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dimethyl disulfide
methyldithiomethane

Sponsors

Flavor Demo Formulas
Name:methyldisulfanylmethane
CAS Number: 624-92-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:210-871-0
FDA UNII:3P8D642K5E
Nikkaji Web:J1.683G
Beilstein Number:1730824
MDL:MFCD00008561
CoE Number:2175
XlogP3:1.80 (est)
Molecular Weight:94.19982000
Formula:C2 H6 S2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:564 dimethyl disulfide
FLAVIS Number:12.026 (Old)
DG SANTE Food Flavourings:12.026 dimethyl disulfide
FEMA Number:3536 dimethyl disulfide
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: METHYL DISULFIDE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.04600 @ 25.00 °C.
Refractive Index:1.52530 @ 20.00 °C.
Melting Point: -85.00 °C. @ 760.00 mm Hg
Boiling Point: 109.00 to 110.00 °C. @ 760.00 mm Hg
Boiling Point: 23.00 °C. @ 30.00 mm Hg
Vapor Pressure:28.733000 mm/Hg @ 25.00 °C. (est)
Vapor Density:3.2 ( Air = 1 )
Flash Point: 76.00 °F. TCC ( 24.44 °C. )
logP (o/w): 1.770
Soluble in:
 alcohol
 water, 3739 mg/L @ 25 °C (est)
 water, 3000 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor Type: sulfurous
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
sulfurous vegetable cabbage onion
Odor Description:at 0.10 % in propylene glycol. sulfurous vegetable cabbage onion
Flavor Type: sulfurous
sulfurous cabbage malty creamy
Taste Description: sulfurous cabbage, malt, cream
Odor and/or flavor descriptions from others (if found).
Frutarom
DIMETHYL DISULPHIDE
Odor Description:Alliaceous, Onion
Suggested Uses: Cabbage, Coffee, Garlic, Savoury, Tropical Fruits, Vegetables
Natural Advantage
Dimethyl Disulfide Nat
Taste Description:Cabbage, Malt, Cream
Flavor Use: Onion, Garlic, Vegetable, Cheese, Poultry, Meat, Soup and Savory Flavors, Fruit Flavors. Use Level: 0.03-9 ppm as consumed.
Lluch Essence
DIMETHYL DISULFIDE
Odor Description:GARLIC LIKE, SULPHUROUS
 
Cosmetic Information:
None found
 
Suppliers:
Arkema
Paladin® (Shank injection)
Odor: characteristic
Use: In response to ever-increasing demands for improved soil fumigation solutions to replace methyl bromide. Arkema is introducing its broad-spectrum Paladin® fumigant. Already use around the globe for a variety of fruits and vegetables in open fields mainly, Paladin® have demonstrated consistent performance enabling marketable yields that are comparable to methyl bromide treatment at a distinctly lower cost to the grower.
Arkema
Paladin® EC (Drip application)
Odor: characteristic
Use: In response to ever-increasing demands for improved soil fumigation solutions to replace methyl bromide, Arkema is introducing its broad-spectrum Paladin® EC soil fumigant. Already use around the globe for a variety of fruits and vegetables protected crops mainly, Paladin® EC have demonstrated consistent performance enabling marketable yields that are comparable to methyl bromide treatment at a distinctly lower cost to the grower.
Augustus Oils
Dimethyl Disulphide
Services
Axxence Aromatic
DIMETHYL DISULFIDE Natural
Kosher
Sustainability
Charkit Chemical
DIMETHYL DISULPHIDE D0800 FEMA 3536
Chevron Phillips
dimethyl disulfide
Diffusions Aromatiques
DIMETHYL DISULFIDE
Ernesto Ventós
DIMETHYL DISULPHIDE
Odor: VEGETABLE, ONION, CABBAGE
Excellentia International
Dimethyl Disulfide Natural
Frutarom
DIMETHYL DISULPHIDE
Odor: Alliaceous, Onion
Use: Suggested Uses: Cabbage, Coffee, Garlic, Savoury, Tropical Fruits, Vegetables
Indukern F&F
DIMETHYL DISULPHIDE
Odor: SULFUROUS, GARLIC
Jiangyin Healthway
Dimethyl disulphide
New functional food ingredients
Jinan Enlighten Chemical Technology(Wutong Aroma )
Dimethyl disulfide, Kosherk
Lluch Essence
DIMETHYL DISULFIDE
Odor: GARLIC LIKE, SULPHUROUS
M&U International
DIMETHYL DISULFIDE, Kosher
Natural Advantage
Dimethyl Disulfide Nat
Flavor: Cabbage, Malt, Cream
Flavor Use: Onion, Garlic, Vegetable, Cheese, Poultry, Meat, Soup and Savory Flavors, Fruit Flavors. Use Level: 0.03-9 ppm as consumed.
Penta International
DIMETHYL DISULFIDE NATURAL, Kosher
Penta International
DIMETHYL DISULFIDE, Kosher
Reincke & Fichtner
Dimethyl Disulfide
Riverside Aromatics
DIMETHYL DISULPHIDE NATURAL
Robertet
DIMETHYL DISULFIDE
Pure & Nat (EU)
Sigma-Aldrich
Dimethyl disulfide, ≥98%, FG
Certified Food Grade Products
Sigma-Aldrich
Dimethyl disulfide, natural, ≥98%, FG
Sunaux International
Dimethyl Disulfide
Taytonn
Dimethyl Disulphide
Odor: Alliaceous, Onion
Tengzhou Jitian Aroma Chemiclal
Dimethyl Disulfide
Tengzhou Xiang Yuan Aroma Chemicals
Dimethyl Disulfide
Treatt
Dimethyl Disulphide 10% in
Kosher
Treatt
Dimethyl Disulphide
Halal, Kosher
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn N - Harmful, Dangerous for the environment.
R 11 - Highly flammable.
R 20/22 - Harmful by inhalation and if swallowed.
R 36 - Irritating to eyes.
R 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 60 - This material and its container must be disposed of as hazardous waste.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 [sex: M,F] 190 mg/kg
(Shapiro et al., 1985)

