EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

6-hydroxydihydrotheaspirane (mixture of isomers)
6-hydroxy-2,6,10,10-tetramethyl-1-oxaspiro[4.5]decane (mixture of isomers)

Supplier Sponsors

Name:2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-6-ol
CAS Number: 65620-50-0Picture of molecule3D/inchi
Nikkaji Web:J1.539.233I
MDL:MFCD00238525
CoE Number:11917
XlogP3-AA:2.50 (est)
Molecular Weight:212.33268000
Formula:C13 H24 O2
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
(EFFA, 2006k). 46-53 % trans isomer (CASrn 65620-50-0), 44-51 % cis isomer (CASrn 57967-68-7) , 0-2 % Isospiranol (CASrn 54344-69-3) Specifications (EFFA, 2006; EFFA. 2010). 46-53% trans isomer (CASrn 65620-50-0), 44-51% cis isomer (CASrn 57967-68-7) , 0-2% Isospiranol (CASrn 54344-69-3).
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1648 6-hydroxydihydrotheaspirane
FLAVIS Number:13.076 (Old)
DG SANTE Food Flavourings:13.076 6-hydroxydihydrotheaspirane
FEMA Number:3549 6-hydroxydihydrotheaspirane
FDA:No longer provide for the use of these seven synthetic flavoring substances
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 97.00 to 100.00 sum of isomers
Food Chemicals Codex Listed: No
Specific Gravity:0.99900 to 1.00500 @ 25.00 °C.
Pounds per Gallon - (est).: 8.313 to 8.363
Refractive Index:1.48100 to 1.48700 @ 20.00 °C.
Boiling Point: 272.00 to 274.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.003000 mm/Hg @ 25.00 °C. (est)
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 2.832 (est)
Soluble in:
 alcohol
 water, very slightly
 water, 161 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: herbal
Odor Strength:medium ,
recommend smelling in a 10.00 % solution or less
camphoreous pine woody earthy green woody
Odor Description:at 10.00 % in dipropylene glycol. camphor pine woody earthy green woody
camphoreous pine earthy green cooling woody
Odor Description:Camphoreous, piney, earthy, green, cooling and woody
Mosciano, Gerard P&F 20, No. 4, 23, (1995)
Flavor Type: camphoreous
camphoreous woody green cooling minty earthy tropical
Taste Description: at 20.00 ppm. Camphoreous, woody, green, cooling and minty with a fenchyl and tropical nuance
Mosciano, Gerard P&F 20, No. 4, 23, (1995)
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
6-Hydroxydihydrotheaspirane
Parchem
6-hydroxydihydrotheaspirane
Penta International
6-HYDROXYDIHYDROTHEASPIRANE, Kosher
Synerzine
6-Hydroxydihydrotheaspirane
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for 6-hydroxydihydrotheaspirane (mixture of isomers) usage levels up to:
  0.5000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.12 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.05 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 6700 (μg/person/day)
Threshold of Concern:540 (μg/person/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 11
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): -0.05000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.20000
fruit ices: --
gelatins / puddings: -0.20000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: -0.20000
soups: --
sugar substitutes: --
sweet sauces: --
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 1.0000010.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): --
Edible ices, including sherbet and sorbet (03.0): 1.000005.00000
Processed fruit (04.1): --
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 100.000001000.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 2.000004.00000
Bakery wares (07.0): 4.000006.00000
Meat and meat products, including poultry and game (08.0): 1.000002.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 1.000002.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 1.000002.00000
Foodstuffs intended for particular nutritional uses (13.0): --
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 10.0000050.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000050.00000
Ready-to-eat savouries (15.0): 1.000005.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on Flavouring Group Evaluation 90 (FGE.90): Consideration of Aliphatic, acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances evaluated by JECFA (68th meeting)FGE.18Rev1 (2009)
View page or View pdf

