EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

phenoxyacetic acid
2-(phenoxy)acetic acid

Sponsors

Name:2-(phenoxy)acetic acid
CAS Number: 122-59-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-556-7
FDA UNII:YRC253429Q
Nikkaji Web:J5.358I
Beilstein Number:0907949
MDL:MFCD00004296
CoE Number:2005
XlogP3:1.30 (est)
Molecular Weight:152.14936000
Formula:C8 H8 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1026 phenoxyacetic acid
FLAVIS Number:08.049 (Old)
DG SANTE Food Flavourings:08.049 phenoxyacetic acid
FEMA Number:2872 phenoxyacetic acid
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: PHENOXYACETIC ACID
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance:colorless crystals (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 99.00 to 103.00 °C. @ 760.00 mm Hg
Boiling Point: 285.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.001000 mm/Hg @ 25.00 °C. (est)
Flash Point: 239.00 °F. TCC ( 115.00 °C. )
logP (o/w): 1.340
Soluble in:
 alcohol
 water, 12000 mg/L @ 10 °C (exp)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: honey
Odor Strength:high ,
recommend smelling in a 1.00 % solution or less
sour sweet
Odor Description:at 1.00 % in propylene glycol. sour sweet
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
Beijing Lys Chemicals
Phenoxyacetic acid
BOC Sciences
For experimental / research use only.
Phenoxyacetic Acid
Penta International
PHENOXYACETIC ACID, Kosher
Santa Cruz Biotechnology
For experimental / research use only.
Phenoxyacetic Acid
Sigma-Aldrich: Aldrich
For experimental / research use only.
Phenoxyacetic acid 98%
TCI AMERICA
For experimental / research use only.
Phenoxyacetic Acid >98.0%(GC)(T)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
2 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 1500 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 94, 1990.

intravenous-mouse LD50 1000 mg/kg
Pharmazie. Vol. 18, Pg. 642, 1963.

oral-mouse LD50 3750 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(1), Pg. 25, 1981.

oral-rabbit LD50 > 200 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 887, 1979.

intraperitoneal-rat LD50 323 mg/kg
Travaux de la Societe de Pharmacie de Montpellier. Vol. 34, Pg. 121, 1974.

unreported-guinea pig LD50 1400 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(1), Pg. 25, 1981.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 887, 1979.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for phenoxyacetic acid usage levels up to:
  0.2000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 30.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.10 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -2.20000
beverages(nonalcoholic): -0.37000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -1.00000
fruit ices: -1.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -2.20000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 23 (FGE.23): Aliphatic, alicyclic and aromatic ethers including anisole derivatives From chemical groups 15, 16 and 26 (Commission Regulation (EC) No 1565/2000 of 18 July 2000
View page or View pdf

Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 53 (FGE.53): Consideration of phenethyl alcohol, aldehyde, acid and related acetals and esters evaluated by JECFA (59th meeting) structurally related to phenethyl alcohol, aldehyde, esters and related phenylacetic acid esters evaluated by EFSA in FGE.14 (2005) and one phenoxyethyl ester evaluated in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 53, Revision 1 (FGE.53Rev1): Consideration of phenethyl alcohol, aldehyde, acid and related acetals and esters evaluated by JECFA (59th meeting) FGE.23Rev1 (2008)
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):122-59-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :19188
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(phenoxy)acetic acid
Chemidplus:0000122598
EPA/NOAA CAMEO:hazardous materials
RTECS:AJ2230000 for cas# 122-59-8
 
