EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

cyclopentanone
ketopentamethylene

Supplier Sponsors

Name:cyclopentanone
CAS Number: 120-92-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-435-9
FDA UNII:220W81TN3S
Nikkaji Web:J5.333C
Beilstein Number:0605573
MDL:MFCD00001409
CoE Number:11050
XlogP3-AA:0.40 (est)
Molecular Weight:84.11796000
Formula:C5 H8 O
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1101 cyclopentanone
FLAVIS Number:07.149 (Old)
DG SANTE Food Flavourings:07.149 cyclopentanone
FEMA Number:3910 cyclopentanone
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):120-92-3 ; CYCLOPENTANONE
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.95000 to 0.96000 @ 25.00 °C.
Pounds per Gallon - (est).: 7.905 to 7.988
Refractive Index:1.43200 to 1.43800 @ 20.00 °C.
Melting Point: -51.00 °C. @ 760.00 mm Hg
Boiling Point: 130.00 to 131.00 °C. @ 760.00 mm Hg
Vapor Pressure:11.400000 mmHg @ 25.00 °C.
Flash Point: 87.00 °F. TCC ( 30.56 °C. )
logP (o/w): 0.200
Soluble in:
 alcohol
 water, 6.081e+004 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Strength:medium ,
recommend smelling in a 1.00 % solution or less
Odor Description:at 1.00 % in dipropylene glycol. minty
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
Charkit Chemical
CYCLOPENTANONE XP
EMD Millipore
For experimental / research use only.
Cyclopentanone
Indenta Group
Cyclopentanone
Parchem
cyclopentanone
Penta International
CYCLOPENTANONE ELECTRONIC GRADE
Penta International
CYCLOPENTANONE, Kosher
Santa Cruz Biotechnology
For experimental / research use only.
Cyclopentanone
Sigma-Aldrich
Cyclopentanone, ≥99%, FG
Certified Food Grade Products
TCI AMERICA
For experimental / research use only.
Cyclopentanone >99.0%(GC)
Tengzhou Xiang Yuan Aroma Chemicals
Cyclopentanone
Wanxiang International
Cyclopentanone
WholeChem
Cyclopentanone
ZEON Chemicals
Cyclopentanone
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 10 - Flammable.
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 23 - Do not breath vapour.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mammal (species unspecified) LD50 2000 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988.

intraperitoneal-mouse LD50 1950 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: COMA
Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 254, Pg. 2245, 1962.

Dermal Toxicity:
subcutaneous-frog LDLo 3000 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) SKIN AND APPENDAGES (SKIN): SWEATING: OTHER AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 50, Pg. 199, 1903.

subcutaneous-mouse LDLo 2600 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: COMA AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 50, Pg. 199, 1903.

Inhalation Toxicity:
inhalation-rat LC50 19500 mg/m3
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA LIVER: OTHER CHANGES
National Technical Information Service. Vol. OTS0572861

 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for cyclopentanone usage levels up to:
  0.1000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.018 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.02 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 19. Update in publication number(s): 20
 average usual ppmaverage maximum ppm
baked goods: 2.000003.00000
beverages(nonalcoholic): 1.0000015.00000
beverages(alcoholic): --
breakfast cereal: 1.000002.00000
cheese: --
chewing gum: --
condiments / relishes: 1.000002.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: 1.000002.00000
sugar substitutes: --
sweet sauces: 1.000002.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 51, (FGE.51)[1] - Consideration of alicyclic ketones and secondary alcohols and related esters evaluated by JECFA (59th meeting) and structurally related to alicyclic ketones, secondary alcohols and related esters evaluated by EFSA in FGE.09 (2004) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 9, Revision 1: (FGE.09 Rev1)[1] - Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical groups 8 and 30, and an ester of a phenol carboxylic acid from chemical group 25 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 9, Revision 2 (FGE.09Rev2): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 51, Revision 1 (FGE.51Rev1): Consideration of alicyclic ketones and secondary alcohols and related esters evaluated by the JECFA (59th meeting) structurally related to alicyclic ketones secondary alcohols and related esters in FGE.09Rev3 (2011)
View page or View pdf

Flavouring Group Evaluation 51, Revision 2 (FGE.51Rev2): Consideration of alicyclic ketones and secondary alcohols and related esters evaluated by JECFA (59th meeting) structurally related to alicyclic ketones secondary alcohols and related esters in FGE.09Rev6 (2015)
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
NLM Hazardous Substances Data Bank:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):120-92-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8452
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2245
WGK Germany:1
cyclopentanone
Chemidplus:0000120923
EPA/NOAA CAMEO:hazardous materials
RTECS:120-92-3
 
References:
 cyclopentanone
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:120-92-3
Pubchem (cid):8452
Pubchem (sid):134975379
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C00557
HMDB (The Human Metabolome Database):HMDB31407
FooDB:FDB003481
Export Tariff Code:2914.29.5000
Haz-Map:View
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
99+% purity grade available from coastal specialty chemicals
 
Potential Blenders and core components note
None Found
 
Potential Uses:
FRherbal
FRmint
 
Occurrence (nature, food, other):note
 coffee aroma
Search PMC Picture
 flour wheat flour
Search PMC Picture
 lavender oil spike spain @ 0.018%
Data GC Search Trop Picture
 potato
Search Trop Picture
 tomato
Search Trop Picture
 
Synonyms:
 adipic ketone
 adipinketon
 cyclopentan-1-one
ketocyclopentane
2-cyclopentanone
 cyclopentanone [UN2245] [Flammable liquid]
 dumasin
ketopentamethylene
 

Articles:

PubMed:Use of solid-phase microextraction coupled to gas chromatography-mass spectrometry for determination of urinary volatile organic compounds in autistic children compared with healthy controls.
PubMed:Effects of Curcumin Analogues for Inhibiting Human Prostate Cancer Cells and the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice.
PubMed:Biocatalysis with Escherichia coli-overexpressing cyclopentanone monooxygenase immobilized in polyvinyl alcohol gel.
PubMed:Involvement of cholesterol membrane transporter Niemann-Pick C1-like 1 in the intestinal absorption of lutein.
PubMed:A toxicologic and dermatologic assessment of cyclopentanones and cyclopentenones when used as fragrance ingredients.
PubMed:Fragrance material review on 2-hexylidene cyclopentanone.
PubMed:Fragrance material review on methyl jasmonate.
PubMed:Fragrance material review on methyl 3-oxo-2-(pent-2-enyl)cyclopentaneacetate.
PubMed:Fragrance material review on cyclotene propionate.
PubMed:Fragrance material review on hexenylcyclopentanone.
PubMed:Fragrance material review on methyl hexyl oxo cyclopentanone carboxylate.
PubMed:Fragrance material review on 2-heptylidenecyclopentan-1-one.
PubMed:Fragrance material review on methyl dihydrojasmonate.
PubMed:Fragrance material review on dihydroisojasmone.
PubMed:Fragrance material review on 3-methyl-2-(pentyloxy)-2-cyclopenten-1-one.
PubMed:Fragrance material review on 2-(3,7-dimethyl-2,6-octadienyl)cyclopentanone.
PubMed:Fragrance material review on 3-methyl-2-(n-pentanyl)-2-cyclopenten-1-one.
PubMed:Fragrance material review on 3-ethyl-2-hydroxy-2-cyclopenten-1-one.
PubMed:Fragrance material review on 3-methyl-2-(2-pentenyl)-2-cyclopenten-1-one.
PubMed:Fragrance material review on cis-jasmone.
PubMed:Fragrance material review on cyclopentanone.
PubMed:Fragrance material review on 2-heptylcyclopentanone.
PubMed:Fragrance material review on 2-pentylcyclopentan-1-one.
PubMed:Fragrance material review on 2-cyclopentylcyclopentanone.
PubMed:Fragrance material review on 2-hexylcyclopentanone.
PubMed:Fragrance material review on 3-methyl-2-pentylcyclopentan-1-one.
PubMed:Fragrance material review on 2-hydroxy-3,4-dimethyl-2-cyclopenten-1-one.
PubMed:Fragrance material review on isojasmone.
PubMed:Fragrance material review on 2-(p-Menth-1-ene-10-yl) cyclopentanone.
PubMed:Fragrance material review on 2,2,5-trimethyl-5-pentylcyclopentanone.
PubMed:Vitamin D intestinal absorption is not a simple passive diffusion: evidences for involvement of cholesterol transporters.
PubMed:Encapsulation of recombinant E. coli expressing cyclopentanone monooxygenase in polyelectrolyte complex capsules for Baeyer-Villiger biooxidation of 8-oxabicyclo[3.2.1]oct-6-en-3-one.
PubMed:New method for determination of epichlorohydrin in epoxy-coated cans by oxolane derivatization and gas chromatography-mass spectrometry.
PubMed:Chemical profile of rums as a function of their origin. The use of chemometric techniques for their identification.
PubMed:Identification and migration of degradation compounds from irradiation of multilayer polyamide 6 films for meat foodstuffs and cheese.
PubMed:Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems.
PubMed:Volatile metabolites from actinomycetes.
PubMed:Migration from polyamide 'microwave and roasting bags' into roast chicken.
PubMed:Determination of potential migrants present in Nylon 'microwave and roasting bags' and migration into olive oil.
PubMed:[Determination of total bromine in foods by ECD gas chromatograph].
PubMed:Effect of reductive alkylation of the epsilon-amino group of lysyl redsidues of casein on its nutritive value in rats.
 
Notes:
Found in various foods, incl. potato and tomato, and cooked foods, e.g. butter, meats, coffee, roasted peanut. Flavouring ingredient Cyclopentanone is a colorless liquid organic compound with a peppermint-like odor. It is a cyclic ketone, structurally similar to cyclopentane, consisting of a five-membered ring containing a ketone functional group.
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