phenoxyacetic acid
2-(phenoxy)acetic acid
 
Notes:
Flavouring ingredient. Present in cocoa beans
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
      Email: Mr. Jia
      Email: Mr. Guo
      Voice: 86-10-68418738
      Fax: 86-10-68418739
      Mr. Guo86-10-68483445
      Mr. Guo86-10-68418739
      News
      Product(s):
      10560 Phenoxyacetic acid
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      Product(s):
      16-18500 PHENOXYACETIC ACID, Kosher
       
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2-(phenoxy)acetic acid (Click)
CAS Number: 122-59-8Picture of molecule
ECHA EINECS - REACH Pre-Reg: 204-556-7
FDA UNII: YRC253429Q
Nikkaji Web: J5.358I
Beilstein Number: 0907949
MDL: MFCD00004296
CoE Number: 2005
XlogP3: 1.30 (est)
Molecular Weight: 152.14936000
Formula: C8 H8 O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 1026  phenoxyacetic acid
Flavis Number: 08.049 (Old)
DG SANTE Food Flavourings: 08.049  phenoxyacetic acid
FEMA Number: 2872  phenoxyacetic acid
FDA Mainterm: PHENOXYACETIC ACID
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
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Physical Properties:
Appearance: colorless crystals (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 99.00 to  103.00 °C. @ 760.00 mm Hg
Boiling Point: 285.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.001000 mm/Hg @ 25.00 °C. (est)
Flash Point: 239.00 °F. TCC ( 115.00 °C. )
logP (o/w): 1.340
Soluble in:
 alcohol
 water, 12000 mg/L @ 10 °C (exp)
Insoluble in:
 water
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Organoleptic Properties:
Odor Type: honey
Odor Strength: high ,
recommend smelling in a 1.00 % solution or less
 sour  sweet  
Odor Description:
at 1.00 % in propylene glycol. 
sour sweet
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
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Suppliers:
Beijing Lys Chemicals
Phenoxyacetic acid
Penta International
PHENOXYACETIC ACID, Kosher
Santa Cruz Biotechnology
For experimental / research use only.
Phenoxyacetic Acid
Sigma-Aldrich: Aldrich
For experimental / research use only.
Phenoxyacetic acid 98%
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
2 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50  1500 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 94, 1990.

intravenous-mouse LD50  1000 mg/kg
Pharmazie. Vol. 18, Pg. 642, 1963.

oral-mouse LD50  3750 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(1), Pg. 25, 1981.

oral-rabbit LD50  > 200 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 887, 1979.

intraperitoneal-rat LD50  323 mg/kg
Travaux de la Societe de Pharmacie de Montpellier. Vol. 34, Pg. 121, 1974.

unreported-guinea pig LD50  1400 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(1), Pg. 25, 1981.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 887, 1979.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavoring agents
Recommendation for phenoxyacetic acid usage levels up to:
  0.2000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 30.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.10 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -2.20000
beverages(nonalcoholic): -0.37000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -1.00000
fruit ices: -1.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -2.20000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of phenethyl alcohol, aldehydes, acids, and related acetals and esters used as flavor ingredients.View pdf
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 23 (FGE.23): Aliphatic, alicyclic and aromatic ethers including anisole derivatives From chemical groups 15, 16 and 26 (Commission Regulation (EC) No 1565/2000 of 18 July 2000
View page or View pdf
Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 53 (FGE.53): Consideration of phenethyl alcohol, aldehyde, acid and related acetals and esters evaluated by JECFA (59th meeting) structurally related to phenethyl alcohol, aldehyde, esters and related phenylacetic acid esters evaluated by EFSA in FGE.14 (2005) and one phenoxyethyl ester evaluated in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Flavouring Group Evaluation 53, Revision 1 (FGE.53Rev1): Consideration of phenethyl alcohol, aldehyde, acid and related acetals and esters evaluated by JECFA (59th meeting) FGE.23Rev1 (2008)
View page or View pdf
EPI System: View
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 122-59-8
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 19188
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 2-(phenoxy)acetic acid
Chemidplus: 0000122598
EPA/NOAA CAMEO: hazardous materials
RTECS: AJ2230000 for cas# 122-59-8
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References:
 2-(phenoxy)acetic acid
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 122-59-8
Pubchem (cid): 19188
Pubchem (sid): 134973890
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
CHEMBL: View
Metabolomics Database: Search
KEGG (GenomeNet): C02181
HMDB (The Human Metabolome Database): HMDB31609
FooDB: FDB008245
Export Tariff Code: 2918.17.0000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
 
