EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

phenyl salicylate
phenyl 2-hydroxybenzoate


Name:phenyl 2-hydroxybenzoate
CAS Number: 118-55-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-259-2
Nikkaji Web:J5.300G
Beilstein Number:0393969
CoE Number:11814
XlogP3:3.80 (est)
Molecular Weight:214.22030000
Formula:C13 H10 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:antimicrobial agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
JECFA Food Flavoring:736 phenyl salicylate
FLAVIS Number:09.689 (Old)
DG SANTE Food Flavourings:09.689 phenyl salicylate
FEMA Number:3960 phenyl salicylate
FDA Regulation:
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1010 Acrylic and modified acrylic plastics, semirigid and rigid.
Physical Properties:
Appearance:colorless crystalline solid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 43.00 to 46.00 °C. @ 760.00 mm Hg
Boiling Point: 172.00 to 173.00 °C. @ 12.00 mm Hg
Boiling Point: 304.00 to 306.00 °C. @ 760.00 mm Hg
Acid Value: 1.00 max. KOH/g
Vapor Pressure:0.000421 mm/Hg @ 25.00 °C. (est)
Flash Point:> 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w): 3.292 (est)
Soluble in:
 water, 76.7 mg/L @ 25 °C (est)
 water, 150 mg/L @ 25 °C (exp)
Insoluble in:
Similar Items:note
allyl salicylate
amyl salicylate
isoamyl salicylate
benzyl salicylate
bornyl salicylate
butyl salicylate
isobutyl salicylate
cinnamyl salicylate
ortho-cresyl salicylate
para-cresyl salicylate
cyclohexyl salicylate
decyl salicylate
2-ethyl hexyl salicylate
ethyl salicylate
heptyl salicylate
(Z)-3-hexen-1-yl salicylate
hexyl salicylate
menthyl salicylate
homomenthyl salicylate
2-methyl butyl salicylate
methyl salicylate
octyl salicylate
phenethyl salicylate
3-phenyl propyl salicylate
prenyl salicylate
propyl salicylate
isopropyl salicylate
Organoleptic Properties:
Odor Type: balsamic
Odor Strength:medium
sweet fruity balsamic
Odor Description:at 100.00 %. mild sweet fruity balsam
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
perfuming agents
Phenyl Salicylate
Happening at Berje
BOC Sciences
For experimental / research use only.
Phenyl Salicylate
phenyl salicylate
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
Phenyl Salicylate
Phenyl salicylate, ≥99%, FG
Certified Food Grade Products
For experimental / research use only.
Phenyl Salicylate >98.0%(GC)
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3000 mg/kg
Food and Cosmetics Toxicology. Vol. 14, Pg. 837, 1976.

intraperitoneal-mouse LD > 500 mg/kg
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 149, 1954.

oral-rabbit LDLo 3000 mg/kg
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
Category: antimicrobial agents
maximum skin levels for fine fragrances:
  0.0200 % and are based on the assumption that the fragrance mixture is used at 20% in a consumer product (IFRA Use Level Survey).
Recommendation for phenyl salicylate usage levels up to:
  2.0000 % in the fragrance concentrate.
use level in formulae for use in cosmetics:
  0.0200 %
Dermal Systemic Exposure in Cosmetic Products:
 0.0005 mg/kg/day
Maximised Survey-derived Daily Intakes (MSDI-EU): 7.30 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 8.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 19
 average usual ppmaverage maximum ppm
baked goods: 40.00000100.00000
beverages(nonalcoholic): 40.00000100.00000
beverages(alcoholic): 40.00000100.00000
breakfast cereal: 40.00000100.00000
cheese: --
chewing gum: 400.000001200.00000
condiments / relishes: --
confectionery froastings: 40.00000100.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 40.00000100.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: 40.00000100.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 40.00000100.00000
soups: --
sugar substitutes: --
sweet sauces: --
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 88, (FGE.88)[1] - Consideration of Phenol and Phenol Derivatives - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
EPI System: View
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):118-55-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8361
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
phenyl 2-hydroxybenzoate
EPA/NOAA CAMEO:hazardous materials
RTECS:VO6125000 for cas# 118-55-8
 phenyl 2-hydroxybenzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:118-55-8
Pubchem (cid):8361
Pubchem (sid):134973877
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
KEGG (GenomeNet):C14163
HMDB (The Human Metabolome Database):HMDB32018
Export Tariff Code:2918.23.5000
RSC Learn Chemistry:View
Potential Blenders and core components note
For Odor
hexyl cinnamate
octyl benzoate
cyclohexyl salicylate
rose undecene
tea acetate
tuberose acetate
cyclohexyl crotonate
fruity butanate
octyl acetate
tropical indene
green carboxylate
hexen-1-yl salicylate
hexoxyacetaldehyde dimethyl acetal
musk decanolide
For Flavor
Potential Uses:
 antimicrobial agents
Occurrence (nature, food, other):note
 not found in nature
 benzoic acid, 2-hydroxy-, phenyl ester
2-hydroxybenzoic acid phenyl ester
2-hydroxybenzoic acid, phenyl ester
 phenol salicylate
2-phenoxycarbonyl phenol
 phenyl 2-hydroxybenzoate
 salicylic acid phenyl ester
 salicylic acid, phenyl ester
 seesorb 201
 seesorb K 201


