EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
BT
 

dihydroanethol
p-propylanisole

Sponsors

Fragrance Demo Formulas
Name: 1-methoxy-4-propylbenzene
CAS Number: 104-45-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 203-203-4
FDA UNII: 932XJ1O77X
Nikkaji Web: J22.133C
Beilstein Number: 2042121
MDL: MFCD00027121
CoE Number: 11835
XlogP3: 3.50 (est)
Molecular Weight: 150.22078000
Formula: C10 H14 O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 1244 p-propylanisole
Flavis Number: 04.039 (Old)
DG SANTE Food Flavourings: 04.039 1-methoxy-4-propylbenzene
FEMA Number: 2930 p-propylanisole
FDA Mainterm: P-PROPYLANISOLE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance: colorless to pale yellow clear oily liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: Yes
Specific Gravity: 0.94000 to 0.94300 25.00 °C.
Pounds per Gallon - (est).: 7.822 to 7.847
Refractive Index: 1.50300 to 1.50600 @ 20.00 °C.
Boiling Point: 212.00 to 213.00 °C. @ 760.00 mm Hg
Boiling Point: 104.00 to 107.00 °C. @ 20.00 mm Hg
Vapor Pressure: 0.266000 mm/Hg @ 25.00 °C. (est)
Flash Point: 194.00 °F. TCC ( 90.00 °C. )
logP (o/w): 3.656 (est)
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage: store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 alcohol
 fixed oils
 water, 63.36 mg/L @ 25 °C (est)
Insoluble in:
 glycerin
 propylene glycol
 water
Similar Items: note
anethol
(E)-anethol
(Z)-anethol
 
Organoleptic Properties:
Odor Type: anisic
Odor Strength: medium ,
recommend smelling in a 10.00 % solution or less
Substantivity: 4 hour(s) at 100.00 %
 sweet anise licorice sassafrass fennel
Odor Description:
at 10.00 % in dipropylene glycol.
sweet anise licorice sassafrass fennel
Luebke, William tgsc, (1993)
 sweet anise licorice black licorice herbal fennel root beer
Odor Description:
at 1.00 % in ethyl alcohol.
Intense, lingering sweet anise, licorice with an herbal fennel nuance. It is reminiscent of black cough drops and root beer
Mosciano, Gerard P&F 25, No. 6, 26, (2000)
Flavor Type: herbal
 herbal fennel sweet licorice black licorice sassafrass anise spicy basil
Taste Description:
at 1.00 - 15.00 ppm.
Intense herbal fennel sweetness reminiscent of black licorice, sassafras and anise. It has slight spicy basil-like nuances
Mosciano, Gerard P&F 25, No. 6, 26, (2000)
Odor and/or flavor descriptions from others (if found).
Moellhausen
DIHYDROANETHOLE
Odor Description: sweet aromatic, herbaceous, less candy-like and drier than anethole
Lluch Essence
DIHYDROANETHOL 99%
Odor Description: WOODY, ANISEED, HERBACEOUS
 
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
Augustus Oils
Dihydro Anethol
Services
Berjé
Dihydro Anethol
Happening at Berje
BOC Sciences
For experimental / research use only.
Dihydroanethol
Excellentia International
Dihydroanethole FCC
Frinton Laboratories
For experimental / research use only.
4-Propylanisole
Frutarom
DIHYDROANETHOLE
Lluch Essence
DIHYDROANETHOL 99%
Odor: WOODY, ANISEED, HERBACEOUS
Moellhausen
DIHYDROANETHOLE
Odor: sweet aromatic, herbaceous, less candy-like and drier than anethole
Northwestern Extract
dihydroanethol
O'Laughlin Industries
DIHYDROANETHOL
Penta International
DIHYDROANETHOLE, Kosher
Reincke & Fichtner
p-Propyl Anisole
Sigma-Aldrich
p-Propyl anisole, ≥99%, FCC, FG
Odor: anise; herbaceous.
Certified Food Grade Products
The Good Scents Company
dihydroanethol
Odor: sweet anise licorice sassafrass fennel
Vigon International
Dihydroanethole FCC
Odor: ANISE-TYPE ODOR, WITH SASSAFRAS BACKGROUND
Wanxiang International
Dihydro Anethole
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi N - Irritant, Dangerous for the environment.
R 36/38 - Irritating to skin and eyes.
R 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Flammable liquids (Category 4), H227
Acute toxicity, Oral (Category 5), H303
Acute aquatic toxicity (Category 2), H401
Chronic aquatic toxicity (Category 2), H411
GHS Label elements, including precautionary statements
 
Pictogramenvironment.jpg
 
Signal word 104-45-0
Hazard statement(s)
H227 - Combustible liquid
H303 - May be harmfulif swallowed
H401 - Toxic to aquatic life
H411 - Toxic to aquatic life with long lasting effects
Precautionary statement(s)
P210 - Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P273 - Avoid release to the environment.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P312 - Call a POISON CENTER or doctor/physician if you feel unwell.
P370 + P378 - In case of fire: Use appropriate media to extinguish.
P391 - Collect spillage. Hazardous to the aquatic environment
P403 + P235 - Store in a well-ventilated place. Keep cool.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Human Experience:
6 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 [sex: M,F] 4400 mg/kg
(Taylor et al., 1964)

oral-rat LD50 [sex: M,F] 4400 mg/kg
(Jenner et al., 1964)

oral-rat LD50 [sex: M,F] 4400 mg/kg
(Bär & Griepentrog, 1967)

oral-mouse LD50 7300 mg/kg
(Jenner et al., 1964)

oral-mouse LD50 7300 mg/kg
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SKIN AND APPENDAGES (SKIN): HAIR: OTHER SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

oral-rat LD50 4400 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 6, Pg. 378, 1964.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 789, 1975.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for dihydroanethol usage levels up to:
  10.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 20.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 114.00 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -67.00000
beverages(nonalcoholic): -4.30000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -9.90000
fruit ices: -9.90000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -64.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 23 (FGE.23): Aliphatic, alicyclic and aromatic ethers including anisole derivatives From chemical groups 15, 16 and 26 (Commission Regulation (EC) No 1565/2000 of 18 July 2000
View page or View pdf
Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010)
View page or View pdf
EPI System: View
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 104-45-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 7702
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 1-methoxy-4-propylbenzene
Chemidplus: 0000104450
RTECS: BZ9450000 for cas# 104-45-0
 
References:
 1-methoxy-4-propylbenzene
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 104-45-0
Pubchem (cid): 7702
Pubchem (sid): 134972876
Pherobase: View
 
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEMBL: View
HMDB (The Human Metabolome Database): HMDB32626
FooDB: FDB010570
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
 
Potential Blenders and core components note
For Odor
anise
star
anise seed oil china
FL/FR
anise seed oil colombia
FL/FR
sweet
fennel absolute
FL/FR
sweet
fennel oleoresin
FL/FR
sweet
fennel seed oil
FL/FR
foeniculum vulgare fruit extract
FL/FR
foeniculum vulgare mill. var. dulce d.c. fruit extract
FL/FR
anisic
para-
anisaldehyde
FL/FR
para-
anisyl propanal
FR
ocimum basilicum herb oil egypt
FL/FR
ocimum basilicum leaf oil CO2 extract
FL/FR
ocimum basilicum leaf oil india
FL/FR
balsamic
2-
acetyl furan
FL/FR
iso
amyl benzoate
FL/FR
amyris wood oil
FL/FR
siam
benzoin resinoid
FL/FR
ethyl cinnamate
FL/FR
fir balsam absolute
FR
3-
phenyl propyl alcohol
FL/FR
berry
raspberry ketone
FL/FR
caramellic
maltol
FL/FR
chocolate
iso
amyl phenyl acetate
FL/FR
citrus
blood
orange oil italy
FL/FR
floral
acetophenone
FL/FR
alpha-
amyl cinnamaldehyde
FL/FR
benzyl acetate
FL/FR
bois de rose oil brazil
FL/FR
coriander seed oil
FL/FR
cyclamen aldehyde
FL/FR
cyclohexyl ethyl alcohol
FL/FR
floral pyranol
FR
heliotropin
FL/FR
heliotropyl diethyl acetal
FR
alpha-
hexyl cinnamaldehyde
FL/FR
hyacinth ether
FR
leerall
FR
lilyall
FR
linalool oxide
FL/FR
methyl dihydrojasmonate
FL/FR
mimosa absolute france
FL/FR
nonanol
FL/FR
ocean propanal
FL/FR
phenethyl acetate
FL/FR
phenethyl alcohol
FL/FR
fruity
iso
amyl butyrate
FL/FR
benzyl propionate
FL/FR
beta-
damascone
FL/FR
gamma-
decalactone
FL/FR
ethyl heptanoate
FL/FR
(E,E)-
ethyl sorbate
FL/FR
methyl 2-methyl valerate
FL/FR
strawberry glycidate 1 (aldehyde C-16 (so-called))
FL/FR
para-
tolualdehyde
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
green
phenyl acetaldehyde dimethyl acetal
FL/FR
herbal
carum carvi fruit oil
FL/FR
daucus carota fruit oil
FL/FR
lavender absolute bulgaria
FL/FR
tricyclo(5.2.1.02,6)dec-3-enyl acetate
FR
licorice
anethol
FL/FR
(E)-
anethol
FL/FR
melon
(Z)-6-
nonenal
FL/FR
minty
laevo-
carvone
FL/FR
carvone
FL/FR
foeniculum vulgare capillaceum fruit extract
FR
spearmint oil america
FL/FR
wintergreen oil
FL/FR
phenolic
anisole
FL/FR
powdery
para-
anisyl acetate
FL/FR
para-
anisyl alcohol
FL/FR
spicy
artemisia dracunculus herb oil
FL/FR
cassia bark oil china
FL/FR
clove bud oil
FL/FR
black
pepper oil
FL/FR
pimenta acris leaf oil
FL/FR
tarragon oil replacer
FL/FR
tonka
tonka bean absolute
FR
vanilla
ethyl vanillin
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillin
FL/FR
woody
guaiacwood oil
FL/FR
patchouli ethanone
FR
santall
FR
(Z)-
woody amylene
FR
For Flavor
No flavor group found for these
anethol
FL/FR
carvone
FL/FR
tarragon oil replacer
FL/FR
beta-
damascone
FL/FR
anise
anise
(E)-
anethol
FL/FR
star
anise seed oil china
FL/FR
anise seed oil colombia
FL/FR
sweet
fennel absolute
FL/FR
sweet
fennel oleoresin
FL/FR
sweet
fennel seed oil
FL/FR
foeniculum vulgare fruit extract
FL/FR
foeniculum vulgare mill. var. dulce d.c. fruit extract
FL/FR
anisic
ocimum basilicum herb oil egypt
FL/FR
aromatic
anisole
FL/FR
balsamic
siam
benzoin resinoid
FL/FR
ethyl cinnamate
FL/FR
berry
raspberry ketone
FL/FR
caramellic
caramel furanone
FL
maltol
FL/FR
cherry
heliotropin
FL/FR
citrus
blood
orange oil italy
FL/FR
creamy
para-
anisaldehyde
FL/FR
gamma-
undecalactone (aldehyde C-14 (so-called))
FL/FR
floral
iso
amyl phenyl acetate
FL/FR
bois de rose oil brazil
FL/FR
methyl dihydrojasmonate
FL/FR
ocean propanal
FL/FR
phenethyl alcohol
FL/FR
fruity
iso
amyl benzoate
FL/FR
para-
anisyl acetate
FL/FR
para-
anisyl alcohol
FL/FR
benzyl acetate
FL/FR
benzyl propionate
FL/FR
gamma-
decalactone
FL/FR
ethyl heptanoate
FL/FR
(E,E)-
ethyl sorbate
FL/FR
methyl 2-methyl valerate
FL/FR
(E,E)-
methyl sorbate
FL
strawberry glycidate 1 (aldehyde C-16 (so-called))
FL/FR
green
cyclamen aldehyde
FL/FR
cyclohexyl ethyl alcohol
FL/FR
linalool oxide
FL/FR
(Z)-6-
nonenal
FL/FR
phenyl acetaldehyde dimethyl acetal
FL/FR
herbal
carum carvi fruit oil
FL/FR
coriander seed oil
FL/FR
daucus carota fruit oil
FL/FR
lavender absolute bulgaria
FL/FR
ocimum basilicum leaf oil CO2 extract
FL/FR
ocimum basilicum leaf oil india
FL/FR
honey
phenethyl acetate
FL/FR
minty
laevo-
carvone
FL/FR
spearmint oil america
FL/FR
wintergreen oil
FL/FR
nutty
2-
acetyl furan
FL/FR
powdery
acetophenone
FL/FR
spicy
artemisia dracunculus herb oil
FL/FR
cassia bark oil china
FL/FR
clove bud oil
FL/FR
black
pepper oil
FL/FR
3-
phenyl propyl alcohol
FL/FR
pimenta acris leaf oil
FL/FR
para-
tolualdehyde
FL/FR
tropical
alpha-
amyl cinnamaldehyde
FL/FR
vanilla
ethyl vanillin
FL/FR
vanilla bean absolute (vanilla planifolia)
FL/FR
vanillin
FL/FR
waxy
iso
amyl butyrate
FL/FR
alpha-
hexyl cinnamaldehyde
FL/FR
mimosa absolute france
FL/FR
nonanol
FL/FR
woody
amyris wood oil
FL/FR
guaiacwood oil
FL/FR
 
Potential Uses:
 absinthe 
 acacia cassie farnesianaFR
 aniseFR
 apple blossomFR
 apricotFR
 azzaro 
 basilFL/FR
 birch beerFL
 blueberryFR
 carnation dianthus oeilletFR
 cattle feed 
 cheese gouda 
 cherryFR
 clover trefle le'trefle incarnatFR
 detergents 
 fennelFL/FR
 fern fougereFR
 gardeniaFR
 gooseberryFR
 hay new mown hay foin coupeFR
 heliotropeFR
 herbalFR
 honey mielFR
 honeysuckle chevrefeuilleFR
 hyacinth jacintheFR
 jasminFR
 licoriceFR
 lilac lilas syringaFR
 lilyFR
 magnoliaFR
 metropolis 
 mimosaFR
 mintFR
 myrrhis odorata 
 nutFL
 pizzaFR
 quinceFR
 root beerFR
 sassafrasFR
 spiceFR
 strawberryFR
 tuberoseFR
 tuscany 
 vanillaFR
 violetFR
 wallflowerFR
 wintergreenFR
 woodyFR
 ylang ylangFR
 
Occurrence (nature, food, other): note
 anise
Search Trop Picture
 bonito mushroom
Search PMC Picture
 caper
Search Trop Picture
 katsuobushi
Search PMC Picture
 mentha rotundifolia
Search Trop Picture
 
Synonyms:
 anisole, 4-propyl-
 benzene, 1-methoxy-4-propyl-
 dihydro anethol
 dihydro anethole
 dihydroanethole
 dihydroanethole FCC
1-methoxy-4-propyl benzene
1-methoxy-4-propylbenzene
 methyl 4-propylphenyl ether
 methyl p-propyl phenyl ether
 methyl p-propylphenyl ether
 methyl para-propyl phenyl ether
4-propyl anisole
4-N-propyl anisole
p-propyl anisole
para-propyl anisole
para-N-propyl anisole
4-propyl methoxybenzene
p-propyl methoxybenzene
para-propyl methoxybenzene
4-propylanisole
4-N-propylanisole
p-propylanisole
p-N-propylanisole
para-propylanisole
p-propylmethoxybenzene
 
 
Notes:
Partial replacement for safrol and root beer types. Flavouring ingredient. Present in dried bonito (Katsuobishi), capers (Caparis spinosa), aniseed (Pimpinella anisum), leaf oil of apple mint (Mentha rotundifolia) and flower honeys
 
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