EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

costus root oil
saussurea lappa root oil

Supplier Sponsors

Name:saussurea lappa root oil
CAS Number: 8023-88-9
FDA UNII:2WF6750061
MDL:MFCD01771687
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
FEMA Number:2336 costus root oil
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: COSTUS ROOT, OIL (SAUSSUREA LAPPA CLARKE)
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.510 Natural flavoring substances and natural substances used in conjunction with flavors.
 
Physical Properties:
Appearance:pale yellow solid (est)
Food Chemicals Codex Listed: No
Soluble in:
 alcohol
 water, 9.376 mg/L @ 25 °C (est)
Insoluble in:
 water
Stability:
 non-discoloring in most media
 
Organoleptic Properties:
Odor Type: animal
Odor Strength:medium
Substantivity:316 hour(s) at 100.00 %
orris green hairy woody melon unripe melon
Odor Description:at 100.00 %. orris green hairy woody unripe melons
Luebke, William tgsc, (1983)
Odor sample from: Berje Inc.
Flavor Type: orris
costus
Taste Description: costus
Odor and/or flavor descriptions from others (if found).
Firmenich
COSTUS EO
Odor Description:orris green hairy woody unripe melons
Taste Description:Tea-like, sweat, fatty, herbal
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: not used anymore
 
Suppliers:
Diffusions Aromatiques
COSTUS HUILE ESSENTIELLE (k) uniquement alim.
Diffusions Aromatiques
COSTUS HUILE ESSENTIELLE
Excellentia International
Costus Oil
Firmenich
COSTUS EO
Flavor: Tea-like, sweat, fatty, herbal
Fleurchem
costus root oil
India Essential Oils
Costus Root Oil
Indo World Trading
Costus Root Oil
Kanta Enterprises
Costus Roots Oil
Lluch Essence
COSTUS ROOTS OIL
Nanda Medicinal Plants
Costus Root Oil
Odor: Extremely tenacious odor reminiscent of old precious wood. The odor has been compared to that of wet dog, human hair, or animal fur.
Noble Molecular Research
For experimental / research use only.
Costus Root Oil (cultivated)
Parchem
Costus Root Oil
Penta International
COSTUS ROOT OIL, Kosher, Halal
Phoenix Aromas & Essential Oils
Costus Root Oil
Robertet
Costus Root Oil
Sigma-Aldrich
Costus oil, natural, FG
Certified Food Grade Products
Silverline Chemicals
Costus Root Oil
Ultra International
Costus Root Oil
Crop Calendar
Vigon International
Costus Oil
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3400 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 867, 1974.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 867, 1974.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
IFRA Critical Effect: Sensitization
IFRA: View Standard
Recommendation for costus root oil usage levels up to:
 PROHIBITED: Should not be used as a fragrance ingredient.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -1.20000
beverages(nonalcoholic): -0.08000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.90000
fruit ices: -0.90000
gelatins / puddings: -0.10000
granulated sugar: --
gravies: --
hard candy: -1.90000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
EPI System: View
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):8023-88-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:2
saussurea lappa root oil
Chemidplus:0008023889
RTECS:GN1775000 for cas# 8023-88-9
 
References:
 saussurea lappa root oil
Canada Domestic Sub. List:8023-88-9
Pubchem (sid):135352797
 
Other Information:
FDA Everything Added to Food in the United States (EAFUS):View
Export Tariff Code:3301.29.6000
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION
 
