EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

cyclohexanol
hydroxycyclohexane

Supplier Sponsors

Name:cyclohexanol
CAS Number: 108-93-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-630-6
FDA UNII:8E7S519M3P
Nikkaji Web:J2.871A
Beilstein Number:0906744
MDL:MFCD00003855
CoE Number:2138
XlogP3-AA:1.20 (est)
Molecular Weight:100.16084000
Formula:C6 H12 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents and cosmetic fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FLAVIS Number:02.070 (Old)
DG SANTE Food Flavourings:02.070 cyclohexanol
FDA Mainterm (IAUFC):108-93-0 ; CYCLOHEXANOL

FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
 
Physical Properties:
Appearance:colorless liquid to crystalline needles (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.94200 to 0.94800 @ 25.00 °C.
Pounds per Gallon - (est).: 7.838 to 7.888
Refractive Index:1.46200 to 1.46800 @ 20.00 °C.
Melting Point: 25.50 °C. @ 760.00 mm Hg
Boiling Point: 158.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.975000 mmHg @ 20.00 °C.
Vapor Density:3.5 ( Air = 1 )
Flash Point: 145.00 °F. TCC ( 62.78 °C. )
logP (o/w): 1.230
Soluble in:
 water, 42000 mg/L @ 10 °C (exp)
 
Organoleptic Properties:
Odor Type: camphoreous
Odor Strength:medium ,
recommend smelling in a 10.00 % solution or less
camphoreous mentholic phenolic
Odor Description:at 10.00 % in dipropylene glycol. camphor menthol phenol
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
Cyclohexanol Purity >99%
EMD Millipore
For experimental / research use only.
Cyclohexanol
Indenta Group
Cyclohexanol
Penta International
CYCLOHEXANOL W/METHANOL
Penta International
CYCLOHEXANOL
Sigma-Aldrich
For experimental / research use only.
Cyclohexanol puriss., ≥99.0% (GC)
 
Safety Information:
European information :
Most important hazard(s):
Xn - Harmful.
R 20/22 - Harmful by inhalation and if swallowed.
R 37/38 - Irritating to respiratory system and skin.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-rat LD50 [sex: M] 1750 mg/kg
(Miller & Sherman, 1965)

oral-rat LD50 1550 mg/kg
(Birch, 1978a)

oral-rat LD50 2060 mg/kg
(Br & Griepentrog, 1967)

oral-rat LD50 [sex: M,F] 1120 mg/kg
(Birch et al., 1981)

oral-rat LD50 2060 mg/kg
Administered as 10 % solution in Tergitol 7.
(Smyth et al., 1946c)

gavage-rabbit LD50 2200 - 2600 mg/kg
Minimum lethal dose.
(Treon et al., 1943)

parenteral-frog LDLo 1914 mg/kg
CARDIAC: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 24, Pg. 405, 1925.

intramuscular-mouse LD50 1000 mg/kg
Journal of Scientific and Industrial Research, Section C: Biological Sciences. Vol. 21, Pg. 342, 1962.

intraperitoneal-mouse LD50 1352 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1254, 1969.

intravenous-mouse LD50 272 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 135, Pg. 330, 1962.

oral-rabbit LDLo 2200 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC
Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 199, 1943.

oral-rat LD50 1400 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
National Technical Information Service. Vol. OTS0538617

Dermal Toxicity:
skin-rabbit LDLo 794 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LIVER: CHANGE IN GALL BLADDER STRUCTURE OR FUNCTION
National Technical Information Service. Vol. OTS0538617

Inhalation Toxicity:
inhalation-human TCLo 75 ppm
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 282, 1943.

inhalation-rat LC > 6500 mg/m3/1H
National Technical Information Service. Vol. OTS0572832

 
Safety in Use Information:
Category: flavoring agents and cosmetic fragrance agents
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 3.70 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 1600 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 3.0000015.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 2.0000010.00000
Edible ices, including sherbet and sorbet (03.0): 3.0000015.00000
Processed fruit (04.1): 2.0000010.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 4.0000020.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 2.0000010.00000
Bakery wares (07.0): 5.0000025.00000
Meat and meat products, including poultry and game (08.0): 1.000005.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 1.000005.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 2.0000010.00000
Foodstuffs intended for particular nutritional uses (13.0): 3.0000015.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 2.0000010.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 4.0000020.00000
Ready-to-eat savouries (15.0): 5.0000025.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 2.0000010.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 9 (FGE.09): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and an ester of a phenol carboxylic acid from chemical group 25
View page or View pdf

