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cyclamen propanal
bourgeonal (Givaudan)

Supplier Sponsors

Fragrance Demo Formulas
Name:3-(4-tert-butylphenyl)propanal
CAS Number: 18127-01-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:242-016-2
FDA UNII:H3XVS6E70V
Nikkaji Web:J260.882K
Beilstein Number:2439407
MDL:MFCD00169819
XlogP3-AA:3.30 (est)
Molecular Weight:190.28566000
Formula:C13 H18 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.95500 to 0.96100 @ 25.00 °C.
Pounds per Gallon - (est).: 7.947 to 7.996
Refractive Index:1.50800 to 1.51200 @ 20.00 °C.
Boiling Point: 111.00 °C. @ 5.00 mm Hg
Boiling Point: 300.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.009000 mm/Hg @ 25.00 °C. (est)
Flash Point:> 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w): 3.486 (est)
Soluble in:
 alcohol
 water, 21.05 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: floral
Odor Strength:medium ,
recommend smelling in a 10.00 % solution or less
Substantivity:104 hour(s) at 100.00 %
fresh watery floral cyclamen sweet
Odor Description:at 10.00 % in dipropylene glycol. fresh watery floral cyclamen sweet
Luebke, William tgsc, (1986)
Odor sample from: Naarden International
Odor and/or flavor descriptions from others (if found).
Givaudan
Bourgeonal
Odor Description:Floral, Green, Muguet, Fresh, Powerful
Bourgeonal is a powerful, diffusive fresh floral muguet, with a watery green character. Its unique muguet-aldehyde character is extensively used in toiletries and alcoholic fragrances.
Moellhausen
BOURGEONAL
Odor Description:fresh, strong-floral, muguet-note, watery
PerfumersWorld
Bourgeonal
Odor Description:fresh floral watery muguet-note lilial sandalwood-depth
Perfumery Laboratory
BURGENAL® Givaudan (Bourgeonal® Givaudan)
Odor Description:powerful, fresh, watery fragrance of lilies of the valley with a touch of greenery
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
3-(4-tert-Butylphenyl)propanal
Odor: characteristic
Use: A potent agonist at hOR17-4 (a human testicular olfactory receptor)
Diffusions Aromatiques
LILIONAL – BOURGEONAL
Ernesto Ventós
BOURGEONAL
Odor: STRONG FLORAL-MUGUET NOTE
Givaudan
Bourgeonal
Odor: Floral, Green, Muguet, Fresh, Powerful
Use: Bourgeonal is a powerful, diffusive fresh floral muguet, with a watery green character. Its unique muguet-aldehyde character is extensively used in toiletries and alcoholic fragrances.
Indukern F&F
BOURGEONAL
Odor: FLORAL, WATERY, MUGUET
Jiangyin Healthway
Bourgeonal
New functional food ingredients
Lluch Essence
BOURGEONAL
M&U International
LILIPHENAL (BOURGEONAL), Kosher
Moellhausen
BOURGEONAL
Odor: fresh, strong-floral, muguet-note, watery
O'Laughlin Industries
LILIONAL FORTE
O'Laughlin Industries
LILIONAL
OQEMA
Langeonal
PCW France
Ligeonal
Steps to a fragranced product
Pearlchem Corporation
Pearlgeonal/Bourgeonal
Penta International
BOURGEONAL
PerfumersWorld
Bourgeonal
Odor: fresh floral watery muguet-note lilial sandalwood-depth
Perfumery Laboratory
BURGENAL® Givaudan (Bourgeonal® Givaudan)
Odor: powerful, fresh, watery fragrance of lilies of the valley with a touch of greenery
Phoenix Aromas & Essential Oils
Bourgeonal
Santa Cruz Biotechnology
For experimental / research use only.
Bourgeonal 98%
The John D. Walsh Company
Bourgeonal
The Lermond Company
Bourgeonal
Vigon International
Bourgeonal (Cyclamen Propanal)
Odor: Floral, Green, Muguet, Fresh, Powerful
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 2700 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 287, 1988.

Dermal Toxicity:
skin-rabbit LDLo 5000 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 287, 1988.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: fragrance agents
IFRA Critical Effect: Sensitization
IFRA fragrance material specification:
 Should not be used such that the level in the finished cosmetic product exceeds 0.6%. Based on test results showing sensitising potential and no sensitisation reactions when tested at 6%. (IFRA guidelines).
Fragrance usage is IFRA RESTRICTED. View Standard for complete information.
Please review all IFRA documents for complete information.
IFRA categories: limits in the finished product: (For a description of the categories, refer to the IFRA QRA Information Booklet.)
Category 1:
See Note (1)
0.03 % (1)
Category 2:  0.04 %
Category 3:  0.20 %
Category 4:  0.50 %
Category 5:  0.30 %
Category 6:  0.80 % (1)
Category 7:  0.10 %
Category 8:  0.60 %
Category 9:  0.60 %
Category 10:  0.60 %
Category 11: See Note (2)
 Notes:
 

For this material, for pragmatic reasons, restrictive levels allowed by the QRA for certain categories but actually being higher than those already in place before applying the QRA, will temporarily not be implemented until the end of a 5 year monitoring phase. At the end of the 5 years the position will be reevaluated again.

 

(1) IFRA would recommend that any material used to impart perfume or flavour in products intended for human ingestion should consist of ingredients that are in compliance with appropriate regulations for foods and food flavourings in the countries of planned distribution and, where these are lacking, with the recommendations laid down in the Code of Practice of IOFI (International Organisation of the Flavor Industry). Further information about IOFI can be found on its website (www.iofi.org).

 

(2) Category 11 includes all non-skin contact or incidental skin contact products. Due to the negligible skin contact from these types of products there is no justification for a restriction of the concentration of this fragrance ingredient in the finished product.

 
Recommendation for cyclamen propanal flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA Substance Registry Services (TSCA):18127-01-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :64832
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:2
3-(4-tert-butylphenyl)propanal
Chemidplus:0018127010
 
References:
 3-(4-tert-butylphenyl)propanal
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:18127-01-0
Pubchem (cid):64832
Pubchem (sid):135021788
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2912.29.0090
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
aldehydic
adoxal (Givaudan)
FL/FR
citrus carbaldehyde
FR
decanal (aldehyde C-10)
FL/FR
6,7,8-
decen-1-ol
FR
9-
decenal
FL/FR
dodecanal (aldehyde C-12 lauric)
FL/FR
fresh carbaldehyde
FR
nonanal (aldehyde C-9)
FL/FR
10-
undecenal (aldehyde C-11 undecylenic)
FL/FR
amber
amber carane
FR
anisic
para-
anisaldehyde
FL/FR
balsamic
amyris wood oil
FL/FR
siam
benzoin resinoid
FL/FR
benzyl salicylate
FL/FR
iso
butyl cinnamate
FL/FR
cinnamyl alcohol
FL/FR
clover nitrile
FR
ethyl cinnamate
FL/FR
fir balsam absolute
FR
3-
phenyl propyl alcohol
FL/FR
berry
raspberry ketone
FL/FR
raspberry ketone acetate
FL/FR
raspberry ketone methyl ether
FL/FR
citrus
citral
FL/FR
citrus specialty
FR
lime oil distilled mexico
FL/FR
lime pyran
FR
limonene aldehyde
FR
tetrahydrocitral
FL/FR
fatty
decanol
FL/FR
(E,Z)-2,6-
dodecadienal
FL/FR
floral
alpha-
amyl cinnamaldehyde
FL/FR
alpha-
amyl cinnamaldehyde diethyl acetal
FR
iso
amyl salicylate
FL/FR
bois de rose oil brazil
FL/FR
iso
butyl salicylate
FL/FR
citronellol
FL/FR
citronellyl acetate
FL/FR
coriander seed oil
FL/FR
cyclamen aldehyde
FL/FR
cyclohexyl ethyl alcohol
FL/FR
dihydrojasmone
FL/FR
dimethyl anthranilate
FL/FR
dimethyl benzyl carbinol
FL/FR
dimethyl benzyl carbinyl acetate
FL/FR
floral pyranol
FR
floral specialty
FR
gardenia oxide
FR
geraniol
FL/FR
geranyl acetate
FL/FR
heliotropin
FL/FR
heliotropyl acetone
FL/FR
heliotropyl diethyl acetal
FR
(Z)-3-
hexen-1-yl salicylate
FL/FR
alpha-
hexyl cinnamaldehyde
FL/FR
hyacinth ether
FR
hydroxycitronellal
FL/FR
jasimia
FR
leerall
FR
linalool
FL/FR
linalool oxide
FL/FR
methyl dihydrojasmonate
FL/FR
mimosa absolute france
FL/FR
muguet carboxaldehyde
FR
muguet octadienol
FR
nerol
FL/FR
nerolidol
FL/FR
neryl acetate
FL/FR
ocean propanal
FL/FR
octahydro-4,7-methano-1H-indene-5-acetaldehyde + 6-methyl-octahydro-4,7-methano-indene-5-carbaldehyd
FR
orris pyridine 25% IPM
FR
peony alcohol
FR
clementine
petitgrain oil
FL/FR
phenethyl alcohol
FL/FR
phenethyl phenyl acetate
FL/FR
phenethyl salicylate
FL/FR
rhodinol
FL/FR
rose butanoate
FL/FR
tetrahydrolinalool
FL/FR
verdyl acetate
FR
violet methyl carbonate
FR
fruity
allyl amyl glycolate
FR
dimethyl benzyl carbinyl isobutyrate
FR
green
acetaldehyde ethyl phenethyl acetal
FL/FR
iso
cyclocitral (IFF)
FL/FR
green carbaldehyde
FR
(Z)-3-
hexen-1-ol
FL/FR
(Z)-3-
hexen-1-yl benzoate
FL/FR
ivy carbaldehyde
FL/FR
2,4-
ivy carbaldehyde
FL/FR
3,5-
ivy carbaldehyde
FL/FR
2,4-
ivy carbaldehyde / methyl anthranilate schiff's base
FR
(Z)-
leaf acetal
FL/FR
melon nonenoate
FL/FR
(E)-2-
octen-1-yl acetate
FL/FR
olive oil absolute
FL/FR
phenyl acetaldehyde dimethyl acetal
FL/FR
phenyl acetaldehyde ethylene glycol acetal
FR
violet leaf absolute
FL/FR
hay
hay absolute
FR
herbal
clary sage oil france
FL/FR
daucus carota fruit oil
FL/FR
linalyl acetate
FL/FR
pine hexanol
FR
marine
marine pyridine
FR
ocean carboxaldehyde
FR
ozone propanal
FR
melon
watermelon ketone
FR
mossy
veramoss (IFF)
FR
naphthyl
beta-
naphthyl ethyl ether
FL/FR
powdery
para-
anisyl alcohol
FL/FR
spicy
iso
eugenyl acetate
FL/FR
terpenic
alpha-
terpineol
FL/FR
tonka
tonka bean absolute
FR
vanilla
ethyl vanillin
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillyl acetate
FL/FR
waxy
decanal diethyl acetal
FL/FR
decyl acetate
FL/FR
1-
dodecanol
FL/FR
ethyl laurate
FL/FR
1-
undecanol
FL/FR
woody
cedryl methyl ether
FR
guaiacwood oil
FL/FR
patchouli ethanone
FR
santall
FR
tobacarol (IFF)
FR
woody acetate
FR
(Z)-
woody amylene
FR
For Flavor
No flavor group found for these
9-
decenal
FL/FR
3,5-
ivy carbaldehyde
FL/FR
ivy carbaldehyde
FL/FR
tetrahydrocitral
FL/FR
aldehydic
aldehydic
nonanal (aldehyde C-9)
FL/FR
1-
undecanol
FL/FR
balsamic
siam
benzoin resinoid
FL/FR
benzyl salicylate
FL/FR
iso
butyl cinnamate
FL/FR
ethyl cinnamate
FL/FR
berry
heliotropyl acetone
FL/FR
raspberry ketone
FL/FR
raspberry ketone acetate
FL/FR
raspberry ketone methyl ether
FL/FR
cherry
heliotropin
FL/FR
citrus
citral
FL/FR
lime oil distilled mexico
FL/FR
linalool
FL/FR
nerol
FL/FR
clementine
petitgrain oil
FL/FR
alpha-
terpineol
FL/FR
cooling
iso
butyl salicylate
FL/FR
creamy
para-
anisaldehyde
FL/FR
fatty
(Z)-3-
hexen-1-yl benzoate
FL/FR
10-
undecenal (aldehyde C-11 undecylenic)
FL/FR
floral
bois de rose oil brazil
FL/FR
citronellol
FL/FR
citronellyl acetate
FL/FR
dihydrojasmone
FL/FR
dimethyl benzyl carbinyl acetate
FL/FR
geraniol
FL/FR
linalyl acetate
FL/FR
methyl dihydrojasmonate
FL/FR
neryl acetate
FL/FR
ocean propanal
FL/FR
phenethyl alcohol
FL/FR
rhodinol
FL/FR
tetrahydrolinalool
FL/FR
fruity
para-
anisyl alcohol
FL/FR
dimethyl anthranilate
FL/FR
rose butanoate
FL/FR
green
acetaldehyde ethyl phenethyl acetal
FL/FR
iso
amyl salicylate
FL/FR
cinnamyl alcohol
FL/FR
cyclamen aldehyde
FL/FR
iso
cyclocitral (IFF)
FL/FR
cyclohexyl ethyl alcohol
FL/FR
(E,Z)-2,6-
dodecadienal
FL/FR
geranyl acetate
FL/FR
(Z)-3-
hexen-1-ol
FL/FR
(Z)-3-
hexen-1-yl salicylate
FL/FR
2,4-
ivy carbaldehyde
FL/FR
(Z)-
leaf acetal
FL/FR
linalool oxide
FL/FR
melon nonenoate
FL/FR
nerolidol
FL/FR
(E)-2-
octen-1-yl acetate
FL/FR
phenyl acetaldehyde dimethyl acetal
FL/FR
violet leaf absolute
FL/FR
herbal
clary sage oil france
FL/FR
coriander seed oil
FL/FR
daucus carota fruit oil
FL/FR
honey
phenethyl phenyl acetate
FL/FR
medicinal
dimethyl benzyl carbinol
FL/FR
phenethyl salicylate
FL/FR
oily
olive oil absolute
FL/FR
powdery
beta-
naphthyl ethyl ether
FL/FR
soapy
dodecanal (aldehyde C-12 lauric)
FL/FR
1-
dodecanol
FL/FR
spicy
iso
eugenyl acetate
FL/FR
3-
phenyl propyl alcohol
FL/FR
tropical
alpha-
amyl cinnamaldehyde
FL/FR
vanilla
ethyl vanillin
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillyl acetate
FL/FR
waxy
adoxal (Givaudan)
FL/FR
decanal (aldehyde C-10)
FL/FR
decanal diethyl acetal
FL/FR
decanol
FL/FR
decyl acetate
FL/FR
ethyl laurate
FL/FR
alpha-
hexyl cinnamaldehyde
FL/FR
hydroxycitronellal
FL/FR
mimosa absolute france
FL/FR
woody
amyris wood oil
FL/FR
guaiacwood oil
FL/FR
 
Potential Uses:
FRaldehydic
FRcyclamen
FRfloral
FRgreen
FRlily
FRlily of the valley
FRorange blossom
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 benzenepropanal, 4-(1,1-dimethylethyl)-
 bourgeonal (Givaudan)
 burgeonal
p-tert-butyl dihydrocinnamaldehyde
para-tert-butyl dihydrocinnamaldehyde
para-tert-butyl hydrocinnamic aldehyde
3-(4-tert-butyl phenyl) propanal
3-(4-tert-butyl phenyl) propionaldehyde
3-(4-tert-butyl-phenyl)propionaldehyde
3-(4-(tert-butyl)phenyl)propanal
p-tert-butyldihydrocinnamaldehyde
para-tert-butyldihydrocinnamaldehyde
p-tert-butylhydrocinnamic aldehyde
3-(4-tert-butylphenyl)propanal
3-(4-tert-butylphenyl)propionaldehyde
 cyclamen propanal
4-(1,1-dimethyl ethyl) benzene propanal
3-(4-(1,1-dimethyl ethyl)-phenyl) propanal
3-(4-(1,1-dimethylethyl)-phenyl)propanal
4-(1,1-dimethylethyl)benzenepropanal
 langeonal
 lilional
 lilional forte
 liliphenal
3-[4-(2-methyl-2-propanyl)phenyl]propanal
 

Articles:

PubMed:Decreased perception of bourgeonal may be linked to male idiopathic infertility.
PubMed:Human olfactory sensitivity for bourgeonal and male infertility: a preliminary investigation.
PubMed:Novel bourgeonal fragrance conjugates for the detection of prostate cancer.
PubMed:The CatSper channel: a polymodal chemosensor in human sperm.
PubMed:Ultra-high olfactory sensitivity for the human sperm-attractant aromatic aldehyde bourgeonal in CD-1 mice.
PubMed:Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm.
PubMed:Designing exons for human olfactory receptor gene subfamilies using a mathematical paradigm.
PubMed:Olfactory sensitivity for sperm-attractant aromatic aldehydes: a comparative study in human subjects and spider monkeys.
PubMed:Human male superiority in olfactory sensitivity to the sperm attractant odorant bourgeonal.
PubMed:Odor interaction between Bourgeonal and its antagonist undecanal.
PubMed:Behavioral response of human spermatozoa to a concentration jump of chemoattractants or intracellular cyclic nucleotides.
PubMed:Odorant design based on the carbon/silicon switch strategy.
PubMed:Prediction of perception: probing the hOR17-4 olfactory receptor model with silicon analogues of bourgeonal and lilial.
PubMed:Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.
PubMed:Olfaction: attracting both sperm and the nose.
PubMed:Dual capacity of a human olfactory receptor.
PubMed:Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis.
PubMed:Identification of a testicular odorant receptor mediating human sperm chemotaxis.
PubMed:Development. Smelling the roses?
 
Notes:
None found
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