References:
 2-(phenoxy)acetic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:122-59-8
Pubchem (cid):19188
Pubchem (sid):134973890
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
KEGG (GenomeNet):C02181
HMDB (The Human Metabolome Database):HMDB31609
FooDB:FDB008245
Export Tariff Code:2918.17.0000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
arnica montana flower extract
FL/FR
acidic
acidic
iso
butyric acid
FL/FR
cyclohexyl acetic acid
FL/FR
2-
ethyl butyric acid
FL/FR
2-
methyl-2-pentenoic acid
FL/FR
aldehydic
citronellyl oxyacetaldehyde
FL/FR
animal
para-
cresyl phenyl acetate
FL/FR
1,2,3,4-
tetrahydroquinoline
FR
anisic
para-
anisyl phenyl acetate
FL/FR
balsamic
iso
bornyl phenyl acetate
FL/FR
guaiacyl phenyl acetate
FL/FR
2-
phenyl propyl alcohol
FL/FR
terpinyl butyrate
FL/FR
valerian rhizome absolute
FL/FR
caramellic
immortelle absolute
FL/FR
cereal
bran absolute
FR
cheesy
heptanoic acid
FL/FR
2-
methyl valeric acid
FL/FR
valeric acid
FL/FR
iso
valeric acid
FL/FR
chocolate
iso
amyl phenyl acetate
FL/FR
cocoa pentenal
FL/FR
tetrahydrofurfuryl phenyl acetate
FL/FR
estery
diisopropyl adipate
CS
ethereal
iso
valeraldehyde propylene glycol acetal
FL/FR
fatty
decanoic acid
FL/FR
hexanoic acid
FL/FR
methyl (E)-2-hexenoate
FL/FR
floral
cardamom absolute
FL/FR
citronellyl isovalerate
FL/FR
citronellyl phenyl acetate
FL/FR
citronellyl valerate
FL/FR
cyclohexyl phenyl acetate
FR
decyl formate
FR
ethyl hydrocinnamate
FL/FR
ethyl phenyl acetate
FL/FR
genet concrete
FR
geranyl anthranilate
FR
geranyl phenyl acetate
FL/FR
honeysuckle absolute
FR
hyacinth acetals
FL/FR
kewda oil
CS
linalyl phenyl acetate
FL/FR
ortho-
methyl acetophenone
FL/FR
neryl isovalerate
FL/FR
octyl isovalerate
FL/FR
bitter
orangeflower absolute morocco
FL/FR
phenethyl acetate
FL/FR
phenethyl anthranilate
FL/FR
phenethyl benzoate
FL/FR
phenethyl hexanoate
FL/FR
phenethyl phenyl acetate
FL/FR
phenethyl propionate
FL/FR
phenyl glycol diacetate
FR
3-
phenyl propyl formate
FL/FR
(E)-2-
phenyl-1(2)-propene-1-yl acetate
FR
iso
propyl anthranilate
FL/FR
iso
propyl phenyl acetate
FL/FR
rhodinyl phenyl acetate
FL/FR
rose absolute (rosa centifolia) morocco
FL/FR
rose carboxylate
FR
rose concrete (rosa centifolia)
FR
tuberose absolute (from concrete)
FL/FR
tuberose absolute (from pommade)
FL/FR
wallflower absolute
FR
fruity
allyl phenoxyacetate
FL/FR
sour
cherry essence
FL/FR
sour
cherry fragrance
FR
(Z)-beta-
damascone
FL/FR
beta-
damascone
FL/FR
(E)-beta-
damascone
FL/FR
(Z)-3-
octen-1-yl propionate
FL/FR
osmanthus flower absolute
FL/FR
strawberry glycidate 1 (aldehyde C-16 (so-called))
FL/FR
strawberry glycidate 2
FL/FR
green
iso
amyl 3-(2-furan) propionate
FL/FR
(E)-2-
hexen-1-yl phenyl acetate
FL/FR
4-
methyl-4-phenyl pentanone
FR
(Z,Z)-3,6-
nonadien-1-ol
FL/FR
phenyl acetaldehyde
FL/FR
hay
beeswax absolute
FL/FR
herbal
artemisyl ketone
FL/FR
american
elder flower absolute
FR
matricaria chamomilla flower oil
FL/FR
honey
allyl phenyl acetate
FL/FR
butyl phenyl acetate
FL/FR
methyl hydrocinnamate
FL/FR
methyl phenyl acetate
FL/FR
phenethyl furoate
FL/FR
phenyl acetic acid
FL/FR
phenyl pyruvic acid
FL/FR
propyl phenyl acetate
FL/FR
meaty
4-
methyl nonanoic acid
FL/FR
melon
(Z)-6-
nonen-1-ol
FL/FR
musty
cocoa butenal
FL/FR
spicy
carnation absolute
FR
clove bud concrete
FR
eugenyl phenyl acetate
FL/FR
iso
eugenyl phenyl acetate