Flavouring Group Evaluation 51, (FGE.51)[1] - Consideration of alicyclic ketones and secondary alcohols and related esters evaluated by JECFA (59th meeting) and structurally related to alicyclic ketones, secondary alcohols and related esters evaluated by EFSA in FGE.09 (2004) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 9, Revision 1: (FGE.09 Rev1)[1] - Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical groups 8 and 30, and an ester of a phenol carboxylic acid from chemical group 25 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 9, Revision 2 (FGE.09Rev2): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 9, Revision 3 (FGE.09Rev3): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 9, Revision 4 (FGE.09Rev4): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 9, Revision 5 (FGE.09Rev5): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 9, Revision 6 (FGE.09Rev6): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):108-93-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7966
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
cyclohexanol
Chemidplus:0000108930
EPA/NOAA CAMEO:hazardous materials
RTECS:108-93-0
 
References:
 cyclohexanol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:108-93-0
Pubchem (cid):7966
Pubchem (sid):134973337
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C00854
HMDB (The Human Metabolome Database):Search
FooDB:FDB003415
YMDB (Yeast Metabolome Database):YMDB01398
Export Tariff Code:2906.12.0000
Haz-Map:View
Household Products:Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
•grade: technical (contains freezing inhibitor) •commercial products: technical and high-grade •some cyclohexanol is shipped with 2.25% methanol as antifreeze. •ka oil used for adipic acid production is 65% cyclohexanol
 
Potential Blenders and core components note
For Odor
balsamic
dextro,laevo-iso
borneol
FL/FR
bornyl acetate
FL/FR
iso
bornyl acetate
FL/FR
camphoreous
dextro-
camphor
FL/FR
camphor tree bark oil
FL/FR
herbal ethanone
FR
verbenone
FL/FR
citrus
neroli ketone
FR
floral
lavender oil
FL/FR
rose pyran
FR
green
seaweed absolute (fucus vesiculosus et serratus)
FL/FR
herbal
artemisia diffusa krasch. ex poljak oil iran
FR
chamomile oil morocco
FR
2,10-
epoxypinane
FR
geranic oxide
FL/FR
herbal dioxane
FR
lavandin concrete
FL/FR
spike
lavender absolute
FL/FR
origanum oil
FL/FR
origanum oil greece
FL/FR
pinocarveol
FL/FR
rosemary oil morocco
FL/FR
rosemary oil spain
FL/FR
safranal
FL/FR
white
thyme oil
FL/FR
thyme oil (thymus zygis gracillis) spain
FL/FR
mentholic
laevo-
menthol
FL/FR
(±)-iso
menthone
FL/FR
minty
artemisia deserti krasch. oil iran
FR
(-)-
menthone
FL/FR
(R)-(+)-
pulegone
FR
spicy
carvacrol
FL/FR
origanum majorana oil
FL/FR
origanum majorana oil cuba
FL/FR
For Flavor
No flavor group found for these
seaweed absolute (fucus vesiculosus et serratus)
FL/FR
verbenone
FL/FR
camphoreous
camphoreous
dextro,laevo-iso
borneol
FL/FR
bornyl acetate
FL/FR
camphor tree bark oil
FL/FR
geranic oxide
FL/FR
pinocarveol
FL/FR
cooling
laevo-
menthol
FL/FR
herbal
lavandin concrete
FL/FR
spike
lavender absolute
FL/FR
lavender oil
FL/FR
origanum majorana oil
FL/FR
origanum oil
FL/FR
origanum oil greece
FL/FR
rosemary oil morocco
FL/FR
rosemary oil spain
FL/FR
white
thyme oil
FL/FR
thyme oil (thymus zygis gracillis) spain
FL/FR
medicinal
dextro-
camphor
FL/FR
minty
(±)-iso
menthone
FL/FR
(-)-
menthone
FL/FR
spicy
carvacrol
FL/FR
cubeb oleoresin
FL
origanum majorana oil cuba
FL/FR
woody
iso
bornyl acetate
FL/FR
safranal
FL/FR
 
Potential Uses:
FLbuchu leaf
FL/FRcajeput
FL/FRcamphor tree bark
FRcardamom oil replacer
FRhinoki oil replacer
FL/FRhyssop
FRlavandin
FRmyrtle oil replacer
FRniaouli
FRoregano
FRthyme oil white replacer
 
Occurrence (nature, food, other):note
 basil oil
Search Trop Picture
 okra fruit
Search Trop Picture
 passion fruit - up to 0.1 mg/kg
Search Trop Picture
 sauromatum guttatum
Search Trop Picture
 tomato fruit
Search Trop Picture
 wine white wine - 0.006 mg/kg
Search Picture
 
Synonyms:
 adronal
 adronol
1-cyclohexanol
 cyclohexanol w/methanol
 cyclohexyl alcohol
 hexahydrophenol
 hexalin
 hydralin
 hydrophenol
 hydroxycyclohexane
 naxol
 

Articles:

