbonyl radical cyclization: enantiospecific formal syntheses of (-)-pinguisenol and (-)-alpha-pinguisene.
PubMed: In vivo studies on the metabolism of the monoterpene pulegone in humans using the metabolism of ingestion-correlated amounts (MICA) approach: explanation for the toxicity differences between (S)-(-)- and (R)-(+)-pulegone.
PubMed: Mitigation of pennyroyal oil hepatotoxicity in the mouse.
PubMed: Metabolism of (R)-(+)-menthofuran in Fischer-344 rats: identification of sulfonic acid metabolites.
PubMed: Comparative disposition of (R)-(+)-pulegone in B6C3F1 mice and F344 rats.
PubMed: Total synthesis of (+)-phomactin a using a B-alkyl Suzuki macrocyclization.
PubMed: Revision of the absolute configuration of the tricyclic sesquiterpene (+)-kelsoene by chemical correlation and enantiospecific total synthesis of its enantiomer.
PubMed: Stereoselective hydroxylation of 4-methyl-2-cyclohexenone in rats: its relevance to R-(+)-pulegone-mediated hepatotoxicity.
PubMed: Metabolism of (R)-(+)-pulegone in F344 rats.
PubMed: Synthesis of (+)-galiellalactone. Absolute configuration of galiellalactone.
PubMed: Ambulation-promoting effect of peppermint oil and identification of its active constituents.
PubMed: Chiral auxiliaries for asymmetric radical cyclization reactions: application to the enantioselective synthesis of (+)-triptocallol.
PubMed: First enantioselective syntheses of (+)- and (-)-wilforonide by using chiral auxiliaries derived from the same chiral source.
PubMed: Effect of ring size in R-(+)-pulegone-mediated hepatotoxicity: studies on the metabolism of R-(+)-4-methyl-2-(1-methylethylidene)-cyclopentanone and DL-camphorone in rats.
PubMed: Synthetic studies of the HIV-1 protease inhibitive didemnaketals: stereocontrolled synthetic approach to the key mother spiroketals.
PubMed: Role of C-5 chiral center in R-(+)-pulegone-mediated hepatotoxicity: metabolic disposition and toxicity of 5, 5-dimethyl-2-(1-Methylethylidene)-cyclohexanone in rats.
PubMed: Biogenetic studies in Mentha x piperita. 2. Stereoselectivity in the bioconversion of pulegone into menthone and isomenthone.
PubMed: Transformation of a monoterpene ketone, (R)-(+)-pulegone, a potent hepatotoxin, in Mucor piriformis.
PubMed: Metabolism of (R)-(+)-pulegone and (R)-(+)-menthofuran by human liver cytochrome P-450s: evidence for formation of a furan epoxide.
PubMed: Metabolic disposition of a monoterpene ketone, piperitenone, in rats: evidence for the formation of a known toxin, p-cresol.
PubMed: Metabolic fate of S-(-)-pulegone in rat.
PubMed: Hepatoprotective effect of C-phycocyanin: protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicty in rats.
PubMed: Synthesis, antiviral activity, and bioavailability studies of gamma-lactam derived HIV protease inhibitors.
PubMed: Studies on the metabolism of a monoterpene ketone, R-(+)-pulegone--a hepatotoxin in rat: isolation and characterization of new metabolites.
PubMed: Investigations of mechanisms of reactive metabolite formation from (R)-(+)-pulegone.
PubMed: Evidence for the formation of a known toxin, p-cresol, from menthofuran.
PubMed: Biotransformations of R-(+)-pulegone and menthofuran in vitro: chemical basis for toxicity.
PubMed: Metabolic activation of (R)-(+)-pulegone to a reactive enonal that covalently binds to mouse liver proteins.
PubMed: Metabolism of a monoterpene ketone, R-(+)-pulegone--a hepatotoxin in rat.
PubMed: Pulegone mediated hepatotoxicity: evidence for covalent binding of R(+)-[14C]pulegone to microsomal proteins in vitro.
PubMed: Contribution of menthofuran to the hepatotoxicity of pulegone: assessment based on matched area under the curve and on matched time course.
PubMed: Effects of drug metabolism modifiers on pulegone-induced hepatotoxicity in mice.
PubMed: The metabolism of the abortifacient terpene, (R)-(+)-pulegone, to a proximate toxin, menthofuran.
PubMed: Synthesis of racemate and enantiomers of 15-methyltritriacontane, sex-stimulant pheromone of stable flyStomoxys calcitrans L.
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