EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

diethyl sebacate
decanedioic acid, diethyl ester

Sponsors

Name:diethyl decanedioate
CAS Number: 110-40-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-764-5
FDA UNII:I41B9FJK6V
Nikkaji Web:J5.519K
Beilstein Number:1790779
MDL:MFCD00009219
CoE Number:623
XlogP3-AA:3.50 (est)
Molecular Weight:258.35802000
Formula:C14 H26 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:624 diethyl sebacate
FLAVIS Number:09.475 (Old)
DG SANTE Food Flavourings:09.475 diethyl sebacate
FEMA Number:2376 diethyl sebacate
FDA Mainterm: DIETHYL SEBACATE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.96000 to 0.96500 @ 25.00 °C.
Pounds per Gallon - (est).: 7.988 to 8.030
Refractive Index:1.43500 to 1.43800 @ 20.00 °C.
Melting Point: 1.00 to 4.00 °C. @ 760.00 mm Hg
Boiling Point: 302.00 to 305.00 °C. @ 760.00 mm Hg
Boiling Point: 151.00 to 153.00 °C. @ 3.00 mm Hg
Acid Value: 1.00 max. KOH/g
Vapor Pressure:0.001000 mm/Hg @ 25.00 °C. (est)
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 3.920 (est)
Soluble in:
 alcohol
 fixed oils
 paraffin oil
 water, 80 mg/L @ 20 °C (exp)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: fruity
Odor Strength:medium
Substantivity:164 hour(s) at 100.00 %
melon fruity quince winey
Odor Description:at 100.00 %. mild melon fruity quince wine
Luebke, William tgsc, (1995)
Odor sample from: Elan Inc.
Flavor Type: fruity
">melon fruity winey cognac cilantro
Taste Description: melon fruity winey cognac cilantro
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: emollients
masking agents
plasticisers
skin conditioning
solvents
 
Suppliers:
Berjé
Diethyl Sebacate
Happening at Berje
BOC Sciences
For experimental / research use only.
Diethyl Sebacate
Chemical-navi - Nikkol
NIKKOL DES-SP
Odor: characteristic
Use: Dibasic acid ester; good solubility and penetration; light feel; penetrating agent for topical drug forms.
Elan Inc.
DIETHYL SEBACATE
FCC, Kosher
EMD Millipore
For experimental / research use only.
Diethyl Sebacate
Inoue Perfumery
DIETHYL SEBACATE
Penta International
DIETHYL SEBACATE FCC, Kosher
Sigma-Aldrich
Diethyl sebacate, ≥98%, FCC, FG
Odor: melon; wine-like; quince.
Certified Food Grade Products
TCI AMERICA
For experimental / research use only.
Diethyl Sebacate >98.0%(GC)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 38 - Irritating to skin.
S 02 - Keep out of the reach of children.
S 24 - Avoid contact with skin.
S 37 - Wear suitable gloves.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
4 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
gavage-rat LD50 [sex: M,F] 14470 mg/kg
(Jenner et al., 1964)

oral-rat LD50 [sex: M] 32000 mg/kg
(Smith, 1953a)

gavage-mouse LD50 [sex: M] > 32000 mg/kg
(Lawrence et al., 1974)

oral-guinea pig LD50 7280 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

oral-rat LD50 14470 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for diethyl sebacate usage levels up to:
  10.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 120.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -41.00000
beverages(nonalcoholic): -4.10000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: 2.70000450.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -9.10000
fruit ices: -9.10000
gelatins / puddings: 3.2000019.00000
granulated sugar: --
gravies: --
hard candy: -21.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf
EPI System: View
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):110-40-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8049
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
diethyl decanedioate
Chemidplus:0000110407
RTECS:VS1180000 for cas# 110-40-7
 
References:
 diethyl decanedioate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:110-40-7
Pubchem (cid):8049
Pubchem (sid):134974349
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEMBL:View
KEGG (GenomeNet):D10682
HMDB (The Human Metabolome Database):HMDB40429
FooDB:FDB020162
Export Tariff Code:2917.12.5000
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
FAO:Diethyl sebacate
 
