EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

thiamine hydrochloride
vitamin B hydrochloride

Supplier Sponsors

Name:2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol chloride
CAS Number: 67-03-8Picture of molecule3D/inchi
Other:108631-50-1
ECHA EINECS - REACH Pre-Reg:200-641-8
FDA UNII:M572600E5P
Beilstein Number:3851771
MDL:MFCD00012780
CoE Number:10493
Molecular Weight:337.27166000
Formula:C12 H18 Cl2 N4 O S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents and adjuvants, nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1875 Thiamine hydrochloride View - review
JECFA Food Flavoring:1030 thiamine hydrochloride
FLAVIS Number:16.027 (Old)
DG SANTE Food Flavourings:16.027 thiamine hydrochloride
FEMA Number:3322 thiamine hydrochloride
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):67-03-8 ; THIAMINE HYDROCHLORIDE
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1875 Thiamine hydrochloride.
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: Yes
Melting Point: 248.00 to 250.00 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -3.930
Soluble in:
 propylene glycol
 water
 water, 1e+006 mg/L @ 25 °C (est)
Insoluble in:
 ether
 
Organoleptic Properties:
Odor Strength:none
Odor Description:at 100.00 %. sour mild bitter
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: masking agents
skin conditioning
 
Suppliers:
Aceto
Thiamine Hydrochloride USP
AIDP
Vitamin B1 HCl Thiamine Hydrochloride 98.0%-102.0%
American International Chemical, LLC.
Thiamine HCL USP
BOC Sciences
For experimental / research use only.
Thiamine Hydrochloride > 95%
Odor: characteristic
Use: Thiamine or vitamin B1 is a water-soluble vitamin of the B complex, its phosphate derivatives are involved in many cellular processes.
Charkit Chemical
THIAMINE HCL (VITAMIN B1 HCL)
EMD Millipore
For experimental / research use only.
Thiamine, Hydrochloride
Farbest-Tallman Foods
Thiamine HCl USP
Flavor: bland
It is used in food, beverage and dietary supplement applications for a Vitamin B1 source including reacted and savory flavors, hard shell capsules and tablets.
Maypro Industries
Thiamine HCI USP
OQEMA
Vitamin B1 HCL
Penta International
THIAMINE HYDROCHLORIDE (Vitamin B1)
Penta International
THIAMINE HYDROCHLORIDE USP GRADE
Qingdao Dacon Trading
Thiamine HCL
Santa Cruz Biotechnology
For experimental / research use only.
Thiamine, Hydrochloride
Sigma-Aldrich
Thiamine hydrochloride, ≥98%, FCC, FG
Odor: sour
Certified Food Grade Products
Silver Fern Chemical
Vitamin B1 Hcl
TCI AMERICA
For experimental / research use only.
Thiamine Hydrochloride Hydrate >98.0%(HPLC)(T)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-rat LD50 [sex: M] 3710 mg/kg
(Sprince et al., 1974)

intravenous-rat LD50 118 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 236, Pg. 149, 1959.

intraperitoneal-rat LD50 481 mg/kg
Farmaco, Edizione Pratica. Vol. 24, Pg. 712, 1969.

intravenous-rabbit LD50 117 mg/kg
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Proceedings of the Society for Experimental Biology and Medicine. Vol. 68, Pg. 153, 1948.

intravenous-cat LD50 75 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 623, 1956.

intravenous-guinea pig LD50 140 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 623, 1956.

intraperitoneal-mouse LD50 200 mg/kg
National Technical Information Service. Vol. AD277-689

intravenous-mouse LD50 74 mg/kg
Farmaco, Edizione Pratica. Vol. 24, Pg. 712, 1969.

oral-mouse LD50 8224 mg/kg
Internationale Zeitschrift fuer Vitaminforschung. International Review of Vitamin Research. Vol. 37, Pg. 82, 1967.

oral-rat LD50 3710 mg/kg
BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Agents and Actions, A Swiss Journal of Pharmacology. Vol. 4, Pg. 125, 1974.

intravenous-pigeon LD50 180 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 623, 1956.

Dermal Toxicity:
subcutaneous-rat LD50 560 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 623, 1956.

subcutaneous-mouse LD50 266 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.

subcutaneous-guinea pig LD50 872 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 623, 1956.

subcutaneous-frog LD50 2600 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 1, 1959.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents and adjuvants, nutrient supplements
Recommendation for thiamine hydrochloride usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 300.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 1200.00 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 5
 average usual ppmaverage maximum ppm
baked goods: -50.00000
beverages(nonalcoholic): -50.00000
beverages(alcoholic): --
breakfast cereal: -50.00000
cheese: --
chewing gum: --
condiments / relishes: -50.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: -50.00000
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -50.00000
milk products: -50.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -50.00000
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 29 (FGE29)[1] - Substance from the priority list: Vinylbenzene from chemical group 31 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 76, (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30
View page or View pdf

Scientific Opinion on the safety and efficacy of thiazoles, thiophene, thiazoline and thienyl derivatives (chemical group 29): 3-acetyl-2,5-dimethylthiophene when used as a flavouring for all animal species
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3
View page or View pdf

Safety and efficacy of thiazoles, thiophene and thiazoline belonging to chemical group 29 when used as flavourings for all animal species
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 49, Revision 1 (FGE.49Rev1): xanthine alkaloids from the priority list
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):67-03-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6202
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol chloride
Chemidplus:0000067038
RTECS:XI7350000 for cas# 67-03-8
 
References:
 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol chloride
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:67-03-8
Pubchem (cid):6202
Pubchem (sid):134970554
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D02094
HMDB (The Human Metabolome Database):Search
FooDB:FDB008416
Export Tariff Code:2936.22.0000
FDA Listing of Food Additive Status:View
Household Products:Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
bulk powder, oral: tablets: 25 mg, 50 mg, 100 mg, 250 mg, 500 mg. parenteral injection: 100 mgml. note: available from one or more manufacturer, distributor, andor repackager by generic (nonproprietary) name.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
FLdairy
FLmilk
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl thiazolium chloride monohydrochloride
3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride monohydrochloride
3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride hydrochloride
2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol chloride
2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl}ethan-1-ol, chloride, chloride
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride hydrochloride
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride hydrochloride (1:1:1)
3-[(4-ammonio-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium dichloride
 aneurine hydrochloride
 betabion hydrochloride
 thiamine chloride hydrochloride
 thiamine HCl
 thiamine HCl USP
 thiamine hydrochloride
 thiamine hydrochloride USP
 thiaminium chloride hydrochloride
 thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-, chloride, hydrochloride (1:1:1)
 vitamin B hydrochloride
 vitamin B1 HCl thiamine hydrochloride 98.0%-102.0%
 vitamin B1 hydrochloride
 vitaneurin
 
 
Notes:
3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride. an important compound functioning as a component of the coenzyme nad. its primary significance is in the prevention and/or cure of blacktongue and pellagra. most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. Nutrient supplement; flavouring ingredient with a bitter taste
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