6-hydroxydihydrotheaspirane (mixture of isomers)
6-hydroxy-2,6,10,10-tetramethyl-1-oxaspiro[4.5]decane (mixture of isomers)

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  Product(s):
  65620-50-0 6-Hydroxydihydrotheaspirane

Name: 2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-6-ol CAS Number: 65620-50-0 3D/inchi FDA UNII: Search Nikkaji Web: J1.539.233I MDL: MFCD00238525 CoE Number: 11917 XlogP3-AA: 2.50 (est) Molecular Weight: 212.33268000 Formula: C13 H24 O2 NMR Predictor: Predict (works with chrome, Edge or firefox) EFSA/JECFA Comments: (EFFA, 2006k). 46-53 % trans isomer (CASrn 65620-50-0), 44-51 % cis isomer (CASrn 57967-68-7) , 0-2 % Isospiranol (CASrn 54344-69-3) Specifications (EFFA, 2006; EFFA. 2010). 46-53% trans isomer (CASrn 65620-50-0), 44-51% cis isomer (CASrn 57967-68-7) , 0-2% Isospiranol (CASrn 54344-69-3). Category:flavor and fragrance agents   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Perfumer and Flavorist: Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search JECFA Food Flavoring: 1648 6-hydroxydihydrotheaspirane (mixture of isomers) DG SANTE Food Flavourings: 13.076 6-hydroxydihydrotheaspirane (mixture of isomers) FEMA Number: 3549 6-hydroxydihydrotheaspirane (mixture of isomers) FDA: No longer provide for the use of these seven synthetic flavoring substances FDA Mainterm (SATF): 53398-90-6 ; 6-HYDROXYDIHYDROTHEASPIRANE   Physical Properties: Appearance: colorless clear liquid (est) Assay: 97.00 to 100.00 sum of isomers Food Chemicals Codex Listed: No Specific Gravity: 0.99900 to 1.00500 @ 25.00 °C. Pounds per Gallon - (est).: 8.313 to 8.363 Refractive Index: 1.48100 to 1.48700 @ 20.00 °C. Boiling Point: 272.00 to 274.00 °C. @ 760.00 mm Hg Vapor Pressure: 0.003000 mmHg @ 25.00 °C. (est) Flash Point: > 230.00 °F. TCC ( > 110.00 °C. ) logP (o/w): 2.832 (est) Soluble in:   alcohol   water, very slightly   water, 161 mg/L @ 25 °C (est) Insoluble in:   water   Organoleptic Properties: Odor Type: herbal camphoreous pine woody earthy green woody Odor Description:at 10.00 % in dipropylene glycol. camphor pine woody earthy green woody camphoreous pine earthy green cooling woody Odor Description:Camphoreous, piney, earthy, green, cooling and woody Mosciano, Gerard P&F 20, No. 4, 23, (1995) Flavor Type: camphoreous camphoreous woody green cooling minty earthy tropical Taste Description: at 20.00 ppm. Camphoreous, woody, green, cooling and minty with a fenchyl and tropical nuance Mosciano, Gerard P&F 20, No. 4, 23, (1995) Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: BOC Sciences For experimental / research use only. 6-Hydroxydihydrotheaspirane Parchem 6-hydroxydihydrotheaspirane   Safety Information:   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: Not determined Dermal Toxicity: Not determined Inhalation Toxicity: Not determined   Safety in Use Information: Category: flavor and fragrance agents RIFM Fragrance Material Safety Assessment: Search IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice Recommendation for 6-hydroxydihydrotheaspirane (mixture of isomers) usage levels up to:   0.5000 % in the fragrance concentrate.   Maximised Survey-derived Daily Intakes (MSDI-EU): 0.12 (μg/capita/day) Maximised Survey-derived Daily Intakes (MSDI-USA): 0.05 (μg/capita/day) Modified Theoretical Added Maximum Daily Intake (mTAMDI): 6700 (μg/person/day) Threshold of Concern: 540 (μg/person/day) Structure Class: II Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library publication number: 11 Click here to view publication 11   average usual ppm average maximum ppm baked goods: - - beverages(nonalcoholic): - 0.05000 beverages(alcoholic): - - breakfast cereal: - - cheese: - - chewing gum: - - condiments / relishes: - - confectionery froastings: - - egg products: - - fats / oils: - - fish products: - - frozen dairy: - 0.20000 fruit ices: - - gelatins / puddings: - 0.20000 granulated sugar: - - gravies: - - hard candy: - - imitation dairy: - - instant coffee / tea: - - jams / jellies: - - meat products: - - milk products: - - nut products: - - other grains: - - poultry: - - processed fruits: - - processed vegetables: - - reconstituted vegetables: - - seasonings / flavors: - - snack foods: - - soft candy: - 0.20000 soups: - - sugar substitutes: - - sweet sauces: - -   Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.   average usage mg/kg maximum usage mg/kg Dairy products, excluding products of category 02.0 (01.0): 1.00000 10.00000 Fats and oils, and fat emulsions (type water-in-oil) (02.0): - - Edible ices, including sherbet and sorbet (03.0): 1.00000 5.00000 Processed fruit (04.1): - - Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): - - Confectionery (05.0): 100.00000 1000.00000 Chewing gum (05.3): - - Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 2.00000 4.00000 Bakery wares (07.0): 4.00000 6.00000 Meat and meat products, including poultry and game (08.0): 1.00000 2.00000 Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 1.00000 2.00000 Eggs and egg products (10.0): - - Sweeteners, including honey (11.0): - - Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 1.00000 2.00000 Foodstuffs intended for particular nutritional uses (13.0): - - Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 10.00000 50.00000 Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.00000 50.00000 Ready-to-eat savouries (15.0): 1.00000 5.00000 Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): - -   Safety References: European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... European Food Safety Authority (EFSA) reference(s): Scientific Opinion on Flavouring Group Evaluation 90 (FGE.90): Consideration of Aliphatic, acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances evaluated by JECFA (68th meeting)FGE.18Rev1 (2009) View page or View pdf Statement on List of Representative Substances for Testing. The current Statement lays down a list of substances in sub-groups with representative substances for which additional data are required prior to their evaluation through the Procedure (Regulation (EC) No 1565/2000). View page or View pdf Scientific Opinion on Flavouring Group Evaluation 90, Revision 1 (FGE.90Rev1): consideration of six substances evaluated by JECFA (68th meeting) structurally related to aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters evaluated by EFSA in FGE.18Rev1 and FGE.75Rev1 View page or View pdf EPI System: View AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :65428 National Institute of Allergy and Infectious Diseases:Data WGK Germany:3 2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-6-ol Chemidplus:0053398906   References:   2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-6-ol NIST Chemistry WebBook: Search Inchi Pubchem (cid): 65428 Pubchem (sid): 135022194   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements FDA Substances Added to Food (formerly EAFUS): View HMDB (The Human Metabolome Database): Search FooDB: FDB017063 VCF-Online: VCF Volatile Compounds in Food ChemSpider: View Wikipedia: View   Potential Blenders and core components note For Odor No odor group found for these octanal propylene glycol acetal FL/FR alliaceous alliaceous ferula assa-foetida gum oil FL/FR anise fennel fragrance FR balsamic laevo- borneol FL/FR dextro- borneol FL/FR bornyl acetate FL/FR iso bornyl acetate FL/FR bornyl formate FL/FR iso bornyl isobutyrate FL/FR iso bornyl propionate FL/FR dextro- fenchone FL/FR fir needle oil siberia FL/FR valerian rhizome absolute FL/FR camphoreous