EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

methyl ortho-anisate
methyl o-methoxybenzoate

Sponsors

Name:methyl 2-methoxybenzoate
CAS Number: 606-45-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:210-118-6
FDA UNII:SB18J2MCQL
Nikkaji Web:J47.046E
Beilstein Number:2207356
MDL:MFCD00008423
CoE Number:2192
XlogP3:2.00 (est)
Molecular Weight:166.17630000
Formula:C9 H10 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
JECFA Food Flavoring:880 methyl o-methoxybenzoate
FLAVIS Number:09.796 (Old)
DG SANTE Food Flavourings:09.796 methyl 2-methoxybenzoate
FEMA Number:2717 methyl o-methoxybenzoate
FDA Mainterm: METHYL O-METHOXYBENZOATE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.15600 to 1.15900 @ 25.00 °C.
Pounds per Gallon - (est).: 9.619 to 9.644
Refractive Index:1.53200 to 1.53500 @ 20.00 °C.
Melting Point: 48.00 to 49.00 °C. @ 760.00 mm Hg
Boiling Point: 254.00 to 255.00 °C. @ 760.00 mm Hg
Acid Value: 1.00 max. KOH/g
Vapor Pressure:0.029000 mm/Hg @ 25.00 °C. (est)
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 2.040
Soluble in:
 alcohol
 dipropylene glycol
 water, 1160 mg/L @ 25 °C (est)
Insoluble in:
 water
Stability:
 cream
 hair spray
 lipstick
 lotion
 non-discoloring in most media
 powder
 shampoo
 soap
 
Organoleptic Properties:
Odor Type: herbal
Odor Strength:medium
herbal floral hyacinth cananga fruity currant black currant
Odor Description:at 100.00 %. herbal floral hyacinth cananga fruity blackcurrant
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
Methyl 2-methoxyacetate
CG Herbals
Methyl Ortho Anisate
EMD Millipore
For experimental / research use only.
Methyl 2-methoxybenzoate
Inoue Perfumery
METHYL 2-METHOXYBENZOATE
Penta International
METHYL-2-METHOXY BENZOATE, Kosher
Santa Cruz Biotechnology
For experimental / research use only.
Methyl 2-methoxybenzoate
Sigma-Aldrich
Methyl 2-methoxybenzoate, ≥97%
Odor: hyacinth; herbaceous
Certified Food Grade Products
Synerzine
Methyl o-methoxy benzoate
TCI AMERICA
For experimental / research use only.
Methyl o-Anisate >99.0%(GC)
Treatt
Methyl 2-methoxybenzoate
Halal, Kosher
Odor: sweet, anisic-odour; green vegetable; berry-currant; melon-like
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3800 mg/kg
(Moreno, 1982l)

oral-rat LD50 3800 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 385, 1988.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 385, 1988.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for methyl ortho-anisate usage levels up to:
  1.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 49.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 8.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -40.00000
beverages(nonalcoholic): -12.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -9.00000
fruit ices: -9.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -30.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23
View page or View pdf

Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):606-45-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :61151
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
methyl 2-methoxybenzoate
Chemidplus:0000606451
RTECS:DH3549000 for cas# 606-45-1
 