Potential Blenders and core components note
For Odor
No odor group found for these
amyl undecylenate
FL/FR
satinaldehyde
FL/FR
aldehydic
aldehydic
nonanal (aldehyde C-9)
FL/FR
10-
undecenal (aldehyde C-11 undecylenic)
FL/FR
amber
angelica root oil
FL/FR
cistus ladaniferus resinoid
FR
animal
animal carbolactone
FR
iso
butyl quinoline
FR
costus valerolactone
FR
para-
cresyl caprylate
FL/FR
methyl (E)-2-octenoate
FL/FR
balsamic
iso
amyl benzoate
FL/FR
amyris wood oil
FL/FR
siam
benzoin resinoid
FL/FR
benzyl benzoate
FL/FR
benzyl salicylate
FL/FR
betula pubescens bud oil
FL/FR
laevo-
bornyl acetate
FL/FR
iso
bornyl acetate
FL/FR
iso
butyl cinnamate
FL/FR
cinnamyl alcohol
FL/FR
clover nitrile
FR
ethyl cinnamate
FL/FR
fir balsam absolute
FR
mastic gum resin
FR
methyl (E)-cinnamate
FL/FR
3-
phenyl propyl alcohol
FL/FR
berry
raspberry ketone
FL/FR
citrus
bergamot oil bergaptene reduced italy
FL/FR
coconut
gamma-
heptalactone
FL/FR
gamma-
nonalactone (aldehyde C-18 (so-called))
FL/FR
gamma-
octalactone
FL/FR
fatty
butyl undecylenate
FL/FR
decanol
FL/FR
floral
alpha-
amyl cinnamaldehyde
FL/FR
iso
amyl salicylate
FL/FR
benzyl acetate
FL/FR
benzyl alcohol
FL/FR
bois de rose oil brazil
FL/FR
boronia absolute
FL/FR
iso
butyl salicylate
FL/FR
cassie absolute
FL/FR
citronellol
FL/FR
coriander seed oil
FL/FR
cyclamen aldehyde
FL/FR
cyclohexyl ethyl alcohol
FL/FR
dimethyl benzyl carbinol
FL/FR
floral pyranol
FR
geranium oil bourbon
FL/FR
heliotropin
FL/FR
heliotropyl acetone
FL/FR
heliotropyl diethyl acetal
FR
(Z)-3-
hexen-1-yl salicylate
FL/FR
alpha-
hexyl cinnamaldehyde
FL/FR
hyacinth ether
FR
laevo-
linalool
FL/FR
linalool
FL/FR
linalool oxide
FL/FR
methyl dihydrojasmonate
FL/FR
mimosa absolute france
FL/FR
muguet carboxaldehyde
FR
nerol
FL/FR
nerolidol
FL/FR
nonanol
FL/FR
ocean propanal
FL/FR
orange leaf absolute
FL/FR
orris pyridine 25% IPM
FR
phenethyl alcohol
FL/FR
phenethyl phenyl acetate
FL/FR
phenethyl salicylate
FL/FR
rhodinol
FL/FR
rose butanoate
FL/FR
tetrahydrolinalool
FL/FR
(E)-2,5,9-
trimethyl-4,9-decadien-1-al
FR
ylang ylang flower oil
FL/FR
ylang ylang flower oil
FL/FR
fruity
benzyl propionate
FL/FR
gamma-
decalactone
FL/FR
green acetate
FR
methyl heptanoate
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
green
para-
dimethyl hydroquinone
FL/FR
galbanum oleoresin
FL/FR
galbanum resinoid
FL/FR
methyl heptine carbonate
FL/FR
methyl octine carbonate
FL/FR
phenyl acetaldehyde dimethyl acetal
FL/FR
hay
hay absolute
FR
herbal
acorus calamus root oil
FR
(+)-alpha-
campholenic aldehyde
FL/FR
canarium luzonicum oil
FL/FR
clary sage oil france
FL/FR
daucus carota fruit oil
FL/FR
iso
dihydrolavandulal
FL/FR
marine
green
algae absolute
FL/FR
marine pyridine
FR
minty
(-)-iso
pulegol
FL/FR
iso
pulegol
FL/FR
mossy
oakmoss absolute
FL/FR
veramoss (IFF)
FR
naphthyl
beta-
naphthyl ethyl ether
FL/FR
orris
iso
eugenyl formate
FL/FR
powdery
para-
anisyl alcohol
FL/FR
spicy
benzyl isoeugenol
FL/FR
cuminaldehyde
FL/FR
iso
eugenyl acetate
FL/FR
ginger root oil china
FL/FR
levisticum officinale root oil
FL/FR
2-
octanol
FL/FR
black
pepper oil
FL/FR
black
pepper oil CO2 extract
FL/FR
terpenic
alpha-
phellandrene
FL/FR
alpha-
terpineol
FL/FR
tonka
coumarin
FR
flouve absolute
FR
gamma-
hexalactone
FL/FR
tonka bean absolute
FR
vanilla
ethyl vanillin
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillyl acetate
FL/FR
waxy
decyl acetate
FL/FR
woody
amber carbinol
FR
alpha-
farnesene
FL/FR
alpha-
farnesene isomer
FL/FR
guaiacwood oil
FL/FR
humulus lupulus extract
