an isomer of estragole; structurally similar to capsaicin; has some neurological and insecticidal and skin absorption effects.
  • Bontoux
    • Bontoux SAS
      Major international supplier
      Major international Producer of aromatic ingredients for the production of fragrances, flavors, cosmetics, pharmaceuticals and Aromathopy.
      Bontoux Inc. was established in 1993 to directly service our North American clientele. The facility primarily serves as a Sales Customer Service, Repacking and Distribution Center for our customers in North America.
      Email: Information
      US Email: Information
      Email: Sales
      US Email: Sales
      Voice: + 33.(0)
      Fax: + 33.(0)
      US Voice: + 1.908.755.4800
      US Fax: + 1.908.755.4844
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
      Email: Sales
      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
      US Fax: 908-359-9002
      A0007B Anethole, Kosher
      N0191 NAT. ANETHOL
  • O'Laughlin Industries
    • O'Laughlin Industries Inc.
      Manufacturer of Aroma
      Leading the Flavor and Fragrance Industry since 1980.
      O'Laughlin was established in 1980 by its owner and chief executive Michael O'Laughlin, when he moved to Beijing, China and established a small office. Since then it has grown to be a world class producer of chemicals, with significant production facilities in China, and distribution and sales in all major world markets.
      Email: Sales
      US Email: Joe Schreiber
      Voice: (852) 2527-1031
      Fax: (852) 2529-0231
      US Voice: (973) 376-4600
      US Fax: (973) 376-4630
      771-2004 ANETHOLE NATURAL
  • Treatt
    • R C Treatt and Co Ltd
      Innovative ingredient solutions
      World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.
      We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products.
      Email: Enquiries
      US Email: Enquiries
      Voice: +44 (0) 1284 702500
      Fax: +44 (0) 1284 703809
      US Voice: +1 863 668 9500
      US Fax: +1 863 668 3388
      Anethol Ex Fennel Natural
Synonyms   Articles   Notes   Search
1-methoxy-4-prop-1-enylbenzene (Click)
CAS Number: 104-46-1Picture of molecule
Other: 12002-40-3
ECHA EINECS - REACH Pre-Reg: 203-205-5
Beilstein Number: 0774229
MDL: MFCD00009284
CoE Number: 183
XlogP3: 3.30 (est)
Molecular Weight: 148.20484000
Formula: C10 H12 O
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
Flavis Number: 04.088 (Old)
DG SANTE Food Flavourings: 04.088  1-methoxy-4-(1-propenyl)benzene
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Physical Properties:
Appearance: colorless to pale yellow liquid to solid (est)
Assay: 98.00 to 100.00 % sum of isomers
Food Chemicals Codex Listed: No
Melting Point: 21.00 to  23.00 °C. @ 760.00 mm Hg
Boiling Point: 235.00 to  239.00 °C. @ 760.00 mm Hg
Boiling Point: 145.00 to  146.00 °C. @ 50.00 mm Hg
Vapor Pressure: 0.069000 mm/Hg @ 25.00 °C. (est)
Flash Point: 191.00 °F. TCC ( 88.40 °C. ) (est)
logP (o/w): 3.390
Soluble in:
 water, 111 mg/L @ 25 °C (exp)
Similar Items: note
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Organoleptic Properties:
Odor Type: licorice
Odor Strength: medium
 sweet  anise  licorice  medicinal  
Odor Description:
at 100.00 %. 
sweet anise licorice medicinal
Odor and/or flavor descriptions from others (if found).
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: denaturants
masking agents
Synonyms   Articles   Notes   Search   Top
Natural Anethol
98.00 to 99 % sum of isomers
CG Herbals
De Monchy Aromatics
Odor: sweet, anise, licorice, mimosa
Inoue Perfumery
M&U International
Anethole, Kosher
M&U International
Noble Molecular Research
For experimental / research use only.
O'Laughlin Industries
Pearlchem Corporation
Anethole Natural
Perfumery Laboratory
Odor: Intense, sweet aroma of anise with aromatic nuances of liquorice
Anethol Ex Fennel Natural
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-guinea pig LD50  2160 mg/kg
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

intraperitoneal-mouse LD50  593 mg/kg
Yakugaku Zasshi. Journal of Pharmacy. Vol. 104, Pg. 793, 1984.