References:
 methyl 2-methoxybenzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:606-45-1
Pubchem (cid):61151
Pubchem (sid):135018019
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB32605
FooDB:FDB010545
Export Tariff Code:2918.99.3500
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
aldehydic
muguet undecadienal
FR
animal
para-
cresyl caprylate
FL/FR
para-
cresyl phenyl acetate
FL/FR
balsamic
benzyl benzoate
FL/FR
benzyl salicylate
FL/FR
cinnamyl alcohol
FL/FR
cyclohexyl benzoate
FL/FR
geranyl benzoate
FL/FR
3-
phenyl propyl alcohol
FL/FR
2-
phenyl propyl alcohol
FL/FR
scotch
pine wood/needles resinoid
FR
prenyl benzoate
FL/FR
terpinyl benzoate
FR
burnt
lepidine
FL/FR
chemical
styralyl alcohol
FL/FR
citrus
acetaldehyde citronellyl methyl acetal
FR
beta-
bisabolol
FL/FR
2-
heptanol
FL/FR
fermented
hexanal diethyl acetal
FL/FR
floral
ortho-
acetyl-para-cresol
FL/FR
amyl salicylate
FL/FR
iso
amyl salicylate
FL/FR
benzyl pivalate
FL/FR
butyl tiglate
FR
cassie absolute replacer
FL/FR
cassis buteneone
FR
cassis cyclohexene
FR
champaca absolute
FR
citronellal
FL/FR
citronellyl isovalerate
FL/FR
coriander seed oil
FL/FR
cymbopogon validus leaf oil
FR
delta-
damascone
FL/FR
dihydromyrcene
FR
2,4-
dimethyl-3-cyclohexene-1-methanol
FR
eau de brouts absolute
FR
ethyl hydrocinnamate
FL/FR
ethyl linalool
FR
ethyl linalyl acetal
FR
ethyl ortho-anisate
FL/FR
heather fragrance
FR
heliotrope absolute
FR
herbal pyran
FR
ho leaf oil
FR
hyacinth ether
FR
ilex paraguariensis oleoresin
FL/FR
beta-
ionol
FL/FR
(Z)-
jasmone
FL/FR
iso
jasmone
FL/FR
karo karounde absolute
FR
kewda oil
CS
lavandin concrete decolorized
FR
lavandin oil
FL/FR
abrialis
lavandin oil
FL/FR
lavandula angustifolia flower oil
FL/FR
lavender absolute replacer
FR
lavender oil
FL/FR
lavender oil bulgaria
FL/FR
lavender oil france
FL/FR
lavender oil greece
FL/FR
lavender oil replacer
FR
nonisyl propionate
FR
(Z)-beta-
ocimene
FL/FR
pelargonium graveolens flower water
FR
phenethyl formate
FL/FR
phenethyl salicylate
FL/FR
phenyl acetaldehyde / methyl anthranilate schiff's base
FR
phenyl glycol diacetate
FR
(S)-2-
phenyl propionaldehyde
FL/FR
2-
phenyl propionaldehyde dimethyl acetal
FL/FR
2-
phenyl propyl acetate
FL/FR
(R)-2-
phenyl propyl alcohol
FL/FR
3-
phenyl propyl formate
FL/FR
phenyl propyl phenyl acetate
FR
3-
phenyl propyl propionate
FL/FR
(E)-2-
phenyl-1(2)-propene-1-yl acetate
FR
2-
phenyl-2-pentenal
FL/FR
iso
phytol
FL/FR
prenyl salicylate
FL/FR
reseda acetal
FR
sambucus nigra flower oil CO2 extract
FR
tea acetate
FR
terpinyl isobutyrate
FL/FR
tetrahydrolinalyl acetate
FR
tuberose absolute (from concrete)
FL/FR
tuberose absolute (from pommade)
FL/FR
tuberose acetate
FR
wallflower absolute
FR
fruity
artemisia pallens herb oil
FL/FR
benzyl methyl ether
FL/FR
(Z)-beta-
damascone
FL/FR
beta-
damascone
FL/FR
(E)-alpha-
damascone
FL/FR
(E)-beta-
damascone
FL/FR
diethyl succinate
FL/FR
sambucus canadensis fruit absolute
FL/FR
green
acetaldehyde di-(Z)-3-hexen-1-yl acetal
FL/FR
acetaldehyde ethyl phenethyl acetal
FL/FR
iso
amyl formate
FL/FR
bromstyrol
CS
iso
butyl benzyl carbinol
FL/FR
citrus carbaldehyde / methyl anthranilate schiff's base
FR
galbascone (IFF)
FR
green ether
FL/FR
heptyl cinnamate
FL/FR
heptyl formate
FL/FR
(Z)-3-
hexen-1-yl angelate
FR
hyacinth butanal
FR
leafy acetal
FL/FR
marigold pot absolute
FL/FR
phenethyl oxyacetaldehyde
FR
phenoxyacetaldehyde 50% in benzyl alcohol
FR
phenyl acetaldehyde
FL/FR
phenyl acetaldehyde ethylene glycol acetal
FR
phenyl acetaldehyde solution
FL/FR
2-
phenyl propionaldehyde
FL/FR
herbal
barosma betulina leaf oil
FL/FR
buchu mercaptan acetate
FL/FR
calendula officinalis flower oil CO2 extract
FR
cananga fruit oil
FR
carrot seed oil (daucus carota ssp. gummifer hook. fil.) spain
FR
chamomile isobutyrate
FR
chrysanthemum ketone
FR
coriander seed absolute
FL/FR
inula root oil
FR
juniper carboxaldehyde
FR
lavandin flower water
FR
lavender absolute bulgaria
FL/FR
lavender absolute france
FL/FR
lavender concrete
FL/FR
lavender oil terpeneless
FL/FR
lavender stem oil lithuania
FR
marigold pot flower oil
FL/FR
laevo-
menthyl propionate
FL/FR
methyl cyclogeranate (Firmenich)
FR
myrtle oil
FL/FR
myrtle oil morocco
FL/FR
nonisyl acetate
FR
minty
diosphenol
FL/FR
naphthyl
para-
methyl anisole
FL/FR
powdery
para-
anisyl alcohol
FL/FR
spicy
carnation absolute
FR
black
currant bud absolute
FL/FR
sulfurous
4-
methoxy-2-methyl butane thiol
FL/FR
4-
methyl 4-mercaptopentan-2-one 1% solution
FL/FR
woody
2-
decalinyl acetate
FR
zdravetz absolute
FR
zdravetz oil
FL/FR
For Flavor
No flavor group found for these
acetaldehyde di-(Z)-3-hexen-1-yl acetal
FL/FR
ortho-
acetyl-para-cresol
FL/FR
benzyl pivalate
FL/FR
cassie absolute replacer
FL/FR
citronellyl isovalerate
FL/FR
cyclohexyl benzoate
FL/FR
diosphenol
FL/FR
ethyl hydrocinnamate
FL/FR
ethyl ortho-anisate
FL/FR
geranyl benzoate
FL/FR
heptyl cinnamate
FL/FR
hexanal diethyl acetal
FL/FR
ilex paraguariensis oleoresin
FL/FR
marigold pot flower oil
FL/FR
laevo-
menthyl propionate
FL/FR
4-
methyl 4-mercaptopentan-2-one 1% solution
FL/FR
myrtle oil morocco
FL/FR
phenyl acetaldehyde solution
FL/FR
(S)-2-
phenyl propionaldehyde
FL/FR
2-
phenyl propyl acetate
FL/FR
(R)-2-
phenyl propyl alcohol
FL/FR
3-
phenyl propyl formate
FL/FR
3-
phenyl propyl propionate
FL/FR
prenyl benzoate
FL/FR
terpinyl isobutyrate
FL/FR
(E)-4-
undecenal
FL
zdravetz oil
FL/FR
beta-
damascone
FL/FR
amber
amber
iso
butyl benzyl carbinol
FL/FR
animal
para-
cresyl caprylate
FL/FR
aromatic
amyl salicylate
FL/FR
leafy acetal
FL/FR
balsamic
benzyl benzoate
FL/FR
benzyl salicylate
FL/FR
chemical
styralyl alcohol
FL/FR
citrus
beta-
bisabolol
FL/FR
fatty
heptyl formate
FL/FR
floral
citronellal
FL/FR
beta-
ionol
FL/FR
lepidine
FL/FR
tuberose absolute (from concrete)
FL/FR
tuberose absolute (from pommade)
FL/FR
fruity
para-
anisyl alcohol
FL/FR
artemisia pallens herb oil
FL/FR
benzyl methyl ether
FL/FR
buchu mercaptan acetate
FL/FR
(E)-alpha-
damascone
FL/FR
(Z)-beta-
damascone
FL/FR
(E)-beta-
damascone
FL/FR
diethyl succinate
FL/FR
2-
heptanol
FL/FR
2-
phenyl propionaldehyde dimethyl acetal
FL/FR
sambucus canadensis fruit absolute
FL/FR
green
acetaldehyde ethyl phenethyl acetal
FL/FR
iso
amyl formate
FL/FR
iso
amyl salicylate
FL/FR
cinnamyl alcohol
FL/FR
green ether
FL/FR
iso
jasmone
FL/FR
marigold pot absolute
FL/FR
(Z)-beta-
ocimene
FL/FR
phenethyl formate
FL/FR
2-
phenyl propionaldehyde
FL/FR
2-
phenyl propyl alcohol
FL/FR
2-
phenyl-2-pentenal
FL/FR
herbal
barosma betulina leaf oil
FL/FR
coriander seed absolute
FL/FR
coriander seed oil
FL/FR
lavandin oil
FL/FR
abrialis
lavandin oil
FL/FR
lavandula angustifolia flower oil
FL/FR
lavender absolute bulgaria
FL/FR
lavender absolute france
FL/FR
lavender concrete
FL/FR
lavender oil
FL/FR
lavender oil bulgaria
FL/FR
lavender oil france
FL/FR
lavender oil greece
FL/FR
lavender oil terpeneless
FL/FR
prenyl salicylate
FL/FR
honey
phenyl acetaldehyde
FL/FR
medicinal,
phenethyl salicylate
FL/FR
naphthyl
para-
methyl anisole
FL/FR
oily
iso
phytol
FL/FR
phenolic
para-
cresyl phenyl acetate
FL/FR
spicy
black
currant bud absolute
FL/FR
myrtle oil
FL/FR
3-
phenyl propyl alcohol
FL/FR
sulfurous
4-
methoxy-2-methyl butane thiol
FL/FR
woody
delta-
damascone
FL/FR
(Z)-
jasmone
FL/FR
 
Potential Uses:
FRberry
FRcurrant black
FRfungus mushroom
 melon watermelon muskmelon cantaloupe
FLnut
 raspberry
 savory
 soup
 spinach
 strawberry
 vegetable
FRwintergreen
 
Occurrence (nature, food, other):note
 currant fruit
Search Picture
 grape
Search Trop Picture
 hyacinthus orientalis absolute @ 0.01-0.10%
Data GC Search Trop Picture
 mushroom
Search PMC Picture
 tea black tea
Search Trop Picture
 ylang ylang oil @ 0.05%
Data GC Search Trop Picture
 ylang ylang oil CO2 extract @ 0.04%
Data GC Search Trop Picture
 
Synonyms:
o-anisic acid methyl ester
ortho-anisic acid methyl ester
 benzoic acid, 2-methoxy-, methyl ester
 dimethyl salicylate
2-methoxy-benzoic acid methyl ester
2-methoxybenzoic acid methyl ester
o-methoxybenzoic acid methyl ester
ortho-methoxybenzoic acid methyl ester
o-methoxymethyl benzoate
ortho-methoxymethyl benzoate
 methyl 2-methoxybenzoate
 methyl o-anisate
 methyl o-methoxy benzoate
 methyl o-methoxybenzoate
 methyl ortho anisate
 methyl ortho-methoxybenzoate
 methyl salicylate o-methyl ether
 methyl salicylate ortho-methyl ether
 methyl-2-methoxy benzoate
 

Articles:

PubMed:Copper-catalysed intramolecular O-arylation: a simple and efficient method for benzoxazole synthesis.
PubMed:Attraction of the orange mint moth and false celery leaftier moth (Lepidoptera: Crambidae) to floral chemical lures.
PubMed:Circumambulatory movement of negative charge ("ring walk") during gas-phase dissociation of 2,3,4-trimethoxybenzoate anion.
PubMed:The first asymmetric total synthesis of (+)-coriandrone A and B.
PubMed:Diagnosis of tuberculosis by trained African giant pouched rats and confounding impact of pathogens and microflora of the respiratory tract.
PubMed:Synthesis of (+/-)- and (-)-vibralactone and vibralactone C.
PubMed:Preparation of lipophilic alkyl (hydroxy)benzoates by solvent-free lipase-catalyzed esterification and transesterification.
PubMed:Synthesis of (+/-)-vibralactone.
PubMed:Optimization of the solid-phase microextraction method in the determination of Ixodes ricinus (L.) volatiles.
PubMed:Field capture of northern and western corn rootworm beetles relative to attractant structure and volatility.
PubMed:Methyl 2-(methylthio)benzoate: the unique sulfur-containing sex pheromone of Phyllophaga crinita.
PubMed:Synthesis of geranyl phenyl ethers based on the cytotoxic monoterpenoids from the liverwort genus trichocolea
 
Notes:
Present in the mushroom Tramates graveolens. Flavouring ingredient
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