FL/FR
methyl cedryl ketone
FL/FR
patchouli ethanone
FR
patchouli oil
FL/FR
sandalwood oil
FL/FR
santall
FR
(±)-
tetrahydronootkatone
FL/FR
tobacarol (IFF)
FR
vetiver oil haiti
FL/FR
woody acetate
FR
(Z)-
woody amylene
FR
For Flavor
No flavor group found for these
green
algae absolute
FL/FR
amyl undecylenate
FL/FR
betula pubescens bud oil
FL/FR
costus root absolute
FL
costus root resinoid
FL
elecampane root oil
FL
iso
eugenyl formate
FL/FR
methyl (E)-cinnamate
FL/FR
(±)-
tetrahydronootkatone
FL/FR
2,4,4-
trimethyl-1,3-oxathiane
FL
aldehydic
aldehydic
nonanal (aldehyde C-9)
FL/FR
animal
para-
cresyl caprylate
FL/FR
balsamic
siam
benzoin resinoid
FL/FR
benzyl benzoate
FL/FR
benzyl salicylate
FL/FR
laevo-
bornyl acetate
FL/FR
iso
butyl cinnamate
FL/FR
ethyl cinnamate
FL/FR
berry
heliotropyl acetone
FL/FR
raspberry ketone
FL/FR
cherry
heliotropin
FL/FR
citrus
bergamot oil bergaptene reduced italy
FL/FR
laevo-
linalool
FL/FR
linalool
FL/FR
nerol
FL/FR
alpha-
terpineol
FL/FR
coconut
gamma-
nonalactone (aldehyde C-18 (so-called))
FL/FR
cooling
iso
butyl salicylate
FL/FR
creamy
gamma-
hexalactone
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
fatty
10-
undecenal (aldehyde C-11 undecylenic)
FL/FR
floral
bois de rose oil brazil
FL/FR
citronellol
FL/FR
geranium oil bourbon
FL/FR
methyl dihydrojasmonate
FL/FR
ocean propanal
FL/FR
orange leaf absolute
FL/FR
phenethyl alcohol
FL/FR
rhodinol
FL/FR
satinaldehyde
FL/FR
tetrahydrolinalool
FL/FR
ylang ylang flower oil
FL/FR
ylang ylang flower oil
FL/FR
fruity
iso
amyl benzoate
FL/FR
para-
anisyl alcohol
FL/FR
benzyl acetate
FL/FR
benzyl alcohol
FL/FR
benzyl propionate
FL/FR
boronia absolute
FL/FR
gamma-
decalactone
FL/FR
methyl (E)-2-octenoate
FL/FR
methyl heptanoate
FL/FR
rose butanoate
FL/FR
green
iso
amyl salicylate
FL/FR
angelica root oil
FL/FR
(+)-alpha-
campholenic aldehyde
FL/FR
canarium luzonicum oil
FL/FR
cinnamyl alcohol
FL/FR
cyclamen aldehyde
FL/FR
cyclohexyl ethyl alcohol
FL/FR
para-
dimethyl hydroquinone
FL/FR
alpha-
farnesene
FL/FR
alpha-
farnesene isomer
FL/FR
galbanum oleoresin
FL/FR
galbanum resinoid
FL/FR
(Z)-3-
hexen-1-yl salicylate
FL/FR
linalool oxide
FL/FR
methyl heptine carbonate
FL/FR
methyl octine carbonate
FL/FR
nerolidol
FL/FR
oakmoss absolute
FL/FR
phenyl acetaldehyde dimethyl acetal
FL/FR
herbal
clary sage oil france
FL/FR
coriander seed oil
FL/FR
daucus carota fruit oil
FL/FR
iso
dihydrolavandulal
FL/FR
honey
phenethyl phenyl acetate
FL/FR
lactonic
gamma-
heptalactone
FL/FR
gamma-
octalactone
FL/FR
medicinal
dimethyl benzyl carbinol
FL/FR
phenethyl salicylate
FL/FR
minty
(-)-iso
pulegol
FL/FR
iso
pulegol
FL/FR
orris
costus root oil CO2 extract
FL
powdery
beta-
naphthyl ethyl ether
FL/FR
spicy
benzyl isoeugenol
FL/FR
cassie absolute
FL/FR
cuminaldehyde
FL/FR
iso
eugenyl acetate
FL/FR
ginger root oil china
FL/FR
levisticum officinale root oil
FL/FR
2-
octanol
FL/FR
black
pepper oil
FL/FR
black
pepper oil CO2 extract
FL/FR
3-
phenyl propyl alcohol
FL/FR
terpenic
alpha-
phellandrene
FL/FR
tropical
alpha-
amyl cinnamaldehyde
FL/FR
vanilla
ethyl vanillin
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillyl acetate
FL/FR
waxy
butyl undecylenate
FL/FR
decanol
FL/FR
decyl acetate
FL/FR
alpha-
hexyl cinnamaldehyde
FL/FR
mimosa absolute france
FL/FR
nonanol
FL/FR
woody
amyris wood oil
FL/FR
iso
bornyl acetate
FL/FR
guaiacwood oil
FL/FR
humulus lupulus extract
FL/FR
methyl cedryl ketone
FL/FR
patchouli oil
FL/FR
sandalwood oil
FL/FR
vetiver oil haiti
FL/FR
 