Statement on List of Representative Substances for Testing. The current Statement lays down a list of substances in sub-groups with representative substances for which additional data are required prior to their evaluation through the Procedure (Regulation (EC) No 1565/2000).
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 90, Revision 1 (FGE.90Rev1): consideration of six substances evaluated by JECFA (68th meeting) structurally related to aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters evaluated by EFSA in FGE.18Rev1 and FGE.75Rev1
View page or View pdf

EPI System: View
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :65428
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-6-ol
Chemidplus:0053398906
 
References:
 2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-6-ol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):65428
Pubchem (sid):135022194
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
FooDB:FDB017063
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
octanal propylene glycol acetal
FL/FR
alliaceous
alliaceous
ferula assa-foetida gum oil
FL/FR
balsamic
laevo-
borneol
FL/FR
dextro-
borneol
FL/FR
bornyl acetate
FL/FR
iso
bornyl acetate
FL/FR
bornyl formate
FL/FR
iso
bornyl propionate
FL/FR
dextro-
fenchone
FL/FR
fir needle oil siberia
FL/FR
valerian rhizome absolute
FL/FR
camphoreous
beta-homo
cyclocitral
FL/FR
fenchol
FL/FR
laevo-
fenchone
FL/FR
hinoki leaf oil
FR
caramellic
2-iso
butyl-3-methyl pyrazine
FL/FR
citrus
(E+Z)-4,8-
dimethyl-3,7-nonadien-2-yl acetate
FL/FR
alpha-
methylene citronellal
FR
neroli ketone
FR
ocimene quintoxide
FL/FR
coconut
delta-
heptalactone
FL/FR
earthy
(-)-alpha-
fenchol
FL/FR
1-
nonen-3-ol
FL/FR
1-
octen-3-ol
FL/FR
ethereal
cyclohexyl formate
FL/FR
fatty
allyl octanoate
FL/FR
floral
cyclohexyl ethyl alcohol
FL/FR
alpha-
damascone
FL/FR
dihydrocarvyl acetate
FL/FR
geranium dihydropyran
FR
linalool oxide
FL/FR
beta-
ocimene
FL/FR
octyl acetate
FL/FR
orange leaf absolute
FL/FR
2-
phenyl propyl acetate
FL/FR
rose butanoate
FL/FR
(R)-
styralyl alcohol
FL/FR
ylang ylang flower oil III
FL/FR
fruity
amyl formate
FL/FR
apple ketal
FL/FR
(E)-alpha-
damascone
FL/FR
(E)-beta-
damascone
FL/FR
decen-1-yl cyclopentanone
FL/FR
(Z)-3-
octen-1-ol
FL/FR
2-
pentyl furan
FL/FR
propyl hexanoate
FL/FR
tropical trithiane
FL/FR
green
bergoxane
FR
cumin acetaldehyde
FL/FR
iso
cyclocitral (IFF)
FL/FR
alpha,alpha-
dimethyl benzyl alcohol
FL/FR
alpha-
elemol
FL/FR
ferula galbaniflua gum extract
FL/FR
fresh nitrile
FR
galbanum oil
FL/FR
galbanum resinoid
FL/FR
galbanum resinoid replacer
FR
geranium absolute
FL/FR
1-
heptanol
FL/FR
(Z)-3-
hepten-1-ol
FL/FR
hexanal (aldehyde C-6)
FL/FR
