EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2-acetoxy-1,8-cineole
1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-yl acetate

Sponsors

Name:1,3,3-trimethyl-2-oxabicyclo[2.2.2]oct-6-yl acetate
CAS Number: 72257-53-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:276-542-9
Nikkaji Web:J299.074A
XlogP3-AA:1.80 (est)
Molecular Weight:212.28900000
Formula:C12 H20 O3
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
Register name to be changed to (1R, 4S, 6S)-2-Oxabicyclo[2.2.2]octan-6-ol, 1,3,3-trimethyl-, 6-acetate. Register name to be changed to (1R, 4S, 6S)-2-Oxabicyclo[2.2.2]octan-6-ol, 1,3,3-trimethyl-, 6-acetate (EFFA, 2007b).
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FLAVIS Number:03.008 (Old)
DG SANTE Food Flavourings:03.008 2-acetoxy-1,8-cineole
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid to solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 89.00 °C. @ 760.00 mm Hg
Boiling Point: 253.00 to 254.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 299.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.018000 mm/Hg @ 25.00 °C. (est)
Flash Point:> 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w): 2.261 (est)
Soluble in:
 alcohol
 water, 227.4 mg/L @ 25 °C (est)
Insoluble in:
 water
Similar Items:note
4,7,7-trimethyl-8-oxabicyclo[2.2.2]octane
 
Organoleptic Properties:
Odor Type: herbal
Odor Strength:medium
minty clean fresh eucalyptus
Odor Description:at 100.00 %. minty clean fresh eucalyptus
Flavor Type: herbal
">eucalyptus
Taste Description: eucalyptus
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for 2-acetoxy-1,8-cineole usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.037 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 3500 (μg/person/day)
Threshold of Concern:540 (μg/person/day)
Structure Class: II
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 3.0000015.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 2.0000010.00000
Edible ices, including sherbet and sorbet (03.0): 3.0000015.00000
Processed fruit (04.1): 2.0000010.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 15.0000075.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 3.0000015.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): --
Ready-to-eat savouries (15.0): --
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 23 (FGE.23): Aliphatic, alicyclic and aromatic ethers including anisole derivatives From chemical groups 15, 16 and 26 (Commission Regulation (EC) No 1565/2000 of 18 July 2000
View page or View pdf

Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 23, Revision 2 (FGE.23Rev2): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 23, Revision 3 (FGE.23Rev3): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 23, Revision 4 (FGE.23Rev4): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):72257-53-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :175002
National Institute of Allergy and Infectious Diseases:Data
1,3,3-trimethyl-2-oxabicyclo[2.2.2]oct-6-yl acetate
Chemidplus:0072257535
 