PubMed:Migration of odorous compounds from adhesives used in market samples of food packaging materials by chromatography olfactometry and mass spectrometry (GC-O-MS).
PubMed:Isolation, purification and identification of nine chemical compounds from Flammulina velutipes fruiting bodies.
PubMed:Identification of raloxifene as a novel CB2 inverse agonist.
PubMed:Opioids in the perifornical lateral hypothalamus suppress ethanol drinking.
PubMed:Preparation and evaluation of poly(4-vinylphenylboronic acid-co-pentaerythritol triacrylate) monolithic column for capillary liquid chromatography of small molecules and proteins.
PubMed:Chronic cannabinoid treatment during young adulthood induces sex-specific behavioural deficits in maternally separated rats.
PubMed:A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): identification, synthesis and antinociceptive activity.
PubMed:Dietary conditions and highly palatable food access alter rat cannabinoid receptor expression and binding density.
PubMed:Glycosidic conjugates of C13 norisoprenoids, monoterpenoids, and cucurbates in Boronia megastigma (Nees).
PubMed:Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist.
PubMed:Chronic Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys: differential tolerance and cross-tolerance among cannabinoids.
PubMed:Electrochromatographic characterization of methacrylate ester-based monolith and capillary electrochromatography separation of flavonoids.
PubMed:The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice.
PubMed:Preparation of a neutral porous monolith and its evaluation in pressurized capillary electrochromatography with neutral and charged solutes.
PubMed:Opioids in the hypothalamic paraventricular nucleus stimulate ethanol intake.
PubMed:Preparation and evaluation of the highly cross-linked poly(1-hexadecane-co-trimethylolpropane trimethacrylate) monolithic column for capillary electrochromatography.
PubMed:Opioids in the nucleus accumbens stimulate ethanol intake.
PubMed:Central cannabinoid signaling mediating food intake: a pharmacological-challenge magnetic resonance imaging and functional histology study in rat.
PubMed:Determination of tetracyclines in food samples by molecularly imprinted monolithic column coupling with high performance liquid chromatography.
PubMed:Fragrance material review on 1-methyl-4-(1-methylvinyl)cyclohexyl acetate.
PubMed:Fragrance material review on cyclohexyl acetate.
PubMed:Fragrance material review on 1-methyl-2-(1-methylpropyl) cyclohexyl acetate.
PubMed:Fragrance material review on dihydrocarveol (R,R,R).
PubMed:Fragrance material review on dihydrocarveol.
PubMed:Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor.
PubMed:The effects of antipsychotics on the density of cannabinoid receptors in the dorsal vagal complex of rats: implications for olanzapine-induced weight gain.
PubMed:Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J mice.
PubMed:PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats.
PubMed:Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents.
PubMed:Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward.
PubMed:Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21.
PubMed:Novel approach to the detection and quantification of phenolic compounds in olive oil based on 31P nuclear magnetic resonance spectroscopy.
PubMed:Analyses of phenolic compounds by microemulsion electrokinetic chromatography.
PubMed:Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus.
PubMed:Structure-function analysis of the vanillin molecule and its antifungal properties.
PubMed:Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat.
PubMed:Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys.
PubMed:Partial agonist-like profile of the cannabinoid receptor antagonist SR141716A in a food-reinforced operant paradigm.
PubMed:Behavioral effects of cannabinoids show differential sensitivity to cannabinoid receptor blockade and tolerance development.
PubMed:Cannabinoid agonist, CP 55,940, facilitates intake of palatable foods when injected into the hindbrain.
PubMed:In vivo studies on the metabolism of the monoterpene pulegone in humans using the metabolism of ingestion-correlated amounts (MICA) approach: explanation for the toxicity differences between (S)-(-)- and (R)-(+)-pulegone.
PubMed:Intrinsic activity estimation of cannabinoid CB1 receptor ligands in a drug discrimination paradigm.
PubMed:Chronic treatment with CP 55,940 during the peri-adolescent period differentially affects the behavioural responses of male and female rats in adulthood.
PubMed:Discriminative stimulus effects of BAY 38-7271, a novel cannabinoid receptor agonist.
PubMed:Delta opioid antagonist effects of buprenorphine in rhesus monkeys.
PubMed:Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys.
PubMed:Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP rats.
PubMed:Estimation of trace amounts of benzene in solvent-extracted vegetable oils and oil seed cakes.
PubMed:Effects of kappa opioids on cocaine self-administration by rhesus monkeys.
PubMed:Applications of High-Temperature Aqueous Media for Synthetic Organic Reactions.
PubMed:Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats.
PubMed:A specific and sensitive method for the determination of linamarin in Urine.
PubMed:The involvement of the sympathetic nervous system in meal-induced thermogenesis in mice.
PubMed:Isolation and characterization of an anaerobic dehydrodivanillin-degrading bacterium.
 
Notes:
None found
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2018 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy