lactoyl ethanolamine phosphate
2-(2-hydroxypropanoylamino)ethyl dihydrogen phosphate
Used as a food additive [EAFUS]
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2-(2-hydroxypropanoylamino)ethyl dihydrogen phosphate (Click)
CAS Number: 782498-03-7Picture of molecule
% from: 90.00% to 94.00%
XlogP3-AA: -2.50 (est)
Molecular Weight: 213.12660200
Formula: C5 H12 N O6 P
NMR Predictor: Predict (works with chrome or firefox)
Also(can) Contains: ammonium formate 6.00% to 10.00%
EFSA/JECFA Comments: (Flavour Industry, 2008; EFFA, 2006). Racemate (EFFA, 2010).
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Perfumer and Flavorist: Search
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Pubchem Patents: Search
JECFA Food Flavoring: 1775  N-lactoyl ethanolamine phosphate
Flavis Number: 16.104 (Old)
DG SANTE Food Flavourings: 16.104  2-[(2-hydroxypropanoyl)amino]ethyl dihydrogen phosphate
FEMA Number: 4257  N-lactoyl ethanolamine phosphate
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Physical Properties:
Appearance: colorless to yellow clear viscous liquid to solid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.51700 to 1.52400 @  25.00 °C.
Pounds per Gallon - (est).: 12.623 to 12.681
Refractive Index: 1.49800 to 1.51400 @  20.00 °C.
Melting Point: 200.00 °C. @ 760.00 mm Hg
Boiling Point: 387.00 to  400.00 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -3.379 (est)
Soluble in:
 alcohol, slightly
 water, 1e+006 mg/L @ 25 °C (est)
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Organoleptic Properties:
Odor Strength: low
 cooked  brown  roasted  
Taste Description:
cooked brown roasted
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Cosmetic Information:
None found
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Aston Chemical
For experimental / research use only.
N-Lactoyl Ethanolamine Phosphonate
lactoyl ethanolamine phosphate
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavoring agents
Recommendation for lactoyl ethanolamine phosphate usage levels up to:
 not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 12.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 5.00 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 2700 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 23
Click here to view publication 23
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): 5.0000015.00000
beverages(alcoholic): 5.0000015.00000
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: 5.0000015.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 5.0000015.00000
fruit ices: 5.0000015.00000
gelatins / puddings: 5.0000015.00000
granulated sugar: --
gravies: 5.0000015.00000
hard candy: 5.0000015.00000
imitation dairy: 5.0000015.00000
instant coffee / tea: --
jams / jellies: 5.0000015.00000
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: 5.0000015.00000
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 5.0000015.00000
snack foods: --
soft candy: 5.0000015.00000
soups: --
sugar substitutes: --
sweet sauces: --
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 5.0000015.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): --
Edible ices, including sherbet and sorbet (03.0): 5.0000015.00000
Processed fruit (04.1): 5.0000015.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 5.0000015.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): --
Bakery wares (07.0): --
Meat and meat products, including poultry and game (08.0): --
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): --
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000015.00000
Foodstuffs intended for particular nutritional uses (13.0): --
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 5.0000015.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 5.0000015.00000
Ready-to-eat savouries (15.0): 5.0000015.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): --
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Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on Flavouring Group Evaluation 94: Consideration of aliphatic amines and amides evaluated in addendum to the JECFA group aliphatic and aromatic amines and amides by JECFA
View page or View pdf
(FGE.94Rev1): Consideration of aliphatic amines and amides evaluated in an addendum to the group of aliphatic and aromatic amines and amides evaluated by the JECFA (68th meeting)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 94, Revision 2 (FGE.94Rev2): Consideration of aliphatic amines and amides evaluated in an addendum to the group of aliphatic and aromatic amines and amides evaluated by the JECFA (68th meeting)
View page or View pdf
EPI System: View
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 11550267
National Institute of Allergy and Infectious Diseases: Data
 2-(2-hydroxypropanoylamino)ethyl dihydrogen phosphate
Chemidplus: 0782498037
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 2-(2-hydroxypropanoylamino)ethyl dihydrogen phosphate
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 11550267
Pubchem (sid): 126514098
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
HMDB (The Human Metabolome Database): HMDB32357
FooDB: FDB009683
ChemSpider: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
For Odor
For Flavor
No flavor group found for these
3,6-diethyl-1,2,4,5-tetrathiane and 3,5-diethyl-1,2,4-trithiolane mixture 1% in vegetable oil triglyceriFL
3-(ethyl thio) butanolFL
(Z+E)-5-ethyl-4-methyl-2-(2-butyl) thiazolineFL
(Z+E)-5-ethyl-4-methyl-2-(2-methyl propyl) thiazolineFL
1-phenyl-3(5)-propyl pyrazoleFL
3-isopropenyl pentane dioic acidFL
3-(methyl thio) methyl thiopheneFL
2-methyl-1-methyl thio-2-buteneFL
 propyl 2-mercaptopropionateFL
 lactoyl ethanolamineFL
(±)-3-(methyl thio) heptanalFL
2,4,6-trithiaheptane 10% in triacetinFL
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Potential Uses:
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Occurrence (nature, food, other): note
 not found in nature
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N-2-hydroxyethyl lactamide phosphate
2-((2-hydroxyproanoyl)amino)ethyl dihydrogen phosphate
2-[(2-hydroxypropanoyl)amino]ethyl dihydrogen phosphate
2-(2-hydroxypropanoylamino)ethyl dihydrogen phosphate
(+/-)-N-lactoyl ethanolamine phosphate
N-lactoyl ethanolamine phosphate
N-lactoyl ethanolamine phosphate, (+/-)-
 propanamide, 2-hydroxy-N-(2-(phosphonooxy)ethyl)-
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 None found yet.
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