calamus leaf oil
acorus calamus leaf oil
 
Notes:
tsca definition 2008: extractives and their physically modified derivatives. acorus calamus, araceae.
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Name: acorus calamus l. leaf oil
CAS Number: 8015-79-0 
CoE Number: 13
Also Contains: acorus calamus root extract
Category: fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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FDA Regulation:
FDA PART 189 -- SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD
Subpart C--Substances Generally Prohibited From Direct Addition or Use as Human Food
Sec. 189.110 Calamus and its derivatives.
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Physical Properties:
Appearance: pale yellow clear liquid (est)
Food Chemicals Codex Listed: No
Soluble in:
 alcohol
Insoluble in:
 water
Similar Items: note
acorus calamus extract hydrogenated
acorus calamus l. rhizome oil
acorus calamus l. root extract
acorus calamus l. root oil
acorus calamus l. root oil mongolia
acorus calamus l. root powder
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Organoleptic Properties:
Odor Type: spicy
Odor Strength: medium
 spicy  clove  calamus  
Odor Description:
at 100.00 %. 
spicy clove
  
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-guinea pig LD50  297 mg/kg
BEHAVIORAL: TETANY BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Antibiotics and Chemotherapy Vol. 7, Pg. 378, 1957.

intraperitoneal-mouse LD50  177 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 11, Pg. 163, 1959.

intravenous-mouse LD50  1138 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Dissertationes Pharmaceuticae. Vol. 16, Pg. 447, 1964.

intraperitoneal-rat LD50  221 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Food and Cosmetics Toxicology. Vol. 15, Pg. 623, 1977.

oral-rat LD50  777 mg/kg
BEHAVIORAL: TREMOR
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

Dermal Toxicity:
skin-guinea pig LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 15, Pg. 623, 1977.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: fragrance agents
IFRA fragrance material specification:
 cis- and trans-Asarone as such should not be used as fragrance ingredients; essential oils containing cis- or trans-asarone (e.g. calamus oils) should not be used at a level such that the total concentration of cis- and trans-asarone exceeds 0.01% in consumer products.
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
methyl eugenol Max. Found: <0.90 % and Reason: Potential carcinogenic activity in animals
Recommendation for calamus leaf oil usage levels up to:
  3.0000 % in the fragrance concentrate.
 
Recommendation for calamus leaf oil flavor usage levels up to:
 not for flavor use.
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Safety References:
Chemical Carcinogenesis Research Information System: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 8015-79-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 acorus calamus l. leaf oil
Chemidplus: 0008015790
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References:
 acorus calamus l. leaf oil
Canada Domestic Sub. List: 8015-79-0
Pubchem (sid): 135326359
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Other Information:
FDA Everything Added to Food in the United States (EAFUS): View
 Typical G.C.
Wikipedia: View
FAO: BASIC PRINCIPLES OF STEAM DISTILLATION
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 calamus leaf
Search Trop  Picture
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Synonyms:
 acorus americanus leaf oil
 acorus angustatus leaf oil
 acorus angustifolius leaf oil
 acorus asiaticus leaf oil
 acorus calamus leaf oil
 acorus calamus var. americanus leaf oil
 acorus calamus var. angustatus leaf oil
 acorus calamus var. angustifolius leaf oil
 acorus calamus var. spurius leaf oil
 acorus calamus var. verus leaf oil
 acorus calamus var. vulgaris leaf oil
 acorus cochinchinensis leaf oil
 acorus griffithii leaf oil
 acorus spurius leaf oil
 acorus triqueter leaf oil
 acorus verus leaf oil
 orontium cochinchinense leaf oil
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Articles:
PubMed: Assessment of litter degradation in medicinal plants subjected to ultraviolet-B radiation.
PubMed: Chemical compositions, phytotoxicity, and biological activities of Acorus calamus essential oils from Nepal.
PubMed: Identification, characterization, and palynology of high-valued medicinal plants.
PubMed: Effects of perchlorate on growth of four wetland plants and its accumulation in plant tissues.
PubMed: [Influence of perennial flooding and drought on growth restoration of Acorus calamus in water-level-fluctuation zone of the Three Gorges Reservoir].
PubMed: Efficacy of natural products against Callosobruchus chinensis (Coleoptera: Bruchidae) in Nepal.
PubMed: Terpenoid composition and antifungal activity of three commercially important essential oils against Aspergillus flavus and Aspergillus niger.
PubMed: Anti-inflammatory activity of a water extract of Acorus calamus L. leaves on keratinocyte HaCaT cells.
PubMed: Antifungal properties of haem peroxidase from Acorus calamus.
PubMed: Long-term anoxia tolerance in leaves of Acorus calamus L. and Iris pseudacorus L.
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