2-acetoxy-1,8-cineole
1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-yl acetate
 
Notes:
None found
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1,3,3-trimethyl-2-oxabicyclo[2.2.2]oct-6-yl acetate (Click)
CAS Number: 72257-53-5Picture of molecule
ECHA EINECS - REACH Pre-Reg: 276-542-9
Nikkaji Web: J299.074A
XlogP3-AA: 1.80 (est)
Molecular Weight: 212.28900000
Formula: C12 H20 O3
NMR Predictor: Predict (works with chrome or firefox)
EFSA/JECFA Comments: Register name to be changed to (1R, 4S, 6S)-2-Oxabicyclo[2.2.2]octan-6-ol, 1,3,3-trimethyl-, 6-acetate. Register name to be changed to (1R, 4S, 6S)-2-Oxabicyclo[2.2.2]octan-6-ol, 1,3,3-trimethyl-, 6-acetate (EFFA, 2007b).
Category: flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
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Perfumer and Flavorist: Search
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Pubchem Patents: Search
PubMed: Search
NCBI: Search
Flavis Number: 03.008 (Old)
DG SANTE Food Flavourings: 03.008  2-acetoxy-1,8-cineole
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Physical Properties:
Appearance: colorless to pale yellow clear liquid to solid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 89.00 °C. @ 760.00 mm Hg
Boiling Point: 253.00 to  254.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 299.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.018000 mm/Hg @ 25.00 °C. (est)
Flash Point: > 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w): 2.261 (est)
Soluble in:
 alcohol
 water, 227.4 mg/L @ 25 °C (est)
Insoluble in:
 water
Similar Items: note
4,7,7-trimethyl-8-oxabicyclo[2.2.2]octane
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Organoleptic Properties:
Odor Type: herbal
Odor Strength: medium
 minty  clean  fresh  eucalyptus  
Odor Description:
at 100.00 %. 
minty clean fresh eucalyptus
 eucalyptus  
Taste Description:
eucalyptus
  
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Cosmetic Information:
None found
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Suppliers:
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
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Safety Information:
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavoring agents
Recommendation for 2-acetoxy-1,8-cineole usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.037 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 3500 (μg/person/day)
Threshold of Concern:540 (μg/person/day)
Structure Class: II
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 3.0000015.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 2.0000010.00000
Edible ices, including sherbet and sorbet (03.0): 3.0000015.00000
Processed fruit (04.1): 2.0000010.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 15.0000075.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 3.0000015.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): --
Ready-to-eat savouries (15.0): --
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
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Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 23 (FGE.23): Aliphatic, alicyclic and aromatic ethers including anisole derivatives From chemical groups 15, 16 and 26 (Commission Regulation (EC) No 1565/2000 of 18 July 2000
View page or View pdf
Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 23, Revision 2 (FGE.23Rev2): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 23, Revision 3 (FGE.23Rev3): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 23, Revision 4 (FGE.23Rev4): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30
View page or View pdf
EPI System: View
EPA Substance Registry Services (TSCA): 72257-53-5
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 175002
National Institute of Allergy and Infectious Diseases: Data
 1,3,3-trimethyl-2-oxabicyclo[2.2.2]oct-6-yl acetate
Chemidplus: 0072257535
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References:
 1,3,3-trimethyl-2-oxabicyclo[2.2.2]oct-6-yl acetate
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 175002
Pubchem (sid): 135153937
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
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Potential Blenders and core components note
 
For Odor
earthy
earthy
(-)-alpha-fencholFL/FR
floral
 lavender oilFL/FR
fruity
3-benzyl-4-heptanoneFL/FR
 cassyraneFL/FR
herbal
1,4-cineoleFL/FR
1,8-cineoleFL/FR
ortho-cresyl salicylateFL/FR
 eucalyptus absoluteFL/FR
 eucalyptus globulus leaf extractFL/FR
 eucalyptus globulus leaf tinctureFL/FR
 eucalyptus globulus leaf/twig oilFL/FR
 eucalyptus globulus oilFL/FR
 eucalyptus globulus oil burundiaFL/FR
 eucalyptus globulus oil pakistanFL/FR
 eucalyptus globulus oil rwandaFL/FR
 eucalyptus globulus oil zambiaFL/FR
 hyssop oilFL/FR
spike lavender oilFL/FR
spike lavender oil spainFL/FR
 melaleuca leucadendron cajaputi oilFL/FR
 melaleuca leucadendron var. cajuputi leaf oilFL/FR
para-menthane-3,8-diolFL/FR
beta-pineneFL/FR
 piperitoneFL/FR
 rosemary absoluteFL/FR
 rosemary oil africaFL/FR
 rosemary oil tunisiaFL/FR
 sabinene hydrateFL/FR
white thyme oilFL/FR
licorice
sweet basil oleoresinFL/FR
mentholic
 cornmint oilFL/FR
 cornmint oil indiaFL/FR
laevo-mentholFL/FR
laevo-menthyl acetateFL/FR
minty
 agathosma crenulata oilFL/FR
 betula lenta bark oil americaFL/FR
laevo-carvoneFL/FR
(+)-dihydrocarvoneFL/FR
homomenthyl acetateFL/FR
 pennyroyal herb oil americaFL/FR
 pennyroyal oil fractionsFL/FR
 tetrahydrocarvoneFL/FR
 elettaria cardamomum seed oilFL/FR
 elettaria cardamomum seed oil guatemalaFL/FR
 marjoram oil (thymus mastichina) spainFL/FR
 piper longum fruit oilFL/FR
 piper longum fruit oil CO2 extractFL/FR
thujonic
 sage oil (salvia lavandulifolia vahl.) spainFL/FR
 sage oil cubaFL/FR
 sage oil dalmatianFL/FR
 sage oil englandFL/FR
 sage oil franceFL/FR
 sage oil germanyFL/FR
 sage oil hydrodistillation franceFL/FR
 sage oil reunionFL/FR
 sage oil sardiniaFL/FR
woody
(+)-campheneFL/FR
 zedoary bark oilFL/FR
 
