EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

diisopropyl adipate
dipropan-2-yl hexanedioate

Supplier Sponsors

CAS Number: 6938-94-9Picture of molecule3D/inchi
Other:121879-14-9
ECHA EINECS - REACH Pre-Reg:230-072-0
FDA UNII:P7E6YFV72X
Nikkaji Web:J14.488F
Beilstein Number:1785346
MDL:MFCD00026391
XlogP3-AA:2.20 (est)
Molecular Weight:230.30414000
Formula:C12 H22 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:food-contact surface of paper and paperboard
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1966 diisopropyl adipate
FEMA Number:4474 diisopropyl adipate
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):6938-94-9 ; DIISOPROPYL ADIPATE
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.96300 to 0.96800 @ 20.00 °C.
Pounds per Gallon - (est).: 8.022 to 8.064
Refractive Index:1.42300 to 1.42700 @ 20.00 °C.
Melting Point: -1.10 °C. @ 760.00 mm Hg
Boiling Point: 251.00 to 253.00 °C. @ 760.00 mm Hg
Acid Value: 1.00 max. KOH/g
Vapor Pressure:0.019000 mmHg @ 25.00 °C. (est)
Flash Point: 229.00 °F. TCC ( 109.44 °C. )
logP (o/w): 2.676 (est)
Soluble in:
 alcohol
 water, 55.61 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Type: estery
Odor Strength:low
estery fatty sour
Odor Description:at 100.00 %. mild estery fatty sour
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: emollients
masking agents
plasticisers
skin conditioning
solvents
 
Suppliers:
Allan Chemical
Diisopropyl Adipate
Alzo International
Dermol DIA
Alzo International
Wickenol 116
American International Chemical, LLC.
Diisopropyl Adipate
Axsyn
For experimental / research use only.
Hexanedioic acid,1,6-bis(1-methylethyl) ester
BOC Sciences
For experimental / research use only.
Diisopropyl Adipate
Charkit Chemical
DIISOPROPYL ADIPATE
Chemical-navi - Nikkol
NIKKOL DID
Odor: characteristic
Use: Dibasic acid ester; good solubility and penetration; light feel; penetrating agent for topical drug forms.
Croda
Crodamol™ DA
Odor: bland
Use: Exceptionally low viscosity emollient. Plasticiser for nail varnish, hair spray and other styling aids. Solvent for lipophilic actives, dyestuff and chemical sunscreens. Excellent water/alcohol solubility.
HallStar
HALLSTAR® DIPA
Odor: characteristic
Use: HallStar DIPA is a multifunctional, (solvent for aromatic oils, coupler, emollient, lubricant, plasticizer) synthetically produced diester of Isopropyl Alcohol and Adipic Acid. It is non-occlusive, non-oily, light emollient with excellent spreading properties. Used in bath oils, it delivers a soft feel to skin. In sunscreens, it solubilizes solid organic UV filters and its relatively high polarilty may assist with Avobenzone photostabilization. Recommended use level: 0.1%-25%, depending upon application (lower end as a plasticizer, higher as an emollient. sunscreen solvent or hydro-alcoholic coupler, high end as a bath oil additive).
Inoue Perfumery
DIISOPROPYL ADIPATE
Lubrizol Corporation
Schercemol™ DIA Ester
Odor: charateristic
Use: Schercemol DIA ester is often used in hydroalcoholic formulations because of its excellent compatibility in such systems. Typical end uses for Schercemol DIA ester in hydroalcohol products are pre-electric and after shave lotions, where it functions as a non-oily emollient. Dry oil sprays are another popular application, where Schercemol DIA ester is valued for its rapid absorbency and low residual tack. Other usages include sun care, deodorants, lipsticks, hand lotions and men's grooming aids.
Penta International
DIISOPROPYL ADIPATE
Santa Cruz Biotechnology
For experimental / research use only.
Diisopropyl Adipate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Diisopropyl adipate
Symrise
IsoAdipate
Odor: characteristic
Use: Excellent film forming capacity on the skin.
SysKem Chemie
Diisopropyl Adipate
TCI AMERICA
For experimental / research use only.
Diisopropyl Adipate >99.0%(GC)
Universal Preserv-A-Chem Inc.
DIISOPROPYL ADIPATE
Odor: characteristic
Use: Is used as an emollient in cosmetics and as a plasticiser.
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-rat LD50 640 mg/kg
U.S. Army, Chemical Corps Medical Laboratories Research Reports. Vol. #256, Pg. 1954

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: food-contact surface of paper and paperboard
Recommendation for diisopropyl adipate usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24
 average usual ppmaverage maximum ppm
baked goods: 200.00000400.00000
beverages(nonalcoholic): 0.100002.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
EPI System: View
Cancer Citations:Search
EPA Substance Registry Services (TSCA):6938-94-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :23368
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
dipropan-2-yl hexanedioate
Chemidplus:0006938949
RTECS:AV1575000 for cas# 6938-94-9
 
References:
 dipropan-2-yl hexanedioate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:6938-94-9
Pubchem (cid):23368
Pubchem (sid):134987529
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C14523
HMDB (The Human Metabolome Database):HMDB41613
FooDB:FDB021768
Export Tariff Code:2917.12.5000
Household Products:Search
ChemSpider:View
FAO:Diisopropyl adipate
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 emollients
 plasticisers
 skin conditioning
 solvents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
isoadipate (Symrise)
 adipic acid diisopropyl ester
 adipic acid isopropyl ester
 adipic acid, diisopropyl ester
 ceraphyl 230
 crodamol DA
 dermol DIA
 dipropan-2-yl hexanedioate
 hallstar DIPA
 hexane dioic acid 1,6-bis(1-methyl ethyl) ester
 hexane dioic acid bis(1-methyl ethyl) ester
 hexanedioic acid 1,6-bis(1-methylethyl) ester
 hexanedioic acid bis(1-methylethyl) ester
 hexanedioic acid, bis (1-methylethyl) ester
 hexanedioic acid, bis(1-methylethyl) ester
 hexanedioic acid,1,6-bis(1-methylethyl) ester
bis(1-methyl ethyl) hexane dioate
bis(1-methylethyl) hexanedioate
bis(1-methylethyl)hexanedioate
 nikkol DID
1,6-bis(propan-2-yl) hexanedioate
 schercemol DIA
 schercemol DIA ester
 standamul DIPA
 tegester 504-D
 wickenol 116
 

Articles:

PubMed:Development of transdermal therapeutic formulation of CNS5161, a novel NMDA receptor antagonist, by utilizing pressure-sensitive adhesives II: improved transdermal absorption and evaluation of efficacy and safety.
PubMed:Conductive microemulsions for template CoNi electrodeposition.
PubMed:Iterative tandem catalysis of secondary diols and diesters to chiral polyesters.
PubMed:Investigation of fatty acid esters to replace isopropyl myristate in the sterility test for ophthalmic ointments.
PubMed:Effect of fatty acid diesters on permeation of anti-inflammatory drugs through rat skin.
PubMed:Final report on the safety assessment of Stearamide DIBA-Stearate.
PubMed:Simultaneous optimization based on artificial neural networks in ketoprofen hydrogel formula containing O-ethyl-3-butylcyclohexanol as percutaneous absorption enhancer.
PubMed:Tacrolimus ointment improves psoriasis in a microplaque assay.
PubMed:Effect of vehicles on diclofenac permeation across excised rat skin.
PubMed:Percutaneous absorption of retinoids: influence of vehicle, light exposure, and dose.
PubMed:Interaction of indomethacin with the vehicle component diisopropyl adipate.
 
Notes:
Food additive [Goodscents]
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