Potential Blenders and core components note
For Odor
anisic
methyl para-anisate
FL/FR
balsamic
opoponax oil (balsamodendron kafal)
FL/FR
opoponax resinoid (balsamodendron kafal)
FR
3-
phenyl propyl alcohol
FL/FR
terpinyl cinnamate
FL/FR
berry
raspberry ketone methyl ether
FL/FR
caramellic
diethyl malate
FL/FR
maltyl isobutyrate
FL/FR
earthy
amyl octanoate
FL/FR
ethereal
iso
amyl acetoacetate
FL/FR
iso
butyl alcohol
FL/FR
ethyl formate
FL/FR
iso
valeraldehyde propylene glycol acetal
FL/FR
fatty
butyl undecylenate
FL/FR
(E,E)-2,4-
decadien-1-ol
FL/FR
2,4-
decadien-1-ol
FL/FR
fermented
methyl decanoate
FL/FR
3-
methyl-1-pentanol
FL/FR
floral
cuminyl acetaldehyde
FL/FR
dimethyl anthranilate
FL/FR
methoxycitronellal
FR
phenethyl acetate
FL/FR
rose oil (rosa damascena) bulgaria
FL/FR
fruity
iso
amyl butyrate
FL/FR
iso
amyl nonanoate
FL/FR
iso
butyl acetoacetate
FL/FR
butyl anthranilate
FL/FR
butyl hexanoate
FL/FR
diethyl laevo-tartrate
FL/FR
ethyl (E)-2-decenoate
FL/FR
ethyl 3,5,5-trimethyl hexanoate
FR
ethyl heptanoate
FL/FR
farnesyl acetone
FL/FR
geranyl acetoacetate
FL/FR
grape butyrate
FL/FR
methyl nonanoate
FL/FR
(Z)-3-
octen-1-ol
FL/FR
(Z)-3-
octen-1-yl propionate
FL/FR
2-
pentanone
FL/FR
propyl heptanoate
FL/FR
propyl isobutyrate
FL/FR
solanone
FL/FR
sorbyl butyrate
FL/FR
green
iso
amyl formate
FL/FR
benzaldehyde dimethyl acetal
FL/FR
3,7-
dimethyl-6-octenoic acid
FL/FR
ethyl (E,Z)-2,4-decadienoate
FL/FR
heptanal dimethyl acetal
FL/FR
(Z)-3-
hexen-1-yl butyrate
FL/FR
(Z)-3-
hexen-1-yl pyruvate
FL/FR
hexyl isobutyrate
FL/FR
hexyl phenyl acetate
FL/FR
melon acetal
FL/FR
melon nonenoate
FL/FR
methyl octine carbonate
FL/FR
(E,Z)-3,6-
nonadien-1-ol
FL/FR
3,6-
nonadien-1-yl acetate
FL/FR
(E,Z)-3,6-
nonadien-1-yl acetate
FL/FR
(Z)-5-
octen-1-ol
FL/FR
3-
phenyl propionaldehyde
FL/FR
herbal
iso
amyl tiglate
FL/FR
ethyl chrysanthemate
FR
phenethyl senecioate
FL/FR
viridiflorol
FL/FR
honey
methyl hydrocinnamate
FL/FR
melon
(Z)-6-
nonen-1-yl acetate
FL/FR
(Z)-6-
nonenal
FL/FR
roasted
2-
methyl-1-butanol
FL/FR
spicy
cinnamyl isovalerate
FL/FR
sulfurous
buchu mercaptan
FL/FR
cassis pentanone
FL/FR
passiflora acetate
FL/FR
tropical
hexyl 2-methyl-3-pentenoate
FL/FR
waxy
allyl nonanoate
FL/FR
iso
amyl laurate
FL/FR
ethyl nonanoate
FL/FR
ethyl octanoate
FL/FR
winey
butyl angelate
FL/FR
2-
hexanol
FL/FR
For Flavor
No flavor group found for these
amyl octanoate
FL/FR
iso
amyl tiglate
FL/FR
2-