beta-homo cyclocitral FL/FR fenchol FL/FR laevo- fenchone FL/FR hinoki leaf oil FR caramellic 2-iso butyl-3-methyl pyrazine FL/FR citrus (E+Z)-4,8- dimethyl-3,7-nonadien-2-yl acetate FL/FR alpha- methylene citronellal FR neroli ketone FR ocimene quintoxide FL/FR coconut delta- heptalactone FL/FR earthy 2- ethyl fenchol FL/FR (-)-alpha- fenchol FL/FR 1- nonen-3-ol FL/FR 1- octen-3-ol FL/FR ethereal cyclohexyl formate FL/FR fatty allyl octanoate FL/FR (Z)-3- octen-1-ol FL/FR floral cyclohexyl ethyl alcohol FL/FR alpha- damascone FL/FR dihydrocarvyl acetate FL/FR geranium dihydropyran FR linalool oxide FL/FR beta- ocimene FL/FR octyl acetate FL/FR orange leaf absolute FL/FR 2- phenyl propyl acetate FL/FR rose butanoate FL/FR (R)- styralyl alcohol FL/FR ylang ylang flower oil III FL/FR fruity amyl formate FL/FR apple ketal FL/FR (E)-beta- damascone FL/FR (E)-alpha- damascone FL/FR decen-1-yl cyclopentanone FL/FR 2- pentyl furan FL/FR propyl hexanoate FL/FR tropical trithiane FL/FR green bergoxane FR cumin acetaldehyde FL/FR iso cyclocitral (IFF) FL/FR alpha,alpha- dimethyl benzyl alcohol FL/FR alpha- elemol FL/FR ferula galbaniflua gum extract FL/FR fresh nitrile FR galbanum oil FL/FR galbanum resinoid FL/FR galbanum resinoid replacer FR geranium absolute FL/FR 1- heptanol FL/FR (Z)-3- hepten-1-ol FL/FR hexanal (aldehyde C-6) FL/FR (Z)-3- hexen-1-yl acetoacetate FL/FR (E)-2- hexen-1-yl salicylate FR (Z)-3- hexen-1-yl tiglate FL/FR manzanate (Givaudan) FL/FR para- methyl hydratropaldehyde FL/FR octanal dimethyl acetal FL/FR 1- phenyl-2-pentanol FL/FR rose furan epoxide FL/FR terpinyl propionate FL/FR 3,5,5- trimethyl hexanol FL/FR 2,4,8- trimethyl-5-oxatricyclo(6.2.1.0*2,6*)undecane FR valerian rhizome oil CO2 extract china FL/FR herbal bornyl salicylate FR camphene carbinyl acetate FR (+)-alpha- campholenic aldehyde FL/FR canarium luzonicum oil FL/FR 1,4- cineole FL/FR croton catatii leaf oil FR iso dihydrolavandulal FL/FR dimethyl cyclormol (IFF) FR geranic oxide FL/FR hyssop oil FL/FR myrtenol FL/FR pine hexanol FR alpha- pinene FL/FR pinocarveol FL/FR piperitone FL/FR rosemary absolute FL/FR sabinene hydrate FL/FR sage oleoresin FL/FR theaspirane FL/FR tricyclo(5.2.1.02,6)dec-3-enyl acetate FR valerian rhizome oil FL/FR melon (Z)-6- nonenal FL/FR mentholic cornmint oil FL/FR cornmint oil china FL/FR dextro,laevo- menthol FL/FR (±)-iso menthone FL/FR peppermint cyclohexanone FL/FR dextro- piperitone FL/FR minty dextro- dihydrocarvone FL/FR trans-para- menthan-2-one FL/FR homo menthol FL/FR homo menthyl acetate FL/FR pennyroyal oil FL/FR pennyroyal oil fractions FL/FR peppermint absolute FL/FR peppermint fragrance FR peppermint oil america FL/FR peppermint oil idaho FL/FR peppermint oil special fractions FL/FR peppermint oil willamette FL/FR laevo- piperitone FL/FR iso propyl tiglate FL/FR iso pulegol FL/FR (-)-iso pulegol FL/FR spearmint oil america FL/FR mossy oakmoss absolute FL/FR orris iso eugenyl formate FL/FR spicy caryophyllene FL/FR beta- caryophyllene FL/FR iso cyclogeraniol (IFF) FR myrtenal FL/FR 2- octanol FL/FR tea tree oil FR sulfurous mango thiol FL/FR tropical 2- tropical oxathiane FL/FR waxy nonyl acetate FL/FR octyl isobutyrate FL/FR woody iso bornyl isovalerate FL/FR (+)- camphene FL/FR camphene FL/FR dihydro-beta-ionone FL/FR beta- terpineol FL/FR For Flavor No flavor group found for these benzyl disulfide FL dextro- borneol FL/FR bornyl formate FL/FR (+)- camphene FL/FR alpha,alpha- dimethyl benzyl alcohol FL/FR (E+Z)-4,8- dimethyl-3,7-nonadien-2-yl acetate FL/FR alpha- elemol FL/FR iso eugenyl formate FL/FR (Z)-3- hepten-1-ol FL/FR (Z)-3- hexen-1-yl acetoacetate FL/FR octanal propylene glycol acetal FL/FR 2- phenyl propyl acetate FL/FR rose furan epoxide FL/FR (R)- styralyl alcohol