EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

green pea pyrazine
2-methoxy-(3,5 or 6)-isopropylpyrazine

Supplier Sponsors

Name:2-methoxy-3-propan-2-ylpyrazine;2-methoxy-5-propan-2-ylpyrazine;2-methoxy-6-propan-2-ylpyrazine
CAS Number: 93905-03-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:299-837-4
FDA UNII:C90S36R5GY
MDL:MFCD00053106
CoE Number:11344
XlogP3:2.00 (est)
Molecular Weight:456.59052000
Formula:C24 H36 N6 O3
NMR Predictor:Predict (works with chrome or firefox)
Also(can) Contains:bean pyrazine
EFSA/JECFA Comments:
Mixture of positional isomers (2-Isopropyl-3/5/6-methoxy), 2-3- (75-85 %); 2-5- (15-25 %) and 2-6-isomers (1-2 %) (sum 97 %) (EFFA, 2010a).
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:790 2-methoxy-(3,5 or 6)-isopropylpyrazine
FLAVIS Number:14.121 (Old)
DG SANTE Food Flavourings:14.121 2-isopropyl-(3,5 or 6)-methoxypyrazine
FEMA Number:3358 2-methoxy-(3,5 or 6)-isopropylpyrazine
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: 2-METHOXY-(3 OR 5 OR 6)-ISOPROPYLPYRAZINE
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.99600 @ 25.00 °C.
Boiling Point: 205.00 to 207.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.360000 mm/Hg @ 25.00 °C. (est)
Flash Point: 152.00 °F. TCC ( 66.67 °C. )
logP (o/w): 2.160 (est)
Soluble in:
 alcohol
 water, 698.6 mg/L @ 25 °C (est)
Stability:
 stable in most media
 
Organoleptic Properties:
Odor Type: earthy
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
earthy pepper bell pepper potato raw potato galbanum pea green pea
Odor Description:at 0.10 % in dipropylene glycol. earthy bell pepper raw potato galbanum
Odor and/or flavor descriptions from others (if found).
Pell Wall Perfumes
Green Pea Pyrazine
Odor Description:Bell-pepper, earthy, green-pea, raw potato
Besides peppers and beans, this pyrazine, which consists of a mixture of isomers, occurs naturally in potatoes and a number of other vegetables and also has a raw-potato, earthy quality. Even at 0.1% this is a very powerful material that can easily dominate your blend, so use with caution in any blend where an original green-note is desired, or to add realism to galbanum, tomato and other green or fruity accords.
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
2-Methoxy-3-isopropyl pyrazine
Jiangyin Healthway
2-Methoxy-3,5(6)-isopropyl pyrazine
New functional food ingredients
Pell Wall Perfumes
Green Pea Pyrazine
Odor: Bell-pepper, earthy, green-pea, raw potato
Use: Besides peppers and beans, this pyrazine, which consists of a mixture of isomers, occurs naturally in potatoes and a number of other vegetables and also has a raw-potato, earthy quality. Even at 0.1% this is a very powerful material that can easily dominate your blend, so use with caution in any blend where an original green-note is desired, or to add realism to galbanum, tomato and other green or fruity accords.
Penta International
ISOPROPYL METHOXY PYRAZINE, Kosher
Sigma-Aldrich
2-Methoxy-3(5 or 6)-isopropylpyrazine, ≥98%, FG
Certified Food Grade Products
Tengzhou Jitian Aroma Chemiclal
2-Methoxy -3(5/6) - isopropyl pyrazine
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-rat LD50 880 mg/kg
(Moran et al., 1980)

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for green pea pyrazine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.0012 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.10 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 6
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -0.02000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: -0.05000
granulated sugar: --
gravies: -0.20000
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -0.20000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -0.20000
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf

EPI System: View
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :71311442
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-methoxy-3-propan-2-ylpyrazine;2-methoxy-5-propan-2-ylpyrazine;2-methoxy-6-propan-2-ylpyrazine
Chemidplus:0093905034
 
References:
 2-methoxy-3-propan-2-ylpyrazine;2-methoxy-5-propan-2-ylpyrazine;2-methoxy-6-propan-2-ylpyrazine
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):71311442
Pubchem (sid):162244287
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB32381
FooDB:FDB009800
Export Tariff Code:2933.90.0000
VCF-Online:VCF Volatile Compounds in Food
 