amyl-5 or 6-keto-1,4-dioxane
FL
butyl angelate
FL/FR
iso
butyraldehyde propylene glycol acetal
FL
(E,E)-2,4-
decadien-1-ol
FL/FR
diethyl laevo-tartrate
FL/FR
diethyl malate
FL/FR
ethyl aconitate
FL
farnesyl acetone
FL/FR
geranyl acetoacetate
FL/FR
2-
hexanol
FL/FR
methyl hydrocinnamate
FL/FR
methyl para-anisate
FL/FR
2-
methyl-1-butanol
FL/FR
phenethyl senecioate
FL/FR
solanone
FL/FR
sorbyl propionate
FL
viridiflorol
FL/FR
balsamic
balsamic
opoponax oil (balsamodendron kafal)
FL/FR
berry
raspberry ketone methyl ether
FL/FR
ethereal
iso
butyl alcohol
FL/FR
ethyl formate
FL/FR
fatty
iso
amyl laurate
FL/FR
2,4-
decadien-1-ol
FL/FR
methyl decanoate
FL/FR
(Z)-3-
octen-1-ol
FL/FR
floral
3,7-
dimethyl-6-octenoic acid
FL/FR
rose oil (rosa damascena) bulgaria
FL/FR
fruity
iso
amyl acetoacetate
FL/FR
iso
butyl acetoacetate
FL/FR
butyl anthranilate
FL/FR
butyl hexanoate
FL/FR
cinnamyl isovalerate
FL/FR
dimethyl anthranilate
FL/FR
ethyl (E)-2-decenoate
FL/FR
ethyl heptanoate
FL/FR
hexyl 2-methyl-3-pentenoate
FL/FR
hexyl phenyl acetate
FL/FR
(Z)-3-
octen-1-yl propionate
FL/FR
2-
pentanone
FL/FR
propyl isobutyrate
FL/FR
sorbyl butyrate
FL/FR
terpinyl cinnamate
FL/FR
iso
valeraldehyde propylene glycol acetal
FL/FR
watermelon distillates
FL
green
iso
amyl formate
FL/FR
benzaldehyde dimethyl acetal
FL/FR
cassis pentanone
FL/FR
cuminyl acetaldehyde
FL/FR
ethyl (E,Z)-2,4-decadienoate
FL/FR
grape butyrate
FL/FR
heptanal dimethyl acetal
FL/FR
(Z)-3-
hexen-1-yl butyrate
FL/FR
(Z)-3-
hexen-1-yl pyruvate
FL/FR
(E)-2-
hexenal diethyl acetal
FL
hexyl isobutyrate
FL/FR
melon acetal
FL/FR
melon nonenoate
FL/FR
methyl octine carbonate
FL/FR
(E,Z)-3,6-
nonadien-1-ol
FL/FR
(E,Z)-3,6-
nonadien-1-yl acetate
FL/FR
3,6-
nonadien-1-yl acetate
FL/FR
(Z)-6-
nonen-1-yl acetate
FL/FR
(Z)-6-
nonenal
FL/FR
(E,E)-2,4-
octadienal
FL
2,4-
octadienal
FL
(Z)-5-
octen-1-ol
FL/FR
3-
phenyl propionaldehyde
FL/FR
honey
phenethyl acetate
FL/FR
jammy
maltyl isobutyrate
FL/FR
melon
watermelon concentrate
FL
musty
propionaldehyde
FL
spicy
3-
phenyl propyl alcohol
FL/FR
sulfurous
buchu mercaptan
FL/FR
methyl 2-(methyl thio) butyrate
FL
1-
methyl thio-2-propanone
FL
methyl thiomethyl butyrate
FL
tropical
passiflora acetate
FL/FR
waxy
allyl nonanoate
FL/FR
iso
amyl butyrate
FL/FR
butyl undecylenate
FL/FR
ethyl nonanoate
FL/FR
ethyl octanoate
FL/FR
propyl heptanoate
FL/FR
whiskey
3-
methyl-1-pentanol
FL/FR
winey
iso
amyl nonanoate
FL/FR
methyl nonanoate
FL/FR
 