unreported-mammal (species unspecified) LD50 138 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 16(6), Pg. 46, 1972.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
inhalation-rat LC50 15850 ug/m3/2H
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 16(6), Pg. 46, 1972.

inhalation-mouse LC50 12300 ug/m3/2H
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 16(6), Pg. 46, 1972.

 
Safety in Use Information:
Category: flavor and fragrance agents
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 6.90 (μg/capita/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 11
 average usual ppmaverage maximum ppm
baked goods: -16.90000
beverages(nonalcoholic): -4.80000
beverages(alcoholic): -2.00000
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -3.80000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -4.80000
fruit ices: --
gelatins / puddings: -8.30000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -2.20000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: -9.40000
soups: --
sugar substitutes: --
sweet sauces: -0.00700
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 8 (FGE.08)[1]: Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20
View page or View pdf

Flavouring Group Evaluation 74 (FGE.74)[1]: Consideration of Simple Aliphatic Sulphides and Thiols evaluated by JECFA (61st meeting) Structurally related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or without Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08 (2008)
View page or View pdf

Flavouring Group Evaluation 8, Revision 1 (FGE.08Rev1): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf

Flavouring Group Evaluation 91 (FGE.91): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev1 (2009)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 08, Revision 4 (FGE.08Rev4): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf

Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):624-92-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :12232
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2381
WGK Germany:2
methyldisulfanylmethane
Chemidplus:0000624920
EPA/NOAA CAMEO:hazardous materials
RTECS:624-92-0
 
References:
 methyldisulfanylmethane
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:624-92-0
Pubchem (cid):12232
Pubchem (sid):134977693
Flavornet:624-92-0
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C08371
HMDB (The Human Metabolome Database):HMDB05879
FooDB:FDB003491
Export Tariff Code:2930.90.9999
Haz-Map:View
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
FAO:Dimethyl disulfide
 