Potential Blenders and core components note
For Odor
balsamic
bornyl formate
FL/FR
chocolate
cocoa hexenal
FL/FR
citrus
(E)-2-
tetradecenal
FL/FR
coconut
delta-
heptalactone
FL/FR
earthy
bean pyrazine
FL/FR
2-
ethyl-3-methoxypyrazine
FL/FR
1-
nonen-3-ol
FL/FR
nutty pyrazine
FL/FR
1-
octen-3-ol
FL/FR
floral
geranyl isobutyrate
FL/FR
hexyl 2-furoate
FL/FR
linalool oxide
FL/FR
octyl acetate
FL/FR
2-
phenyl propyl acetate
FL/FR
fruity
amyl formate
FL/FR
iso
butyl hexanoate
FL/FR
butyl isovalerate
FL/FR
ethyl 2-cyclohexyl propionate
FR
2-
pentyl furan
FL/FR
propyl 2,4-decadienoate
FL/FR
tropical trithiane
FL/FR
green
2-sec-
butyl-3-methoxypyrazine
FL/FR
2-iso
butyl-3-methoxypyrazine
FL/FR
cortex pyridine
FL/FR
galbanum decatriene
FL/FR
galbanum oleoresin
FL/FR
galbanum resinoid
FL/FR
geranium absolute
FL/FR
2-
heptyl tetrahydrofuran
FR
(Z)-3-
hexen-1-yl propionate
FL/FR
(Z)-3-
hexen-1-yl tiglate
FL/FR
(E,Z)-3,6-
nonadien-1-ol
FL/FR
1-
phenyl-2-pentanol
FL/FR
herbal
6-
hydroxydihydrotheaspirane (mixture of isomers)
FL/FR
nutty
2-
acetyl-3-ethyl pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
shoyu pyrazine
FL/FR
tropical
ethyl (Z)-3-hexenoate
FL/FR
vegetable
methional
FL/FR
waxy
octyl isobutyrate
FL/FR
For Flavor
No flavor group found for these
bean pyrazine
FL/FR
benzyl disulfide
FL
bornyl formate
FL/FR
ethyl (Z)-3-hexenoate
FL/FR
2-
ethyl-3-methoxypyrazine
FL/FR
2-
methoxy-3-propyl pyrazine
FL
methyl 2-(methyl thio) acetate
FL
4-(
methyl thio) butanol
FL
2-
phenyl propyl acetate
FL/FR
alliaceous
alliaceous
3-
mercapto-2-pentanone
FL
2-
methyl thioacetaldehyde
FL
camphoreous
6-
hydroxydihydrotheaspirane (mixture of isomers)
FL/FR
cocoa
cocoa hexenal
FL/FR
creamy
octyl isobutyrate
FL/FR
earthy
1-
nonen-3-ol
FL/FR
floral
geranyl isobutyrate
FL/FR
fruity
amyl formate
FL/FR
iso
butyl hexanoate
FL/FR
butyl isovalerate
FL/FR
1-
phenyl-2-pentanol
FL/FR
tropical trithiane
FL/FR
green
2-iso
butyl-3-methoxypyrazine
FL/FR
cortex pyridine
FL/FR
galbanum decatriene
FL/FR
galbanum oleoresin
FL/FR
galbanum resinoid
FL/FR
geranium absolute
FL/FR
(Z)-3-
hexen-1-yl propionate
FL/FR
(Z)-3-
hexen-1-yl tiglate
FL/FR
hexyl 2-furoate
FL/FR
linalool oxide
FL/FR
(E,Z)-3,6-
nonadien-1-ol
FL/FR
2-
pentyl furan
FL/FR
propylene glycol acetone ketal
FL
lactonic
delta-
heptalactone
FL/FR
melon
propyl 2,4-decadienoate
FL/FR
milky
dextro,laevo-3-(
methyl thio) butanone
FL
mushroom
1-
octen-3-ol
FL/FR
musty
shoyu pyrazine
FL/FR
nutty
2-
acetyl-3-ethyl pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
2-
ethyl-6-methyl pyrazine
FL
nutty pyrazine
FL/FR
sulfurous
potato butanone
FL
tomato
methional
FL/FR
vegetable
2-sec-
butyl-3-methoxypyrazine
FL/FR
potato butyraldehyde
FL
waxy
octyl acetate
FL/FR
(E)-2-
tetradecenal
FL/FR
winey
5-
ethyl-2-methyl pyridine
FL
 
Potential Uses:
FRearth
FRgalbanum
 krill
FLpepper bell pepper
FLpotato
FLtomato
FLvegetable
 
Occurrence (nature, food, other):note
 pea green pea
Search PMC Picture
 potato
Search Trop Picture
 vegetables
Search Picture
 
Synonyms:
2-methoxy-(3,5 or 6)-isopropylpyrazine
2-methoxy-3-propan-2-ylpyrazine;2-methoxy-5-propan-2-ylpyrazine;2-methoxy-6-propan-2-ylpyrazine
2-methoxy-3,5(6)-isopropyl pyrazine
2-methoxy-3(5 or 6)-isopropylpyrazine
isopropyl methoxy pyrazine
isopropyl methoxypyrazine
isopropyl methylpyrazine
2-isopropyl-(3,5 or 6)-methoxypyrazine
2-3,(5 or 6)-isopropyl-2-methoxypyrazine
2-isopropyl-3,(5 or 6)-methoxypyrazine
2-isopropyl-3,5 or 6-methoxypyrazine
isopropylmethoxypyrazine
 

Articles:

PubMed:Application of plastic polymers in remediating wine with elevated alkyl-methoxypyrazine levels.
PubMed:Methoxypyrazine analysis and influence of viticultural and enological procedures on their levels in grapes, musts, and wines.
PubMed:Development of a rapid method for the quantitative analysis of four methoxypyrazines in white and red wine using multi-dimensional Gas Chromatography-Mass Spectrometry.
PubMed:Occurrence and contribution of alkyl methoxypyrazines in wine tainted by Harmonia axyridis and Coccinella septempunctata.
 
Notes:
Used as a food additive [EAFUS]
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