EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

humulus lupulus extract
extract of the hops, humulus lupulus l., cannabidaceae

Sponsors

Name:humulus lupulus l. extract
CAS Number: 8060-28-4
ECHA EC Number:232-504-3
Category:cosmetic, flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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NCBI:Search
FEMA Number:2578 hop extract
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: HOPS, EXTRACT (HUMULUS LUPULUS L.)
FDA Regulation:
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart C--Solvents, Lubricants, Release Agents and Related Substances
Sec. 173.240 Isopropyl alcohol.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart C--Solvents, Lubricants, Release Agents and Related Substances
Sec. 173.250 Methyl alcohol residues.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart C--Solvents, Lubricants, Release Agents and Related Substances
Sec. 173.255 Methylene chloride.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart C--Solvents, Lubricants, Release Agents and Related Substances
Sec. 173.270 Hexane.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart A--General Provisions
Sec. 182.20 Essential oils, oleoresins (solvent-free), and natural extractives (including distillates).
 
Physical Properties:
Appearance:pale brown to dark brown liquid (est)
Food Chemicals Codex Listed: No
Specific Gravity:0.97180 to 1.04180 @ 25.00 °C.
Pounds per Gallon - (est).: 8.086 to 8.669
Refractive Index:1.35540 to 1.37140 @ 20.00 °C.
Shelf Life: 6.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light.
 
Organoleptic Properties:
Odor Type: woody
woody green citrus malty tagette
Odor Description:woody green citrus malt tagette
Flavor Type: woody
">hops
Taste Description: hops
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
astringents
emollients
perfuming agents
skin conditioning
soothing agents
tonic
 
Suppliers:
AuNutra® Industries
Hops P.E
Bristol Botanicals
Hops fluid extract Humulis lupulus 1:1 25%
Carrubba
hop extract
Excellentia International
Hop Extract
Grau Aromatics
HOPS EXTRACT HS 2367 G
(hydrosoluble)
Grau Aromatics
HOPS EXTRACT LS 3473 G
(liposoluble)
H. Erhard Wagner
PhytoVital Hops
Hopsteiner
Ethanol Hop Extract
Brewing Products
Naturex
Hops Extract
NAT arom®, liquid or powder forms
SRS Aromatics
HOPS EXTRACT HS 2367 G
SRS Aromatics
HOPS EXTRACT LS 3473 G
Symrise
Extrapone® Hop GW
Life Essentials - Botanicals
Symrise
Hop CL
Life Essentials - Botanicals
Vege Tech
hop extract
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: cosmetic, flavor and fragrance agents
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): -160.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
humulus lupulus l. extract
Chemidplus:0008060284
 
References:
 humulus lupulus l. extract
Pubchem (sid):135325910
 
Other Information:
FDA Everything Added to Food in the United States (EAFUS):View
Export Tariff Code:1302.13.0000
Wikipedia:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
humulus lupulus distillates
FL/FR
aldehydic
aldehydic
dodecanal (aldehyde C-12 lauric)
FL/FR
green hexanal
FL/FR
undecanal
FL/FR
balsamic
betula pubescens bud oil
FL/FR
fir balsam absolute
FR
fir balsam concrete
FR
citrus
citral diethyl acetal
FL/FR
citral dimethyl acetal
FL/FR
(R)-
citronellyl nitrile
FR
iso
decyl acetate
FR
lime oil fractions
FR
limonene aldehyde
FR
litsea cubeba fruit oil
FL/FR
methyl heptenone
FL/FR
1-
methyl-4-methyl ethenyl cyclohexene sulfurized
FL/FR
alpha-
methylene citronellal
FR
neroli ketone
FR
tangerine acetate
FR
fatty
6-
methyl-5-hepten-2-one propylene glycol acetal
FL/FR
floral
citronellol
FL/FR
dihydrocitronellyl ethyl ether
FR
glycoacetal
FR
karo karounde absolute
FR
linalool
FL/FR
melaleuca ericifolia leaf oil
FR
(E)-
nerolidol
FL/FR
orange leaf absolute
FL/FR
fruity
iso
butyl 2-methyl butyrate
FL/FR
cyclohexyl crotonate
FR
1,4-
dibutyl-6,8-dioxabicyclo(3.2.1)octane
FR
1,4-
diisopropyl-6,8-dioxabicyclo(3.2.1)octane
FR
grapefruit acetal
FR
methyl acetoacetate
FL/FR
green
bergoxane
FR
citral / diisotridecyl acetal
FR
citrus carbaldehyde / methyl anthranilate schiff's base
FR
fresh nitrile
FR
galbanum oleoresin
FL/FR
galbanum resinoid
FL/FR
green carboxylate
FR
hop oil CO2 extract
FL/FR
dextro-
limonene oxide
FL/FR
octanal diethyl acetal
FL/FR
octanal dimethyl acetal
FL/FR
(E)-2-
octen-1-ol
FL/FR
herbal
(+)-alpha-
campholenic aldehyde
FL/FR
canarium luzonicum oil
FL/FR
iso
dihydrolavandulal
FL/FR
2-
dodecenal
FL/FR
hop absolute
FL/FR
hop cone oil
FL/FR
hop fragrance
FR
hop oil
FL/FR
hop oleoresin
FL/FR
humulus lupulus cone extract
FL/FR
linalyl formate
FL/FR
nonisyl formate
FR
tricyclo(5.2.1.02,6)dec-3-enyl acetate
FR
minty
iso
pulegol
FL/FR
(-)-iso
pulegol
FL/FR
2,4,4,6-
tetramethyl cyclohexa-2,5-diene-1-one
FR
pine
pine oil 85
FR
spicy
2,5-
dimethyl bicyclo(3.2.1)-2-octen-3-yl acetate + 1,4-dimethyl bicyclo(3.2.1)-2-octen-3-yl acetate
FR
2-
octanol
FL/FR
black
pepper oil CO2 extract
FL/FR
terpenic
juniper branch oil
FR
alpha-
phellandrene
FL/FR
waxy
decanal dimethyl acetal
FL/FR
woody
bruyere root absolute
FR
alpha-
farnesene
FL/FR
alpha-
farnesene isomer
FL/FR
humulus lupulus tincture
FL/FR
moss naphthaleneol
FR
(±)-
tetrahydronootkatone
FL/FR
xanthoxylum alatum roxb. oil
FR
yeasty
beer CO2 extract
FL/FR
beer extract
CS
For Flavor
No flavor group found for these
betula pubescens bud oil
FL/FR
decanal dimethyl acetal
FL/FR
linalyl formate
FL/FR
methyl acetoacetate
FL/FR
6-
methyl-5-hepten-2-one propylene glycol acetal
FL/FR
(±)-
tetrahydronootkatone
FL/FR
2,4,4-
trimethyl-1,3-oxathiane
FL
dextro-
limonene oxide
FL/FR
citrus
citrus
citral diethyl acetal
FL/FR
citral dimethyl acetal
FL/FR
linalool
FL/FR
litsea cubeba fruit oil
FL/FR
1-
methyl-4-methyl ethenyl cyclohexene sulfurized
FL/FR
fatty
2-
dodecenal
FL/FR
(E)-2-
octen-1-ol
FL/FR
floral
citronellol
FL/FR
orange leaf absolute
FL/FR
fruity
iso
butyl 2-methyl butyrate
FL/FR
green
(+)-alpha-
campholenic aldehyde
FL/FR
canarium luzonicum oil
FL/FR
alpha-
farnesene
FL/FR
alpha-
farnesene isomer
FL/FR
galbanum oleoresin
FL/FR
galbanum resinoid
FL/FR
methyl heptenone
FL/FR
(E)-
nerolidol
FL/FR
(E,E)-2,6-
nonadienal
FL
2,4-
octadienal
FL
octanal diethyl acetal
FL/FR
octanal dimethyl acetal
FL/FR
herbal
beer flavor
FL
iso
dihydrolavandulal
FL/FR
green hexanal
FL/FR
hop absolute
FL/FR
hop cone oil
FL/FR
hop flavor
FL
hop oil
FL/FR
hop oleoresin
FL/FR
humulus lupulus cone extract
FL/FR
humulus lupulus distillates
FL/FR
humulus lupulus extract modified
FL
humulus lupulus extract solid
FL
humulus lupulus tincture
FL/FR
malty
yeast thiazoline
FL
minty
(-)-iso
pulegol
FL/FR
iso
pulegol
FL/FR
orris
costus root oil
FL
soapy
dodecanal (aldehyde C-12 lauric)
FL/FR
spicy
hop oil CO2 extract
FL/FR
2-
octanol
FL/FR
black
pepper oil CO2 extract
FL/FR
terpenic
alpha-
phellandrene
FL/FR
waxy
undecanal
FL/FR
yeasty
beer
FL
beer CO2 extract
FL/FR
 
Potential Uses:
 antimicrobial agents
FRapple
 astringents
FLbeverage
 chocolate cocoa
 emollients
FRherbal
FRmalt
FRorange
FRpear
 skin conditioning
 soothing agents
FLtomato
FLtonic
FLtropical
 
Occurrence (nature, food, other):note
 hop
Search Trop Picture
 
Synonyms:
 extract of the hops, humulus lupulus l., cannabidaceae
 hop CL (Symrise)
 hop extract
extrapone hop GW (Symrise)
 hops extract
 hops extract HS 2367 G
 hops extract LS 3473 G
 hops extract natural
 hops P.E
 phytovital hops
 

Articles:

PubMed:Effects of Xanthohumol-Rich Hop Extract on the Differentiation of Preadipocytes.
PubMed:Comprehensive separation and structural analyses of polyphenols and related compounds from bracts of hops (Humulus lupulus L.).
PubMed:Effects of xanthohumol-rich extract from the hop on fatty acid metabolism in rats fed a high-fat diet.
PubMed:A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine.
PubMed:Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols.
PubMed:In vitro and in vivo antioxidant and antimutagenic activities of polyphenols extracted from hops (Humulus lupulus L.).
PubMed:Antiadherent and antibiofilm activity of Humulus lupulus L. derived products: new pharmacological properties.
PubMed:Comparative study of antioxidant properties and total phenolic content of the extracts of Humulus lupulus L. and quantification of bioactive components by LC-MS/MS and GC-MS.
PubMed:A semi-automatic microextraction in packed sorbent, using a digitally controlled syringe, combined with ultra-high pressure liquid chromatography as a new and ultra-fast approach for the determination of prenylflavonoids in beers.
PubMed:Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo.
PubMed:Effects of extracts of Humulus lupulus (hops) and Yucca schidigera applied alone or in combination with monensin on rumen fermentation and microbial populations in vitro.
PubMed:Evaluation of the effect of Humulus lupulus alcoholic extract on rifampin-sensitive and resistant isolates of Mycobacterium tuberculosis.
PubMed:Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells.
PubMed:Optimized mixture of hops rho iso-alpha acids-rich extract and acacia proanthocyanidins-rich extract reduces insulin resistance in 3T3-L1 adipocytes and improves glucose and insulin control in db/db mice.
PubMed:META060 protects against diet-induced obesity and insulin resistance in a high-fat-diet fed mouse.
PubMed:The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm.
PubMed:Hop bitter acids inhibit tumorigenicity of hepatocellular carcinoma cells in vitro.
PubMed:Hop (Humulus lupulus L.) extract inhibits obesity in mice fed a high-fat diet over the long term.
PubMed:Dose-response relationships for the antifeedant effects of Humulus lupulus extracts against larvae and adults of the Colorado potato beetle.
PubMed:Hop bitter acids exhibit anti-fibrogenic effects on hepatic stellate cells in vitro.
PubMed:Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).
PubMed:[Effects of ethanol extracts of herbal medicines on dermatitis in an atopic dermatitis mouse model].
PubMed:The extract from hop cones (Humulus lupulus) as a modulator of oxidative stress in blood platelets.
PubMed:Increased sexual motivation in female rats treated with Humulus lupulus L. extract.
PubMed:A dietary supplement to improve the quality of sleep: a randomized placebo controlled trial.
PubMed:Effects of hops (Humulus lupulus L.) extract on volatile fatty acid production by rumen bacteria.
PubMed:Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes.
PubMed:Experimental evidence of the anaphrodisiac activity of Humulus lupulus L. in naïve male rats.
PubMed:The antimicrobial effects of hops (Humulus lupulus L.) on ruminal hyper ammonia-producing bacteria.
PubMed:Oestrogenicity of prenylflavonoids from hops: activation of pro-oestrogens by intestinal bacteria.
PubMed:In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.
PubMed:Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS.
PubMed:Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system.
PubMed:Antimutagenicity of hops (Humulus lupulus L.): bioassay-directed fractionation and isolation of xanthohumol.
PubMed:Effects of aqueous hop (Humulus Lupulus L.) extract on vascular reactivity in rats: mechanisms and influence of gender and hormonal status.
PubMed:Modulation of breast cancer cell survival by aromatase inhibiting hop (Humulus lupulus L.) flavonoids.
PubMed:NMR assignment of iso-alpha-acids from isomerised extracts of Humulus lupulus L. cones.
PubMed:Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in mice.
PubMed:Determination of xanthohumol in hops (Humulus lupulus L.) by nonaqueous CE.
PubMed:Flavonoid glycosides extracted from hop (Humulus lupulus L.) as inhibitors of chemical mediator release from human basophilic KU812 cells.
PubMed:Behavioural response of Colorado potato beetle (Leptinotarsa decemlineata) larvae to selected plant extracts.
PubMed:Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy.
PubMed:Effects of hop extracts on nasal rubbing and sneezing in BALB/c mice.
PubMed:Effects of beer and hop on ionotropic gamma-aminobutyric acid receptors.
PubMed:Selective inhibition of COX-2 by a standardized CO2 extract of Humulus lupulus in vitro and its activity in a mouse model of zymosan-induced arthritis.
PubMed:A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts.
PubMed:Anti-inflammatory acylphloroglucinol derivatives from Hops (Humulus lupulus).
PubMed:Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1.
PubMed:Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.
PubMed:Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense).
PubMed:New insight in the neuropharmacological activity of Humulus lupulus L.
PubMed:Estrogens and congeners from spent hops (Humulus lupulus).
PubMed:The antimycobacterial components of hops (Humulus lupulus) and their dereplication.
PubMed:Direct characterization of bitter acids in a crude hop extract by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
PubMed:Occupational airborne and hand dermatitis to hop (Humulus lupulus) with non-occupational relapses.
PubMed:Comparison of the most odor-active compounds in fresh and dried hop cones (Humulus lupulus L. variety spalter select) based on GC-olfactometry and odor dilution techniques.
PubMed:Molecular characterization and genome organization of 7SL RNA genes from hop (Humulus lupulus L.).
PubMed:Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones.
PubMed:Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus.
 
Notes:
Relaxant in bath preparations, Anti-fungal agent.
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