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2-methoxy-3-propyl pyrazine
pyrazine, 2-methoxy-3-propyl-

Supplier Sponsors

Name:2-methoxy-3-propylpyrazine
CAS Number: 25680-57-3Picture of molecule3D/inchi
XlogP3:2.20 (est)
Molecular Weight:152.19684000
Formula:C8 H12 N2 O
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Perfumer and Flavorist:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
FLAVIS Number:14.127 (Old)
DG SANTE Food Flavourings:14.127 2-methoxy-3-propylpyrazine
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 111.00 °C. @ 760.00 mm Hg
Boiling Point: 196.00 to 197.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 271.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.558000 mm/Hg @ 25.00 °C. (est)
Flash Point: 158.00 °F. TCC ( 69.80 °C. ) (est)
logP (o/w): 2.194 (est)
Soluble in:
 alcohol
 water, slightly
 water, 604.6 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: earthy
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
earthy pepper bell pepper potato raw potato galbanum
Odor Description:at 0.10 % in dipropylene glycol. earthy bell pepper raw potato galbanum
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
2-Methoxy-3-n-propyl-1,4-diazine
Synerzine
2-Methoxy-3-n-Propylpyrazine
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for 2-methoxy-3-propyl pyrazine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.061 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 270 (μg/person/day)
Threshold of Concern:540 (μg/person/day)
Structure Class: II
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.400002.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.100000.50000
Edible ices, including sherbet and sorbet (03.0): 0.400002.00000
Processed fruit (04.1): 0.400002.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 1.000005.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 1.000005.00000
Meat and meat products, including poultry and game (08.0): 0.100000.40000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.100000.40000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.100000.50000
Foodstuffs intended for particular nutritional uses (13.0): 0.200001.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 0.200001.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 1.000005.00000
Ready-to-eat savouries (15.0): 1.000005.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.200001.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 3 (FGE.17Rev3): Pyrazine derivatives from chemical group 24
View page or View pdf

EPI System: View
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :528308
National Institute of Allergy and Infectious Diseases:Data
2-methoxy-3-propylpyrazine
 
References:
 2-methoxy-3-propylpyrazine
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):528308
Pubchem (sid):125760971
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
balsamic
bornyl formate
FL/FR
cotinus coggygria branch/leaf oil
FL/FR
chocolate
cocoa hexenal
FL/FR
citrus
(E)-2-
tetradecenal
FL/FR
coconut
delta-
heptalactone
FL/FR
earthy
2-
ethyl-3-methoxypyrazine
FL/FR
1-
nonen-3-ol
FL/FR
nutty pyrazine
FL/FR
1-
octen-3-ol
FL/FR
floral
linalool oxide
FL/FR
octyl acetate
FL/FR
2-
phenyl propyl acetate
FL/FR
fruity
amyl formate
FL/FR
2-
pentyl furan
FL/FR
rhubarb undecane
FR
tropical trithiane
FL/FR
green
S-sec-
butyl thioisovalerate
FL/FR
2-iso
butyl-3-methoxypyrazine
FL/FR
2-sec-
butyl-3-methoxypyrazine
FL/FR
cortex pyridine
FL/FR
galbanum decatriene
FL/FR
galbanum oleoresin
FL/FR
galbanum resinoid
FL/FR
geranium absolute
FL/FR
(Z)-3-
hexen-1-yl tiglate
FL/FR
(E,Z)-3,6-
nonadien-1-ol
FL/FR
1-
phenyl-2-pentanol
FL/FR
iso
propyl 3-methyl thiocrotonate
FL/FR
iso
propyl thioisovalerate
FL/FR
sorbyl isobutyrate
FL/FR
violet dienyne
FR
herbal
6-
hydroxydihydrotheaspirane (mixture of isomers)
FL/FR
nutty
2-
acetyl-3-ethyl pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
shoyu pyrazine
FL/FR
tropical
cis-
galbanum oxathiane
FL/FR
2-
tropical oxathiane
FL/FR
vegetable
methional
FL/FR
waxy
octyl isobutyrate
FL/FR
For Flavor
No flavor group found for these
benzyl disulfide
FL
bornyl formate
FL/FR
S-sec-
butyl thioisovalerate
FL/FR
cotinus coggygria branch/leaf oil
FL/FR
2-
ethyl-3-methoxypyrazine
FL/FR
green pea pyrazine
FL
methyl 2-(methyl thio) acetate
FL
4-(
methyl thio) butanol
FL
2-
phenyl propyl acetate
FL/FR
iso
propyl 3-methyl thiocrotonate
FL/FR
iso
propyl thioisovalerate
FL/FR
2-
tropical oxathiane
FL/FR
sorbyl isobutyrate
FL/FR
alliaceous
alliaceous
3-
mercapto-2-pentanone
FL
2-
methyl thioacetaldehyde
FL
camphoreous
6-
hydroxydihydrotheaspirane (mixture of isomers)
FL/FR
cocoa
cocoa hexenal
FL/FR
creamy
octyl isobutyrate
FL/FR
earthy
1-
nonen-3-ol
FL/FR
fruity
amyl formate
FL/FR
1-
phenyl-2-pentanol
FL/FR
tropical trithiane
FL/FR
green
2-iso
butyl-3-methoxypyrazine
FL/FR
cortex pyridine
FL/FR
galbanum decatriene
FL/FR
galbanum oleoresin
FL/FR
cis-
galbanum oxathiane
FL/FR
galbanum resinoid
FL/FR
geranium absolute
FL/FR
(Z)-3-
hexen-1-yl tiglate
FL/FR
linalool oxide
FL/FR
(E,Z)-3,6-
nonadien-1-ol
FL/FR
2-
pentyl furan
FL/FR
propylene glycol acetone ketal
FL
lactonic
delta-
heptalactone
FL/FR
milky
dextro,laevo-3-(
methyl thio) butanone
FL
mushroom
1-
octen-3-ol
FL/FR
musty
shoyu pyrazine
FL/FR
nutty
2-
acetyl-3-ethyl pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
2-
ethyl-6-methyl pyrazine
FL
nutty pyrazine
FL/FR
sulfurous
potato butanone
FL
tomato
methional
FL/FR
vegetable
2-sec-
butyl-3-methoxypyrazine
FL/FR
potato butyraldehyde
FL
waxy
octyl acetate
FL/FR
(E)-2-
tetradecenal
FL/FR
winey
5-
ethyl-2-methyl pyridine
FL
 
Potential Uses:
FRearth
FRgalbanum
FLpepper bell pepper
FLpotato
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
2-methoxy-3-N-propylpyrazine
2-methoxy-3-propyl-pyrazine
2-methoxy-3-propylpyrazine
 pyrazine, 2-methoxy-3-propyl-
 
 
Notes:
None found
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