For Flavor
 
No flavor group found for these
4-butyl thiazoleFL
(+)-campheneFL/FR
ortho-cresyl salicylateFL/FR
(+)-dihydrocarvoneFL/FR
 melaleuca leucadendron cajaputi oilFL/FR
 melaleuca leucadendron var. cajuputi leaf oilFL/FR
para-menthane-3,8-diolFL/FR
 piper longum fruit oil CO2 extractFL/FR
 piperitenone oxideFL
 piperitoneFL/FR
buttery
 bovolideFL
camphoreous
(-)-alpha-fencholFL/FR
 rosemary oil tunisiaFL/FR
cooling
1,4-cineoleFL/FR
spike lavender oilFL/FR
laevo-mentholFL/FR
homomenthyl acetateFL/FR
 sabinene hydrateFL/FR
fruity
3-benzyl-4-heptanoneFL/FR
 cassyraneFL/FR
herbal
1,8-cineoleFL/FR
 eucalyptus absoluteFL/FR
 eucalyptus flavorFL
 eucalyptus globulus leaf extractFL/FR
 eucalyptus globulus leaf tinctureFL/FR
 eucalyptus globulus leaf/twig oilFL/FR
 eucalyptus globulus oilFL/FR
 eucalyptus globulus oil burundiaFL/FR
 eucalyptus globulus oil pakistanFL/FR
 eucalyptus globulus oil rwandaFL/FR
 eucalyptus globulus oil zambiaFL/FR
 hyssop oilFL/FR
 lavender oilFL/FR
spike lavender oil spainFL/FR
 rosemary absoluteFL/FR
 rosemary oil africaFL/FR
 sage oil (salvia lavandulifolia vahl.) spainFL/FR
white thyme oilFL/FR
licorice
sweet basil oleoresinFL/FR
mentholic
 cornmint oilFL/FR
minty
 agathosma crenulata oilFL/FR
 betula lenta bark oil americaFL/FR
laevo-carvoneFL/FR
 cornmint oil indiaFL/FR
laevo-menthyl acetateFL/FR
 pennyroyal herb oil americaFL/FR
 pennyroyal oil fractionsFL/FR
 tetrahydrocarvoneFL/FR
pine
beta-pineneFL/FR
spicy
 elettaria cardamomum seed oilFL/FR
 elettaria cardamomum seed oil guatemalaFL/FR
 marjoram oil (thymus mastichina) spainFL/FR
 piper longum fruit oilFL/FR
thujonic
 sage oil cubaFL/FR
 sage oil dalmatianFL/FR
 sage oil englandFL/FR
 sage oil franceFL/FR
 sage oil germanyFL/FR
 sage oil hydrodistillation franceFL/FR
 sage oil reunionFL/FR
 sage oil sardiniaFL/FR
woody
 zedoary bark oilFL/FR
 
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Potential Uses:
 berry mixedFL
 blackberryFL
 cascarillaFL/FR
 clean 
 cornmintFL/FR
 cuminFL/FR
 currant blackFL
 eucalyptusFL/FR
 fruit 
 gingerFL/FR
 herbalFL
 mintFL
 pea green pea 
 pennyroyalFL/FR
 peppermintFL
 spearmintFL
 tansy tanaisie 
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Occurrence (nature, food, other): note
 bay laurel
Search Trop  Picture
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Synonyms:
2-oxabicyclo(2.2.2)octan-6-ol, 1,3,3-trimethyl-, acetate
(1R, 4S, 6S)-2-oxabicyclo[2.2.2]octan-6-ol, 1,3,3-trimethyl-, 6-acetate
2-oxabicyclo[2.2.2]octan-6-ol, 1,3,3-trimethyl-, acetate
exo-2-hydroxycineole acetate
1,3,3-trimethyl-2-oxabicyclo(2.2.2)octan-6-ol acetate
1,3,3-trimethyl-2-oxabicyclo(2.2.2)octan-6-yl acetate
1,3,3-trimethyl-2-oxabicyclo[2.2.2]oct-6-yl acetate
1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ol acetate
1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-yl acetate
alpha,alpha,6-trimethyl-7-oxabicycloheptane-3-methanol acetate
(4,7,7-trimethyl-8-oxabicyclo[2.2.2]octan-5-yl) acetate
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