(Z)-3-
hexen-1-yl acetoacetate
FL/FR
(E)-2-
hexen-1-yl salicylate
FR
(Z)-3-
hexen-1-yl tiglate
FL/FR
manzanate (Givaudan)
FL/FR
para-
methyl hydratropaldehyde
FL/FR
octanal dimethyl acetal
FL/FR
1-
phenyl-2-pentanol
FL/FR
rose furan epoxide
FL/FR
terpinyl propionate
FL/FR
3,5,5-
trimethyl hexanol
FL/FR
2,4,8-
trimethyl-5-oxatricyclo(6.2.1.0*2,6*)undecane
FR
valerian rhizome oil CO2 extract china
FL/FR
herbal
bornyl salicylate
FR
camphene carbinyl acetate
FR
(+)-alpha-
campholenic aldehyde
FL/FR
canarium luzonicum oil
FL/FR
1,4-
cineole
FL/FR
iso
dihydrolavandulal
FL/FR
dimethyl cyclormol (IFF)
FR
geranic oxide
FL/FR
hyssop oil
FL/FR
myrtenol
FL/FR
pine hexanol
FR
alpha-
pinene
FL/FR
pinocarveol
FL/FR
rosemary absolute
FL/FR
sabinene hydrate
FL/FR
sage oleoresin
FL/FR
theaspirane
FL/FR
tricyclo(5.2.1.02,6)dec-3-enyl acetate
FR
valerian rhizome oil
FL/FR
melon
(Z)-6-
nonenal
FL/FR
mentholic
cornmint oil china
FL/FR
dextro,laevo-
menthol
FL/FR
(±)-iso
menthone
FL/FR
peppermint cyclohexanone
FL/FR
minty
dextro-
dihydrocarvone
FL/FR
trans-para-
menthan-2-one
FL/FR
pennyroyal oil fractions
FL/FR
peppermint absolute
FL/FR
peppermint oil america
FL/FR
peppermint oil idaho
FL/FR
iso
propyl tiglate
FL/FR
iso
pulegol
FL/FR
spearmint oil america
FL/FR
mossy
oakmoss absolute
FL/FR
orris
iso
eugenyl formate
FL/FR
spicy
beta-
caryophyllene
FL/FR
caryophyllene
FL/FR
iso
cyclogeraniol (IFF)
FR
myrtenal
FL/FR
2-
octanol
FL/FR
sulfurous
mango thiol
FL/FR
tropical
2-
tropical oxathiane
FL/FR
waxy
nonyl acetate
FL/FR
octyl isobutyrate
FL/FR
woody
iso
bornyl isovalerate
FL/FR
camphene
FL/FR
(+)-
camphene
FL/FR
dihydro-beta-ionone
FL/FR
beta-
terpineol
FL/FR
For Flavor
No flavor group found for these
benzyl disulfide
FL
dextro-
borneol
FL/FR
bornyl formate
FL/FR
(+)-
camphene
FL/FR
alpha,alpha-
dimethyl benzyl alcohol
FL/FR
(E+Z)-4,8-
dimethyl-3,7-nonadien-2-yl acetate
FL/FR
alpha-
elemol
FL/FR
iso
eugenyl formate
FL/FR
(Z)-3-
hepten-1-ol
FL/FR
(Z)-3-
hexen-1-yl acetoacetate
FL/FR
octanal propylene glycol acetal
FL/FR
2-
phenyl propyl acetate
FL/FR
rose furan epoxide
FL/FR
(R)-
styralyl alcohol
FL/FR
beta-
terpineol
FL/FR
2-
tropical oxathiane
FL/FR
alliaceous
alliaceous
ferula assa-foetida gum oil
FL/FR
balsamic
iso
bornyl propionate
FL/FR
fir needle oil siberia
FL/FR
camphoreous
laevo-
borneol
FL/FR
bornyl acetate
FL/FR
camphene
FL/FR
fenchol
FL/FR
(-)-alpha-
fenchol
FL/FR
laevo-
fenchone
FL/FR
geranic oxide
FL/FR
pinocarveol
FL/FR
cooling
1,4-
cineole
FL/FR
beta-homo
cyclocitral
FL/FR
dextro-
fenchone
FL/FR
manzanate (Givaudan)
FL/FR
dextro,laevo-
menthol
FL/FR
peppermint oil america
FL/FR
sabinene hydrate
FL/FR
theaspirane
FL/FR
WS-3
FL
creamy
octyl isobutyrate