Potential Uses:
FRbanana
FRcurrant
 emollients
 melon watermelon muskmelon cantaloupe
FRpeach
FRpineapple
 plasticisers
FRraspberry
 skin conditioning
 solvents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 decane dioic acid diethyl ester
 decanedioic acid diethyl ester
 decanedioic acid, diethyl ester
 diethyl 1,10-decane dioate
 diethyl 1,10-decanedioate
 diethyl 1,8-octane dicarboxylate
 diethyl 1,8-octanedicarboxylate
 diethyl decane dioate
 diethyl decane-1,10-dioate
 diethyl decanedioate
 diethyl sebacate FCC
 ethyl decane dioate
 ethyl sebacate
 nikkol DES-SP
 sebacic acid diethyl ester
 sebacic acid, diethyl ester
 

Articles:

PubMed:Exploring the Solid State Properties of Enzymatic Poly(amine-co-ester) Terpolymers to Expand their Applications in Gene Transfection.
PubMed:Development and evaluation of a tacrolimus cream formulation using a binary solvent system.
PubMed:Micelles of enzymatically synthesized PEG-poly(amine-co-ester) block copolymers as pH-responsive nanocarriers for docetaxel delivery.
PubMed:Enzyme-catalyzed synthesis of aliphatic-aromatic oligoamides.
PubMed:Sebacic and succinic acid derived plasticised PVC for the inhibition of biofouling in its initial stages.
PubMed:Potentially important nighttime heterogeneous chemistry: NO3 with aldehydes and N2O5 with alcohols.
PubMed:Reactive uptake kinetics of NO3 on multicomponent and multiphase organic mixtures containing unsaturated and saturated organics.
PubMed:Reactive uptake studies of NO3 and N2O5 on alkenoic acid, alkanoate, and polyalcohol substrates to probe nighttime aerosol chemistry.
PubMed:Discovery of synergistic permeation enhancers for oral drug delivery.
PubMed:A systematic selection of the non-aqueous phase in a bacterial two liquid phase bioreactor treating alpha-pinene.
PubMed:Allergic contact dermatitis due to diethyl sebacate in a hand cream.
PubMed:Biodegradation of phenol at low temperature using two-phase partitioning bioreactors.
PubMed:Skin permeation of lidocaine from crystal suspended oily formulations.
PubMed:Effects of accelerators on mobility of 14C-2,4-dichlorophenoxy butyric acid in plant cuticles depends on type and concentration of accelerator.
PubMed:Sorption in reconstituted waxes of homologous series of alcohol ethoxylates and n-alkyl esters and their effects on the mobility of 2,4-dichlorophenoxybutyric acid.
PubMed:Contact dermatitis due to lanoconazole, cetyl alcohol and diethyl sebacate in lanoconazole cream.
PubMed:Effect of fatty acid diesters on permeation of anti-inflammatory drugs through rat skin.
PubMed:Calcium chloride penetrates plant cuticles via aqueous pores.
PubMed:Allergic contact dermatitis from diethyl sebacate in lanoconazole cream.
PubMed:Contact dermatitis due to diethyl sebacate.
PubMed:Allergic contact dermatitis due to diethyl sebacate.
PubMed:Effect of vehicles on diclofenac permeation across excised rat skin.
PubMed:Effect of topical preparation of mycophenolic acid on experimental allergic contact dermatitis of guinea-pigs induced by dinitrofluorobenzene.
PubMed:Allergic contact dermatitis from ethyl sebacate.
PubMed:In vivo activity and metabolic fate of 2-(2,3,3-triiodoallyl)tetrazole (ME1401), a novel antifungal agent.
PubMed:Effects of penetration enhancers on percutaneous absorption of nifedipine. Comparison between Deet and Azone.
PubMed:Enhancement of transdermal delivery by superfluous thermodynamic potential. II. In vitro-in vivo correlation of percutaneous nifedipine transport.
PubMed:Contact dermatitis due to diethyl sebacate.
 
Notes:
causes contact dermatitis. Flavouring ingredient
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