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2,5-dimethyl pyrazine and 2,6-dimethyl pyrazine mixture
2,5-dimethylpyrazine and 2,6-dimethylpyrazine mixture

Supplier Sponsors

Name:2,5-dimethylpyrazine
CAS Number: 123-32-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-618-3
FDA UNII:V99Y0MUY1Q
Nikkaji Web:J2.009E
Beilstein Number:0107052
MDL:MFCD00006147
CoE Number:2210
XlogP3:0.60 (est)
Molecular Weight:108.14376000
Formula:C6 H8 N2
NMR Predictor:Predict (works with chrome or firefox)
Also(can) Contains:2,6-dimethyl pyrazine
EFSA/JECFA Comments:
Mixture of positional isomers (2,5- and 2,6-isomers), 2,5- (45-65 %) and 2,6-isomers (35-55 %) (sum 98 %) (EFFA, 2010a).
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:766 2,5-dimethylpyrazine
FEMA Number:3272 2,5-dimethylpyrazine and 2,6-dimethylpyrazine mixture
FDA:No longer provide for the use of these seven synthetic flavoring substances
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 15.00 °C. @ 760.00 mm Hg
Boiling Point: 155.00 °C. @ 760.00 mm Hg
Vapor Pressure:1.500000 mmHg @ 27.00 °C. (est)
Flash Point: 147.00 °F. TCC ( 63.90 °C. ) (est)
logP (o/w): 0.630
Soluble in:
 alcohol
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: chocolate
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
nutty roasted potato baked potato
Odor Description:at 0.10 % in dipropylene glycol. nutty roasted baked potato
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Advanced Biotech
2 (5,6) DIMETHYL PYRAZINE
Advanced Biotech
PYRAZINE MIXTURE IIII NATURAL
Advanced Biotech
PYRAZINE MIXTURE NATURAL
Anhui Suzhou Jinli Aromatic Chemicals
2,5 or 6, 1-Dimethyl pyrazine
Odor: baked potato
Frutarom
2,5/2,6 DIMETHYL PYRAZINE
Jinan Enlighten Chemical Technology(Wutong Aroma )
2,5(or6)-Dimethyl pyrazine, Kosherk
M&U International
2,5(OR6)-DIMETHYL PYRAZINE, Kosher
Penta International
2,5 + 2,6-DIMETHYL PYRAZINE MIXTURE NATURAL
Penta International
2,5 + 2,6-DIMETHYL PYRAZINE MIXTURE
Reincke & Fichtner
Dimethyl Pyrazine natural
Synerzine
Mixture of 2,5-Dimeythlpyrazine and 2,6-Dimethylpyrazine
Synerzine
Natural mixture of 2,5-dimeythlpyrazine and 2,6-dimethylpyrazine
WholeChem
2,5 & 2,6-Dimethylpyrazines Mixture
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 1350 mg/kg
Toxicology and Applied Pharmacology. Vol. 17, Pg. 244, 1970.

oral-rat LD50 1020 mg/kg
Drug and Chemical Toxicology. Vol. 3, Pg. 249, 1980.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for 2,5-dimethyl pyrazine and 2,6-dimethyl pyrazine mixture usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 5
 average usual ppmaverage maximum ppm
baked goods: -10.00000
beverages(nonalcoholic): -10.00000
beverages(alcoholic): --
breakfast cereal: -10.00000
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -10.00000
fruit ices: -10.00000
gelatins / puddings: -10.00000
granulated sugar: --
gravies: -10.00000
hard candy: -10.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -10.00000
milk products: -10.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -10.00000
sugar substitutes: --
sweet sauces: --
 
Safety References:
Chemical Carcinogenesis Research Information System:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):123-32-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :31252
National Institute of Allergy and Infectious Diseases:Data
2,5-dimethylpyrazine
Chemidplus:0000123320
RTECS:UQ2800000 for cas# 123-32-0
 
References:
 2,5-dimethylpyrazine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:123-32-0
Pubchem (cid):31252
Pubchem (sid):134974393
Flavornet:123-32-0
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB35289
FooDB:FDB013954
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
caramellic
iso
propenyl pyrazine
FL/FR
chocolate
2,5-
dimethyl pyrazine
FL/FR
green
2-tert-
butyl pyrazine
FL/FR
2-
heptyl furan
FL/FR
nutty
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
filbert heptenone B
FL/FR
methoxymethyl pyrazine
FL/FR
nutty quinoxaline
FL/FR
sesame absolute
FL/FR
For Flavor
No flavor group found for these
2-tert-
butyl pyrazine
FL/FR
6,7-
dimethyl dihydrocyclopentapyrazine
FL
methyl 2-(methyl thio) acetate
FL
pyrazines mixture
FL
5-
acetyl-2,3-dihydro-1,4-thiazine
FL
burnt
burnt
iso
propenyl pyrazine
FL/FR
fatty
2-
heptyl furan
FL/FR
fishy
4,5-
dimethyl thiazole
FL
fruity
2-
ethyl-2,5-dihydro-4-methyl thiazole
FL
musty
2,5-
dimethyl pyrazine
FL/FR
2-
ethoxythiazole
FL
nutty
3-
acetyl-2,5-dimethyl thiophene
FL
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR
arachis hypogaea fruit extract
FL
3,6-
cocoa pyrazine
FL/FR
1-
ethyl-2-acetyl pyrrole
FL
2-
ethyl-6-methyl pyrazine
FL
filbert heptenone B
FL/FR
methoxymethyl pyrazine
FL/FR
nutty quinoxaline
FL/FR
sesame absolute
FL/FR
roasted
3,5-
diisobutyl-1,2,4-trithiolane
FL
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 can be natural
 fenugreek seed
Search Trop Picture
 garlic bulb
Search Trop Picture
 kohlrabi stem
Search Trop Picture
 
Synonyms:
2 (5,6)-dimethyl pyrazine
2,6-dimethyl pyrazine and 2,5-dimethyl pyrazine mixture
2,5 & 2,6-dimethyl pyrazine mixture
2,5 & 2,6-dimethyl pyrazine mixture natural
2,5-dimethylpyrazine (contains 2,6-isomer)
2,6-dimethylpyrazine and 2,5-dimethylpyrazine mixture
2,5-dimethylpyrazine and 2,6-dimethylpyrazine
2,5-dimethylpyrazine and 2,6-dimethylpyrazine mixture
2,5(2,6)-dimethylpyrazine mixture
 
 
Notes:
Used as flavour additive and odorant in foods. Present in asparagus, wheat bread, crispbread, Swiss cheeses, black or green tea, soya, malt, raw shrimp and squid
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