Potential Uses:
FRaldehydic
FRanimal
 bellodgia
 cachet
FRchypre
 diffusion
FRfern
FRfloral
 fur
 hair
 my sin
FRnarcissus
FRoriental
FRorris
FRpatchouli oil replacer
 presence
 scandal
 tabu
 topnotes
FRtuberose
FRvetiver
FLviolet
 vol de nuit
FRwoody
 
Occurrence (nature, food, other):note
 costus root
Search Trop Picture
 
Synonyms:
 aplotaxis lappa root oil
 aucklandia costus root oil
 auklandra costus root oil
 costus oil
 costus oil 100
 costus root oil (saussurea lappa clarke)
 saussurea costus root oil
 saussurea lappa root oil
 spiral flag root oil (saussurea lappa clarke)
 

Articles:

PubMed:UPLC/MS/MS method for quantification and cytotoxic activity of sesquiterpene lactones isolated from Saussurea lappa.
PubMed:Volatile constituents of Saussurea costus roots cultivated in Uttarakhand Himalayas, India.
PubMed:Evaluation of anti-resistant activity of Auklandia (Saussurea lappa) root against some human pathogens.
PubMed:Aqueous extract of Saussurea lappa root ameliorate oxidative myocardial injury induced by isoproterenol in rats.
PubMed:Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells.
PubMed:Larvicidal activity of medicinal plant extracts and lignan identified in Phryma leptostachya var. asiatica roots against housefly (Musca domestica L.).
PubMed:Matrix solid-phase dispersion extraction coupled with HPLC-diode array detection method for the analysis of sesquiterpene lactones in root of Saussurea lappa C.B.Clarke.
PubMed:Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells.
PubMed:A new sesquiterpene and other constituents from Saussurea lappa root.
PubMed:Antihepatotoxic activity of Saussurea lappa extract on D-galactosamine and lipopolysaccharide-induced hepatitis in mice.
PubMed:Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa.
PubMed:Authentication of Saussurea lappa, an endangered medicinal material, by ITS DNA and 5S rRNA sequencing.
PubMed:Effects of Saussurea lappa roots extract in ethanol on leukocyte phagocytic activity, lymphocyte proliferation and interferon-gamma (IFN-gamma).
PubMed:Presence of cholinergic and calcium antagonist constituents in Saussurea lappa explains its use in constipation and spasm.
PubMed:Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells.
PubMed:Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells.
PubMed:Cytotoxic sesquiterpene lactones from the root of Saussurea lappa.
PubMed:Germacrenes from fresh costus roots.
PubMed:Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release.
PubMed:Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28 in macrophage cell line.
PubMed:Effect of dehydrocostus lactone and costunolide from Saussurea root on the central nervous system in mice.
PubMed:Effect of polyols on heat inactivation of Aspergillus niger van Teighem inulinase.
PubMed:Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells.
PubMed:Saussureamines A, B, C, D, and E, new anti-ulcer principles from Chinese Saussureae Radix.
PubMed:Sesquiterpenoids from costum root oil (Saussurea lappa Clarke)
 
Notes:
Do not use on any part of the body because of potential sensitizing. Steam distilled from the roots of Saussurea Lappa. extract from roots of saussurea lappa used in perfumery & cosmetics; contains sesquiterpene lactones reported to cause contact hypersensitivity; structures of components. tsca definition 2008: extractives and their physically modified derivatives. saussurea lappa, compositae.
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