For Odor
acidic
isobutyric acidFL/FR
 cyclohexyl acetic acidFL/FR
2-ethyl butyric acidFL/FR
aldehydic
 citronellyl oxyacetaldehydeFL/FR
animal
para-cresyl phenyl acetateFL/FR
1,2,3,4-tetrahydroquinolineFR
anisic
para-anisyl phenyl acetateFL/FR
balsamic
 guaiacyl phenyl acetateFL/FR
2-phenyl propyl alcoholFL/FR
 terpinyl butyrateFL/FR
 valerian rhizome absoluteFL/FR
caramellic
 immortelle absoluteFL/FR
cereal
 bran absoluteFR
cheesy
 heptanoic acidFL/FR
2-methyl valeric acidFL/FR
isovaleric acidFL/FR
chocolate
isoamyl phenyl acetateFL/FR
 cocoa pentenalFL/FR
ethereal
isovaleraldehyde propylene glycol acetalFL/FR
fatty
 decanoic acidFL/FR
 hexanoic acidFL/FR
 methyl (E)-2-hexenoateFL/FR
 cardamom absoluteFL/FR
 citronellyl isovalerateFL/FR
 citronellyl phenyl acetateFL/FR
 citronellyl valerateFL/FR
 cyclohexyl phenyl acetateFR
 decyl formateFR
 ethyl hydrocinnamateFL/FR
 ethyl phenyl acetateFL/FR
 genet concreteFR
 geranyl anthranilateFR
 geranyl phenyl acetateFL/FR
 honeysuckle absoluteFR
 hyacinth acetalsFL/FR
 kewda absolute 
 linalyl phenyl acetateFL/FR
ortho-methyl acetophenoneFL/FR
 octyl isovalerateFL/FR
bitter orangeflower absolute moroccoFL/FR
 phenethyl acetateFL/FR
 phenethyl anthranilateFL/FR
 phenethyl benzoateFL/FR
 phenethyl hexanoateFL/FR
 phenethyl phenyl acetateFL/FR
 phenethyl propionateFL/FR
 phenyl glycol diacetateFR
3-phenyl propyl formateFL/FR
(E)-2-phenyl-1(2)-propene-1-yl acetateFR
isopropyl anthranilateFL/FR
isopropyl phenyl acetateFL/FR
 rhodinyl phenyl acetateFL/FR
 rose absolute (rosa centifolia) moroccoFL/FR
 rose carboxylateFR
 rose concrete (rosa centifolia)FR
 tuberose absolute (from concrete)FL/FR
 tuberose absolute (from pommade)FL/FR
 wallflower absoluteFR
fruity
 allyl phenoxyacetateFL/FR
beta-damasconeFL/FR
(E)-beta-damasconeFL/FR
(Z)-beta-damasconeFL/FR
(Z)-3-octen-1-yl propionateFL/FR
 osmanthus flower absoluteFL/FR
 strawberry glycidate 1 (aldehyde C-16 (so-called))FL/FR
 strawberry glycidate 2FL/FR
green
isoamyl 3-(2-furan) propionateFL/FR
(E)-2-hexen-1-yl phenyl acetateFL/FR
4-methyl-4-phenyl pentanoneFR
(Z,Z)-3,6-nonadien-1-olFL/FR
 phenyl acetaldehydeFL/FR
hay
 beeswax absoluteFL/FR
herbal
 artemisyl ketoneFL/FR
american elder flower absoluteFR
 matricaria chamomilla flower oilFL/FR
honey
 allyl phenyl acetateFL/FR
 butyl phenyl acetateFL/FR
 methyl hydrocinnamateFL/FR
 methyl phenyl acetateFL/FR
 phenethyl furoateFL/FR
 phenyl acetic acidFL/FR
 phenyl pyruvic acidFL/FR
 propyl phenyl acetateFL/FR
melon
(Z)-6-nonen-1-olFL/FR
musty
 cocoa butenalFL/FR
spicy
 carnation absoluteFR
 clove bud concreteFR
 eugenyl phenyl acetateFL/FR
isoeugenyl phenyl acetateFL/FR
sulfurous
 ethyl 3-mercaptobutyrateFL/FR
thujonic
 cistus cyclohexanoneFL/FR
waxy
 dihydrocitronellyl acetateFL/FR
1-dodecanolFL/FR
 methyl butyl phenyl acetateFL/FR
 waxy acetateFR
woody
 santalyl phenyl acetateFL/FR
 
