monoterpene; flavor component of lime citrus medica l. var acida. Constit. of Piper cubeba (cubeb pepper)
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
      Email: Mr. Jia
      Email: Mr. Guo
      Voice: 86-10-68418738
      Fax: 86-10-68418739
      Mr. Guo86-10-68483445
      Mr. Guo86-10-68418739
      20049 1,4-Cineole (natural)
  • CTC Organics
    • CTC Organics
      For More Than 40 Year
      Your source for rare aroma chemicals for the flavor and fragrance industy.
      “The world is run by middle men.” The number of times I have heard Dr. Liu utter those words are innumerable. He loved reciting and recording famous quotes and had many of his own. Among his many talents, Dr. Liu had a unique genius in the area of chemistry. He had an uncanny understanding of the pulse of the chemical industry and was a superb salesman.
      US Email: Customer Service
      US Voice: (404) 524-6744
      US Fax: (404) 577-1651
      W0335 1,4-cineole
  • Foreverest Resources
    • Foreverest Resources Ltd.
      Leading pine based chemicals supplier
      Supplying turpentine based and natural/extracted flavor & fragrance ingredients.
      Foreverest Resources Ltd. is a materials supplier, exporting gum turpentine based, terpene derivertives and natural/extracted monomers and intermediates from China since 1988. We offers high quality raw materials for flavors and fragrances synthetic manufacturing in the world.
      Email: Info
      Email: Sales
      Voice: +86 (0)592 5105533
      Fax: +86 (0)592 5151667
      foreverest Skype Skype
      1,4-Cineole 90%
      1,4-Cineole is a monoterpene, has camphor odor, natural exists in cubeb and chamomile.
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
      Email: Info
      Voice: 34 93 379 38 49
      Fax: 34 93 370 65 04
      1,4-CINEOL 85%
  • Moellhausen
    • Moellhausen S.P.A.
      Innovation and commitment in the name of excellence.
      After 50 years in business, Moellhausen stands out as one of the world’s leading family-run companies in the industry of flavors and fragrances, raw materials, and specialties. My personal history is inextricably bound to that of the company, and I continue to dedicate all my energy to it along with our partners and collaborators who have supported us thus far with dedication, passion, love, and experience. Continuous investments and a professionalism aimed at achieving the highest levels of performance in service and quality, along with that same dedication, passion, love, and experience, have together enabled us to reach the absolute avant-garde level that characterizes Moellhausen today, recognized worldwide for its modernity, innovation, creativity, and respect for the environment and the safety and rights of those who work with us. As President and CEO of the company for 32 years, I offer a well-deserved thank you to all of our numerous customers, suppliers, employees, and company friends for helping to sustain our unstoppable and honorable growth. And it is with the support of all of our stakeholders that we will confidently continue to pursue our commitment to further advancing the excellence that our industry demands.
      Voice: +39 039.685.6262
      Fax: +39 039.685.6263
      A network of knowledge to grow together
      Sustainability is at the foundation of a
      Pervasive technology and total control
      1000488 1,4-CINEOLE
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      03-23500 1,4-CINEOLE, NATURAL, Kosher
      03-23495 1,4-CINEOLE, SYNTHETIC, Kosher
  • Sigma-Aldrich
    • Sigma-Aldrich
      Complete Supply Chain
      The perfect blend of products and services that bring your creativity to life.
      Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards.
      Email: Information
      US Email: Sales
      US Voice: 800-244-1173
      US Fax: 800-368-4661
      Certified Food Grade Products
      W365820 1,4-Cineole, ≥95%, FG
  • Taytonn
      Supplying Asia Pacific
      We fully understand the demands of the F&F industry and we endeavour to supply quality products, with ready availability and a personalised service.
      Since 2001 TAYTONN has been distributing key ingredients to the Fragrance and Flavor industry in Asia. We work closely with customers, principals and vendors. Together we forecast demand and match it with supply of aroma chemicals, essential oils and natural isolates & extracts. Sourced from around the world, our F&F ingredient inventory in Singapore is ready to ship to any location in Asia and beyond. Time and again, we help our principals introduce new discoveries to the F&F market - stimulating creativity and bringing value added proposition to our customers.
      Email: Info
      Email: Sales
      Voice: + 65 - 6861 8113
      Fax: + 65 - 6861 8115
Synonyms   Articles   Notes   Search
    Flavor Demo Formulas
4-methyl-1-propan-2-yl-7-oxabicyclo[2.2.1]heptane (Click)
CAS Number: 470-67-7Picture of molecule
ECHA EINECS - REACH Pre-Reg: 207-428-9
Nikkaji Web: J5.939K
Beilstein Number: 0104974
MDL: MFCD00209502
CoE Number: 11225
XlogP3-AA: 2.50 (est)
Molecular Weight: 154.25266000
Formula: C10 H18 O
NMR Predictor: Predict (works with chrome or firefox)
EFSA/JECFA Comments: 1,4-Cineole (75%), secondary component 1,8-cineole (20-25%) (EFFA, 2010a)
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 1233  1,4-cineole
Flavis Number: 03.007 (Old)
DG SANTE Food Flavourings: 03.007  1,4-cineole
FEMA Number: 3658  1,4-cineole
FDA Mainterm: 1,4-CINEOLE
FDA Regulation:
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: colorless clear liquid (est)
Assay: 75.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 0.88700 @  25.00 °C.
Refractive Index: 1.45700 @  20.00 °C.
Melting Point: -46.00 °C. @ 760.00 mm Hg
Boiling Point: 65.00 °C. @ 16.00 mm Hg
Boiling Point: 172.00 to  174.00 °C. @ 760.00 mm Hg
Vapor Pressure: 1.930000 mm/Hg @ 25.00 °C.
Flash Point: 118.00 °F. TCC ( 47.78 °C. )
logP (o/w): 2.970
Soluble in:
 water, 211.3 mg/L @ 25 °C (est)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: herbal
Odor Strength: high ,
recommend smelling in a 10.00 % solution or less
 cooling  pine  minty  camphoreous  terpenic  green  
Odor Description:
at 10.00 % in dipropylene glycol. 
cooling pine minty camphor terpene green
 minty  cooling  pine  camphoreous  eucalyptus  
Odor Description:
Minty, cooling piney, camphoraceous, eucalyptol-like
Mosciano, Gerard P&F 17, No. 3, 57, (1992)
 cooling  minty  mentholic  green  herbal  terpenic  camphoreous  
Taste Description:
at 40.00 ppm.  
Cooling, minty, menthol-like, green and herbal, with a terpy and camphoraceous nuance
Mosciano, Gerard P&F 17, No. 3, 57, (1992)
Substantivity: 4 Hour(s)
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data2
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
Synonyms   Articles   Notes   Search   Top
Beijing Lys Chemicals
1,4-Cineole (natural)
CTC Organics
Foreverest Resources
1,4-Cineole 90%
Odor: characteristic
Use: 1,4-Cineole is a monoterpene, has camphor odor, natural exists in cubeb and chamomile.
Fuzhou Farwell
Lluch Essence
1,4-CINEOL 85%
Odor: Fresh; Minty; Aromatic; Coniferous
Flavor: Fresh; Minty; Aromatic; Coniferous
Nippon Terpene Chemicals
Penta International
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
1,4-Cineole, ≥95%, FG
Certified Food Grade Products
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Safety Information:
Preferred SDS: View
European information :
R 10 - Flammable.
R 36 - Irritating to eyes.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  3100 mg/kg
(Moreno, 1981c)

oral-rat LD50  > 5000 mg/kg
(Moreno, 1972d)

oral-rat LD50  3100 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 291, 1988.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 291, 1988.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for 1,4-cineole usage levels up to:
  40.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 3.90 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 146.00 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 13
Click here to view publication 13
 average usual ppmaverage maximum ppm
baked goods: -12.40000
beverages(nonalcoholic): -9.21000
beverages(alcoholic): -4.71000
breakfast cereal: --
cheese: --
chewing gum: -25.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -9.62000
fruit ices: --
gelatins / puddings: -9.91000
granulated sugar: --
gravies: --
hard candy: -50.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -8.29000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: -11.49000
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 23 (FGE.23): Aliphatic, alicyclic and aromatic ethers including anisole derivatives From chemical groups 15, 16 and 26 (Commission Regulation (EC) No 1565/2000 of 18 July 2000
View page or View pdf
Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Flavouring Group Evaluation 33 (FGE.33)[1] - Six Tetrahydrofuran Derivatives from Chemical Groups 13, 14, 16 and 26 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010)
View page or View pdf
EPI System: View
NLM Hazardous Substances Data Bank: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 470-67-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 10106
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 1993
WGK Germany: 2
Chemidplus: 0000470677
RTECS: OS9274000 for cas# 470-67-7
Synonyms   Articles   Notes   Search   Top
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 470-67-7
Pubchem (cid): 10106
Pubchem (sid): 134975326
Flavornet: 470-67-7
Pherobase: View
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
KEGG (GenomeNet): C16909
HMDB (The Human Metabolome Database): HMDB36096
FooDB: FDB014936
Haz-Map: View
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
For Odor
 hinoki leaf oilFR
 petitgrain combava oilFR
 barosma betulina leaf oilFL/FR
ortho-cresyl salicylateFL/FR
 herbal undecaneFR
 herbal undecanolFR
6-hydroxydihydrotheaspirane (mixture of isomers)FL/FR
 hyssop oilFL/FR
spike lavender oilFL/FR
spike lavender oil spainFL/FR
 melaleuca leucadendron cajaputi oilFL/FR
 melaleuca leucadendron var. cajuputi leaf oilFL/FR
 niaouli oilFR
 sabinene hydrateFL/FR
 elettaria cardamomum seed oilFL/FR
 marjoram oil (thymus mastichina) spainFL/FR
 armoise oilFR
 sage oil dalmatianFL/FR
For Flavor
No flavor group found for these
ortho-cresyl salicylateFL/FR
 melaleuca leucadendron cajaputi oilFL/FR
 melaleuca leucadendron var. cajuputi leaf oilFL/FR
(Z,Z)-photocitral AFL
6-hydroxydihydrotheaspirane (mixture of isomers)FL/FR
spike lavender oilFL/FR
 sabinene hydrateFL/FR
 barosma betulina leaf oilFL/FR
 hyssop oilFL/FR
spike lavender oil spainFL/FR
 elettaria cardamomum seed oilFL/FR
 marjoram oil (thymus mastichina) spainFL/FR
 sage oil dalmatianFL/FR
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 fruit tropical fruit 
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 anise star anise fruit
Search Trop  Picture
 anise star anise seed
Search Trop  Picture
 boldo leaf oil italy @ 0.92%
Data  GC  Search Trop  Picture
 boldus leaf oil chile @ 0.51%
Data  GC  Search Trop  Picture
Search  Picture
 cardamom fruit
Search Trop  Picture
 cardamom seed oil
Search Trop  Picture
Search Trop  Picture
Search Trop  Picture
Search  Picture
 grapefruit juice
Search Trop  Picture
 juniper needle oil @ 4.00%
Data  GC  Search Trop  Picture
 lavender spike water @ 29.13%
Data  GC  Search Trop  Picture
Search Trop  Picture
 lime fruit
Search Trop  Picture
 lime oil CO2 extract mexico @ 3.36%
Data  GC  Search Trop  Picture
 lime oil distilled mexico @ 2.32%
Data  GC  Search Trop  Picture
 lime oil distilled peru @ 3.52%
Data  GC  Search Trop  Picture
Search Trop  Picture
 orange fruit
Search Trop  Picture
 roselle calyx
Search Trop  Picture
 tea tree oil australia @ trace%
Data  GC  Search Trop  Picture
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7-oxabicyclo(2.2.1)heptane, 1-isopropyl-4-methyl-
7-oxabicyclo(2.2.1)heptane, 1-methyl-4-(1-methylethyl)-
7-oxabicyclo[2.2.1]heptane, 1-methyl-4-(1-methylethyl)-
1,4-cineole (natural)
1,4-cineole natural
1,4-cineole synthetic
p-menthane, 1,4-epoxy
1-methyl-4-(1-methyl ethyl)-7-oxabicyclo(2.2.1)heptane
Synonyms   Articles   Notes   Search   Top
PubMed: Nematicidal activity of the essential oil of Rhododendron anthopogonoides aerial parts and its constituent compounds against Meloidogyne incognita.
PubMed: Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves.
PubMed: 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.
PubMed: Toxicity of Rhododendron anthopogonoides essential oil and its constituent compounds towards Sitophilus zeamais.
PubMed: Interactions between novel terpenes and main components of rat and human skin: mechanistic view for transdermal delivery of propranolol hydrochloride.
PubMed: Herbicidal activity of cineole derivatives.
PubMed: [Analysis of the chemical constituents of essential oil from Chimonanthus zhejiangensis by GC-MS].
PubMed: Anxiolytic-like effect of the monoterpene 1,4-cineole in mice.
PubMed: Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.
PubMed: Inhibition of plant asparagine synthetase by monoterpene cineoles.
PubMed: [GC-MS analysis of constituents of essential oils from stems of Ephedra sinica Stapf, E. intermedia Schrenk et C.A. Mey. and E. equisetina Bge].
PubMed: A soluble Bacillus cereus cytochrome P-450cin system catalyzes 1,4-cineole hydroxylations.
PubMed: Biotransformation of 1,4-cineole, a monoterpene ether.
PubMed: Microbial hydroxylation of 1,4-cineole.
PubMed: Effect of odor quality and intensity on conditioned odor aversion learning in the rat.
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