FL/FR beta- terpineol FL/FR alliaceous alliaceous ferula assa-foetida gum oil FL/FR balsamic iso bornyl isobutyrate FL/FR iso bornyl propionate FL/FR fir needle oil siberia FL/FR camphoreous laevo- borneol FL/FR bornyl acetate FL/FR camphene FL/FR fenchol FL/FR (-)-alpha- fenchol FL/FR laevo- fenchone FL/FR geranic oxide FL/FR pinocarveol FL/FR cooling 1,4- cineole FL/FR beta-homo cyclocitral FL/FR dextro- fenchone FL/FR manzanate (Givaudan) FL/FR dextro,laevo- menthol FL/FR homo menthyl acetate FL/FR peppermint oil america FL/FR sabinene hydrate FL/FR theaspirane FL/FR WS-3 FL creamy octyl isobutyrate FL/FR earthy 2- ethyl fenchol FL/FR 1- nonen-3-ol FL/FR fatty allyl octanoate FL/FR (Z)-3- octen-1-ol FL/FR floral dihydrocarvyl acetate FL/FR orange leaf absolute FL/FR ylang ylang flower oil III FL/FR fruity amyl formate FL/FR apple ketal FL/FR (E)-alpha- damascone FL/FR alpha- damascone FL/FR (E)-beta- damascone FL/FR decen-1-yl cyclopentanone FL/FR 1- phenyl-2-pentanol FL/FR propyl hexanoate FL/FR rose butanoate FL/FR tropical trithiane FL/FR valerian rhizome absolute FL/FR valerian rhizome oil FL/FR valerian rhizome oil CO2 extract china FL/FR green 2-iso butyl-3-methyl pyrazine FL/FR (+)-alpha- campholenic aldehyde FL/FR canarium luzonicum oil FL/FR cumin acetaldehyde FL/FR iso cyclocitral (IFF) FL/FR cyclohexyl ethyl alcohol FL/FR cyclohexyl formate FL/FR dextro- dihydrocarvone FL/FR ferula galbaniflua gum extract FL/FR galbanum oil FL/FR galbanum resinoid FL/FR geranium absolute FL/FR hexanal (aldehyde C-6) FL/FR (Z)-3- hexen-1-yl tiglate FL/FR horseradish oil FL linalool oxide FL/FR para- methyl hydratropaldehyde FL/FR (Z)-6- nonenal FL/FR oakmoss absolute FL/FR beta- ocimene FL/FR ocimene quintoxide FL/FR octanal dimethyl acetal FL/FR 2- pentyl furan FL/FR iso phorone FL iso propyl tiglate FL/FR propylene glycol acetone ketal FL terpinyl propionate FL/FR 3,5,5- trimethyl hexanol FL/FR herbal iso dihydrolavandulal FL/FR hyssop oil FL/FR oregano oleoresin FL rosemary absolute FL/FR sage oleoresin FL/FR lactonic delta- heptalactone FL/FR mentholic cornmint oil FL/FR peppermint cyclohexanone FL/FR minty cornmint oil china FL/FR trans-para- menthan-2-one FL/FR homo menthol FL/FR (±)-iso menthone FL/FR mint flavor FL myrtenal FL/FR myrtenol FL/FR pennyroyal oil FL/FR pennyroyal oil fractions FL/FR peppermint absolute FL/FR peppermint flavor FL peppermint oil idaho FL/FR peppermint oil special fractions FL/FR peppermint oil willamette FL/FR dextro- piperitone FL/FR piperitone FL/FR laevo- piperitone FL/FR iso pulegol FL/FR (-)-iso pulegol FL/FR spearmint oil america FL/FR mushroom 1- octen-3-ol FL/FR nutty peanut oxazole FL solvent 1- heptanol FL/FR spicy beta- caryophyllene FL/FR caryophyllene FL/FR galanga flavor FL 2- octanol FL/FR sulfurous mango thiol FL/FR methyl 2-(methyl thio) butyrate FL terpenic para- menthatriene FL tropical 2- tropical oxathiane FL/FR waxy nonyl acetate FL/FR octyl acetate FL/FR woody iso bornyl acetate FL/FR iso bornyl isovalerate FL/FR dihydro-beta-ionone FL/FR alpha- pinene FL/FR   Potential Uses: FR berry FR mint FR pine FR raspberry FR spice FL tropical FR woody   Occurrence (nature, food, other):note   tea black tea Search Trop Picture   Synonyms:   herbal spirane 6- hydroxy-2,6,10,10-tetramethyl-1-oxaspiro-4,5-decane (mixture of isomers) 6- hydroxy-2,6,10,10-tetramethyl-1-oxaspiro[4.5]decane (mixture of isomers) 1-oxa spiro(4.5)decan-6-ol, 2,6,10,10-tetramethyl- 1-oxa spiro[4.5]decan-6-ol, 2,6,10,10-tetramethyl- 2,6,10,10- tetramethyl-1-oxaspiro(4.5)decan-6-ol 2,6,10,10- tetramethyl-1-oxaspiro[4.5]decan-6-ol   Articles: US Patents:4,014,905 - Esters of certain tetramethyl and pentamethyl-1-oxa-spiro [4-5] decan-6-ols with certain alkanoic acids

Notes: None found