For Flavor
 
No flavor group found for these
1-acetyl cyclohexyl acetateFL
para-anisyl phenyl acetateFL/FR
 artemisyl ketoneFL/FR
isobutyric acidFL/FR
 cistus cyclohexanoneFL/FR
 citronellyl isovalerateFL/FR
 citronellyl phenyl acetateFL/FR
 citronellyl valerateFL/FR
(Z)-beta-damasconeFL/FR
 dihydrocitronellyl acetateFL/FR
 ethyl 3-mercaptobutyrateFL/FR
 ethyl hydrocinnamateFL/FR
 eugenyl phenyl acetateFL/FR
 fig leaf absoluteFL
(E)-2-hexen-1-yl phenyl acetateFL/FR
 kewda absolute 
 linalyl phenyl acetateFL/FR
 methyl (E)-2-hexenoateFL/FR
ortho-methyl acetophenoneFL/FR
 methyl hydrocinnamateFL/FR
 octyl isovalerateFL/FR
 osmanthus flower absoluteFL/FR
 phenethyl anthranilateFL/FR
 phenethyl benzoateFL/FR
 phenethyl furoateFL/FR
2-phenyl propyl alcoholFL/FR
3-phenyl propyl formateFL/FR
isopropyl anthranilateFL/FR
 pyridineFL
 santalyl phenyl acetateFL/FR
 terpinyl butyrateFL/FR
 thiamine hydrochlorideFL
acidic
2-ethyl butyric acidFL/FR
aromatic
para-cresyl phenyl acetateFL/FR
 hyacinth acetalsFL/FR
brown
 beeswax absoluteFL/FR
buttery
2-methyl valeric acidFL/FR
caramellic
 pyruvic acidFL
cheesy
 hexanoic acidFL/FR
isovaleric acidFL/FR
citrus
 citronellyl oxyacetaldehydeFL/FR
fatty
(E)-2-octenoic acidFL
floral
isoamyl phenyl acetateFL/FR
 cardamom absoluteFL/FR
 cocoa pentenalFL/FR
 geranyl phenyl acetateFL/FR
 methyl phenyl acetateFL/FR
bitter orangeflower absolute moroccoFL/FR
 phenyl acetic acidFL/FR
 rose absolute (rosa centifolia) moroccoFL/FR
 tuberose absolute (from concrete)FL/FR
 tuberose absolute (from pommade)FL/FR
fruity
 allyl phenoxyacetateFL/FR
(Z)-3-octen-1-yl propionateFL/FR
 phenethyl propionateFL/FR
 strawberry glycidate 1 (aldehyde C-16 (so-called))FL/FR
 strawberry glycidate 2FL/FR
isovaleraldehyde propylene glycol acetalFL/FR
 valerian rhizome absoluteFL/FR
green
isoamyl 3-(2-furan) propionateFL/FR
 cocoa butenalFL/FR
beta-damasconeFL/FR
(E)-beta-damasconeFL/FR
(E)-3-hexenoic acidFL
 immortelle absoluteFL/FR
herbal
 matricaria chamomilla flower oilFL/FR
honey
 allyl phenyl acetateFL/FR
 butyl phenyl acetateFL/FR
 ethyl phenyl acetateFL/FR
 phenethyl acetateFL/FR
 phenethyl phenyl acetateFL/FR
 phenyl acetaldehydeFL/FR
 propyl phenyl acetateFL/FR
isopropyl phenyl acetateFL/FR
leafy
 methyl butyl phenyl acetateFL/FR
phenolic
 guaiacyl phenyl acetateFL/FR
 phenyl pyruvic acidFL/FR
soapy
 decanoic acidFL/FR
1-dodecanolFL/FR
sour
 acetic acidFL
2,4-dimethyl-2-pentenoic acidFL
spicy
isoeugenyl phenyl acetateFL/FR
sweet
 cyclohexyl acetic acidFL/FR
waxy
 heptanoic acidFL/FR
(Z,Z)-3,6-nonadien-1-olFL/FR
(Z)-6-nonen-1-olFL/FR
 phenethyl hexanoateFL/FR
 rhodinyl phenyl acetateFL/FR
 
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Potential Uses:
 chocolate cocoa 
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Occurrence (nature, food, other): note
 cocoa bean
Search Trop  Picture
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Synonyms:
 acetic acid, 2-phenoxy-
 acetic acid, phenoxy-
 glycol acid phenyl ether
 glycolic acid phenyl ether
 glycollic acid phenyl ether
 phenoxacetic acid
 phenoxy acetic acid
 phenoxy-acetic acid
2-(phenoxy)acetic acid
2-phenoxyacetic acid
 phenoxyaceticacid
 phenoxyethanoic acid
o-phenyl glycolic acid
ortho-phenyl glycolic acid
o-phenylglycolic acid
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Articles:
PubMed: Exposure of German residents to ethylene and propylene glycol ethers in general and after cleaning scenarios.
PubMed: Synthesis and insect antifeedant activity of aurones against Spodoptera litura larvae.
PubMed: Studies on water transport through the sweet cherry fruit surface. 11. FeCl3 decreases water permeability of polar pathways.
PubMed: The comparative toxicology of 4-chloro-2-methylphenoxyacetic acid and its plant metabolite 4-chloro-2-carboxyphenoxyacetic acid in rats.
PubMed: Development of an enzyme-linked immunosorbent assay for the pyrethroid cypermethrin.
PubMed: Enzyme-linked immunosorbent assay for the pyrethroid deltamethrin.
PubMed: Synthesis of haptens and protein conjugates for the development of immunoassays for the insect growth regulator fenoxycarb.
PubMed: Phenoxyacetic acid residue incorporation in cell walls of soybean (Glycine max.).
PubMed: Percutaneous penetration of 2-phenoxyethanol through rat and human skin.
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