References:
 1,3,3-trimethyl-2-oxabicyclo[2.2.2]oct-6-yl acetate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):175002
Pubchem (sid):135153937
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
earthy
(-)-alpha-
fenchol
FL/FR
floral
lavender oil
FL/FR
fruity
3-
benzyl-4-heptanone
FL/FR
cassyrane
FL/FR
herbal
1,8-
cineole
FL/FR
1,4-
cineole
FL/FR
ortho-
cresyl salicylate
FL/FR
eucalyptus absolute
FL/FR
eucalyptus globulus leaf extract
FL/FR
eucalyptus globulus leaf tincture
FL/FR
eucalyptus globulus leaf/twig oil
FL/FR
eucalyptus globulus oil
FL/FR
eucalyptus globulus oil burundia
FL/FR
eucalyptus globulus oil pakistan
FL/FR
eucalyptus globulus oil rwanda
FL/FR
eucalyptus globulus oil zambia
FL/FR
hyssop oil
FL/FR
spike
lavender oil
FL/FR
spike
lavender oil spain
FL/FR
melaleuca leucadendron cajaputi oil
FL/FR
melaleuca leucadendron var. cajuputi leaf oil
FL/FR
para-
menthane-3,8-diol
FL/FR
beta-
pinene
FL/FR
piperitone
FL/FR
rosemary absolute
FL/FR
rosemary oil africa
FL/FR
rosemary oil tunisia
FL/FR
sabinene hydrate
FL/FR
white
thyme oil
FL/FR
licorice
sweet
basil oleoresin
FL/FR
mentholic
cornmint oil
FL/FR
cornmint oil india
FL/FR
laevo-
menthol
FL/FR
laevo-
menthyl acetate
FL/FR
minty
agathosma crenulata leaf oil
FL/FR
betula lenta bark oil america
FL/FR
laevo-
carvone
FL/FR
(+)-
dihydrocarvone
FL/FR
homo
menthyl acetate
FL/FR
pennyroyal herb oil america
FL/FR
pennyroyal oil fractions
FL/FR
tetrahydrocarvone
FL/FR
spicy
elettaria cardamomum seed oil
FL/FR
elettaria cardamomum seed oil guatemala
FL/FR
marjoram oil (thymus mastichina) spain
FL/FR
piper longum fruit oil
FL/FR
piper longum fruit oil CO2 extract
FL/FR
thujonic
sage oil (salvia lavandulifolia vahl.) spain
FL/FR
sage oil cuba
FL/FR
sage oil dalmatian
FL/FR
sage oil england
FL/FR
sage oil france
FL/FR
sage oil germany
FL/FR
sage oil hydrodistillation france
FL/FR
sage oil reunion
FL/FR
sage oil sardinia
FL/FR
woody
(+)-
camphene
FL/FR
zedoary bark oil
FL/FR
For Flavor
No flavor group found for these
4-
butyl thiazole
FL
(+)-
camphene
FL/FR
ortho-
cresyl salicylate
FL/FR
(+)-
dihydrocarvone
FL/FR
melaleuca leucadendron cajaputi oil
FL/FR
melaleuca leucadendron var. cajuputi leaf oil
FL/FR
para-
menthane-3,8-diol
FL/FR
piper longum fruit oil CO2 extract
FL/FR
piperitenone oxide
FL
buttery
buttery
bovolide
FL
camphoreous
(-)-alpha-
fenchol
FL/FR
rosemary oil tunisia
FL/FR
cooling
1,4-
cineole
FL/FR
spike
lavender oil
FL/FR
laevo-
menthol
FL/FR
homo
menthyl acetate
FL/FR
sabinene hydrate
FL/FR
fruity
3-
benzyl-4-heptanone
FL/FR
cassyrane
FL/FR
herbal
eucalyptus absolute
FL/FR
eucalyptus flavor
FL
eucalyptus globulus leaf extract
FL/FR
eucalyptus globulus leaf tincture
FL/FR
eucalyptus globulus leaf/twig oil
FL/FR
eucalyptus globulus oil
FL/FR
eucalyptus globulus oil burundia
FL/FR
eucalyptus globulus oil pakistan
FL/FR
eucalyptus globulus oil rwanda
FL/FR
eucalyptus globulus oil zambia
FL/FR
hyssop oil
FL/FR
lavender oil
FL/FR
spike
lavender oil spain
FL/FR
rosemary absolute
FL/FR
rosemary oil africa
FL/FR
sage oil (salvia lavandulifolia vahl.) spain
FL/FR
white
thyme oil
FL/FR
licorice
sweet
basil oleoresin
FL/FR
mentholic
cornmint oil
FL/FR
minty
agathosma crenulata leaf oil
FL/FR
betula lenta bark oil america
FL/FR
laevo-
carvone
FL/FR
1,8-
cineole
FL/FR
cornmint oil india
FL/FR
laevo-
menthyl acetate
FL/FR
pennyroyal herb oil america
FL/FR
pennyroyal oil fractions
FL/FR
piperitone
FL/FR
tetrahydrocarvone
FL/FR
pine
beta-
pinene
FL/FR
spicy
elettaria cardamomum seed oil
FL/FR
elettaria cardamomum seed oil guatemala
FL/FR
marjoram oil (thymus mastichina) spain
FL/FR
piper longum fruit oil
FL/FR
thujonic
sage oil cuba
FL/FR
sage oil dalmatian
FL/FR
sage oil england
FL/FR
sage oil france
FL/FR
sage oil germany
FL/FR
sage oil hydrodistillation france
FL/FR
sage oil reunion
FL/FR
sage oil sardinia
FL/FR
woody
zedoary bark oil
FL/FR
 
Potential Uses:
FLberry mixed berry
FLblackberry
 clean
FL/FRcornmint
FL/FRcroton eluteria bark
FRcumin oil replacer
FLcurrant black currant
FReucalyptus oil replacer
 fruit
FRginger root oil replacer
FLherbal
FLmint
 pea green pea
FL/FRpennyroyal
FLpeppermint
FLspearmint
FL/FRtansy oil replacer
 
Occurrence (nature, food, other):note
 bay laurel
Search Trop Picture
 
Synonyms:
2-oxabicyclo(2.2.2)octan-6-ol, 1,3,3-trimethyl-, acetate
(1R, 4S, 6S)-2-oxabicyclo[2.2.2]octan-6-ol, 1,3,3-trimethyl-, 6-acetate
2-oxabicyclo[2.2.2]octan-6-ol, 1,3,3-trimethyl-, acetate
exo-2-hydroxycineole acetate
1,3,3-trimethyl-2-oxabicyclo(2.2.2)octan-6-ol acetate
1,3,3-trimethyl-2-oxabicyclo(2.2.2)octan-6-yl acetate
1,3,3-trimethyl-2-oxabicyclo[2.2.2]oct-6-yl acetate
1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ol acetate
1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-yl acetate
alpha,alpha,6-trimethyl-7-oxabicycloheptane-3-methanol acetate
(4,7,7-trimethyl-8-oxabicyclo[2.2.2]octan-5-yl) acetate
 
 
Notes:
None found
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