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Category:flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | pale yellow clear oily liquid to solid (est) |
| Assay: | 98.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.96500 to 0.96900 @ 20.00 °C.
|
| Pounds per Gallon - (est).: | 8.039 to 8.072
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| Refractive Index: | 1.51700 to 1.52100 @ 20.00 °C.
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| Melting Point: | 23.00 to 28.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 117.00 to 118.00 °C. @ 12.00 mm Hg
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| Boiling Point: | 242.00 to 244.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.063000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 222.00 °F. TCC ( 105.56 °C. )
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| logP (o/w): | 3.970 |
| Soluble in: |
| | alcohol | | | water, 101.3 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor Type: animal |
| leathery animal |
| Odor Description:at 0.10 % in dipropylene glycol. russian leather |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xn - Harmful. |
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
Acute toxicity, Oral (Category 4), H302
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
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| GHS Label elements, including precautionary statements |
| |
| Pictogram |  |
| |
| Signal word | Warning |
| Hazard statement(s) |
H302 - Harmful if swallowed
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H335 - May cause respiratory irritation
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| Precautionary statement(s) |
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 - Wash skin thouroughly after handling.
P270 - Do not eat, drink or smoke when using this product.
P271 - Use only outdoors or in a well-ventilated area.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P301 + P312 - IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302 + P352 - IF ON SKIN: wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 - Call a POISON CENTER or doctor/physician if you feel unwell.
P330 - Rinse mouth.
P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention.
P337 + P313 - IF eye irritation persists: Get medical advice/attention.
P362 - Take off contaminated clothing and wash before reuse.
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed.
P405 - Store locked up.
P501 - Dispose of contents/ container to an approved waste disposal plant.
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| Oral/Parenteral Toxicity: |
gavage-mouse LD50 [sex: M] 1080 mg/kg
(McOmie et al., 1949)
oral-mouse LD50 1080 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 38, Pg. 366, 1949.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| Recommendation for 6-tert-butyl-meta-cresol usage levels up to: | | | 0.0200 % in the fragrance concentrate.
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| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.061 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 420 (μg/person/day) |
| Threshold of Concern: | 1800 (μg/person/day) |
| Structure Class: | I |
| |
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| | average usage mg/kg | maximum usage mg/kg |
| Dairy products, excluding products of category 02.0 (01.0): | 0.50000 | 2.50000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 0.20000 | 1.00000 |
| Edible ices, including sherbet and sorbet (03.0): | 0.50000 | 2.50000 |
| Processed fruit (04.1): | 0.40000 | 2.00000 |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
| Confectionery (05.0): | 1.00000 | 5.00000 |
| Chewing gum (05.3): | - | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 0.20000 | 1.00000 |
| Bakery wares (07.0): | 2.00000 | 10.00000 |
| Meat and meat products, including poultry and game (08.0): | 0.20000 | 1.00000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 0.20000 | 1.00000 |
| Eggs and egg products (10.0): | - | - |
| Sweeteners, including honey (11.0): | - | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 0.30000 | 1.50000 |
