EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
BT
 

ortho-cresyl salicylate
o-tolyl salicylate

Sponsors

Name: (2-methylphenyl) 2-hydroxybenzoate
CAS Number: 617-01-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 210-500-2
FDA UNII: MXU84PJ614
Nikkaji Web: J136.477D
XlogP3: 3.80 (est)
Molecular Weight: 228.24724000
Formula: C14 H12 O3
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 907 o-tolyl salicylate
Flavis Number: 09.807 (Old)
DG SANTE Food Flavourings: 09.807 o-tolyl salicylate
FEMA Number: 3734 o-tolyl salicylate
FDA Mainterm: O-TOLYL SALICYLATE
 
Physical Properties:
Appearance: colorless semi-solid to solid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 1.16400 to 1.17400 25.00 °C.
Pounds per Gallon - (est).: 9.686 to 9.769
Refractive Index: 1.57600 to 1.58400 @ 20.00 °C.
Melting Point: 25.00 °C. @ 760.00 mm Hg
Boiling Point: 180.00 °C. @ 2.00 mm Hg
Boiling Point: 378.00 to 379.00 °C. @ 760.00 mm Hg
Acid Value: 1.00 max. KOH/g
Flash Point: 324.00 °F. TCC ( 162.22 °C. )
logP (o/w): 3.688 (est)
Soluble in:
 alcohol
 water, 22.02 mg/L @ 25 °C (est)
Insoluble in:
 water
Similar Items: note
allyl salicylate
amyl salicylate
isoamyl salicylate
benzyl salicylate
bornyl salicylate
butyl salicylate
isobutyl salicylate
cinnamyl salicylate
para-cresyl salicylate
cyclohexyl salicylate
decyl salicylate
2-ethyl hexyl salicylate
ethyl salicylate
heptyl salicylate
(E)-2-hexen-1-yl salicylate
(Z)-3-hexen-1-yl salicylate
hexyl salicylate
menthyl salicylate
homomenthyl salicylate
2-methyl butyl salicylate
methyl salicylate
octyl salicylate
phenethyl salicylate
3-phenyl propyl salicylate
phenyl salicylate
prenyl salicylate
propyl salicylate
isopropyl salicylate
 
Organoleptic Properties:
Odor Type: herbal
Odor Strength: medium ,
recommend smelling in a 1.00 % solution or less
 herbal eucalyptus
Odor Description:
at 1.00 % in dipropylene glycol.
herbal eucalyptus
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Axsyn
For experimental / research use only.
Benzoic acid,2-hydroxy-, 2-methylphenyl ester
BOC Sciences
For experimental / research use only.
(2-methylphenyl) 2-hydroxybenzoate
Parchem
ortho-cresyl salicylate
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 [sex: M,F] 1.81 ml/kg
(Sterner & Chibanguza, 1983)

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for ortho-cresyl salicylate usage levels up to:
  0.1000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 28.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 30.00 (μg/capita/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 13
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -100.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -15.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of hydroxyl- and alkoxy-substituted benzyl derivatives used as flavor ingredients.View pdf
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23
View page or View pdf
Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87.
View page or View pdf
EPI System: View
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 61159
National Institute of Allergy and Infectious Diseases: Data
 (2-methylphenyl) 2-hydroxybenzoate
Chemidplus: 0000617016
 
References:
 (2-methylphenyl) 2-hydroxybenzoate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 617-01-6
Pubchem (cid): 61159
Pubchem (sid): 135018163
 
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
HMDB (The Human Metabolome Database): HMDB37667
FooDB: FDB016794
Export Tariff Code: 2918.23.0000
ChemSpider: View
 
