monoterpene; flavor component of lime citrus medica l. var acida.
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      03-23500 1,4-CINEOLE, NATURAL, Kosher
      03-23495 1,4-CINEOLE, SYNTHETIC, Kosher
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      W365807 1,4-Cineole FG
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    Flavor Demo Formulas
4-methyl-1-propan-2-yl-7-oxabicyclo[2.2.1]heptane (Click)
CAS Number: 470-67-7
ECHA EC Number: 207-428-9
Beilstein Number: 0104974
MDL: MFCD00209502
FEMA Number: 3658
CoE Number: 11225
XlogP3-AA: 2.50 (est)
Molecular Weight: 154.25266000
Formula: C10 H18 O
NMR Predictor: Predict
EFSA/JECFA Comments: 1,4-Cineole (75%), secondary component 1,8-cineole (20-25%) (EFFA, 2010a)
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients: Read Report
A GRAS assessment program for flavor ingredients: Read Report
Sensory testing for flavorings with modifying properties. Food Technology: Read Report
Criteria for the safety evaluation of flavoring substances: Read Report
A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils: Read Report
FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry: Read Report
Consumption ratio and food predominance of flavoring materials: Read Report
JECFA Food Flavoring: 1233  1,4-cineole
Flavis Number: 03.007 (Old)
EU SANCO Food Flavourings: 03.007  1,4-cineole

FEMA Number: 3658  1,4-cineole
FDA Mainterm: 1,4-CINEOLE
FDA Regulation:
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
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Physical Properties:
Appearance: colorless clear liquid (est)
Assay: 75.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 0.88700 @  25.00 °C.
Refractive Index: 1.45700 @  20.00 °C.
Melting Point: -46.00 °C. @ 760.00 mm Hg
Boiling Point: 65.00 °C. @ 16.00 mm Hg
Boiling Point: 172.00 to  174.00 °C. @ 760.00 mm Hg
Vapor Pressure: 1.930000 mm/Hg @ 25.00 °C.
Flash Point: 118.00 °F. TCC ( 47.78 °C. )
logP (o/w): 2.970
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Organoleptic Properties:
Odor Type: herbal
Odor Strength: high ,
recommend smelling in a 10.00 % solution or less
Odor Description:
at 10.00 % in dipropylene glycol. 
cooling pine minty camphor terpene green
Odor Description:
Minty, cooling piney, camphoraceous, eucalyptol-like
Mosciano, Gerard P&F 17, No. 3, 57, (1992)
Taste Description:
at 40.00 ppm.  
Cooling, minty, menthol-like, green and herbal, with a terpy and camphoraceous nuance
Mosciano, Gerard P&F 17, No. 3, 57, (1992)
Substantivity: 4 Hour(s)
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Cosmetic Information:
CosIng: cosmetic data2
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
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CTC Organics
Nippon Terpene Chemicals
Penta International
Penta International
SAFC Global
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Safety Information:
European information :
  R 10 - Flammable.
R 36 - Irritating to eyes.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
  oral-rat LD50  3100 mg/kg
(Moreno, 1981c)

oral-rat LD50  > 5000 mg/kg
(Moreno, 1972d)

oral-rat LD50  3100 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 291, 1988.

Dermal Toxicity:
  skin-rabbit LD50 > 5000 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 291, 1988.

Inhalation Toxicity:
  Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
Maximised Survey-derived Daily Intakes (MSDI-EU): 3.90 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 146.00 (μg/capita/day)
Structure Class: II
Recommendation for 1,4-cineole usage levels up to:
  40.0000 % in the fragrance concentrate.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 13
Click here to view publication 13
 average usual ppmaverage maximum ppm
baked goods: -12.40000
beverages(nonalcoholic): -9.21000
beverages(alcoholic): -4.71000
breakfast cereal: --
cheese: --
chewing gum: -25.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -9.62000
fruit ices: --
gelatins / puddings: -9.91000
granulated sugar: --
gravies: --
hard candy: -50.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -8.29000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: -11.49000
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 23 (FGE.23): Aliphatic, alicyclic and aromatic ethers including anisole derivatives From chemical groups 15, 16 and 26 (Commission Regulation (EC) No 1565/2000 of 18 July 2000
View page or View pdf
Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Flavouring Group Evaluation 33 (FGE.33)[1] - Six Tetrahydrofuran Derivatives from Chemical Groups 13, 14, 16 and 26 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010)
View page or View pdf
EPI System: View
Chemicalize.org: Calculate predicted properties
NLM Hazardous Substances Data Bank: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 470-67-7
EPA ACToR: Toxicology Data
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 1993
WGK Germany: 2
Chemidplus: 0000470677
RTECS: OS9274000 for cas# 470-67-7
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NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 470-67-7
Pubchem (cid): 10106
Pubchem (sid): 134975326
Flavornet: 470-67-7
Pherobase Floral: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
Haz-Map: View
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 armoise oilFR
 buchu leaf oilFL/FR
 cajuput leaf oilFL/FR
 cajuput oilFL/FR
 cardamom seed oilFL/FR
ortho-cresyl salicylateFL/FR
 herbal undecaneFR
 herbal undecanolFR
 hinoki leaf oilFR
6-hydroxydihydrotheaspirane (mixture of isomers)FL/FR
 hyssop oilFL/FR
spike lavender oilFL/FR
spike lavender oil spainFL/FR
 marjoram oil (thymus mastichina) spainFL/FR
 niaouli oilFR
 petitgrain combava oilFR
(Z,Z)-photocitral AFL
 sabinene hydrateFL/FR
 sage oil dalmatianFL/FR
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Potential Uses:
 fruit tropical fruit 
Synonyms   Articles   Notes   Search   Top
Natural Occurrence in: note
 boldo leaf oil italy @ 0.92%
Data  GC  GRIN Trop Picture
 boldus leaf oil chile @ 0.51%
Data  GC  GRIN Trop Picture
GRIN Trop Picture
GRIN Trop Picture
 grapefruit juice
GRIN Trop Picture
 juniper needle oil @ 4.00%
Data  GC  GRIN Trop Picture
 lavender spike water @ 29.13%
Data  GC  GRIN Trop Picture
 lime oil CO2 extract mexico @ 3.36%
Data  GC  GRIN Trop Picture
 lime oil distilled mexico @ 2.32%
Data  GC  GRIN Trop Picture
 lime oil distilled peru @ 3.52%
Data  GC  GRIN Trop Picture
 tea tree oil australia @ trace%
Data  GC  GRIN Trop Picture
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7-oxabicyclo(2.2.1)heptane, 1-isopropyl-4-methyl-
7-oxabicyclo(2.2.1)heptane, 1-methyl-4-(1-methylethyl)-
7-oxabicyclo[2.2.1]heptane, 1-methyl-4-(1-methylethyl)-
1,4-cineole (natural)
1,4-cineole natural
1,4-cineole synthetic
p-menthane, 1,4-epoxy
1-methyl-4-(1-methyl ethyl)-7-oxabicyclo(2.2.1)heptane
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PubMed: Nematicidal activity of the essential oil of Rhododendron anthopogonoides aerial parts and its constituent compounds against Meloidogyne incognita.
PubMed: Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves.
PubMed: 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.
PubMed: Toxicity of Rhododendron anthopogonoides essential oil and its constituent compounds towards Sitophilus zeamais.
PubMed: Interactions between novel terpenes and main components of rat and human skin: mechanistic view for transdermal delivery of propranolol hydrochloride.
PubMed: Herbicidal activity of cineole derivatives.
PubMed: [Analysis of the chemical constituents of essential oil from Chimonanthus zhejiangensis by GC-MS].
PubMed: Anxiolytic-like effect of the monoterpene 1,4-cineole in mice.
PubMed: Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.
PubMed: Inhibition of plant asparagine synthetase by monoterpene cineoles.
PubMed: [GC-MS analysis of constituents of essential oils from stems of Ephedra sinica Stapf, E. intermedia Schrenk et C.A. Mey. and E. equisetina Bge].
PubMed: A soluble Bacillus cereus cytochrome P-450cin system catalyzes 1,4-cineole hydroxylations.
PubMed: Biotransformation of 1,4-cineole, a monoterpene ether.
PubMed: Microbial hydroxylation of 1,4-cineole.
PubMed: Effect of odor quality and intensity on conditioned odor aversion learning in the rat.
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Picture of molecule
Soluble in:
 water, 211.3 mg/L @ 25 °C (est)
Insoluble in:
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