Potential Blenders and core components note
For Odor
alliaceous
ferula assa-foetida gum oil
FL/FR
propyl mercaptan
FL/FR
cheesy
S-(
methyl thio) butyrate
FL/FR
coffee
coffee difuran
FL/FR
sulfurous
dimethyl sulfide
FL/FR
methyl 3-(methyl thio) propionate
FL/FR
methyl mercaptan
FL/FR
S-
tropical 2-thiobutyrate
FL/FR
For Flavor
No flavor group found for these
diisopropyl sulfide
FL
3-
ethyl thiopropanol
FL
mercaptoacetaldehyde
FL
3-
methyl mercaptopropyl amine
FL
4-(
methyl thio) butanol
FL
2-(
methyl thio) methyl-2-butenal
FL
4-
methyl thiobutyl isothiocyanate
FL
5-
methyl thiopentyl isothiocyanate
FL
2-
methyl-5-methoxythiazole
FL
iso
propyl disulfide
FL
propyl mercaptan
FL/FR
tetrahydrothiophene
FL
S-
tropical 2-thiobutyrate
FL/FR
alliaceous
alliaceous
benzyl mercaptan
FL
1,3-
butane dithiol
FL
ferula assa-foetida gum oil
FL/FR
2-
methyl thioacetaldehyde
FL
caramellic
caramel malted mambo flavor
FL
coffee
coffee difuran
FL/FR
fruity
methionyl butyrate
FL
green
horseradish oil
FL
meaty
bis(2-
methyl-3-furyl) disulfide
FL
pyrazinyl ethane thiol
FL
musty
S-(
methyl thio) butyrate
FL/FR
sulfurous
dimethyl sulfide
FL/FR
ethyl methyl sulfide
FL
furfuryl methyl sulfide
FL
methyl 2-methyl-3-furyl disulfide
FL
methyl 4-(methyl thio) butyrate
FL
methyl benzyl disulfide
FL
methyl mercaptan
FL/FR
1-(
methyl thio)-2-butanone
FL
methyl thioacetate
FL
potato butanone
FL
vegetable
methyl 3-(methyl thio) propionate
FL/FR
radish isothiocyanate
FL
 
Potential Uses:
FLbeef
FLcabbage
FLcoffee
FLdairy
FLgarlic
FLmalt
FLrice
FLrum
 
Occurrence (nature, food, other):note
 allium spp.
Search Trop Picture
 beef cooked beef
Search PMC Picture
 blood orange oil italy @ 0.30%
Data GC Search Trop Picture
 brassica oleracea
Search Trop Picture
 broccoli asparagus broccoli plant
Search Trop Picture
 cabbage leaf
Search Trop Picture
 cauliflower
Search Trop Picture
 chive plant
Search Trop Picture
 coffee
Search PMC Picture
 filbert
Search Trop Picture
 fish
Search PMC Picture
 fruits
Search PMC Picture
 garlic bulb
Search Trop Picture
 garlic bulb oil
Search Trop Picture
 garlic fruit juice
Search Trop Picture
 garlic oil
Search Trop Picture
 guava fruit
Search Trop Picture
 hazelnut roasted hazelnut
Search Trop Picture
 kohlrabi stem
Search Trop Picture
 leek
Search Trop Picture
 leek wild leek plant
Search Trop Picture
 mushroom shiitake mushroom fruit
Search PMC Picture
 oleracea
Search PMC Picture
 onion bulb
Search Trop Picture
 onion oil
Search Trop Picture
 parsley leaf
Search Trop Picture
 parsley plant
Search Trop Picture
 pineapple fruit
Search Trop Picture
 radish
Search Trop Picture
 rutabaga
Search Trop Picture
 strawberry wild strawberry fruit
Search Trop Picture
 yogurt
Search Picture
 
Synonyms:
 dimethyl disulfane
 dimethyl disulfide natural
 dimethyl disulphide
 disulfide, dimethyl
2,3-dithiabutane
 DMDS
 methyl disulfide
 methyl disulphide
(methyl dithio) methane
 methyl dithiomethane
(methyldisulfanyl)methane
 methyldisulfanylmethane
(methyldithio)methane
 methyldithiomethane
 
 
Notes:
Isol. from garlic oil (Allium sativum), also in onion (Allium cepa), ramsons (Allium ursinum), morello cherry, melon, pineapple, strawberry, wheat bread, cocoa, roasted barley, roasted filberts, roasted peanuts, crispbread, American potato chips, soybean and other foodstuffs. Flavouring ingredient. Dimethyldisulfide is a volatile organic compound. Methyl disulfide is occasionally found as a volatile component of normal human breath and biofluids. Dimethyldisulfide is one of the representative volatile components found in oral malodor. Dimethyldisulfide concentrations in breath is a practical noninvasive way to assess recent exposure to sulfur compounds in sulfate pulp mills, and therefore it should be applicable to workplaces contaminated. (PMID: 5556886, 14691119, 11236158, 8481097)
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