Potential Blenders and core components note
For Odor
balsamic
amyl cinnamate
FL/FR
iso
amyl cinnamate
FL/FR
clover nitrile
FR
burnt
lepidine
FL/FR
citrus
beta-
bisabolol
FL/FR
citral dimethyl acetal
FL/FR
2-
heptanol
FL/FR
earthy
2-
octanone
FL/FR
floral
amyl anthranilate
FL/FR
amyl salicylate
FL/FR
iso
amyl salicylate
FL/FR
anisyl propanal / methyl anthranilate schiff's base
FR
iso
butyl salicylate
FL/FR
butyl tiglate
FR
coriander seed oil
FL/FR
coriander seed oil CO2 extract
FL/FR
cuminyl acetaldehyde
FL/FR
2,4-
dimethyl-3-cyclohexene-1-methanol
FR
ethyl 2-benzyl butyrate
FL/FR
2-
ethyl hexyl salicylate
FR
ethyl linalool
FR
ethyl linalyl acetal
FR
farnesyl acetate
FL/FR
gardenia absolute
FR
herbal pyran
FR
hydroxycitronellal diethyl acetal
FL/FR
beta-
ionol
FL/FR
(Z)-
jasmone
FL/FR
karo karounde absolute
FR
abrialis
lavandin oil
FL/FR
lavandula angustifolia flower oil
FL/FR
lavender oil france
FL/FR
lavender oil greece
FL/FR
ocean propanal / methyl anthranilate schiff's base
FR
(Z)-beta-
ocimene
FL/FR
phenyl acetaldehyde diisobutyl acetal
FL/FR
iso
phytol
FL/FR
prenyl salicylate
FL/FR
propyl salicylate
FR
rhodinyl formate
FL/FR
styralyl formate
FL/FR
terpinyl isobutyrate
FL/FR
tetrahydrolinalyl acetate
FR
fruity
benzyl methyl ether
FL/FR
dimethyl succinate
FL/FR
fruity butanate
FR
peach pivalate
FR
green
iso
amyl 3-(2-furan) propionate
FL/FR
iso
butyl benzyl carbinol
FL/FR
chrysanthemum oxide
FL/FR
decanal propylene glycol acetal
FL/FR
earthy acetal
FL/FR
flower hexene
FR
heptyl formate
FL/FR
(Z)-3-
hexen-1-yl benzoate
FL/FR
(E)-2-
hexen-1-yl butyrate
FL/FR
hexen-1-yl oxypropane nitrile
FR
hyacinth absolute
FL/FR
ivy carbaldehyde / methyl anthranilate schiff's base
FR
methyl cyclocitrone (IFF)
FR
4-
methyl-4-phenyl pentanone
FR
octyl oxyacetaldehyde
FR
phenyl acetaldehyde
FL/FR
phenyl acetaldehyde solution
FL/FR
iso
propyl salicylate
FR
herbal
bornyl salicylate
FR
cananga fruit oil
FR
carrot seed oil (daucus carota ssp. gummifer hook. fil.) spain
FR
chamomile isobutyrate
FR
chrysanthemum ketone
FR
clary sage absolute
FL/FR
coriander seed absolute
FL/FR
freesia heptanol
FL/FR
hexyl salicylate
FL/FR
lavender absolute bulgaria
FL/FR
lavender absolute france
FL/FR
lavender concrete
FL/FR
lavender oil terpeneless
FL/FR
lavender oil terpenes
FL/FR
lavender stem oil lithuania
FR
2-
methyl butyl salicylate
FL/FR
methyl cyclogeranate (Firmenich)
FR
methyl ortho-anisate
FL/FR
myrtle oil
FL/FR
rosmarinus officinalis extract
FL/FR
marine
marine hexane
FR
minty
methyl salicylate
FL/FR
naphthyl
ortho-
methyl anisole
FL/FR
spicy
carnation absolute
FR
woody
2-
decalinyl acetate
FR
zdravetz oil
FL/FR
For Flavor
No flavor group found for these
amyl anthranilate
FL/FR
decanal propylene glycol acetal
FL/FR
8,9-
dehydrotheaspirone
FL
earthy acetal
FL/FR
ethyl 2-benzyl butyrate
FL/FR
hyacinth absolute
FL/FR
lavender oil terpenes
FL/FR
2-
methyl butyl salicylate
FL/FR
methyl ortho-anisate
FL/FR
phenyl acetaldehyde solution
FL/FR
styralyl formate
FL/FR
terpinyl isobutyrate
FL/FR
zdravetz oil
FL/FR
iso
amyl 3-(2-furan) propionate
FL/FR
amber
amber
iso
butyl benzyl carbinol
FL/FR
aromatic
amyl salicylate
FL/FR
balsamic
amyl cinnamate
FL/FR
camphoreous
ortho-
methyl anisole
FL/FR
citrus
beta-
bisabolol
FL/FR
citral dimethyl acetal
FL/FR
freesia heptanol
FL/FR
cooling
iso
butyl salicylate
FL/FR
cucumber
2-
ethyl octine carbonate
FL
dairy
2-
octanone
FL/FR
fatty
heptyl formate
FL/FR
(Z)-3-
hexen-1-yl benzoate
FL/FR
floral
iso
amyl cinnamate
FL/FR
butyl 2-furoate
FL
farnesyl acetate
FL/FR
beta-
ionol
FL/FR
lepidine
FL/FR
fruity
benzyl methyl ether
FL/FR
dimethyl succinate
FL/FR
2-
heptanol
FL/FR
rhodinyl formate
FL/FR
green
iso
amyl salicylate
FL/FR
chrysanthemum oxide
FL/FR
clary sage absolute
FL/FR
cuminyl acetaldehyde
FL/FR
(E)-2-
hexen-1-yl butyrate
FL/FR
methyl 2-undecynoate
FL
(Z)-beta-
ocimene
FL/FR
phenyl acetaldehyde diisobutyl acetal
FL/FR
herbal
coriander seed absolute
FL/FR
coriander seed oil
FL/FR
coriander seed oil CO2 extract
FL/FR
hexyl salicylate
FL/FR
abrialis
lavandin oil
FL/FR
lavandula angustifolia flower oil
FL/FR
lavender absolute bulgaria
FL/FR
lavender absolute france
FL/FR
lavender concrete
FL/FR
lavender oil france
FL/FR
lavender oil greece
FL/FR
lavender oil terpeneless
FL/FR
prenyl salicylate
FL/FR
rosmarinus officinalis extract
FL/FR
honey
phenyl acetaldehyde
FL/FR
melon
hydroxycitronellal diethyl acetal
FL/FR
minty
methyl salicylate
FL/FR
oily
iso
phytol
FL/FR
spicy
myrtle oil
FL/FR
tea
black
tea leaf distillates
FL
woody
(Z)-
jasmone
FL/FR
 
Potential Uses:
 balsamFR
 herbalFR
 
Occurrence (nature, food, other): note
 not found in nature
 
Synonyms:
 benzoic acid, 2-hydroxy-, 2-methylphenyl ester
o-cresyl salicylate
 cresyl salicylate, o-
2-hydroxybenzoic acid 2-methyl phenyl ester
2-hydroxybenzoic acid 2-methylphenyl ester
2-methyl phenyl 2-hydroxybenzoate
(2-methyl phenyl) 2-hydroxybenzoate
2-methylphenyl 2-hydroxybenzoate
2-methylphenyl salicylate
(2-methylphenyl) 2-hydroxybenzoate
 salicylic acid o-tolyl ester
 salicylic acid ortho-tolyl ester
 salicylic acid, o-tolyl ester
o-tolyl salicylate
ortho-tolyl salicylate
 tolyl salicylate, o-
 
 
Notes:
Flavouring ingredient
 
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