oral-mouse LD50  3050 mg/kg
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

oral-rat LD50  2090 mg/kg
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

intraperitoneal-rat LD50  70 mg/kg
Journal of Agricultural and Food Chemistry. Vol. 17, Pg. 497, 1969.

oral-bird - wild LD50  316 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.

intraperitoneal-rat LDLo  70 mg/kg
Journal of Agricultural and Food Chemistry. Vol. 17, Pg. 497, 1969.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 11, Pg. 863, 1973.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
Synonyms   Articles   Notes   Search   Top
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of trans-anethole used as a flavor ingredient.View pdf
EPI System: View search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 104-46-1
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 7703
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
Chemidplus: 0000104461
EPA/NOAA CAMEO: hazardous materials
RTECS: BZ9275000 for cas# 104-46-1
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NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 104-46-1
Pubchem (cid): 7703
Pubchem (sid): 134972877
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
KEGG (GenomeNet): C10428
HMDB (The Human Metabolome Database): Search
YMDB (Yeast Metabolome Database): YMDB01637
Haz-Map: View
MedlinePlusSupp: View
Typical G.C.
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
grades: usp (technical); fcc (food chemicals codex).
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
For Odor
alpha-allyl-4-methyl-3-cyclohexene methanol 
sweet fennel absoluteFL/FR
sweet fennel oleoresinFL/FR
 foeniculum vulgare fruit extractFL/FR
 foeniculum vulgare mill. var. dulce d.c. fruit extractFL/FR
para-anisyl propanalFR
 ocimum basilicum leaf oil indiaFL/FR
(E,E)-ethyl sorbateFL/FR
 foeniculum vulgare capillaceum fruit extractFR
 tarragon oil replacerFL/FR
For Flavor
No flavor group found for these
 tarragon oil replacerFL/FR
alpha-allyl-4-methyl-3-cyclohexene methanol 
sweet fennel absoluteFL/FR
sweet fennel oleoresinFL/FR
 foeniculum vulgare fruit extractFL/FR
 foeniculum vulgare mill. var. dulce d.c. fruit extractFL/FR
(E,E)-ethyl sorbateFL/FR
(E,E)-methyl sorbateFL
 ocimum basilicum leaf oil indiaFL/FR
Synonyms   Articles   Notes   Search   Top
Potential Uses:
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 celery seed oil egypt @ 0.61%
Data  GC  Search Trop  Picture
 helichrysum arenarium (l.) moench oil hungary @ 3.20%
Data  GC  Search Trop  Picture
 liriodendron chinense
Search Trop  Picture
 liriodendron tulipifera
Search Trop  Picture
 magnolia southern magnolia
Search Trop  Picture
 michelia compressa
Search Trop  Picture
 osmanthus absolute @ 0.06%
Data  GC  Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
 acintene O
 anethol ex fennel natural
 anethol natural
 anethol natural isolate
 anethole natural
 anethole NF/FCC synthetic
 anethole rectified, natural
 anise camphor
4-methoxy-1-propenyl benzene
1-methoxy-4-(1-propenyl) benzene
1-methoxy-4-propenyl benzene
p-methoxy-beta-methyl styrene
para-methoxy-beta-methyl styrene
4-methoxypropenyl benzene
4-propenyl anisole
p-propenyl anisole
para-propenyl anisole
para-1-propenyl anisole
p-propenyl methoxybenzene
para-propenyl methoxybenzene
p-propenyl phenyl methyl ether
para-propenyl phenyl methyl ether
Synonyms   Articles   Notes   Search   Top
PubMed: Oral fennel (Foeniculum vulgare) drop effect on primary dysmenorrhea: Effectiveness of herbal drug.
PubMed: Effect of naturally occurring antimicrobials and chemical preservatives on the growth of Aspergillus Parasiticus.
PubMed: Anti-inflammatory effects of several plant extracts on porcine alveolar macrophages in vitro.