| Foodstuffs intended for particular nutritional uses (13.0): | 0.50000 | 2.50000 |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 0.20000 | 1.00000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 1.00000 | 5.00000 |
| Ready-to-eat savouries (15.0): | 2.00000 | 10.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 0.40000 | 2.00000 |
Safety References:
References:
Other Information:
Potential Blenders and core components note
| For Odor |
| animal |
iso butyl quinoline
FR |
iso butyl quinoline
FR |
2-iso butyl quinoline
FR |
6- methyl quinoline
FL/FR |
| chocolate |
vanillyl ethyl ether
FL/FR |
| coffee |
furfuryl mercaptan
FL/FR |
| floral |
alpha- amyl cinnamyl acetate
FL/FR |
cananga oil
FL/FR |
cananga oil china
FL/FR |
citronellol
FL/FR |
dimethyl octanol
FL/FR |
floral methanol
FR |
orris pyridine 25% IPM
FR |
| fruity |
ethyl 3-hydroxyhexanoate
FL/FR |
leather propionate
FR |
osmanthus flower absolute
FL/FR |
| green |
3,7- dimethyl-6-octenoic acid
FL/FR |
oakmoss oil
FR |
phenoxyacetaldehyde 50% in benzyl alcohol
FR |
| herbal |
saffron indenone
FL/FR |
thyme undecane
FR |
| leathery |
4-tert- butyl phenol
CS |
castoreum absolute
FL/FR |
leather cyclohexanol
FR |
| marine |
marine pyridine
FR |
| nutty |
2,3- dimethyl pyrazine
FL/FR |
| phenolic |
2,3- dimethyl benzofuran
FL/FR |
ortho- guaiacol
FL/FR |
4- methyl-2,6-dimethoxyphenol
FL/FR |
piper betle leaf oil
FR |
2- propyl phenol
FL/FR |
2,5- xylenol
FL/FR |
| smoky |
birch tar oil
FL/FR |
cade oil
FR |
2,6- dimethoxyphenol
FL/FR |
alpha- ethoxy-ortho-cresol
FL/FR |
4- ethyl phenol
FL/FR |
propyl paraben
CS |
pyroligneous acids
FL/FR |
pyroligneous acids hickory
FL/FR |
| spicy |
cubeb oil
FL/FR |
cuminyl alcohol
FL/FR |
4- ethyl guaiacol
FL/FR |
4- methyl guaiacol
FL/FR |
pepper tree berry oil
FL/FR |
| tobacco |
3- ethyl pyridine
FL/FR |
| woody |
guaiacyl acetate
FL/FR |
methyl cedryl ketone
FL/FR |
| For Flavor |
| No flavor group found for these |
benzyl disulfide
FL |
birch tar oil
FL/FR |
2,6- dimethoxy-4-vinyl phenol
FL |
alpha- ethoxy-ortho-cresol
FL/FR |
2- furfurylidene butyraldehyde
FL |
1- methyl pyrrole
FL |
prenyl mercaptan
FL |
2- propyl phenol
FL/FR |
| animal |
| animal |
6- methyl quinoline
FL/FR |
| caramellic |
3- ethyl pyridine
FL/FR |
| chemical |
2,3- dimethyl benzofuran
FL/FR |
| coffee |
furfuryl mercaptan
FL/FR |
| earthy |
alpha- amyl cinnamyl acetate
FL/FR |
| fatty |
dimethyl octanol
FL/FR |
| floral |
cananga oil
FL/FR |
cananga oil china
FL/FR |
citronellol
FL/FR |
3,7- dimethyl-6-octenoic acid
FL/FR |
| fruity |
ethyl 3-hydroxyhexanoate
FL/FR |
osmanthus flower absolute
FL/FR |
| herbal |
saffron indenone
FL/FR |
| leathery |
castoreum absolute
FL/FR |
| meaty |
4- allyl-2,6-dimethoxyphenol
FL |
| medicinal |
2,6- dimethoxyphenol
FL/FR |
| musty |
2,5- xylenol
FL/FR |
| nutty |
2,3- dimethyl pyrazine
FL/FR |
| onion |
2- methyl-1,3-dithiolane
FL |
| phenolic |
4- methyl-2,6-dimethoxyphenol
FL/FR |
| rummy |
vanillyl ethyl ether
FL/FR |
| smoky |
4- ethyl phenol
FL/FR |
pyroligneous acids
FL/FR |
pyroligneous acids hickory
FL/FR |
dextro- xylose
FL |
| spicy |
chipotle chili oleoresin
FL |
cubeb oil
FL/FR |
cuminyl alcohol
FL/FR |
4- methyl guaiacol
FL/FR |
pepper tree berry oil
FL/FR |
| woody |
4- ethyl guaiacol
FL/FR |
ortho- guaiacol
FL/FR |
guaiacyl acetate
FL/FR |
methyl cedryl ketone
FL/FR |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzene, 1-tert-butyl-2-hydroxy-4-methyl- | | 6-tert- | butyl-3-cresol | | 4-tert- | butyl-3-methyl phenol | | 4-tert- | butyl-3-methylphenol | | 6-tert- | butyl-3-methylphenol | | 2-tert- | butyl-5-methyl phenol | | 2-tert- | butyl-5-methylphenol | | 6-tert- | butyl-m-cresol | | p-tert- | butyl-m-cresol | | para-tert- | butyl-meta-cresol | | 2-(tert- | butyl)-5-methylphenol | | m- | cresol, 6-tert-butyl- | | 2-(1,1- | dimethylethyl)-5-methylphenol | | 5- | methyl-2-(2-methyl-2-propanyl)phenol | | 5- | methyl-2-(tert-butyl) phenol | | 5- | methyl-2-(tert-butyl)phenol | | 5- | methyl-2-tert-butylphenol | | 3- | methyl-6-tert-butylphenol | | | phenol, 2- (1, 1-dimethylethyl)-5-methyl- | | | phenol, 2-(1,1-dimethylethyl)-5-methyl- | | | phenol, 2-tert-butyl-5-methyl- |
Articles:
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3D/inchi