FL/FR
sulfurous
ethyl 3-mercaptobutyrate
FL/FR
thujonic
cistus cyclohexanone
FL/FR
waxy
dihydrocitronellyl acetate
FL/FR
1-
dodecanol
FL/FR
methyl butyl phenyl acetate
FL/FR
waxy acetate
FR
woody
santalyl phenyl acetate
FL/FR
(±)-
tetrahydronootkatone
FL/FR
For Flavor
No flavor group found for these
1-
acetyl cyclohexyl acetate
FL
arnica montana flower extract
FL/FR
artemisyl ketone
FL/FR
iso
bornyl phenyl acetate
FL/FR
cistus cyclohexanone
FL/FR
citronellyl isovalerate
FL/FR
citronellyl valerate
FL/FR
dihydrocitronellyl acetate
FL/FR
ethyl 3-mercaptobutyrate
FL/FR
ethyl hydrocinnamate
FL/FR
eugenyl phenyl acetate
FL/FR
fig leaf absolute
FL
(E)-2-
hexen-1-yl phenyl acetate
FL/FR
2-
hexyl acetate
FL
3-
hydroxypyruvic acid
FL
linalyl phenyl acetate
FL/FR
methyl (E)-2-hexenoate
FL/FR
methyl hydrocinnamate
FL/FR
octyl isovalerate
FL/FR
osmanthus flower absolute
FL/FR
phenethyl furoate
FL/FR
3-
phenyl propyl formate
FL/FR
iso
propyl anthranilate
FL/FR
santalyl phenyl acetate
FL/FR
terpinyl butyrate
FL/FR
tetrahydrofurfuryl phenyl acetate
FL/FR
(±)-
tetrahydronootkatone
FL/FR
thiamine hydrochloride
FL
iso
amyl 3-(2-furan) propionate
FL/FR
beta-
damascone
FL/FR
acidic
acidic
iso
butyric acid
FL/FR
2-
ethyl butyric acid
FL/FR
valeric acid
FL/FR
anisic
para-
anisyl phenyl acetate
FL/FR
ortho-
methyl acetophenone
FL/FR
aromatic
hyacinth acetals
FL/FR
berry
prunus spinosa extract
FL
brown
beeswax absolute
FL/FR
buttery
2-
methyl valeric acid
FL/FR
caramellic
pyruvic acid
FL
cheesy
(E)-2,4-
dimethyl-2-pentenoic acid
FL
hexanoic acid
FL/FR
iso
valeric acid
FL/FR
citrus
citronellyl oxyacetaldehyde
FL/FR
fatty
4-
methyl nonanoic acid
FL/FR
(E)-2-
octenoic acid
FL
floral
iso
amyl phenyl acetate
FL/FR
cardamom absolute
FL/FR
citronellyl phenyl acetate
FL/FR
cocoa pentenal
FL/FR
geranyl phenyl acetate
FL/FR
methyl phenyl acetate
FL/FR
bitter
orangeflower absolute morocco
FL/FR
phenethyl anthranilate
FL/FR
phenethyl benzoate
FL/FR
phenethyl propionate
FL/FR
phenyl acetic acid
FL/FR
rose absolute (rosa centifolia) morocco
FL/FR
tuberose absolute (from concrete)
FL/FR
tuberose absolute (from pommade)
FL/FR
fruity
allyl phenoxyacetate
FL/FR
sour
cherry essence
FL/FR
(E)-beta-
damascone
FL/FR
(Z)-beta-
damascone
FL/FR
neryl isovalerate
FL/FR
(Z)-3-
octen-1-yl propionate
FL/FR
strawberry glycidate 1 (aldehyde C-16 (so-called))
FL/FR
strawberry glycidate 2
FL/FR
tamarindus indica extract
FL
iso
valeraldehyde propylene glycol acetal
FL/FR
valerian rhizome absolute
FL/FR
green
cocoa butenal
FL/FR
(E)-3-
hexenoic acid
FL
immortelle absolute
FL/FR
2-
phenyl propyl alcohol
FL/FR
herbal
matricaria chamomilla flower oil
FL/FR
honey
allyl phenyl acetate
FL/FR
butyl phenyl acetate
FL/FR
ethyl phenyl acetate
FL/FR
phenethyl acetate
FL/FR
phenethyl phenyl acetate
FL/FR
phenyl acetaldehyde
FL/FR
iso
propyl phenyl acetate
FL/FR
propyl phenyl acetate
FL/FR
leafy
methyl butyl phenyl acetate
FL/FR
phenolic
para-
cresyl phenyl acetate
FL/FR
guaiacyl phenyl acetate
FL/FR
phenyl pyruvic acid
FL/FR
soapy
decanoic acid
FL/FR
1-
dodecanol
FL/FR
sour
acetic acid
FL
2,4-
dimethyl-2-pentenoic acid
FL
2-
methyl-2-pentenoic acid
FL/FR
spicy
iso
eugenyl phenyl acetate
FL/FR
sweet
cyclohexyl acetic acid
FL/FR
waxy
heptanoic acid
FL/FR
(Z,Z)-3,6-
nonadien-1-ol
FL/FR
(Z)-6-
nonen-1-ol
FL/FR
phenethyl hexanoate
FL/FR
rhodinyl phenyl acetate
FL/FR
 