PubMed: Chemical composition and in vitro cytotoxic, genotoxic effects of essential oil from Urtica dioica L.
PubMed: Perinatal flavour learning and adaptation to being weaned: all the pig needs is smell.
PubMed: An examination of the potential effect of lipids on the first-pass metabolism of the lipophilic drug anethol trithione.
PubMed: Brazilian red propolis: unreported substances, antioxidant and antimicrobial activities.
PubMed: Functional involvement of Ca(2+) and Ca(2+)-activated K(+) channels in anethol-induced changes in Ca(2+) dependent excitability of F1 neurons in Helix aspersa.
PubMed: [The clinical therapic efficiency of anethol trithione on dry eye].
PubMed: Phytochemical analysis and allelopathic activity of essential oils of Ecballium elaterium A. Richard growing in Iran.
PubMed: Lipid-based formulations to enhance oral bioavailability of the poorly water-soluble drug anethol trithione: effects of lipid composition and formulation.
PubMed: Development of an attractant-baited trap for Oxythyrea funesta Poda (Coleoptera: Scarabaeidae, Cetoniinae).
PubMed: The life of an anise-flavored alcoholic beverage: does its stability cloud or confirm theory?
PubMed: Effects of essential oils from fennel (Foeniculi aetheroleum) and caraway (Carvi aetheroleum) in pigs.
PubMed: Molecular targets of dietary agents for prevention and therapy of cancer.
PubMed: Plant extracts affect in vitro rumen microbial fermentation.
PubMed: Secondary metabolites from Ganoderma lucidum and Spongiporus leucomallellus.
PubMed: Spontaneously formed trans-anethol/water/alcohol emulsions: mechanism of formation and stability.
PubMed: Effect of some volatile oils on the affinity of intact and oxidized low-density lipoproteins for adrenal cell surface receptors.
PubMed: Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning.
PubMed: Role of chemopreventive agents in cancer therapy.
PubMed: From chemoprevention to chemotherapy: common targets and common goals.
PubMed: Improved growth and essential oil yield and quality in Foeniculum vulgare mill on mycorrhizal inoculation supplemented with P-fertilizer.
PubMed: Phytochemical characterization of essential oil from Ocimum selloi.
PubMed: [New data on composition of esssential oil from inflorescence of everlasting (Helichrysum arenarium(L.) Moench.)].
PubMed: Inhibition of oxidation of human low-density lipoproteins by phenolic substances in different essential oils varieties.
PubMed: Assessment of the role of glutathione conjugation in the protection afforded by anethol dithiolthione against hexachloro-1,3-butadiene-induced nephrotoxicity.
PubMed: Kairomone from dandelion,Taraxacum officinale, attractant for scarab beetleAnomala octiescostata.
PubMed: Protective effect of anethol dithiolthione against acetaminophen hepatotoxicity in mice.
PubMed: Cerebral chemosensory evoked potentials elicited by chemical stimulation of the human olfactory and respiratory nasal mucosa.
PubMed: Identification and quantitation of a metabolite of anethol dithiolthione in rat and mouse urine using high-performance liquid chromatography.
PubMed: Inhibitory effects of spices on growth and toxin production of toxigenic fungi.
PubMed: [Experimental psychotropic action of cis and trans isomers of anethol].
PubMed: [Quantitative determination of anethol in the raw materials and products of hydrobromine treatment in the production of sinestrol].
PubMed: [Studies on the solubility of terpin hydrate and anethol].
PubMed: [Chronic toxicity of trans-anethol and of anisated liqueurs with a base of anethol and licorice].
PubMed: [Studies on the pattern of metal-catalyzed oxidation in ethereal oils (anethol)].
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