FL/FR
earthy
1-
nonen-3-ol
FL/FR
fatty
allyl octanoate
FL/FR
(Z)-3-
octen-1-ol
FL/FR
floral
dihydrocarvyl acetate
FL/FR
orange leaf absolute
FL/FR
ylang ylang flower oil III
FL/FR
fruity
amyl formate
FL/FR
apple ketal
FL/FR
alpha-
damascone
FL/FR
(E)-alpha-
damascone
FL/FR
(E)-beta-
damascone
FL/FR
decen-1-yl cyclopentanone
FL/FR
1-
phenyl-2-pentanol
FL/FR
propyl hexanoate
FL/FR
rose butanoate
FL/FR
tropical trithiane
FL/FR
valerian rhizome absolute
FL/FR
valerian rhizome oil
FL/FR
valerian rhizome oil CO2 extract china
FL/FR
green
2-iso
butyl-3-methyl pyrazine
FL/FR
(+)-alpha-
campholenic aldehyde
FL/FR
canarium luzonicum oil
FL/FR
cumin acetaldehyde
FL/FR
iso
cyclocitral (IFF)
FL/FR
cyclohexyl ethyl alcohol
FL/FR
cyclohexyl formate
FL/FR
dextro-
dihydrocarvone
FL/FR
ferula galbaniflua gum extract
FL/FR
galbanum oil
FL/FR
galbanum resinoid
FL/FR
geranium absolute
FL/FR
hexanal (aldehyde C-6)
FL/FR
(Z)-3-
hexen-1-yl tiglate
FL/FR
horseradish oil
FL
linalool oxide
FL/FR
para-
methyl hydratropaldehyde
FL/FR
(Z)-6-
nonenal
FL/FR
oakmoss absolute
FL/FR
beta-
ocimene
FL/FR
ocimene quintoxide
FL/FR
octanal dimethyl acetal
FL/FR
2-
pentyl furan
FL/FR
iso
phorone
FL
iso
propyl tiglate
FL/FR
propylene glycol acetone ketal
FL
terpinyl propionate
FL/FR
3,5,5-
trimethyl hexanol
FL/FR
herbal
iso
dihydrolavandulal
FL/FR
hyssop oil
FL/FR
rosemary absolute
FL/FR
sage oleoresin
FL/FR
lactonic
delta-
heptalactone
FL/FR
mentholic
peppermint cyclohexanone
FL/FR
minty
cornmint oil china
FL/FR
trans-para-
menthan-2-one
FL/FR
(±)-iso
menthone
FL/FR
myrtenal
FL/FR
myrtenol
FL/FR
pennyroyal oil fractions
FL/FR
peppermint absolute
FL/FR
peppermint oil idaho
FL/FR
iso
pulegol
FL/FR
spearmint oil america
FL/FR
mushroom
1-
octen-3-ol
FL/FR
nutty
peanut oxazole
FL
solvent
1-
heptanol
FL/FR
spicy
beta-
caryophyllene
FL/FR
caryophyllene
FL/FR
2-
octanol
FL/FR
sulfurous
mango thiol
FL/FR
methyl 2-(methyl thio) butyrate
FL
waxy
nonyl acetate
FL/FR
octyl acetate
FL/FR
woody
iso
bornyl acetate
FL/FR
iso
bornyl isovalerate
FL/FR
dihydro-beta-ionone
FL/FR
alpha-
pinene
FL/FR
 
Potential Uses:
FRberry
FRmint
FRpine
FRraspberry
FRspice
FLtropical
FRwoody
 
Occurrence (nature, food, other):note
 tea black tea
Search Trop Picture
 
Synonyms:
 herbal spirane
6-hydroxy-2,6,10,10-tetramethyl-1-oxaspiro-4,5-decane (mixture of isomers)
6-hydroxy-2,6,10,10-tetramethyl-1-oxaspiro[4.5]decane (mixture of isomers)
1-oxaspiro(4.5)decan-6-ol, 2,6,10,10-tetramethyl-
1-oxaspiro[4.5]decan-6-ol, 2,6,10,10-tetramethyl-
2,6,10,10-tetramethyl-1-oxaspiro(4.5)decan-6-ol
2,6,10,10-tetramethyl-1-oxaspiro[4.5]decan-6-ol
 
 
Notes:
None found
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