Potential Uses:
 chocolate cocoa
 
Occurrence (nature, food, other):note
 cocoa bean
Search Trop Picture
 
Synonyms:
 acetic acid, 2-phenoxy-
 acetic acid, phenoxy-
 glycol acid phenyl ether
 glycolic acid phenyl ether
 glycollic acid phenyl ether
 phenoxacetic acid
 phenoxy acetic acid
 phenoxy-acetic acid
2-(phenoxy)acetic acid
2-phenoxyacetic acid
 phenoxyaceticacid
 phenoxyethanoic acid
o-phenyl glycolic acid
ortho-phenyl glycolic acid
o-phenylglycolic acid
 

Articles:

PubMed:Exposure of German residents to ethylene and propylene glycol ethers in general and after cleaning scenarios.
PubMed:Synthesis and insect antifeedant activity of aurones against Spodoptera litura larvae.
PubMed:Studies on water transport through the sweet cherry fruit surface. 11. FeCl3 decreases water permeability of polar pathways.
PubMed:The comparative toxicology of 4-chloro-2-methylphenoxyacetic acid and its plant metabolite 4-chloro-2-carboxyphenoxyacetic acid in rats.
PubMed:Development of an enzyme-linked immunosorbent assay for the pyrethroid cypermethrin.
PubMed:Enzyme-linked immunosorbent assay for the pyrethroid deltamethrin.
PubMed:Synthesis of haptens and protein conjugates for the development of immunoassays for the insect growth regulator fenoxycarb.
PubMed:Phenoxyacetic acid residue incorporation in cell walls of soybean (Glycine max.).
PubMed:Percutaneous penetration of 2-phenoxyethanol through rat and human skin.
 
Notes:
Flavouring ingredient. Present in cocoa beans
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2018 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy