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2,4-dihydroxybenzoic acid
2,4-resorcylic acid

Supplier Sponsors

Name:2,4-dihydroxybenzoic acid
CAS Number: 89-86-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:201-946-9
FDA UNII:LU39SC9JYL
Nikkaji Web:J4.310I
Beilstein Number:1946213
MDL:MFCD00002451
XlogP3:1.60 (est)
Molecular Weight:154.12162000
Formula:C7 H6 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
According to JECFA: Melting point is "225 (decomposes, rapid heating required)".
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:908 2,4-dihydroxybenzoic acid
FLAVIS Number:08.076 (Old)
DG SANTE Food Flavourings:08.076 2,4-dihydroxybenzoic acid
FEMA Number:3798 2,4-dihydroxybenzoic acid
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):89-86-1 ; 2,4-DIHYDROXYBENZOIC ACID
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 225.00 to 227.00 °C. @ 760.00 mm Hg
Flash Point: 425.00 °F. TCC ( 218.33 °C. )
logP (o/w): 1.630
Soluble in:
 alcohol
 water, 1.122e+004 mg/L @ 25 °C (est)
 water, 5780 mg/L @ 25 °C (exp)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Strength:low
Odor Description:at 100.00 %. mild phenolic
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Beijing Lys Chemicals
2,4-Dihydroxybenzoic Acid
BOC Sciences
For experimental / research use only.
2,4-Dihydroxybenzoic Acid 98%
EMD Millipore
For experimental / research use only.
2,4-Dihydroxybenzoic Acid
Endeavour Specialty Chemicals
2,4-Dihydroxybenzoic acid
Speciality Chemical Product Groups
ExtraSynthese
For experimental / research use only.
beta-Resorcylic acid (HPLC) ≥90%
Jalor-Chem
For experimental / research use only.
2,4-Dihydroxybenzoic Acid
Parchem
2,4-dihydroxybenzoic acid
Penta International
2,4-DIHYDROXYBENZOIC ACID
Robinson Brothers
2,4-Dihydroxybenzoic acid F&F
https://www.robinsonbrothers.uk/chemistry-competences
Santa Cruz Biotechnology
For experimental / research use only.
2,4-Dihydroxybenzoic Acid
Sigma-Aldrich
2,4-Dihydroxybenzoic acid, ≥97%
Certified Food Grade Products
TCI AMERICA
For experimental / research use only.
2,4-Dihydroxybenzoic Acid >98.0%(T)
WholeChem
2,4-Dihydroxybenzoic Acid, 97+%
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 > 800 mg/kg
Highest dose applied was not lethal.
(Grady et al., 1976)

intraperitoneal-mouse LD50 > 800 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 196, Pg. 478, 1976.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
Recommendation for 2,4-dihydroxybenzoic acid usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 5.50 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 6.00 (μg/capita/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 17
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): 500.00000500.00000
beverages(alcoholic): 500.00000500.00000
breakfast cereal: 500.00000500.00000
cheese: 500.00000500.00000
chewing gum: 3333.000003333.00000
condiments / relishes: 500.00000500.00000
confectionery froastings: --
egg products: 500.00000500.00000
fats / oils: 500.00000500.00000
fish products: 500.00000500.00000
frozen dairy: 450.00000450.00000
fruit ices: 500.00000500.00000
gelatins / puddings: 500.00000500.00000
granulated sugar: --
gravies: 500.00000500.00000
hard candy: --
imitation dairy: 500.00000500.00000
instant coffee / tea: 125.00000125.00000
jams / jellies: 500.00000500.00000
meat products: 100.00000100.00000
milk products: 100.00000100.00000
nut products: 500.00000500.00000
other grains: --
poultry: 500.00000500.00000
processed fruits: --
processed vegetables: 100.00000100.00000
reconstituted vegetables: 500.00000500.00000
seasonings / flavors: 25000.0000025000.00000
snack foods: 500.00000500.00000
soft candy: 500.00000500.00000
soups: 250.00000250.00000
sugar substitutes: 12500.0000012500.00000
sweet sauces: 500.00000500.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23
View page or View pdf

Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87.
View page or View pdf

EPI System: View
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):89-86-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :1491
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
2,4-dihydroxybenzoic acid
Chemidplus:0000089861
RTECS:VH3708050 for cas# 89-86-1
 
References:
 2,4-dihydroxybenzoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):1491
Pubchem (sid):134970609
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB29666
FooDB:FDB000842
Export Tariff Code:2918.29.7500
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 avocado
Search Trop Picture
 beer
Search PMC Picture
 chamomile sweet false chamomile plant
Search Trop Picture
 coffee
Search PMC Picture
 willow leaf
Search Picture
 
Synonyms:
4-carboxyresorcinol
2,4-dihydroxy benzoic acid
2,4-dihydroxy-benzoic acid
4-hydroxysalicylic acid
p-hydroxysalicylic acid
para-hydroxysalicylic acid
beta-resorcinolic acid
2,4-resorcylic acid
b-resorcylic acid
beta-resorcylic acid
 
 
Notes:
Found in avocado, beer, wine and coffee. Food flavour ingredient and flavour modifier
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