EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

meta-cresol
m-cresol

Sponsors

Name:3-methylphenol
CAS Number: 108-39-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-577-9
FDA UNII:GGO4Y809LO
Nikkaji Web:J1.186J
Beilstein Number:0506719
MDL:MFCD00002302
CoE Number:617
XlogP3:2.00 (est)
Molecular Weight:108.13996000
Formula:C7 H8 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:food contact resinous and polymeric coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:692 m-cresol
FLAVIS Number:04.026 (Old)
DG SANTE Food Flavourings:04.026 3-methylphenol
DG SANTE Food Contact Materials:3-methylphenol
FEMA Number:3530 m-cresol
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: M-CRESOL
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2410 Phenolic resins in molded articles.
 
Physical Properties:
Appearance:white to amber liquid to crystals (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.03400 to 1.03700 @ 20.00 °C.
Pounds per Gallon - (est).: 8.614 to 8.639
Refractive Index:1.53800 to 1.54200 @ 20.00 °C.
Melting Point: 11.00 to 12.00 °C. @ 760.00 mm Hg
Boiling Point: 202.00 to 203.00 °C. @ 760.00 mm Hg
Boiling Point: 120.00 to 121.00 °C. @ 50.00 mm Hg
Vapor Pressure:0.110000 mm/Hg @ 25.00 °C.
Vapor Density:7.07 ( Air = 1 )
Flash Point: 187.00 °F. TCC ( 86.11 °C. )
logP (o/w): 1.960
Soluble in:
 alcohol
 water, 8890 mg/L @ 25 °C (est)
 water, 2.27E+04 mg/L @ 25 °C (exp)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: phenolic
Odor Strength:high ,
recommend smelling in a 0.01 % solution or less
Substantivity:43 hour(s) at 100.00 %
medicinal woody leathery phenolic
Odor Description:at 0.01 % in dipropylene glycol. medicinal woody leather phenolic
Luebke, William tgsc, (1995)
Odor sample from: Sigma-Aldrich
Odor and/or flavor descriptions from others (if found).
Sigma-Aldrich
m-Cresol, ≥98%, FG
Odor Description:medicinal; woody; ethereal
Pell Wall Perfumes
m-Cresol, 1% in DPG
Odor Description:Medicinal, woody, leather, phenolic
Arctander has this to say about it: “Dry-tarry, medicinal-leathery odor, conventionally described as “phenolic. Useful as a floralizing companion to Indole in sharp-exotic flower fragrances, Lily (Bermuda-lily, etc.), Narcisse, etc. Concentration in the perfume composition will usually be about 0.1%, sometimes slightly higher, mostly lower than 0.1%.”
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
perfuming agents
 
Suppliers:
EMD Millipore
For experimental / research use only.
m-Cresol
Pell Wall Perfumes
m-Cresol, 1% in DPG
Odor: Medicinal, woody, leather, phenolic
Use: Arctander has this to say about it: “Dry-tarry, medicinal-leathery odor, conventionally described as “phenolic. Useful as a floralizing companion to Indole in sharp-exotic flower fragrances, Lily (Bermuda-lily, etc.), Narcisse, etc. Concentration in the perfume composition will usually be about 0.1%, sometimes slightly higher, mostly lower than 0.1%.”
Penta International
m-CRESOL FOOD GRADE, Kosher, Halal
Penta International
Meta-CRESOL USP GRADE, Kosher, Halal
Santa Cruz Biotechnology
For experimental / research use only.
m-Cresol
Sigma-Aldrich
m-Cresol, ≥98%, FG
Odor: medicinal; woody; ethereal
Certified Food Grade Products
TCI AMERICA
For experimental / research use only.
m-Cresol >98.0%(GC)
The Good Scents Company
NOVOLAK 562
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
T - Toxic.
R 24/25 - Toxic in contact with skin and if swallowed.
R 34 - Causes burns.
S 02 - Keep out of the reach of children.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 [sex: M] 242 mg/kg
(E.I. du Pont de Nemours & Company, 1969a)

oral-mouse LD50 828 mg/kg
(E.I. du Pont de Nemours & Company, 1969a)

intraperitoneal-mouse LD50 168 mg/kg
(E.I. du Pont de Nemours & Company, 1969a)

gavage-rat LD50 [sex: M] 520 mg/kg
(Carpenter, 1949b)

oral-rat LD50 242 mg/kg
GASTROINTESTINAL: PERITONITIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 3-5/1969

oral-rabbit LDLo 1400 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.

intravenous-rabbit LDLo 280 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.

oral-mouse LD50 828 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974.

intraperitoneal-mouse LD50 168 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 56, 1959.

intraperitoneal-guinea pig LDLo 100 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.

Dermal Toxicity:
subcutaneous-rat LDLo 900 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 56, 1959.

skin-rat LD50 1100 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974.

subcutaneous-rabbit LDLo 500 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.

subcutaneous-mouse LDLo 450 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.

subcutaneous-guinea pig LDLo 300 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 56, 1959.

subcutaneous-cat LDLo 180 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.

Inhalation Toxicity:
inhalation-rat LC50 > 710 mg/m3/1H
Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.

 
Safety in Use Information:
Category: food contact resinous and polymeric coatings
Recommendation for meta-cresol usage levels up to:
  0.0100 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.12 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.10 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 11
 average usual ppmaverage maximum ppm
baked goods: -1.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: -0.50000
hard candy: --
imitation dairy: --
instant coffee / tea: -0.50000
jams / jellies: --
meat products: -0.50000
milk products: --
nut products: -0.50000
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: -0.50000
snack foods: -0.50000
soft candy: --
soups: -0.50000
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 22 (FGE.22): Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 58 (FGE.58) Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 60 (FGE.60): Consideration of eugenol and related hydroxyallylbenzene derivatives evaluated by JECFA (65th meeting) structurally related to ring- substituted phenolic substances evaluated by EFSA in FGE.22 (2006)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25
View page or View pdf

Scientific Opinion on the safety and efficacy of phenol derivatives containing ring-alkyl, ring-alkoxy and side-chains with an oxygenated functional group (chemical group 25) when used as flavourings for all species
View page or View pdf

EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):108-39-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :342
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2076
WGK Germany:1
3-methylphenol
Chemidplus:0000108394
EPA/NOAA CAMEO:hazardous materials
RTECS:108-39-4
 
References:
 3-methylphenol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:108-39-4
Pubchem (cid):342
Pubchem (sid):134970512
Flavornet:108-39-4
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C01467
HMDB (The Human Metabolome Database):HMDB02048
FooDB:FDB008788
YMDB (Yeast Metabolome Database):YMDB01730
Export Tariff Code:2907.12.0000
FDA Listing of Food Additive Status:View
Haz-Map:View
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
Wikipedia2:View2
RSC Learn Chemistry:View
Formulations/Preparations:
•grade: technical (95-98%) •pure cresol is a mixture of ortho-, meta- & para-isomers. crude cresol (commercial cresol) is a mixture of aromatic cmpd containing about 20% of o-cresol, 40% of m-cresol, & 30% of p-cresol with small amt of phenol & xylenols. •franklin cresolis, 50% m-cresol, 31% soap cancelled •saponated cresol solution n.f., 50% m-cresol, 35% soap cancelled •bacticin, 0.4660% m-cresol, 0.4630% 2,4-xylenol cancelled •celcure dry mix (chemicals for wood preserving), 5% m-cresol, 50% copper sulfate pentahydrate, 45% potassium dichromate cancelled •rover's dog shampoo, 0.4% m-cresol, 1.0% paradichlorobenzene, 0.1% pine oil, 19.3% soap cancelled •gallex, 0.4660% m-cresol, 0.4630% 2,4-xylenol active •generally m- and p- isomers are used industrially as a mixture containing 40% to 65% m-cresol.
 
Potential Blenders and core components note
For Odor
animal
2-iso
butyl quinoline
FR
floral
cananga oil
FL/FR
floral methanol
FR
herbal
ajowan seed oil
FL/FR
cananga fruit oil
FR
2,10-
epoxypinane
FR
matricaria chamomilla flower oil
FL/FR
white
thyme oil
FL/FR
thyme oil (thymus zygis gracillis) spain
FL/FR
red
thyme oil spain
FL/FR
thymol
FL/FR
leathery
2-tert-
butyl-6-methyl phenol
FR
medicinal
2,6-
xylenol
FL/FR
orris
2(1)-
orris butanal
FL/FR
phenolic
ortho-
cresol
FR
2-
propyl phenol
FL/FR
4-
vinyl phenol
FL/FR
resinous
amber oil CO2 extract
FR
smoky
birch tar oil
FL/FR
spicy
4-
methyl guaiacol
FL/FR
For Flavor
No flavor group found for these
birch tar oil
FL/FR
2(1)-
orris butanal
FL/FR
2-
propyl phenol
FL/FR
burnt
burnt
2,6-
xylenol
FL/FR
floral
cananga oil
FL/FR
herbal
ajowan seed oil
FL/FR
matricaria chamomilla flower oil
FL/FR
white
thyme oil
FL/FR
thyme oil (thymus zygis gracillis) spain
FL/FR
red
thyme oil spain
FL/FR
phenolic
thymol
FL/FR
4-
vinyl phenol
FL/FR
vanilla
4-
methyl guaiacol
FL/FR
 
Potential Uses:
 antimicrobial agents
FRcastoreum
FRmyrrh
 
Occurrence (nature, food, other):note
 asparagus shoot
Search Trop Picture
 coal tar
Search PMC Picture
 coffee arabica coffee bean
Search Trop Picture
 jasmin absolute china @ 2.33%
Data GC Search Trop Picture
 myrrh oil
Search Trop Picture
 osmanthus absolute @ trace%
Data GC Search Trop Picture
 prangos uechtritzii boiss. et hausskn. fruit oil turkey @ 1.40%
Data GC Search Trop Picture
 sauromatum guttatum
Search Trop Picture
 tea leaf
Search Trop Picture
 
Synonyms:
3-cresol
m-cresol
m-cresol food grade
 cresol meta pure
meta-cresol N- grade
m-cresylic acid
meta-cresylic acid
1-hydroxy-3-methyl benzene
1-hydroxy-3-methylbenzene
3-hydroxytoluene
3-methyl phenol
meta-methyl phenol
3-methyl-1-hydroxybenzene
1-methyl-3-hydroxybenzene
3-methylphenol
m-methylphenol
 
 
Notes:
Flavouring ingredient
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