PubMed:Kinetics and Mechanism of the Flexible Nanoparticle-Catalyzed Piperidinolysis of Anionic Phenyl Salicylate.
PubMed:Kinetics and mechanism of nanoparticles-catalyzed piperidinolysis of anionic phenyl salicylate.
PubMed:A universal modified van der Waals equation of state. Part I: Polymer and mineral glass formers.
PubMed:Transition from Arrhenius to non-Arrhenius temperature dependence of structural relaxation time in glass-forming liquids: continuous versus discontinuous scenario.
PubMed:Study of the transformation of two salicylates used in personal care products in chlorinated water.
PubMed:Screening alternative therapies to control Nosemosis type C in honey bee (Apis mellifera iberiensis) colonies.
PubMed:Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity.
PubMed:Phenyl salicylates - a new group of potential antituberculotics.
PubMed:Synthesis of biologically active and photostable rigid poly(vinyl chloride).
PubMed:Modeling dynamics of isotropic dielectrics in a laminar heterogeneous configuration.
PubMed:The estrogenic potential of salicylate esters and their possible risks in foods and cosmetics.
PubMed:Temperature dependence of the Landau-Placzek ratio in glass forming liquids.
PubMed:Positron annihilation response and broadband dielectric spectroscopy: salol.
PubMed:The role of nucleation in vitrification of supercooled liquids.
PubMed:Kinetic and rheological measurements of the effects of inert 2-, 3- and 4-bromobenzoate ions on the cationic micellar-mediated rate of piperidinolysis of ionized phenyl salicylate.
PubMed:A new semi-empirical kinetic method for the determination of ion exchange constants for the counterions of cationic micelles.
PubMed:Determination of an ion exchange constant by the use of a kinetic probe: a new semiempirical kinetic approach involving the effects of 3-F- and 4-F-substituted benzoates on the rate of piperidinolysis of anionic phenyl salicylate in aqueous cationic micelles.
PubMed:Infrared spectroscopy study of structural changes in glass-forming salol.
PubMed:Density scaling and dynamic correlations in viscous liquids.
PubMed:Kinetic evidence for the occurrence of independent ion-exchange processes in the cationic micellar-mediated reaction of piperidine with anionic phenyl salicylate.
PubMed:The temperature dependence of free volume in phenyl salicylate and its relation to structural dynamics: a positron annihilation lifetime and pressure-volume-temperature study.
PubMed:A direct test of the correlation between elastic parameters and fragility of ten glass formers and their relationship to elastic models of the glass transition.
PubMed:Facilitation, complexity growth, mode coupling, and activated dynamics in supercooled liquids.
PubMed:Preparation of lipophilic alkyl (hydroxy)benzoates by solvent-free lipase-catalyzed esterification and transesterification.
PubMed:Mass spectrometric identification of covalent adducts of the skin allergen 2,4-dinitro-1-chlorobenzene and model skin proteins.
PubMed:Fragrance material review on phenyl salicylate.
PubMed:Degradation kinetics of hydrolytically susceptible drugs in O/W emulsions--effects of interfacial area and lecithin.
PubMed:Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein.
PubMed:Depolarized light scattering versus optical Kerr effect spectroscopy of supercooled liquids: comparative analysis.
PubMed:Cole-Cole law for critical dynamics in glass-forming liquids.
PubMed:Pharmaceutical quality control of acid and neutral drugs based on competitive self-assembly in amphiphilic systems.
PubMed:Interfacial effects on vitrification of confined glass-forming liquids.
PubMed:Slow dynamics of salol: a pressure- and temperature-dependent light scattering study.
PubMed:Brillouin scattering study of salol: exploring the effects of rotation-translation coupling.
PubMed:Can experiments select the configurational component of excess entropy?
PubMed:Viscosity at the dynamic crossover in o-terphenyl and salol under high pressure.
PubMed:Nearly logarithmic decay of correlations in glass-forming liquids.
PubMed:Effect of ultraviolet light absorbers on photostabilization of azadirachtin-A in solution (part: II).
PubMed:[Determination of 4 antiseptics and 6 sunscreen agents in cosmetic products by reversed-phase high performance liquid chromatography].
PubMed:Effect of some ultraviolet light absorbers on photo-stabilization of azadirachtin-A.
PubMed:Temperature and pressure dependence of the alpha relaxation and configurational entropy of a prototype glass former.
PubMed:[Determination of sunscreen agents in cosmetic products by reversed-phase high performance liquid chromatography].
PubMed:Orientational dynamics in supercooled liquids near T(c) and comparison with ideal mode-coupling theory
PubMed:Effects of
PubMed:Effects of Nonionic, Cationic, and Mixed Nonionic-Cationic Surfactants on the Acid-Base Behavior of Phenyl Salicylate.
PubMed:Effects of [NaOH] and [KBr] on Intramolecular General Base-Catalyzed Methanolysis of Ionized Phenyl Salicylate in the Presence of Cationic Micelles.
PubMed:Screening of antiadherent activity on Streptococcus sobrinus culture.
PubMed:Neighboring group catalysis in the design of nucleotide prodrugs.
PubMed:The effectiveness of benzyl benzoate and different chemicals as acaricides.
PubMed:[Stability of phenyl salicylate in alcoholic-aqueous solution].
PubMed:Biologic testing of leachable aromatic compounds from denture base materials.
PubMed:Tc of the mode coupling theory evaluated from impulsive stimulated light scattering on salol.
PubMed:Leaching from denture base materials in vitro.
PubMed:Reply to "Comment on 'Light-scattering investigation of alpha and beta relaxation near the liquid-glass transition of the molecular glass Salol' " and "Reexamination of the depolarized-light-scattering spectra of glass-forming liquids"
PubMed:Comment on "Light-scattering investigation of alpha and beta relaxation near the liquid-glass transition of the molecular glass Salol"
PubMed:Leaching of additives and degradation products from cold-cured orthodontic resins.
PubMed:Light-scattering spectroscopy of the liquid-glass transition in CaKNO3 and in the molecular glass Salol: Extended-mode-coupling-theory analysis.
PubMed:Brillouin scattering in salol: Determining Tc of the mode coupling theory.
PubMed:Light-scattering investigation of alpha and beta relaxation near the liquid-glass transition of the molecular glass Salol.
PubMed:Cross-sensitivity between resorcinol, resorcinol monobenzoate and phenyl salicylate.
PubMed:Specific-heat spectroscopy and dielectric susceptibility measurements of salol at the glass transition.
PubMed:Contact dermatitis from phenyl salicylate in a galenic cream.
PubMed:Direct observation of microbubbles in directional solidification of salol.
PubMed:Synthesis and evaluation of the analgesic and antiinflammatory activities of N,N'-bis(2-hydroxybenzoyl)-diaminoalkanes.
PubMed:Light scattering study of the glass transition in salol.
PubMed:Synthesis and evaluation of the analgesic and antiinflammatory activities of N-substituted salicylamides.
PubMed:Spectrophotometric determination of alkyl salicylate from the mixture of phenyl and alkyl salicylates by the use of the selective reactivity of phenyl salicylate toward secondary amines.
PubMed:Bile salt roles in bile-salt-stimulated lipase activity.
PubMed:Dermatitis from phenyl salicylate in safety spectacle frames.
PubMed:[Novel N-pyrazolylsalicylamides with antifungal activity].
PubMed:Transesterification: an analytical and formulation problem.
PubMed:High-performance liquid chromatographic analysis of iodochlorhydroxyquin and hydrocortisone in ointments and creams.
PubMed:Allergic contact dermatitis to various salols (phenyl salicylates). A structure-activity relationship study in man and in animal (guinea pig).
PubMed:Allergy to phenyl salicylate.
PubMed:In vitro transformation of hamster embryo cells by 3-(N-salicyloyl)amino-1,2,4-triazole.
PubMed:Phenyl salicylate (Salol) in a lip salve.
PubMed:Potassium hydroxide solution 10% for the fast hydrolysis of esters for analysis.
PubMed:Elevated urinary phenol levels in beagle dogs treated with salol.
PubMed:Elevated urinary phenol levels not related to benzene exposure.
PubMed:Reactions to aspirin and food additives in patients with chronic urticaria, including the physical urticarias.
PubMed:Fluroescence of phenyl salicylate.
PubMed:[Aluminiumlactate and salol for the prevention of periodontal diseases, AGEPHA oral hygiene drugs].
PubMed:[Assays of sodium noraminophenazone methanesulphonate, phenyl salicylate and papaverine hydrochloride in compound prescription forms].
PubMed:Experimental production of malformations due to acetyl salicylate and phenyl salicylate in rats.
PubMed:[Effect of additional components and of the granulation method on some properties of salol tablets].
PubMed:[Effect of aspirin and salol on gastrointestinal secretion in normal conditions and in experimental fever].
PubMed:[Possibilities of determination of salol in combination with thymol and chloride of pilocarpine in combination with chloride of novocaine].
PubMed:The salol reaction.
PubMed:The Treatment of Small-Pox by Salol.
PubMed:Salol Calculi.
Used as a food additive [EAFUS]
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